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MaIlz
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moledit-prompt-completion_all_tasks

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help me reduce QED score and improve molecular weight and synthetic accessibility of molecule CC(C)OCc1noc(CN2C[C@@H](C(=O)O)C3(CCCC3)C2)n1.
CCCC(CCBr)CC(C)OCc1noc(CN2C[C@@H](C(=O)O)C3(CCCC3)C2)n1
Help me improve the QED of molecule CC(C)c1cccc(OCc2c[nH]c(C(=O)N3CC[C@@]4(CN(C(=O)c5ccc(C(F)(F)F)nc5)CCO4)C3)c2)c1 to make it more like a drug
COCc1c[nH]c(C(=O)N2CC[C@@]3(CN(C(=O)c4ccc(C(F)(F)F)nc4)CCO3)C2)c1
help me reduce H-bond donors and improve LogP value and QED score of molecule Cn1ncc(C(N)=S)c1NC(=O)c1ccc(Cl)c(C(N)=[NH2+])c1.
Cc1cc(C(=O)Nc2c(C(N)=S)cnn2C)ccc1Cl
help me reduce LogP value and improve synthetic accessibility of molecule CC(C)(F)c1cc2c(c(C(CN)C(=O)O)c1)OCCO2.
CC(F)(C(N)=[NH2+])c1cc2c(c(C(CN)C(=O)O)c1)OCCO2
help me reduce GSK3β inhibitory activity and improve LogP value of molecule CC(C)(C)c1ccc(C(C)(C)C(N)=[NH2+])c(Oc2ccc(C(=O)[O-])cc2)c1.
CC(C)(C)c1ccc(C(C)(C)C)c(Oc2ccc(C(=O)[O-])cc2)c1
help me reduce hydrogen bond acceptors and H-bond donors of molecule CCOc1ccc2oc(C(=O)OC(C(=O)N(C)C)c3ccccc3)c(B(O)O)c2c1.
CCOc1ccc2oc(C(=O)OC(C(=O)N(C)C)c3ccccc3)c(C)c2c1
help me improve DRD2 binding affinity and synthetic accessibility of molecule Cc1cc(NC(c2ccc(F)cc2Cl)c2ccc3cccnc3c2O)ncc1F.
C=C[C@@H](CCCCCCC)c1cc(NC(c2ccc(F)cc2Cl)c2ccc3cccnc3c2O)ncc1F
help me reduce molecular weight and synthetic accessibility and improve LogP value and QED score of molecule CC(C[NH+](Cc1ccccc1)CN1CC2CNCC2(C(=O)NCCN2CCCOC2=O)C1)C(=O)[O-].
O=C1OCCCN1CCNC(=O)C12CNCC1CN(Cc1ccccc1)C2
help me reduce GSK3β inhibitory activity and improve QED score of molecule CC1C[NH+](Cc2coc(-c3ccc(C(N)=[NH2+])cc3)n2)CCC1[NH3+].
Cc1ccc(-c2nc(C[NH+]3CCC([NH3+])C(C)C3)co2)cc1
help me reduce GSK3β inhibitory activity and improve LogP value of molecule Cc1nc(CN)cc(-c2ccc3oc(=O)[nH]c3c2)n1.
CCCCCCCc1cc(-c2ccc3oc(=O)[nH]c3c2)nc(C)n1
Help me improve the QED of molecule CCCCC(C(C)C)N(Cc1ocnc1C)C[C@@H]1CCCN1C(=O)[C@H](C)c1cccs1 to make it more like a drug
Cc1ncoc1CN(C)C[C@@H]1CCCN1C(=O)[C@H](C)c1cccs1
help me reduce GSK3β inhibitory activity and JNK3 binding affinity of molecule Cc1ccc(-c2ccc(Cl)c(Cl)c2)c(CN2CC[C@H](C)[C@@H](CNC(=O)OC(C)(C)C)C2)c1.
