MaIlz/moledit-prompt-completion_all_tasks · Datasets at Hugging Face

prompt stringlengths 72 358	completion stringlengths 17 265
help me improve hydrogen bond acceptors and H-bond donors of molecule CCOc1c(Cl)cccc1CC(=O)N1Cc2ccccc2OC[C@H]1C.	CCOc1c(CC(=O)N2Cc3ccccc3OC[C@H]2C)cccc1C(=NN)NN
help me improve H-bond donors and JNK3 binding affinity of molecule Cc1csc(Cn2c(=S)[nH]c3cc(Br)ccc32)n1.	OB(O)c1csc(Cn2c(=S)[nH]c3cc(Br)ccc32)n1
help me improve JNK3 binding affinity and molecular weight of molecule CCc1oc(C(=O)N[C@@H]2CCC[C@@H]2CNc2ncc(F)cn2)cc1C.	CCC=CC=CC(C)C(C)c1oc(C(=O)N[C@@H]2CCC[C@@H]2CNc2ncc(F)cn2)cc1C
help me reduce QED score and improve DRD2 binding affinity and molecular weight and rotatable bonds of molecule COc1cccc(C[C@H]2CCCCCN2C[C@H](O)CC2(O)CCC2)c1.	COc1cccc(C[C@H]2CCCCCN2C[C@H](O)CC2(C(C)=CCCBr)CCC2)c1
help me improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule COc1ccc(CC(=O)N2CCO[C@@]3(CCN(C(=O)c4cc(O)ccc4F)C3)C2)c(Cl)c1.	CC[NH2+]C(COc1ccc(F)c(C(=O)N2CC[C@]3(CN(C(=O)Cc4ccc(OC)cc4Cl)CCO3)C2)c1)C(=O)[O-]
help me improve GSK3β inhibitory activity and JNK3 binding affinity of molecule CC[C@@H](CNC(=O)c1cscc1C)NC(=O)[C@@H](OC)C1CC1.	CC[C@@H](CNC(=O)c1cscc1-c1cc(C)c(Br)c(F)c1)NC(=O)[C@@H](OC)C1CC1
Help me reduce the number of hydrogen bond donors in molecule Cc1cccc(Cn2c(=O)c(C(=O)NCN)nn(-c3ccc(F)cc3)c2=O)c1	Cc1cccc(Cn2c(=O)c(C(=O)Nc3ccccc3)nn(-c3ccc(F)cc3)c2=O)c1
help me improve H-bond donors and synthetic accessibility of molecule Cc1cc([N+](=O)[O-])nn1CC(=O)N(C)C1CCCCC1.	CN(C(=O)Cn1nc([N+](=O)[O-])cc1C(N)=[NH2+])C1CCCCC1
help me improve JNK3 binding affinity and LogP value and molecular weight of molecule COC(=O)c1ccc2c(c1)[nH]c(=O)c1cnn(C3CCOCC3)c12.	O=C(Oc1ccc(Cl)cc1Cl)c1ccc2c(c1)[nH]c(=O)c1cnn(C3CCOCC3)c12
help me reduce molecular weight and improve QED score of molecule CCOc1cccc([C@H]2C[C@H]2NC(=O)c2cnn(C3CCCCC3)c2-c2cc(Cl)cc(Cl)c2)c1.	CCOc1cccc([C@H]2C[C@H]2NC(=O)c2cnn(C3CCCCC3)c2C)c1
Help me reduce the number of hydrogen bond donors in molecule Cc1nc(C[NH+]2CCC(C(=O)NCCC(C)O)CC2)cs1	CCC(C)(C)C(C)CCNC(=O)C1CC[NH+](Cc2csc(C)n2)CC1
help me reduce H-bond donors and improve QED score of molecule NC(=[NH2+])c1nc[nH]c1C(=O)N[C@@H]1CCN([C@H]2CCNC2=O)C1.	Cc1nc[nH]c1C(=O)N[C@@H]1CCN([C@H]2CCNC2=O)C1
Help me make the molecule COCCN1CC[C@H](NC(=O)Cn2ccnc2C)[C@H](C(C)=CCCBr)C1 with more hydrogen bond donors	COCCN1CC[C@H](NC(=O)Cn2ccnc2C)[C@H](O)C1
