MaIlz/moledit-prompt-completion_all_tasks · Datasets at Hugging Face

prompt stringlengths 72 358	completion stringlengths 17 265
help me reduce rotatable bonds and synthetic accessibility and improve QED score of molecule CCCC(CCBr)CC(F)(F)[C@@H](C)NC(=O)c1cnn(-c2ccc(F)cc2F)c1C.	Cc1c(C(=O)N[C@H](C)C(C)(F)F)cnn1-c1ccc(F)cc1F
help me reduce QED score and improve hydrogen bond acceptors and H-bond donors of molecule Fc1ccc(C2N=C(c3ccco3)N=C3CCCC=C32)c(Cl)c1.	NN=C(NN)c1cc(F)ccc1C1N=C(c2ccco2)N=C2CCCC=C21
Help me reduce the number of hydrogen bond donors in molecule COc1ccc(C(=O)NC[C@@]23CCCO[C@@H]2CCN(C(=O)[C@@H]2Cc4ccccc4CN2C)C3)cc1	C=CC(C[C@@]12CCCO[C@@H]1CCN(C(=O)[C@@H]1Cc3ccccc3CN1C)C2)C(CCCC)c1ccc(OC)cc1
help me improve GSK3β inhibitory activity and H-bond donors of molecule CC(C)(C)CCN1CC[C@H](NC(=O)c2ccc(OCC3CC3)nc2)C1.	NC(=[NH2+])SCCN1CC[C@H](NC(=O)c2ccc(OCC3CC3)nc2)C1
help me reduce H-bond donors and JNK3 binding affinity and rotatable bonds of molecule C[NH+]1CCC([NH+](C)CC(F)(F)c2n[nH]c3ccc(C(=O)N4CC[C@]5(C4)CN(C(=O)c4cc6cccnn6n4)CCO5)cc23)CC1.	O=C(c1ccc2[nH]nc(C(F)(F)F)c2c1)N1CC[C@]2(C1)CN(C(=O)c1cc3cccnn3n1)CCO2
Help me reduce the QED of molecule Cc1cc(C(=O)NCC[C@@H](C)NC(=O)c2cc(C)c(C)o2)ccc1F to make it less like a drug	CCC(CC)(CC)S[C@H](CCNC(=O)c1ccc(F)c(C)c1)NC(=O)c1cc(C)c(C)o1
help me improve hydrogen bond acceptors and H-bond donors and synthetic accessibility of molecule CN(CC(=O)N1CCO[C@]2(CCN(C(=O)c3cc(Cl)cc4nn[nH]c34)C2)C1)C(=O)OC(C)(C)C.	CC(=O)NC(C(=O)O)C(O)OC(=O)N(C)CC(=O)N1CCO[C@]2(CCN(C(=O)c3cc(Cl)cc4nn[nH]c34)C2)C1
help me reduce DRD2 binding affinity and LogP value and molecular weight and rotatable bonds of molecule CCCC(CCBr)Cn1ccnc1C(=O)NCc1cnc(C)nc1C1CCCN1C.	Cc1ncc(CNC(=O)c2nccn2C)c(C2CCCN2C)n1
help me improve molecular weight and rotatable bonds of molecule COC1CC(C(=O)N2CCCC[C@H]2CNCc2ccc(F)cc2C)C1.	Cc1cc(F)ccc1CNC[C@@H]1CCCCN1C(=O)C1CC(OCCC2CCC(C)CC2)C1
help me improve DRD2 binding affinity and GSK3β inhibitory activity of molecule Cc1cccc2[nH]c(CN3C[C@H](C(=O)O)Oc4cc(F)ccc43)cc12.	CCCC(CC)[C@H]1CN(Cc2cc3c(C)cccc3[nH]2)c2ccc(F)cc2O1
help me reduce QED score and improve hydrogen bond acceptors of molecule CC(C)(C)OC(=O)N1CC[C@@H]2C[C@@]21C(=O)NC[C@H]1CCN(C(=O)c2ccnnc2)[C@H]1c1cccnc1.	CC(=O)NC(C(=O)O)C(O)OC(=O)N1CC[C@@H]2C[C@@]21C(=O)NC[C@H]1CCN(C(=O)c2ccnnc2)[C@H]1c1cccnc1
Help me reduce the number of hydrogen bond donors in molecule Cc1nc(C(=O)N2CCC[C@@H](C(C)(C)C)CC2)ccc1B(O)O	Cc1ccc(C(=O)N2CCC[C@@H](C(C)(C)C)CC2)nc1C
help me reduce JNK3 binding affinity and molecular weight and improve QED score of molecule C=CC(Br)=C(C=C(C)OC)c1cc(NC(=O)N2CCC[C@@](C)(CO)C2)cc2ccccc12.	C[C@@]1(CO)CCCN(C(=O)Nc2cc(C(=O)O)c3ccccc3c2)C1
help me reduce LogP value and QED score of molecule CC(C)[C@H](CNC(=O)c1scnc1C(F)(F)F)c1ccnn1C.	CC(C(N)=[NH2+])[C@H](CNC(=O)c1scnc1C(F)(F)F)c1ccnn1C
Help me make the molecule O=Cc1ccc(-c2ccc(-c3ncc(N4CCN(CCc5ccccc5)CC4)cn3)cc2)cc1C1=CCNCC1 with more hydrogen bond acceptors	CCCNC(=O)C(=O)NCCN1CCN(c2cnc(-c3ccc(-c4ccc(C=O)c(C5=CCNCC5)c4)cc3)nc2)CC1
Help me reduce the number of hydrogen bond acceptors in molecule CCC(CC)(CC)S[C@@H](NCC1CCC1)[C@@H]1CCCCN1C(=O)CC1OCCCO1	C[C@@H](NCC1CCC1)[C@@H]1CCCCN1C(=O)CC1OCCCO1
help me reduce LogP value and QED score and improve synthetic accessibility of molecule CC(C)C[C@H](CNC(=O)C1=Cc2cc(F)ccc2OC1)C(=O)O.	CC(C[C@H](CNC(=O)C1=Cc2cc(F)ccc2OC1)C(=O)O)C(N)=[NH2+]
help me improve GSK3β inhibitory activity and JNK3 binding affinity and LogP value and synthetic accessibility of molecule C[C@@H](NC(=O)CN1CCn2c(nn(CC(=O)N(C)C)c2=O)C1)c1ccc(Cl)cc1Cl.	C=C[C@@H](CCCCCCC)[C@@H](NC(=O)CN1CCn2c(nn(CC(=O)N(C)C)c2=O)C1)c1ccc(Cl)cc1Cl
Help me improve the QED of molecule CCCCC(CC)COCOc1ccc(-c2nc(NCc3ccco3)n(C(=O)c3ccco3)n2)cc1 to make it more like a drug	COc1ccc(-c2nc(NCc3ccco3)n(C(=O)c3ccco3)n2)cc1
help me reduce LogP value and molecular weight of molecule C=C[C@@H](CCCCCCC)OC(C)(C)CNC(=O)N(C)CC1CCC[NH+](CC)C1c1cnn(C)c1.	CC[NH+]1CCCC(CN(C)C(=O)NCC(C)(C)OC)C1c1cnn(C)c1
Help me reduce the number of hydrogen bond donors in molecule CC(N=CNC=C(S)c1cccc(CCO)c1)C(N)Cc1ccc(C(F)(F)F)cc1	C=C(CCc1cccc(C(S)=CNC=NC(C)C(N)Cc2ccc(C(F)(F)F)cc2)c1)c1ccccc1
help me reduce hydrogen bond acceptors and improve LogP value of molecule C[C@H](CNc1ncccn1)N(C)C(=O)c1cscc1C(F)NC(=O)C(=O)NN.	C[C@H](CNc1ncccn1)N(C)C(=O)c1cscc1C(F)F
help me reduce QED score and improve H-bond donors of molecule CC(C)CC(C)(O)CNC(=O)CCc1ccccn1.	CC(CC(C)(O)CNC(=O)CCc1ccccn1)C(N)=[NH2+]
help me reduce hydrogen bond acceptors and H-bond donors of molecule NC(=O)C(N)Cn1ccc(-c2cc(C(=O)N3CCC(N4CCCC4)CC3)c3ccccn23)n1.	O=C(c1cc(-c2ccn(CC3CC3)n2)n2ccccc12)N1CCC(N2CCCC2)CC1