Cc1ccc(C)c(CN2CC[C@H](C)[C@@H](CNC(=O)OC(C)(C)C)C2)c1
help me reduce DRD2 binding affinity and JNK3 binding affinity of molecule CCN(C(=O)c1cc(C)ccc1-c1ccc(Cl)c(Cl)c1)[C@H]1CCN(Cc2cncs2)C1.
CCN(C(=O)c1cc(C)ccc1C)[C@H]1CCN(Cc2cncs2)C1
help me reduce LogP value and molecular weight of molecule Cc1cc(C)n(-c2ccc(C(=O)N3CCC(c4ccc(Cl)s4)C3)cn2)n1.
Cc1cc(C)n(-c2ccc(C(=O)N3CCC(O)C3)cn2)n1
help me improve DRD2 binding affinity and JNK3 binding affinity of molecule Cc1cccc(-c2nnc(N3CCN(C[C@@H]4CN(C(C)C)CCO4)CC3)n2C[C@H](C)N(C)C)n1.
CSc1ccc(C)c(Br)c1N1CCO[C@H](CN2CCN(c3nnc(-c4cccc(C)n4)n3C[C@H](C)N(C)C)CC2)C1
help me reduce LogP value and molecular weight of molecule CCNC(=O)CNC(=O)C[NH+](C)Cc1ccc(C(=O)NSC(CC)(CC)CC)cc1.
CCNC(=O)CNC(=O)C[NH+](C)Cc1ccc(C(=O)NC)cc1
help me reduce GSK3β inhibitory activity and LogP value and rotatable bonds of molecule C=C[C@@H](CCCCCCC)c1[nH]nc(C(=O)N2CCOC[C@]3(C2)CN(C(=O)[C@@H]2CCc4ccccc4[C@@H]2O)CCO3)c1F.
Cc1[nH]nc(C(=O)N2CCOC[C@]3(C2)CN(C(=O)[C@@H]2CCc4ccccc4[C@@H]2O)CCO3)c1F
help me improve DRD2 binding affinity and LogP value and molecular weight of molecule C[NH+]=C(NCCC1=CCCCC1)N1CCN(c2cnn(C)c2)C(=O)C1.
CC([NH+]=C(NCCC1=CCCCC1)N1CCN(c2cnn(C)c2)C(=O)C1)c1ccc(Cl)cc1
Help me make the molecule CCN(CC(=O)O)C1CC(NC(=O)NC2c3ccccc3CC2C(C)(C)CC)C1 with more hydrogen bond acceptors
CCN(CC(=O)O)C1CC(NC(=O)NC2c3ccccc3CC2O)C1
Help me improve the QED of molecule C[C@@H](CN1CCC[C@@H](CNC(=O)Cn2ccc3ccccc32)C1)C(N)=[NH2+] to make it more like a drug
CC(C)CN1CCC[C@@H](CNC(=O)Cn2ccc3ccccc32)C1
help me reduce JNK3 binding affinity and LogP value of molecule C=C(C)C(C)(C(C)C)C(OC(=O)C1=CN2C(=O)C(NC(=O)C(=NOC)c3csc(N)n3)C2SC1)c1ccccc1.
CON=C(C(=O)NC1C(=O)N2C=C(C(=O)OC(C)OC(=O)c3ccccc3)CSC12)c1csc(N)n1
Help me make the molecule CC(C)[C@@H](c1ccccc1)C1C2CC(=O)NC3CC(C(=O)N4CCOC(CN(C(=O)C5CCOCC5)CC(O2)C1O)C4)N(C1CCCC1)C3 with more hydrogen bond acceptors
O=C1CC2OC(CN(C(=O)C3CCOCC3)CC3CN(CCO3)C(=O)C3CC(CN3C3CCCC3)N1)C(O)C2O
Help me improve the QED of molecule C=C(C=CC(=CC)Cc1oncc1C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@@H]2CC[C@H]3CCC(=O)N3C2)CC1)C(C)CC to make it more like a drug
COCc1oncc1C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@@H]2CC[C@H]3CCC(=O)N3C2)CC1
Help me reduce the number of hydrogen bond donors in molecule CC(C)C(N)c1nc(C(C)(C)C(N)=[NH2+])c(C(=O)O)s1
CC(C)C(N)c1nc(C(C)(C)C)c(C(=O)O)s1
help me reduce molecular weight and improve QED score of molecule CC(C[NH+](Cc1ccc(C(C)(C)C)cc1)CN1CC[C@](C)(NC(=O)c2cc[nH]n2)C1)C(=O)[O-].