help me reduce QED score and improve molecular weight of molecule CC(C)[C@H](CNc1cc(N(C)C)ccn1)c1ccccc1.	Cc1cccc(N(C)c2ccnc(NC[C@H](c3ccccc3)C(C)C)c2)c1Cl
Help me reduce the QED of molecule COc1cc(F)cc(CNc2ccc(S[C@@H](C)C(=O)O)cc2)c1 to make it less like a drug	CC(C)c1cccc(Oc2cc(F)cc(CNc3ccc(S[C@@H](C)C(=O)O)cc3)c2)c1
help me reduce hydrogen bond acceptors and molecular weight and synthetic accessibility and improve QED score of molecule CC(C)C[NH+](CC(=O)[O-])C(F)(F)C[C@@H](NC(=O)N1CCCC[C@@H]1C[C@H](C)O)c1ccccc1.	C[C@H](O)C[C@H]1CCCCN1C(=O)N[C@H](CC(F)(F)F)c1ccccc1
Help me reduce the number of hydrogen bond donors in molecule C=CC(=CC(=CC)c1ccc(NC)c(C(=C)c2nc3c(-c4ccsc4)cncc3[nH]2)c1)N(C)C	C=CC(=CC(=CC)c1ccc(-c2ccc(C(C)(C)C)cc2)c(C(=C)c2nc3c(-c4ccsc4)cncc3[nH]2)c1)N(C)C
Help me make the molecule O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(C2CCC(CCCC3CCCC3)CC2)C1 with more hydrogen bond acceptors	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(NCC2CCCC2)C1
help me improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule O=C(NC[C@@H]1CCC[C@@H]1O)c1cccc(Nc2cnccn2)c1.	CC(C[NH+](CNC(=O)c1cccc(Nc2cnccn2)c1)C[C@@H]1CCC[C@@H]1O)C(=O)[O-]
help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors and synthetic accessibility of molecule Cc1ccc(C)n1-c1ccc(C#N)cc1N.	Cc1ccc(B(O)O)n1-c1ccc(C#N)cc1N
help me improve GSK3β inhibitory activity and JNK3 binding affinity of molecule COc1cc(C(=O)N2CCC(Oc3ccccc3C(F)(F)F)CC2)ccc1-n1cnc(C)c1.	Cc1cn(-c2ccc(C(=O)N3CCC(Oc4ccccc4C(F)(F)F)CC3)cc2-c2ccc(C(F)(F)F)cc2)cn1
help me reduce LogP value and improve synthetic accessibility of molecule O=C(Cc1ccc2nc[nH]c2c1)N[C@@H]1COCc2ccccc21.	CC(C[NH+](CC(=O)N[C@@H]1COCc2ccccc21)Cc1ccc2nc[nH]c2c1)C(=O)[O-]
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule CC(C)(C)OC(=O)NC1(C(=O)NC(C#N)Cc2ccc(-c3ccc(F)c(C#N)c3)cc2)CCOCC1.	CC(=O)NC(C(=O)O)C(O)OC(=O)NC1(C(=O)NC(C#N)Cc2ccc(-c3ccc(F)c(C#N)c3)cc2)CCOCC1
help me improve hydrogen bond acceptors and H-bond donors of molecule CCS(=O)(=O)N(CC(F)F)c1sc2ccccc2c1C.	CCS(=O)(=O)N(CC(F)F)c1sc2ccccc2c1B(O)O
help me improve GSK3β inhibitory activity and H-bond donors of molecule CC(C)[C@H]1CCO[C@H]1CNC(=O)NCc1noc2c1CC(C)(C)CC2.	CC(C)[C@H]1CCO[C@H]1CNC(=O)NCc1noc2c1CC(C)(C(N)=[NH2+])CC2