help me reduce QED score and improve molecular weight and rotatable bonds of molecule Cc1nnsc1[C@@H](C)N1CCC([C@H](O)c2ccnn2C)CC1.	CCCC(CCBr)C[C@H](c1snnc1C)N1CCC([C@H](O)c2ccnn2C)CC1
help me reduce LogP value and QED score of molecule CCn1ccc(Nc2nnc([C@H](C)CCC#N)n2CC(C)C)n1.	CCn1ccc(Nc2nnc([C@H](C)CCCNC(N)=[NH+]C)n2CC(C)C)n1
Help me reduce the QED of molecule CC(C)COc1ccccc1N[C@H](C)C(=O)N1CCc2ccccc21 to make it less like a drug	CC(C)COc1ccccc1N[C@@H](C(=O)N1CCc2ccccc21)c1cc(Cl)cc(Cl)c1
help me improve DRD2 binding affinity and LogP value of molecule CC(C)N1CCN(C2CCN(C(=O)Nc3cccc4c3CCN(C)C4=O)C2)CC1.	CC(C)N1CCN(C2CCN(C(=O)Nc3cccc4c3CCN(c3csc5ccccc35)C4=O)C2)CC1
help me improve LogP value and rotatable bonds of molecule COC(=O)[C@H]1CC12CCN(c1nc(O)c3ccccc3n1)CC2.	CCCCCCCCOC(=O)[C@H]1CC12CCN(c1nc(O)c3ccccc3n1)CC2
Help me make the molecule CC(=CCCBr)[C@@H](C)C1CCN(C(=O)c2ccc(O[C@H]3CCOC3)cc2)CC1 with more hydrogen bond donors	C[C@H](O)C1CCN(C(=O)c2ccc(O[C@H]3CCOC3)cc2)CC1
help me reduce LogP value and synthetic accessibility of molecule CCC(CC)(CC)SOc1ccc(CN2CCc3nc(N)[nH]c(=O)c3C2)cc1[N+](=O)[O-].	COc1ccc(CN2CCc3nc(N)[nH]c(=O)c3C2)cc1[N+](=O)[O-]
help me reduce hydrogen bond acceptors and rotatable bonds and improve LogP value of molecule CC(C[NH+](CO)Cc1cc(CNC(=O)C(C)n2cccc2)ccc1F)C(=O)[O-].	CC(C(=O)NCc1ccc(F)c(CO)c1)n1cccc1
help me reduce synthetic accessibility and improve LogP value of molecule CCc1ccccc1NC(=O)Cn1ncn2nc(-c3cc(C(N)=[NH+]O)ccc3F)cc2c1=O.	CCc1ccccc1NC(=O)Cn1ncn2nc(-c3ccc(F)cc3)cc2c1=O
help me improve hydrogen bond acceptors and synthetic accessibility of molecule Oc1cnc(NCCSCc2ccc(CNCc3ccco3)o2)[nH]1.	CC(C[NH+](CNCc1ccco1)Cc1ccc(CSCCNc2ncc(O)[nH]2)o1)C(=O)[O-]
help me reduce hydrogen bond acceptors and synthetic accessibility of molecule CC(C[NH+](CNC(=O)N[C@@H](C)c1nc(-c2ccc(Cl)cc2)no1)C[C@@H]1C[C@H]2CC[C@H]1C2)C(=O)[O-].	C[C@H](NC(=O)NC[C@@H]1C[C@H]2CC[C@H]1C2)c1nc(-c2ccc(Cl)cc2)no1
help me reduce molecular weight and improve QED score of molecule CCC(CC)(CC)SC(CN[C@H](CSC)c1ccc(C(F)(F)F)cc1)N(C)C1CC1.	CSC[C@@H](NC[C@@H](C)N(C)C1CC1)c1ccc(C(F)(F)F)cc1
Help me reduce the number of hydrogen bond donors in molecule CNC(=O)c1c(CCc2cccc(CF)c2)oc2nc(NCC(F)(F)F)c(-c3cccc(C(=O)NC45CC(C4)C5)c3)cc12	C=C(C(C)=CC)C(=CC)C(c1cccc(-c2cc3c(C(=O)NC)c(CCc4cccc(CF)c4)oc3nc2NCC(F)(F)F)c1)C12CC(C1)C2
help me reduce JNK3 binding affinity and molecular weight of molecule CC(C)c1cccc(Oc2ccc(-n3ccnc3[C@H]3CC(=O)NCc4nc5ccccn5c43)cc2)c1.	COc1ccc(-n2ccnc2[C@H]2CC(=O)NCc3nc4ccccn4c32)cc1
help me improve DRD2 binding affinity and GSK3β inhibitory activity and rotatable bonds of molecule O=c1[nH]c(CN2CCN(c3ccc(C(F)(F)F)cc3[N+](=O)[O-])CC2)nc2sc3c(c12)CCC3.	CCCCCCC(CN1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1)c1nc2sc3c(c2c(=O)[nH]1)CCC3
Help me reduce the QED of molecule CN(C(=O)CCn1[nH]c(=O)c2ccccc2c1=O)C1CCC(c2ccccc2)CC1 to make it less like a drug	O=C(CCn1[nH]c(=O)c2ccccc2c1=O)N(c1csc2ccccc12)C1CCC(c2ccccc2)CC1
help me reduce hydrogen bond acceptors and H-bond donors of molecule CC(=O)NC(C)C(O)(O)C(=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)[C@@H]3ON=C(c4ccccc4)O3)[C@H]2C1.	CCC[C@H](NC(C)=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)[C@@H]3ON=C(c4ccccc4)O3)[C@H]2C1
help me reduce rotatable bonds and synthetic accessibility and improve LogP value of molecule CC(=O)N1CCCN(COCC(O)CO)CCN(C(=O)c2noc(C)c2CN(C)C)Cc2cc(F)c(F)cc21.	CC(=O)N1CCCN(Cc2ccccc2)CCN(C(=O)c2noc(C)c2CN(C)C)Cc2cc(F)c(F)cc21
help me reduce LogP value and improve H-bond donors of molecule CC(=O)c1ccc(S(=O)(=O)NCC(=O)O[C@@H](C)C(=O)Nc2ccc(N3CCOCC3)cc2)cc1.	CC(=O)c1cc(C(N)=[NH+]O)ccc1S(=O)(=O)NCC(=O)O[C@@H](C)C(=O)Nc1ccc(N2CCOCC2)cc1
Help me reduce the QED of molecule Cc1cc(C(=O)N2CC[C@]3(C2)CN(C(=O)c2cc4sccc4[nH]2)CCO3)nc2nccn12 to make it less like a drug	C=C[C@@H](CCCCCCC)c1cc(C(=O)N2CC[C@]3(C2)CN(C(=O)c2cc4sccc4[nH]2)CCO3)nc2nccn12
help me reduce H-bond donors and JNK3 binding affinity and improve LogP value of molecule O=C(NCCOc1ccc(F)cc1)c1c(-n2ccc(B(O)O)n2)sc2c1CCSC2.	O=C(NCCOc1ccc(F)cc1)c1c(-n2cccc2)sc2c1CCSC2
help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors of molecule CCOc1cccn2c(C(=O)Nc3c(C)cccc3CC)c(CC)nc12.	CCOc1cccn2c(C(=O)Nc3c(CC)cccc3B(O)O)c(CC)nc12
help me improve hydrogen bond acceptors and H-bond donors and JNK3 binding affinity of molecule Cc1ccc(OCCNS(=O)(=O)c2ccccc2F)cc1.	O=S(=O)(NCCOc1ccc(B(O)O)cc1)c1ccccc1F
help me reduce synthetic accessibility and improve LogP value of molecule Cc1nc2c(NC(=O)N3CCC(C[NH+](CO)CC(C)C(=O)[O-])CC3)cccc2o1.	Cc1nc2c(NC(=O)N3CCC(CO)CC3)cccc2o1
help me reduce LogP value and improve hydrogen bond acceptors of molecule O=C(NC1[C@@H]2CN(C(=O)C(F)F)C[C@@H]12)[C@@H]1COCCO1.	NNC(=O)C(=O)N[C@@H](F)C(=O)N1C[C@H]2C(NC(=O)[C@@H]3COCCO3)[C@@H]2C1