CC(C)(C)c1ccc(CN2CC[C@](C)(NC(=O)c3cc[nH]n3)C2)cc1
help me reduce H-bond donors and JNK3 binding affinity of molecule O=S(=O)(c1ccc(B(O)O)cc1)n1cc(I)c2c(C3CC3)ncnc21.
Cc1ccc(S(=O)(=O)n2cc(I)c3c(C4CC4)ncnc32)cc1
help me improve DRD2 binding affinity and JNK3 binding affinity and molecular weight of molecule CCN(Cc1occc1C)C(=O)N[C@@H]1CCO[C@H](c2ccc(F)cc2)C1.
CCN(Cc1occc1-c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H]1CCO[C@H](c2ccc(F)cc2)C1
Help me reduce the number of hydrogen bond acceptors in molecule CCOCCOc1cccc(C(=O)OC)c1B(O)O
CCOCCOc1cccc(C(=O)OC)c1C
help me reduce H-bond donors and improve LogP value of molecule Cc1cc([C@@H]2C[C@H]2C(=O)O[C@@H](C(N)=O)c2ccc(F)cc2)ccc1B(O)O.
Cc1ccc([C@@H]2C[C@H]2C(=O)O[C@@H](C(N)=O)c2ccc(F)cc2)cc1C
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule Cc1ncc(C(=O)N2CC[C@@H](CN(C)C(=O)[C@H]3C[C@@H]3C)C2)s1.
Cc1ncc(C(=O)N2CC[C@@H](C[NH+](CC(C)C(=O)[O-])CN(C)C(=O)[C@H]3C[C@@H]3C)C2)s1
help me improve GSK3β inhibitory activity and molecular weight of molecule COc1ccccc1CNC(=O)c1cc(Nc2cc(C)on2)ccn1.
COc1ccccc1CNC(=O)c1cc(Nc2cc(-c3ccc(Cl)c(Cl)c3)on2)ccn1
help me reduce hydrogen bond acceptors and H-bond donors of molecule O=C(c1ccccc1B(O)O)N1CCCC1C1CCCN1.
Cc1ccccc1C(=O)N1CCCC1C1CCCN1
help me reduce GSK3β inhibitory activity and improve DRD2 binding affinity of molecule NN=C(NN)c1cccc2ncc(C(=O)N3CCO[C@]4(CCN(C(=O)CCN5CCCC5)C4)C3)cc12.
O=C(CCN1CCCC1)N1CC[C@]2(C1)CN(C(=O)c1cnc3cccc(Cl)c3c1)CCO2
help me improve molecular weight and synthetic accessibility of molecule N#Cc1ccc(NC(=O)CCN2CCC3(O)CCCCC3C2)cc1Cl.
CC(CCBr)C12CCCCC1CN(CCC(=O)Nc1ccc(C#N)c(Cl)c1)CC2
help me improve LogP value and rotatable bonds of molecule Cc1cccc(NC(=O)[C@H](C)n2cc(-c3cnn(C)c3)nn2)c1.
CCC(CC)(CC)S[C@@H](C(=O)Nc1cccc(C)c1)n1cc(-c2cnn(C)c2)nn1
Help me reduce the QED of molecule Cc1ccccc1[C@H](NC(=O)CSCC(N)=O)[C@@H]1CCC[C@H](C)C1 to make it less like a drug
C[C@H]1CCC[C@@H]([C@@H](NC(=O)CSCC(N)=O)c2ccccc2-c2cc(Br)ccc2Br)C1
Help me reduce the QED of molecule Cc1coc(C)c1C(=O)N[C@H](CNC(=O)[C@@H](F)C(C)C)C(C)(C)C to make it less like a drug
CCCCCCCCC(C)[C@H](F)C(=O)NC[C@@H](NC(=O)c1c(C)coc1C)C(C)(C)C
help me improve hydrogen bond acceptors and H-bond donors of molecule CC=CC(=CC(C)C)c1ccc2c(n1)CC(C(F)(F)F)C=C2.