help me reduce JNK3 binding affinity and LogP value and improve molecular weight and rotatable bonds and synthetic accessibility of molecule CC(NC(=O)c1cc(N)[nH]c(=S)c1)c1ccc(OCC(F)(F)F)nc1.	CC(C[NH+](COc1ccc(C(C)NC(=O)c2cc(N)[nH]c(=S)c2)cn1)CC(F)(F)F)C(=O)[O-]
help me reduce hydrogen bond acceptors and JNK3 binding affinity and rotatable bonds and improve QED score of molecule CC(C)C(C)SSC(C)(C)c1ccc(C(=O)Nc2nc(C(=O)N(C)Cc3cccnc3)cs2)c(Cl)c1.	CN(Cc1cccnc1)C(=O)c1csc(NC(=O)c2ccc(Cl)cc2Cl)n1
Help me reduce the QED of molecule Cc1c(Cn2c(-c3ccc(Cl)cc3Cl)nnc2N2CC[C@H](S(C)(=O)=O)C2)cnn1C to make it less like a drug	Cc1c(Cn2c(-c3ccc(C(=NN)NN)cc3Cl)nnc2N2CC[C@H](S(C)(=O)=O)C2)cnn1C
help me reduce molecular weight and rotatable bonds of molecule CCC(CC)(CC)SOc1cccc2c1ncc1cc(C=C3SC(=S)NC3=O)oc12.	COc1cccc2c1ncc1cc(C=C3SC(=S)NC3=O)oc12
help me reduce molecular weight and rotatable bonds of molecule CC1CCC(CCC(C)n2ccc(CN3CC[C@H](N(C)C(=O)[C@@H]4CCCC4(C)C)C3)n2)CC1.	CC(C)n1ccc(CN2CC[C@H](N(C)C(=O)[C@@H]3CCCC3(C)C)C2)n1
help me reduce synthetic accessibility and improve LogP value and QED score of molecule CC(CNS(=O)(=O)N1CCCC(C)(O)CC1)C(N)=[NH2+].	CC(C)CNS(=O)(=O)N1CCCC(C)(O)CC1
help me reduce JNK3 binding affinity and synthetic accessibility and improve QED score of molecule NC(=[NH+]O)c1ccc(Br)c(Oc2ccc(C(=O)N[C@H]3CS(=O)(=O)C[C@@H]3N3CCOCC3)cn2)c1.	O=C(N[C@H]1CS(=O)(=O)C[C@@H]1N1CCOCC1)c1ccc(Oc2ccc(Br)cc2)nc1
help me reduce LogP value and improve H-bond donors and synthetic accessibility of molecule CC(C)C(=O)Nc1ccc(OC(=O)[C@@H]2CCN2C2CCCC2)cc1.	C[C@@H](C(N)=[NH2+])C(=O)Nc1ccc(OC(=O)[C@@H]2CCN2C2CCCC2)cc1
help me reduce GSK3β inhibitory activity and improve LogP value and QED score of molecule C[C@@H]1C[C@H](CNS(=O)(=O)Cc2ccc(F)cc2F)[C@@H](C(N)=[NH2+])O1.	C[C@@H]1C[C@H](CNS(=O)(=O)Cc2ccc(F)cc2F)[C@@H](C)O1
help me improve H-bond donors and synthetic accessibility of molecule CC(C)C[C@@H](NCCn1cnnc1C1CC1)c1ccccc1.	CC(C[C@@H](NCCn1cnnc1C1CC1)c1ccccc1)C(N)=[NH2+]
help me reduce hydrogen bond acceptors and H-bond donors of molecule Cc1ccnc(SC(C)C(=O)Nc2cc(N)ccc2B(O)O)n1.	Cc1ccnc(SC(C)C(=O)Nc2cc(N)ccc2C)n1
help me improve DRD2 binding affinity and molecular weight of molecule OCc1ccc(F)cc1NC[C@H](O)COc1cccc(F)c1.	CC(=CCCBr)Cc1ccc(F)cc1NC[C@H](O)COc1cccc(F)c1
help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors and JNK3 binding affinity of molecule Cc1nccc(N[C@H]2C[C@@H](CNC(=O)c3ccccc3O)C2)n1.	O=C(NC[C@H]1C[C@@H](Nc2ccnc(B(O)O)n2)C1)c1ccccc1O
help me reduce molecular weight and rotatable bonds of molecule CSCC[C@H](CC(C)CCBr)NC(=O)NC[C@H]1CC2CCC1CC2.	CSCC[C@H](CO)NC(=O)NC[C@H]1CC2CCC1CC2
help me reduce GSK3β inhibitory activity and improve molecular weight of molecule Cc1cccc(Nc2nc(NC3CCCC(F)(F)C3N)nnc2C(N)=O)c1.	C=CCCCCCC(=O)C1C(Nc2nnc(C(N)=O)c(Nc3cccc(C)c3)n2)CCCC1(F)F
help me reduce H-bond donors and improve DRD2 binding affinity of molecule COc1c(C)cnc(CN2CC[C@H]2Cc2ccccc2)c1B(O)O.	COc1c(C)cnc(CN2CC[C@H]2Cc2ccccc2)c1C
help me reduce DRD2 binding affinity and GSK3β inhibitory activity of molecule CC(c1ccc(Cl)cc1I)N1CCC[C@H](N(C)C(=O)c2c(Cl)n[nH]c2C2CC2)CC1.	CC(C)N1CCC[C@H](N(C)C(=O)c2c(Cl)n[nH]c2C2CC2)CC1
Help me reduce the QED of molecule COc1ccc(Nc2ccc(S(N)(=O)=O)c(C(F)(F)F)c2)c(OC)c1 to make it less like a drug	CCSc1ccccc1Oc1ccc(Nc2ccc(S(N)(=O)=O)c(C(F)(F)F)c2)c(OC)c1
Help me reduce the number of hydrogen bond acceptors in molecule CO[C@H](C(=O)N1CCO[C@]2(COCCN(C(=O)c3ccc(C)cc3O)C2)C1)c1ccccc1	CCCCC(CC(C)C(=O)N1CCO[C@]2(COCCN(C(=O)c3ccc(C)cc3O)C2)C1)c1ccccc1
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule C=CCn1c(=NC(=O)c2ccc(S(C)(=O)=O)cc2)sc2cc(Br)ccc21.	C=CC[NH+](CC(C)C(=O)[O-])Cn1c(=NC(=O)c2ccc(S(C)(=O)=O)cc2)sc2cc(Br)ccc21
help me reduce QED score and improve molecular weight and rotatable bonds and synthetic accessibility of molecule CCN(C)c1ccc(C(=O)N2C[C@H]3CC[C@H]2[C@H](NC(C)C)C3)cc1.	CCC=CC=CC(C)C(C)N(C)c1ccc(C(=O)N2C[C@H]3CC[C@H]2[C@H](NC(C)C)C3)cc1
help me reduce H-bond donors and improve LogP value of molecule NC(=[NH2+])c1cncc(C(=O)N2CC[C@H](NC(=O)C3CCCCC3)C2)c1.	Cc1cncc(C(=O)N2CC[C@H](NC(=O)C3CCCCC3)C2)c1
help me reduce rotatable bonds and improve QED score of molecule CCCCC(c1[nH]c(C)cc1C(=O)NC1(C)CCN([C@H](C)c2ncc(C)o2)CC1)C(C)C.	Cc1cc(C(=O)NC2(C)CCN([C@H](C)c3ncc(C)o3)CC2)c(C)[nH]1
Help me reduce the QED of molecule COc1ccc(Br)c(-c2nnc(N3CCN(C(C)=O)C[C@@H]3C)n2C[C@@H]2CCOC2)c1 to make it less like a drug	CC(=O)N1CCN(c2nnc(-c3cc(Oc4ccc(Br)c(Cl)c4)ccc3Br)n2C[C@@H]2CCOC2)[C@@H](C)C1
help me reduce LogP value and improve hydrogen bond acceptors of molecule CCOC(=O)Cn1nc(-c2ccccc2)cc1NC(=O)C[C@@H](CC)C(C)C.	CCOC(=O)Cn1nc(-c2ccccc2)cc1NC(=O)CC(NC(N)=O)C(=O)NC(C)C
help me reduce H-bond donors and improve LogP value and QED score of molecule COC(=O)[C@H](OC(C(F)(F)F)C(F)(F)NC(=O)C(=O)NN)c1ccc(Cl)cc1.	COC(=O)[C@H](OC(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
help me reduce GSK3β inhibitory activity and JNK3 binding affinity and improve LogP value of molecule CCc1cc(C(N)=[NH+]O)ccc1C(=O)NN=C(C)c1cccc(N2CCCC2=O)c1.	CCc1ccc(C(=O)NN=C(C)c2cccc(N3CCCC3=O)c2)cc1
help me reduce LogP value and improve GSK3β inhibitory activity and JNK3 binding affinity of molecule CSc1cccc(NC(=O)[C@@H](C)NC(=O)C2CCCC2)n1.	CSc1cccc(NC(=O)C(NC(=O)C2CCCC2)C(N)=[NH2+])n1
help me reduce QED score and improve H-bond donors of molecule C[C@@H]1CCCN1CC(=O)N[C@H]1CC[C@H](NCC(N)=O)CC1.	NC(=[NH2+])[C@@H]1CCCN1CC(=O)N[C@H]1CC[C@H](NCC(N)=O)CC1
Help me reduce the QED of molecule CC[C@H](Cn1c(-c2cccc(S(C)(=O)=O)c2)nnc1N1CC[C@@H]2NC(=O)OC[C@H]2C1)OC to make it less like a drug	C#CCCCCCCC#C[C@H](CC)Cn1c(-c2cccc(S(C)(=O)=O)c2)nnc1N1CC[C@@H]2NC(=O)OC[C@H]2C1
help me reduce molecular weight and improve QED score of molecule C[C@@H](c1ccco1)N(C)c1nnc(-c2ccc(Cl)c(Cl)c2)n1C[C@](C)(O)c1cccs1.	Cc1nnc(N(C)[C@@H](C)c2ccco2)n1C[C@](C)(O)c1cccs1
help me reduce LogP value and improve H-bond donors of molecule Cc1oc(C(C)(C)C)nc1CCOc1ccc2c(c1)C(C(=O)O)N(CC(C)(C)C)CC2.	CC(C)(C)CN1CCc2ccc(OCCc3nc(C(C)(C)C)oc3C(N)=[NH2+])cc2C1C(=O)O
Help me make the molecule CC(C)(c1ccc(C2NC(N3CCC4(CCN(c5ncccn5)C4)C3)NC(=O)C2c2nc3ccccc3s2)cc1)C1CCCNC1 with more hydrogen bond donors	O=C1NC(N2CCC3(CCN(c4ncccn4)C3)C2)NC(NC2CCCNC2)C1c1nc2ccccc2s1
help me reduce QED score and improve JNK3 binding affinity and molecular weight of molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)Oc1ccc2c(c1)CCC2.	O=C(C[C@@H]1c2ccccc2C=CN1C(=O)Sc1cccc(Cl)c1)Oc1ccc2c(c1)CCC2
help me reduce JNK3 binding affinity and synthetic accessibility and improve LogP value of molecule Cc1cc(B(O)O)n(-c2ccc(C(N)=O)cc2Br)n1.	Cc1cc(C)n(-c2ccc(C(N)=O)cc2Br)n1
help me reduce LogP value and QED score and improve synthetic accessibility of molecule CC(C)CCCC(C)NC(=O)c1cn(CCN)nn1.	CC(CCCC(C)C(N)=[NH2+])NC(=O)c1cn(CCN)nn1
help me reduce H-bond donors and improve DRD2 binding affinity and LogP value and QED score of molecule NC(=[NH2+])[C@]1(CNC(=O)c2ocnc2C2CC2)CCCN(C/C=C/Cl)C1.	C[C@]1(CNC(=O)c2ocnc2C2CC2)CCCN(C/C=C/Cl)C1
Help me make the molecule CCN(CC)c1cc2c(cc1F)c(=O)c(S(=O)(=O)c1ccc(C)cc1)cn2Cc1ccc(F)cc1 with more hydrogen bond acceptors	CCN(CC)c1cc2c(cc1F)c(=O)c(S(=O)(=O)c1ccc(-c3csc4ccccc34)cc1)cn2Cc1ccc(F)cc1
help me reduce molecular weight and rotatable bonds and improve QED score of molecule CCC(CC)(CC)Sc1cc(C(=O)N2CCCC[C@H]2C)ccc1NC(=O)[C@@H]1C[C@H]1c1ccco1.	Cc1cc(C(=O)N2CCCC[C@H]2C)ccc1NC(=O)[C@@H]1C[C@H]1c1ccco1
help me reduce DRD2 binding affinity and LogP value and improve H-bond donors of molecule CC(C)N1CCCC(Cc2ncc3n2CCCC3CO)C1.	CC(C(N)=[NH2+])N1CCCC(Cc2ncc3n2CCCC3CO)C1
help me reduce rotatable bonds and improve QED score of molecule CCCC(CCBr)CC(NC(=O)N1CCN(Cc2cccs2)CC1)c1ccc(Cl)c(Cl)c1.	CC(NC(=O)N1CCN(Cc2cccs2)CC1)c1ccc(Cl)c(Cl)c1
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule C[C@]1(c2ccccc2)CCCN(C(=O)Nc2cnn(CC(F)(F)F)c2)C1.	CC(C)C[NH+](CC(=O)[O-])C(F)(F)Cn1cc(NC(=O)N2CCC[C@](C)(c3ccccc3)C2)cn1
Help me improve the QED of molecule CCCCCCCCOS(=O)(=O)[C@@H]1CCN(c2nnc(C(=O)N3CCCC3)n2CCc2ccc(Cl)s2)C1 to make it more like a drug	CS(=O)(=O)[C@@H]1CCN(c2nnc(C(=O)N3CCCC3)n2CCc2ccc(Cl)s2)C1
help me improve hydrogen bond acceptors and H-bond donors of molecule COc1ccc([C@@H](NC(=O)c2cccc(OC3CCCC3)c2)C2CC2)cc1.	COc1ccc([C@@H](NC(=O)c2cccc(OC3CCCC3)c2)C(N)C(N)=O)cc1
Help me make the molecule Cc1[nH]c(=O)sc1S(=O)(=O)NCCCC(C)C(=O)O with more hydrogen bond acceptors	CC(CCCNS(=O)(=O)c1sc(=O)[nH]c1B(O)O)C(=O)O
Help me reduce the number of hydrogen bond donors in molecule C=C(C(CC1CCN(c2ccccc2CN2CCCC2=O)CC1)NC(=O)c1cc(=O)c2cc(OC)ccc2o1)N(C)CC1COCC1NC	C=C(c1ccc(Cl)cc1)C(CC1CCN(c2ccccc2CN2CCCC2=O)CC1)NC(=O)c1cc(=O)c2cc(OC)ccc2o1
Help me reduce the QED of molecule Cc1nc2c(C(=O)N3CC[C@H](CNCC4CC(C)C4)C3)cccc2o1 to make it less like a drug	C=CCC(=CC[C@H]1CCN(C(=O)c2cccc3oc(C)nc23)C1)CC1CC(C)C1
help me reduce LogP value and improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule CCN(CC)S(=O)(=O)c1ccc(Cl)c(C(=O)NCc2cccc(NC(=O)c3ccco3)c2)c1.	CCN(CC)S(=O)(=O)c1ccc(Cl)c(C(=O)NCc2cccc(NC(=O)c3n[nH]c(=O)[nH]c3=O)c2)c1
help me reduce QED score and improve molecular weight and rotatable bonds of molecule Cc1ccccc1[C@@H](C)NC(=O)NC1CCN(CC(F)(F)F)CC1.	Cc1ccccc1[C@@H](C)NC(=O)NC1CCN(CC(F)(F)[NH+](CC(=O)[O-])CC(C)C)CC1
help me reduce synthetic accessibility and improve QED score of molecule CNC(OC)(C(=O)NCCN(C)c1nnc(COc2ccc(C)c(C)c2)n1C[C@]1(O)CCN(C)C1)C(N=C[O-])N(C)C.	Cc1ccc(OCc2nnc(N(C)CCNC(=O)C(C)C)n2C[C@]2(O)CCN(C)C2)cc1C
help me reduce GSK3β inhibitory activity and H-bond donors and improve QED score of molecule COCCOCCCN[C@H](C(N)=[NH2+])c1ccc(Br)c(F)c1.	COCCOCCCN[C@H](C)c1ccc(Br)c(F)c1