CC=CC(=CC(C)C)c1ccc2c(n1)CC(C(F)(F)NC(=O)C(=O)NN)C=C2
Help me reduce the QED of molecule CC(C)(C)OC(=O)N1CC[C@]2(C[C@@H]2C(=O)Nc2cc([C@@H]3CCCCN3C(=O)[C@H]3[C@@H]4COC[C@@H]43)[nH]n2)C1 to make it less like a drug
CC(C)C(=O)NC(OC(=O)N1CC[C@]2(C[C@@H]2C(=O)Nc2cc([C@@H]3CCCCN3C(=O)[C@@H]3[C@H]4COC[C@H]43)[nH]n2)C1)P(=O)([O-])[O-]
help me reduce QED score and improve synthetic accessibility of molecule COC(=O)c1cccc(C#Cc2cccc(NC(=O)CCc3ccccc3O)c2)c1.
C=C[C@@H](CCCCCCC)OC(=O)c1cccc(C#Cc2cccc(NC(=O)CCc3ccccc3O)c2)c1
help me reduce LogP value and improve H-bond donors of molecule CC(=O)Nc1cccc(-c2nc(C(=O)NCCN3CCOCC3)c(C)s2)c1.
CC(=O)Nc1cccc(-c2nc(C(=O)NCCN3CCOCC3)c(B(O)O)s2)c1
Help me reduce the number of hydrogen bond acceptors in molecule COc1ccc(Cn2c([C@H]3CCS(=O)(=O)C3)nnc2N2CCCC[C@H](SC)C2)cc1O
CCCCC1C(CC)CCC1[C@H]1CCCCN(c2nnc([C@H]3CCS(=O)(=O)C3)n2Cc2ccc(OC)c(O)c2)C1
Help me reduce the QED of molecule CC(=O)Nc1ccc(NC(=O)c2cccc(C(=O)N3CCN(C)CC3)c2)cc1 to make it less like a drug
CC(=O)Nc1ccc(NC(=O)c2cccc(C(=O)N3CCN(c4c(C)cc(C)cc4C)CC3)c2)cc1
help me improve LogP value and synthetic accessibility of molecule COCCN1C[C@@H](Cn2c([C@@H](C)NS(C)(=O)=O)nnc2N2CCc3c(C)cccc3C2)CC1=O.
C=NC(C)C=C(CC)[C@H](C)c1nnc(N2CCc3c(C)cccc3C2)n1C[C@H]1CC(=O)N(CCOC)C1
Help me make the molecule CC1=C(C)CN(C(=O)C2(C)COC2)CC1 with more hydrogen bond donors
CC1=C(C(N)=[NH2+])CCN(C(=O)C2(C)COC2)C1
help me reduce GSK3β inhibitory activity and hydrogen bond acceptors of molecule NCCNCN1CCO[C@@H](C(=O)N2CCO[C@@]3(CCN(C(=O)c4cc(Cl)ccn4)C3)C2)C1.
O=C(c1cc(Cl)ccn1)N1CC[C@@]2(C1)CN(C(=O)[C@H]1CN(Cc3ccccc3)CCO1)CCO2
help me reduce rotatable bonds and improve JNK3 binding affinity of molecule CCC(CC)CC(CC)c1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccc(C#N)cn23)n1.
COc1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccc(C#N)cn23)n1
help me reduce QED score and improve GSK3β inhibitory activity of molecule CC1(C)CCCC[C@@H]1C(=O)NCc1ccc(Oc2cccnc2)c(F)c1.