help me reduce rotatable bonds and synthetic accessibility and improve QED score of molecule CCCC(CCBr)CC(F)(F)[C@@H](C)NC(=O)c1cnn(-c2ccc(F)cc2F)c1C.

Cc1c(C(=O)N[C@H](C)C(C)(F)F)cnn1-c1ccc(F)cc1F

help me reduce QED score and improve hydrogen bond acceptors and H-bond donors of molecule Fc1ccc(C2N=C(c3ccco3)N=C3CCCC=C32)c(Cl)c1.

NN=C(NN)c1cc(F)ccc1C1N=C(c2ccco2)N=C2CCCC=C21

Help me reduce the number of hydrogen bond donors in molecule COc1ccc(C(=O)NC[C@@]23CCCO[C@@H]2CCN(C(=O)[C@@H]2Cc4ccccc4CN2C)C3)cc1

C=CC(C[C@@]12CCCO[C@@H]1CCN(C(=O)[C@@H]1Cc3ccccc3CN1C)C2)C(CCCC)c1ccc(OC)cc1

help me improve GSK3β inhibitory activity and H-bond donors of molecule CC(C)(C)CCN1CC[C@H](NC(=O)c2ccc(OCC3CC3)nc2)C1.

NC(=[NH2+])SCCN1CC[C@H](NC(=O)c2ccc(OCC3CC3)nc2)C1

help me reduce H-bond donors and JNK3 binding affinity and rotatable bonds of molecule C[NH+]1CCC([NH+](C)CC(F)(F)c2n[nH]c3ccc(C(=O)N4CC[C@]5(C4)CN(C(=O)c4cc6cccnn6n4)CCO5)cc23)CC1.

O=C(c1ccc2[nH]nc(C(F)(F)F)c2c1)N1CC[C@]2(C1)CN(C(=O)c1cc3cccnn3n1)CCO2

Help me reduce the QED of molecule Cc1cc(C(=O)NCC[C@@H](C)NC(=O)c2cc(C)c(C)o2)ccc1F to make it less like a drug

CCC(CC)(CC)S[C@H](CCNC(=O)c1ccc(F)c(C)c1)NC(=O)c1cc(C)c(C)o1

help me improve hydrogen bond acceptors and H-bond donors and synthetic accessibility of molecule CN(CC(=O)N1CCO[C@]2(CCN(C(=O)c3cc(Cl)cc4nn[nH]c34)C2)C1)C(=O)OC(C)(C)C.

CC(=O)NC(C(=O)O)C(O)OC(=O)N(C)CC(=O)N1CCO[C@]2(CCN(C(=O)c3cc(Cl)cc4nn[nH]c34)C2)C1

help me reduce DRD2 binding affinity and LogP value and molecular weight and rotatable bonds of molecule CCCC(CCBr)Cn1ccnc1C(=O)NCc1cnc(C)nc1C1CCCN1C.

Cc1ncc(CNC(=O)c2nccn2C)c(C2CCCN2C)n1

help me improve molecular weight and rotatable bonds of molecule COC1CC(C(=O)N2CCCC[C@H]2CNCc2ccc(F)cc2C)C1.

Cc1cc(F)ccc1CNC[C@@H]1CCCCN1C(=O)C1CC(OCCC2CCC(C)CC2)C1

help me improve DRD2 binding affinity and GSK3β inhibitory activity of molecule Cc1cccc2[nH]c(CN3C[C@H](C(=O)O)Oc4cc(F)ccc43)cc12.

CCCC(CC)[C@H]1CN(Cc2cc3c(C)cccc3[nH]2)c2ccc(F)cc2O1

help me reduce QED score and improve hydrogen bond acceptors of molecule CC(C)(C)OC(=O)N1CC[C@@H]2C[C@@]21C(=O)NC[C@H]1CCN(C(=O)c2ccnnc2)[C@H]1c1cccnc1.

CC(=O)NC(C(=O)O)C(O)OC(=O)N1CC[C@@H]2C[C@@]21C(=O)NC[C@H]1CCN(C(=O)c2ccnnc2)[C@H]1c1cccnc1

Help me reduce the number of hydrogen bond donors in molecule Cc1nc(C(=O)N2CCC[C@@H](C(C)(C)C)CC2)ccc1B(O)O

Cc1ccc(C(=O)N2CCC[C@@H](C(C)(C)C)CC2)nc1C

help me reduce JNK3 binding affinity and molecular weight and improve QED score of molecule C=CC(Br)=C(C=C(C)OC)c1cc(NC(=O)N2CCC[C@@](C)(CO)C2)cc2ccccc12.

C[C@@]1(CO)CCCN(C(=O)Nc2cc(C(=O)O)c3ccccc3c2)C1

help me reduce LogP value and QED score of molecule CC(C)[C@H](CNC(=O)c1scnc1C(F)(F)F)c1ccnn1C.

CC(C(N)=[NH2+])[C@H](CNC(=O)c1scnc1C(F)(F)F)c1ccnn1C

Help me make the molecule O=Cc1ccc(-c2ccc(-c3ncc(N4CCN(CCc5ccccc5)CC4)cn3)cc2)cc1C1=CCNCC1 with more hydrogen bond acceptors

CCCNC(=O)C(=O)NCCN1CCN(c2cnc(-c3ccc(-c4ccc(C=O)c(C5=CCNCC5)c4)cc3)nc2)CC1

Help me reduce the number of hydrogen bond acceptors in molecule CCC(CC)(CC)S[C@@H](NCC1CCC1)[C@@H]1CCCCN1C(=O)CC1OCCCO1

C[C@@H](NCC1CCC1)[C@@H]1CCCCN1C(=O)CC1OCCCO1

help me reduce LogP value and QED score and improve synthetic accessibility of molecule CC(C)C[C@H](CNC(=O)C1=Cc2cc(F)ccc2OC1)C(=O)O.

CC(C[C@H](CNC(=O)C1=Cc2cc(F)ccc2OC1)C(=O)O)C(N)=[NH2+]

help me improve GSK3β inhibitory activity and JNK3 binding affinity and LogP value and synthetic accessibility of molecule C[C@@H](NC(=O)CN1CCn2c(nn(CC(=O)N(C)C)c2=O)C1)c1ccc(Cl)cc1Cl.

C=C[C@@H](CCCCCCC)[C@@H](NC(=O)CN1CCn2c(nn(CC(=O)N(C)C)c2=O)C1)c1ccc(Cl)cc1Cl

Help me improve the QED of molecule CCCCC(CC)COCOc1ccc(-c2nc(NCc3ccco3)n(C(=O)c3ccco3)n2)cc1 to make it more like a drug

COc1ccc(-c2nc(NCc3ccco3)n(C(=O)c3ccco3)n2)cc1

help me reduce LogP value and molecular weight of molecule C=C[C@@H](CCCCCCC)OC(C)(C)CNC(=O)N(C)CC1CCC[NH+](CC)C1c1cnn(C)c1.

CC[NH+]1CCCC(CN(C)C(=O)NCC(C)(C)OC)C1c1cnn(C)c1

Help me reduce the number of hydrogen bond donors in molecule CC(N=CNC=C(S)c1cccc(CCO)c1)C(N)Cc1ccc(C(F)(F)F)cc1

C=C(CCc1cccc(C(S)=CNC=NC(C)C(N)Cc2ccc(C(F)(F)F)cc2)c1)c1ccccc1

help me reduce hydrogen bond acceptors and improve LogP value of molecule C[C@H](CNc1ncccn1)N(C)C(=O)c1cscc1C(F)NC(=O)C(=O)NN.

C[C@H](CNc1ncccn1)N(C)C(=O)c1cscc1C(F)F

help me reduce QED score and improve H-bond donors of molecule CC(C)CC(C)(O)CNC(=O)CCc1ccccn1.

CC(CC(C)(O)CNC(=O)CCc1ccccn1)C(N)=[NH2+]

help me reduce hydrogen bond acceptors and H-bond donors of molecule NC(=O)C(N)Cn1ccc(-c2cc(C(=O)N3CCC(N4CCCC4)CC3)c3ccccn23)n1.

O=C(c1cc(-c2ccn(CC3CC3)n2)n2ccccc12)N1CCC(N2CCCC2)CC1

help me reduce QED score and improve molecular weight and rotatable bonds of molecule Cc1nnsc1[C@@H](C)N1CCC([C@H](O)c2ccnn2C)CC1.

CCCC(CCBr)C[C@H](c1snnc1C)N1CCC([C@H](O)c2ccnn2C)CC1

help me reduce LogP value and QED score of molecule CCn1ccc(Nc2nnc([C@H](C)CCC#N)n2CC(C)C)n1.

CCn1ccc(Nc2nnc([C@H](C)CCCNC(N)=[NH+]C)n2CC(C)C)n1

Help me reduce the QED of molecule CC(C)COc1ccccc1N[C@H](C)C(=O)N1CCc2ccccc21 to make it less like a drug

CC(C)COc1ccccc1N[C@@H](C(=O)N1CCc2ccccc21)c1cc(Cl)cc(Cl)c1

help me improve DRD2 binding affinity and LogP value of molecule CC(C)N1CCN(C2CCN(C(=O)Nc3cccc4c3CCN(C)C4=O)C2)CC1.

CC(C)N1CCN(C2CCN(C(=O)Nc3cccc4c3CCN(c3csc5ccccc35)C4=O)C2)CC1

help me improve LogP value and rotatable bonds of molecule COC(=O)[C@H]1CC12CCN(c1nc(O)c3ccccc3n1)CC2.

CCCCCCCCOC(=O)[C@H]1CC12CCN(c1nc(O)c3ccccc3n1)CC2

Help me make the molecule CC(=CCCBr)[C@@H](C)C1CCN(C(=O)c2ccc(O[C@H]3CCOC3)cc2)CC1 with more hydrogen bond donors

C[C@H](O)C1CCN(C(=O)c2ccc(O[C@H]3CCOC3)cc2)CC1

help me reduce LogP value and synthetic accessibility of molecule CCC(CC)(CC)SOc1ccc(CN2CCc3nc(N)[nH]c(=O)c3C2)cc1[N+](=O)[O-].

COc1ccc(CN2CCc3nc(N)[nH]c(=O)c3C2)cc1[N+](=O)[O-]

help me reduce hydrogen bond acceptors and rotatable bonds and improve LogP value of molecule CC(C[NH+](CO)Cc1cc(CNC(=O)C(C)n2cccc2)ccc1F)C(=O)[O-].

CC(C(=O)NCc1ccc(F)c(CO)c1)n1cccc1

help me reduce synthetic accessibility and improve LogP value of molecule CCc1ccccc1NC(=O)Cn1ncn2nc(-c3cc(C(N)=[NH+]O)ccc3F)cc2c1=O.

CCc1ccccc1NC(=O)Cn1ncn2nc(-c3ccc(F)cc3)cc2c1=O

help me improve hydrogen bond acceptors and synthetic accessibility of molecule Oc1cnc(NCCSCc2ccc(CNCc3ccco3)o2)[nH]1.

CC(C[NH+](CNCc1ccco1)Cc1ccc(CSCCNc2ncc(O)[nH]2)o1)C(=O)[O-]

help me reduce hydrogen bond acceptors and synthetic accessibility of molecule CC(C[NH+](CNC(=O)N[C@@H](C)c1nc(-c2ccc(Cl)cc2)no1)C[C@@H]1C[C@H]2CC[C@H]1C2)C(=O)[O-].

C[C@H](NC(=O)NC[C@@H]1C[C@H]2CC[C@H]1C2)c1nc(-c2ccc(Cl)cc2)no1

help me reduce molecular weight and improve QED score of molecule CCC(CC)(CC)SC(CN[C@H](CSC)c1ccc(C(F)(F)F)cc1)N(C)C1CC1.

CSC[C@@H](NC[C@@H](C)N(C)C1CC1)c1ccc(C(F)(F)F)cc1

Help me reduce the number of hydrogen bond donors in molecule CNC(=O)c1c(CCc2cccc(CF)c2)oc2nc(NCC(F)(F)F)c(-c3cccc(C(=O)NC45CC(C4)C5)c3)cc12

C=C(C(C)=CC)C(=CC)C(c1cccc(-c2cc3c(C(=O)NC)c(CCc4cccc(CF)c4)oc3nc2NCC(F)(F)F)c1)C12CC(C1)C2

help me reduce JNK3 binding affinity and molecular weight of molecule CC(C)c1cccc(Oc2ccc(-n3ccnc3[C@H]3CC(=O)NCc4nc5ccccn5c43)cc2)c1.

COc1ccc(-n2ccnc2[C@H]2CC(=O)NCc3nc4ccccn4c32)cc1

help me improve DRD2 binding affinity and GSK3β inhibitory activity and rotatable bonds of molecule O=c1[nH]c(CN2CCN(c3ccc(C(F)(F)F)cc3[N+](=O)[O-])CC2)nc2sc3c(c12)CCC3.

CCCCCCC(CN1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1)c1nc2sc3c(c2c(=O)[nH]1)CCC3

Help me reduce the QED of molecule CN(C(=O)CCn1[nH]c(=O)c2ccccc2c1=O)C1CCC(c2ccccc2)CC1 to make it less like a drug

O=C(CCn1[nH]c(=O)c2ccccc2c1=O)N(c1csc2ccccc12)C1CCC(c2ccccc2)CC1

help me reduce hydrogen bond acceptors and H-bond donors of molecule CC(=O)NC(C)C(O)(O)C(=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)[C@@H]3ON=C(c4ccccc4)O3)[C@H]2C1.

CCC[C@H](NC(C)=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)[C@@H]3ON=C(c4ccccc4)O3)[C@H]2C1

help me reduce rotatable bonds and synthetic accessibility and improve LogP value of molecule CC(=O)N1CCCN(COCC(O)CO)CCN(C(=O)c2noc(C)c2CN(C)C)Cc2cc(F)c(F)cc21.

CC(=O)N1CCCN(Cc2ccccc2)CCN(C(=O)c2noc(C)c2CN(C)C)Cc2cc(F)c(F)cc21

help me reduce LogP value and improve H-bond donors of molecule CC(=O)c1ccc(S(=O)(=O)NCC(=O)O[C@@H](C)C(=O)Nc2ccc(N3CCOCC3)cc2)cc1.

CC(=O)c1cc(C(N)=[NH+]O)ccc1S(=O)(=O)NCC(=O)O[C@@H](C)C(=O)Nc1ccc(N2CCOCC2)cc1

Help me reduce the QED of molecule Cc1cc(C(=O)N2CC[C@]3(C2)CN(C(=O)c2cc4sccc4[nH]2)CCO3)nc2nccn12 to make it less like a drug

C=C[C@@H](CCCCCCC)c1cc(C(=O)N2CC[C@]3(C2)CN(C(=O)c2cc4sccc4[nH]2)CCO3)nc2nccn12

help me reduce H-bond donors and JNK3 binding affinity and improve LogP value of molecule O=C(NCCOc1ccc(F)cc1)c1c(-n2ccc(B(O)O)n2)sc2c1CCSC2.

O=C(NCCOc1ccc(F)cc1)c1c(-n2cccc2)sc2c1CCSC2

help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors of molecule CCOc1cccn2c(C(=O)Nc3c(C)cccc3CC)c(CC)nc12.

CCOc1cccn2c(C(=O)Nc3c(CC)cccc3B(O)O)c(CC)nc12

help me improve hydrogen bond acceptors and H-bond donors and JNK3 binding affinity of molecule Cc1ccc(OCCNS(=O)(=O)c2ccccc2F)cc1.

O=S(=O)(NCCOc1ccc(B(O)O)cc1)c1ccccc1F

help me reduce synthetic accessibility and improve LogP value of molecule Cc1nc2c(NC(=O)N3CCC(C[NH+](CO)CC(C)C(=O)[O-])CC3)cccc2o1.

Cc1nc2c(NC(=O)N3CCC(CO)CC3)cccc2o1

help me reduce LogP value and improve hydrogen bond acceptors of molecule O=C(NC1[C@@H]2CN(C(=O)C(F)F)C[C@@H]12)[C@@H]1COCCO1.

NNC(=O)C(=O)N[C@@H](F)C(=O)N1C[C@H]2C(NC(=O)[C@@H]3COCCO3)[C@@H]2C1

help me reduce JNK3 binding affinity and LogP value and improve molecular weight and rotatable bonds and synthetic accessibility of molecule CC(NC(=O)c1cc(N)[nH]c(=S)c1)c1ccc(OCC(F)(F)F)nc1.