CCCc1ccc(-c2cc(CNC(=O)[C@H]3CCCCC3(C)C)ccc2Oc2cccnc2)s1
help me reduce LogP value and improve hydrogen bond acceptors and JNK3 binding affinity of molecule O=C(COC(=O)[C@@H]1Cc2ccccc21)Nc1ccc(OC(F)F)cc1.
CC(C[NH+](COC(=O)[C@@H]1Cc2ccccc21)CC(=O)Nc1ccc(OC(F)F)cc1)C(=O)[O-]
help me improve molecular weight and synthetic accessibility of molecule C[C@H](Nc1ccc(C(N)=O)nn1)c1ccc(-c2ccc(Cl)cc2)s1.
CCC(CC)(CC)SC(Nc1ccc(C(N)=O)nn1)c1ccc(-c2ccc(Cl)cc2)s1
help me reduce JNK3 binding affinity and molecular weight and rotatable bonds of molecule CCCc1ccc(-c2ccc(CN3CCC4(CCOC[C@H]4COCC)CC3)c3ccccc23)s1.
CCOC[C@@H]1COCCC12CCN(Cc1ccc(F)c3ccccc13)CC2
help me reduce QED score and improve rotatable bonds of molecule Cc1ccc(C(=O)N[C@@H]2CCCN(C(=O)[C@@]3(C)C=CCC3)CC2)cc1.
CCCCCCCCc1ccc(C(=O)N[C@@H]2CCCN(C(=O)[C@@]3(C)C=CCC3)CC2)cc1
Help me reduce the number of hydrogen bond donors in molecule CC(C)(C)OC(=O)N1CCN(CCNc2nc(Cl)nc(N3CCOCC3)c2N)CC1
C=CC(C)=CC=C(C=C)Cc1c(NCCN2CCN(C(=O)OC(C)(C)C)CC2)nc(Cl)nc1N1CCOCC1
Help me improve the QED of molecule COc1ccc(C(=O)Nc2cc([N+](=O)[O-])ccc2F)cc1OC(F)c1ccc(SF)c(F)c1 to make it more like a drug
COc1ccc(C(=O)Nc2cc([N+](=O)[O-])ccc2F)cc1OC(F)F
help me improve hydrogen bond acceptors and rotatable bonds and synthetic accessibility of molecule Cc1cc(C(=O)N2CCCC23CN(C(=O)[C@]2(n4ccnc4)CCN(C(=O)OC(C)(C)C)C2)C3)n(C)n1.
COC(C)C(=O)N1CC[NH+](OC(=O)N2CC[C@](C(=O)N3CC4(CCCN4C(=O)c4cc(C)nn4C)C3)(n3ccnc3)C2)CC1
help me reduce GSK3β inhibitory activity and JNK3 binding affinity and rotatable bonds and synthetic accessibility of molecule CCOc1ccc(C(=O)NC(CCl)C(Cc2cccs2)[C@@H]2OC[C@@H]3CCN(C(=O)c4n[nH]c5c(C)cccc45)C[C@@H]32)nn1.
CCOc1ccc(C(=O)NC[C@@H]2OC[C@@H]3CCN(C(=O)c4n[nH]c5c(C)cccc45)C[C@@H]32)nn1
help me reduce LogP value and improve hydrogen bond acceptors and synthetic accessibility of molecule CC(C)C(O)CNC(=O)Cc1csc(Cc2ccccc2)n1.
CC(C[NH+](CC(=O)NCC(O)C(C)C)Cc1csc(Cc2ccccc2)n1)C(=O)[O-]
help me improve molecular weight and synthetic accessibility of molecule Cc1cc(C(=O)NC2CCc3nc(C(C)C)nn3C2)nc(C)n1.
CCCC(CCBr)CC(C)c1nc2n(n1)CC(NC(=O)c1cc(C)nc(C)n1)CC2
help me improve molecular weight and synthetic accessibility of molecule CCc1cccc(CC)c1NC(=O)N1CCC[C@@H](c2nc(O)n[nH]2)C1.
CCC=CC=CC(C)C(C)c1cccc(CC)c1NC(=O)N1CCC[C@@H](c2nc(O)n[nH]2)C1