CC(C[NH+](COc1ccc(C(C)NC(=O)c2cc(N)[nH]c(=S)c2)cn1)CC(F)(F)F)C(=O)[O-]

help me reduce hydrogen bond acceptors and JNK3 binding affinity and rotatable bonds and improve QED score of molecule CC(C)C(C)SSC(C)(C)c1ccc(C(=O)Nc2nc(C(=O)N(C)Cc3cccnc3)cs2)c(Cl)c1.

CN(Cc1cccnc1)C(=O)c1csc(NC(=O)c2ccc(Cl)cc2Cl)n1

Help me reduce the QED of molecule Cc1c(Cn2c(-c3ccc(Cl)cc3Cl)nnc2N2CC[C@H](S(C)(=O)=O)C2)cnn1C to make it less like a drug

Cc1c(Cn2c(-c3ccc(C(=NN)NN)cc3Cl)nnc2N2CC[C@H](S(C)(=O)=O)C2)cnn1C

help me reduce molecular weight and rotatable bonds of molecule CCC(CC)(CC)SOc1cccc2c1ncc1cc(C=C3SC(=S)NC3=O)oc12.

COc1cccc2c1ncc1cc(C=C3SC(=S)NC3=O)oc12

help me reduce molecular weight and rotatable bonds of molecule CC1CCC(CCC(C)n2ccc(CN3CC[C@H](N(C)C(=O)[C@@H]4CCCC4(C)C)C3)n2)CC1.

CC(C)n1ccc(CN2CC[C@H](N(C)C(=O)[C@@H]3CCCC3(C)C)C2)n1

help me reduce synthetic accessibility and improve LogP value and QED score of molecule CC(CNS(=O)(=O)N1CCCC(C)(O)CC1)C(N)=[NH2+].

CC(C)CNS(=O)(=O)N1CCCC(C)(O)CC1

help me reduce JNK3 binding affinity and synthetic accessibility and improve QED score of molecule NC(=[NH+]O)c1ccc(Br)c(Oc2ccc(C(=O)N[C@H]3CS(=O)(=O)C[C@@H]3N3CCOCC3)cn2)c1.

O=C(N[C@H]1CS(=O)(=O)C[C@@H]1N1CCOCC1)c1ccc(Oc2ccc(Br)cc2)nc1

help me reduce LogP value and improve H-bond donors and synthetic accessibility of molecule CC(C)C(=O)Nc1ccc(OC(=O)[C@@H]2CCN2C2CCCC2)cc1.

C[C@@H](C(N)=[NH2+])C(=O)Nc1ccc(OC(=O)[C@@H]2CCN2C2CCCC2)cc1

help me reduce GSK3β inhibitory activity and improve LogP value and QED score of molecule C[C@@H]1C[C@H](CNS(=O)(=O)Cc2ccc(F)cc2F)[C@@H](C(N)=[NH2+])O1.

C[C@@H]1C[C@H](CNS(=O)(=O)Cc2ccc(F)cc2F)[C@@H](C)O1

help me improve H-bond donors and synthetic accessibility of molecule CC(C)C[C@@H](NCCn1cnnc1C1CC1)c1ccccc1.

CC(C[C@@H](NCCn1cnnc1C1CC1)c1ccccc1)C(N)=[NH2+]

help me reduce hydrogen bond acceptors and H-bond donors of molecule Cc1ccnc(SC(C)C(=O)Nc2cc(N)ccc2B(O)O)n1.

Cc1ccnc(SC(C)C(=O)Nc2cc(N)ccc2C)n1

help me improve DRD2 binding affinity and molecular weight of molecule OCc1ccc(F)cc1NC[C@H](O)COc1cccc(F)c1.

CC(=CCCBr)Cc1ccc(F)cc1NC[C@H](O)COc1cccc(F)c1

help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors and JNK3 binding affinity of molecule Cc1nccc(N[C@H]2C[C@@H](CNC(=O)c3ccccc3O)C2)n1.

O=C(NC[C@H]1C[C@@H](Nc2ccnc(B(O)O)n2)C1)c1ccccc1O

help me reduce molecular weight and rotatable bonds of molecule CSCC[C@H](CC(C)CCBr)NC(=O)NC[C@H]1CC2CCC1CC2.

CSCC[C@H](CO)NC(=O)NC[C@H]1CC2CCC1CC2

help me reduce GSK3β inhibitory activity and improve molecular weight of molecule Cc1cccc(Nc2nc(NC3CCCC(F)(F)C3N)nnc2C(N)=O)c1.

C=CCCCCCC(=O)C1C(Nc2nnc(C(N)=O)c(Nc3cccc(C)c3)n2)CCCC1(F)F

help me reduce H-bond donors and improve DRD2 binding affinity of molecule COc1c(C)cnc(CN2CC[C@H]2Cc2ccccc2)c1B(O)O.

COc1c(C)cnc(CN2CC[C@H]2Cc2ccccc2)c1C

help me reduce DRD2 binding affinity and GSK3β inhibitory activity of molecule CC(c1ccc(Cl)cc1I)N1CCC[C@H](N(C)C(=O)c2c(Cl)n[nH]c2C2CC2)CC1.

CC(C)N1CCC[C@H](N(C)C(=O)c2c(Cl)n[nH]c2C2CC2)CC1

Help me reduce the QED of molecule COc1ccc(Nc2ccc(S(N)(=O)=O)c(C(F)(F)F)c2)c(OC)c1 to make it less like a drug

CCSc1ccccc1Oc1ccc(Nc2ccc(S(N)(=O)=O)c(C(F)(F)F)c2)c(OC)c1

Help me reduce the number of hydrogen bond acceptors in molecule CO[C@H](C(=O)N1CCO[C@]2(COCCN(C(=O)c3ccc(C)cc3O)C2)C1)c1ccccc1

CCCCC(CC(C)C(=O)N1CCO[C@]2(COCCN(C(=O)c3ccc(C)cc3O)C2)C1)c1ccccc1

help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule C=CCn1c(=NC(=O)c2ccc(S(C)(=O)=O)cc2)sc2cc(Br)ccc21.

C=CC[NH+](CC(C)C(=O)[O-])Cn1c(=NC(=O)c2ccc(S(C)(=O)=O)cc2)sc2cc(Br)ccc21

help me reduce QED score and improve molecular weight and rotatable bonds and synthetic accessibility of molecule CCN(C)c1ccc(C(=O)N2C[C@H]3CC[C@H]2[C@H](NC(C)C)C3)cc1.

CCC=CC=CC(C)C(C)N(C)c1ccc(C(=O)N2C[C@H]3CC[C@H]2[C@H](NC(C)C)C3)cc1

help me reduce H-bond donors and improve LogP value of molecule NC(=[NH2+])c1cncc(C(=O)N2CC[C@H](NC(=O)C3CCCCC3)C2)c1.

Cc1cncc(C(=O)N2CC[C@H](NC(=O)C3CCCCC3)C2)c1

help me reduce rotatable bonds and improve QED score of molecule CCCCC(c1[nH]c(C)cc1C(=O)NC1(C)CCN([C@H](C)c2ncc(C)o2)CC1)C(C)C.

Cc1cc(C(=O)NC2(C)CCN([C@H](C)c3ncc(C)o3)CC2)c(C)[nH]1

Help me reduce the QED of molecule COc1ccc(Br)c(-c2nnc(N3CCN(C(C)=O)C[C@@H]3C)n2C[C@@H]2CCOC2)c1 to make it less like a drug

CC(=O)N1CCN(c2nnc(-c3cc(Oc4ccc(Br)c(Cl)c4)ccc3Br)n2C[C@@H]2CCOC2)[C@@H](C)C1

help me reduce LogP value and improve hydrogen bond acceptors of molecule CCOC(=O)Cn1nc(-c2ccccc2)cc1NC(=O)C[C@@H](CC)C(C)C.

CCOC(=O)Cn1nc(-c2ccccc2)cc1NC(=O)CC(NC(N)=O)C(=O)NC(C)C

help me reduce H-bond donors and improve LogP value and QED score of molecule COC(=O)[C@H](OC(C(F)(F)F)C(F)(F)NC(=O)C(=O)NN)c1ccc(Cl)cc1.

COC(=O)[C@H](OC(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1

help me reduce GSK3β inhibitory activity and JNK3 binding affinity and improve LogP value of molecule CCc1cc(C(N)=[NH+]O)ccc1C(=O)NN=C(C)c1cccc(N2CCCC2=O)c1.

CCc1ccc(C(=O)NN=C(C)c2cccc(N3CCCC3=O)c2)cc1

help me reduce LogP value and improve GSK3β inhibitory activity and JNK3 binding affinity of molecule CSc1cccc(NC(=O)[C@@H](C)NC(=O)C2CCCC2)n1.

CSc1cccc(NC(=O)C(NC(=O)C2CCCC2)C(N)=[NH2+])n1

help me reduce QED score and improve H-bond donors of molecule C[C@@H]1CCCN1CC(=O)N[C@H]1CC[C@H](NCC(N)=O)CC1.

NC(=[NH2+])[C@@H]1CCCN1CC(=O)N[C@H]1CC[C@H](NCC(N)=O)CC1

Help me reduce the QED of molecule CC[C@H](Cn1c(-c2cccc(S(C)(=O)=O)c2)nnc1N1CC[C@@H]2NC(=O)OC[C@H]2C1)OC to make it less like a drug

C#CCCCCCCC#C[C@H](CC)Cn1c(-c2cccc(S(C)(=O)=O)c2)nnc1N1CC[C@@H]2NC(=O)OC[C@H]2C1

help me reduce molecular weight and improve QED score of molecule C[C@@H](c1ccco1)N(C)c1nnc(-c2ccc(Cl)c(Cl)c2)n1C[C@](C)(O)c1cccs1.

Cc1nnc(N(C)[C@@H](C)c2ccco2)n1C[C@](C)(O)c1cccs1

help me reduce LogP value and improve H-bond donors of molecule Cc1oc(C(C)(C)C)nc1CCOc1ccc2c(c1)C(C(=O)O)N(CC(C)(C)C)CC2.

CC(C)(C)CN1CCc2ccc(OCCc3nc(C(C)(C)C)oc3C(N)=[NH2+])cc2C1C(=O)O

Help me make the molecule CC(C)(c1ccc(C2NC(N3CCC4(CCN(c5ncccn5)C4)C3)NC(=O)C2c2nc3ccccc3s2)cc1)C1CCCNC1 with more hydrogen bond donors

O=C1NC(N2CCC3(CCN(c4ncccn4)C3)C2)NC(NC2CCCNC2)C1c1nc2ccccc2s1

help me reduce QED score and improve JNK3 binding affinity and molecular weight of molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)Oc1ccc2c(c1)CCC2.

O=C(C[C@@H]1c2ccccc2C=CN1C(=O)Sc1cccc(Cl)c1)Oc1ccc2c(c1)CCC2

help me reduce JNK3 binding affinity and synthetic accessibility and improve LogP value of molecule Cc1cc(B(O)O)n(-c2ccc(C(N)=O)cc2Br)n1.

Cc1cc(C)n(-c2ccc(C(N)=O)cc2Br)n1

help me reduce LogP value and QED score and improve synthetic accessibility of molecule CC(C)CCCC(C)NC(=O)c1cn(CCN)nn1.

CC(CCCC(C)C(N)=[NH2+])NC(=O)c1cn(CCN)nn1

help me reduce H-bond donors and improve DRD2 binding affinity and LogP value and QED score of molecule NC(=[NH2+])[C@]1(CNC(=O)c2ocnc2C2CC2)CCCN(C/C=C/Cl)C1.

C[C@]1(CNC(=O)c2ocnc2C2CC2)CCCN(C/C=C/Cl)C1

Help me make the molecule CCN(CC)c1cc2c(cc1F)c(=O)c(S(=O)(=O)c1ccc(C)cc1)cn2Cc1ccc(F)cc1 with more hydrogen bond acceptors

CCN(CC)c1cc2c(cc1F)c(=O)c(S(=O)(=O)c1ccc(-c3csc4ccccc34)cc1)cn2Cc1ccc(F)cc1

help me reduce molecular weight and rotatable bonds and improve QED score of molecule CCC(CC)(CC)Sc1cc(C(=O)N2CCCC[C@H]2C)ccc1NC(=O)[C@@H]1C[C@H]1c1ccco1.

Cc1cc(C(=O)N2CCCC[C@H]2C)ccc1NC(=O)[C@@H]1C[C@H]1c1ccco1

help me reduce DRD2 binding affinity and LogP value and improve H-bond donors of molecule CC(C)N1CCCC(Cc2ncc3n2CCCC3CO)C1.

CC(C(N)=[NH2+])N1CCCC(Cc2ncc3n2CCCC3CO)C1

help me reduce rotatable bonds and improve QED score of molecule CCCC(CCBr)CC(NC(=O)N1CCN(Cc2cccs2)CC1)c1ccc(Cl)c(Cl)c1.

CC(NC(=O)N1CCN(Cc2cccs2)CC1)c1ccc(Cl)c(Cl)c1

help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule C[C@]1(c2ccccc2)CCCN(C(=O)Nc2cnn(CC(F)(F)F)c2)C1.

CC(C)C[NH+](CC(=O)[O-])C(F)(F)Cn1cc(NC(=O)N2CCC[C@](C)(c3ccccc3)C2)cn1

Help me improve the QED of molecule CCCCCCCCOS(=O)(=O)[C@@H]1CCN(c2nnc(C(=O)N3CCCC3)n2CCc2ccc(Cl)s2)C1 to make it more like a drug

CS(=O)(=O)[C@@H]1CCN(c2nnc(C(=O)N3CCCC3)n2CCc2ccc(Cl)s2)C1

help me improve hydrogen bond acceptors and H-bond donors of molecule COc1ccc([C@@H](NC(=O)c2cccc(OC3CCCC3)c2)C2CC2)cc1.

COc1ccc([C@@H](NC(=O)c2cccc(OC3CCCC3)c2)C(N)C(N)=O)cc1

Help me make the molecule Cc1[nH]c(=O)sc1S(=O)(=O)NCCCC(C)C(=O)O with more hydrogen bond acceptors

CC(CCCNS(=O)(=O)c1sc(=O)[nH]c1B(O)O)C(=O)O

Help me reduce the number of hydrogen bond donors in molecule C=C(C(CC1CCN(c2ccccc2CN2CCCC2=O)CC1)NC(=O)c1cc(=O)c2cc(OC)ccc2o1)N(C)CC1COCC1NC

C=C(c1ccc(Cl)cc1)C(CC1CCN(c2ccccc2CN2CCCC2=O)CC1)NC(=O)c1cc(=O)c2cc(OC)ccc2o1

Help me reduce the QED of molecule Cc1nc2c(C(=O)N3CC[C@H](CNCC4CC(C)C4)C3)cccc2o1 to make it less like a drug

C=CCC(=CC[C@H]1CCN(C(=O)c2cccc3oc(C)nc23)C1)CC1CC(C)C1

help me reduce LogP value and improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule CCN(CC)S(=O)(=O)c1ccc(Cl)c(C(=O)NCc2cccc(NC(=O)c3ccco3)c2)c1.

CCN(CC)S(=O)(=O)c1ccc(Cl)c(C(=O)NCc2cccc(NC(=O)c3n[nH]c(=O)[nH]c3=O)c2)c1

help me reduce QED score and improve molecular weight and rotatable bonds of molecule Cc1ccccc1[C@@H](C)NC(=O)NC1CCN(CC(F)(F)F)CC1.

Cc1ccccc1[C@@H](C)NC(=O)NC1CCN(CC(F)(F)[NH+](CC(=O)[O-])CC(C)C)CC1

help me reduce synthetic accessibility and improve QED score of molecule CNC(OC)(C(=O)NCCN(C)c1nnc(COc2ccc(C)c(C)c2)n1C[C@]1(O)CCN(C)C1)C(N=C[O-])N(C)C.

Cc1ccc(OCc2nnc(N(C)CCNC(=O)C(C)C)n2C[C@]2(O)CCN(C)C2)cc1C

help me reduce GSK3β inhibitory activity and H-bond donors and improve QED score of molecule COCCOCCCN[C@H](C(N)=[NH2+])c1ccc(Br)c(F)c1.

COCCOCCCN[C@H](C)c1ccc(Br)c(F)c1