help me reduce hydrogen bond acceptors and H-bond donors of molecule O=S(=O)(Nc1cccc(-c2cn3c(B(O)O)csc3n2)c1)c1ccccc1F.	Cc1csc2nc(-c3cccc(NS(=O)(=O)c4ccccc4F)c3)cn12
help me reduce synthetic accessibility and improve QED score of molecule CCCC(CCBr)CC(C)(CCC)Sc1ccc(NC(=O)C2CCNCC2C)cc1.	CCCC(C)(C)Sc1ccc(NC(=O)C2CCNCC2C)cc1
help me reduce DRD2 binding affinity and molecular weight and rotatable bonds of molecule CCCCSC(C)n1c(C)cnc1CN1CCC[C@@H](Oc2ncccc2F)C1.	Cc1cnc(CN2CCC[C@@H](Oc3ncccc3F)C2)n1C
help me reduce H-bond donors and improve LogP value of molecule C[C@@H](CCNC(=O)C1CCC(C)(C)CC1)NC(=O)CCC(F)NC(=O)C(=O)NN.	C[C@@H](CCNC(=O)C1CCC(C)(C)CC1)NC(=O)CCC(F)F
help me reduce H-bond donors and improve LogP value of molecule C=C(Cl)CN[C@H]1C[C@H]2CC[C@H]1N(C(=O)c1c(B(O)O)coc1C)C2.	C=C(Cl)CN[C@H]1C[C@H]2CC[C@H]1N(C(=O)c1c(C)coc1C)C2
help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and synthetic accessibility of molecule O=C(c1ccc(-c2cccs2)o1)N(Cc1ccco1)C[C@H]1CCCO1.	CC(C[NH+](C[C@H]1CCCO1)CN(Cc1ccco1)C(=O)c1ccc(-c2cccs2)o1)C(=O)[O-]
help me reduce hydrogen bond acceptors and JNK3 binding affinity and improve DRD2 binding affinity and QED score of molecule C=CCCN1C[C@H](NC(=O)c2ccc(C(F)[NH+](CC(=O)[O-])CC(C)C)nc2)CC[C@@H]1C.	C=CCCN1C[C@H](NC(=O)c2ccc(C(F)F)nc2)CC[C@@H]1C
help me reduce hydrogen bond acceptors and H-bond donors of molecule O=C(Nc1ccc(B(O)O)c(S(=O)(=O)N2CCOCC2)c1)C(c1ccccc1)[NH+]1CCCC1.	Cc1ccc(NC(=O)C(c2ccccc2)[NH+]2CCCC2)cc1S(=O)(=O)N1CCOCC1
Help me reduce the number of hydrogen bond acceptors in molecule O=C1CCCN1N1CCC(COC(CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1	C=C(CC(OCC1(c2ccccc2)CCN(N2CCCC2=O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1
help me reduce LogP value and QED score and improve synthetic accessibility of molecule C=C(C)CN[C@H]1CCN(C(=O)c2ccc(CC(C)C)cc2)C1.	C=C(C)CN[C@H]1CCN(C(=O)c2ccc(C[C@@H](C)C(N)=[NH2+])cc2)C1
Help me make the molecule C[C@H](NC(=O)CCc1cncs1)[C@@H](C)Nc1nc2ccccc2o1 with more hydrogen bond acceptors	CCC(CC)(CC)SC(NC(=O)CCc1cncs1)[C@@H](C)Nc1nc2ccccc2o1
help me reduce hydrogen bond acceptors and H-bond donors of molecule CCC(=O)Nc1ccc(C(=O)NCCNS(=O)(=O)c2ccc(OC)c(B(O)O)c2)cc1.	CCC(=O)Nc1ccc(C(=O)NCCNS(=O)(=O)c2ccc(OC)c(C)c2)cc1
help me improve DRD2 binding affinity and rotatable bonds and synthetic accessibility of molecule C[C@H]1CN(c2nnc(-c3ccccc3)n2C[C@@H]2CC2(C)C)CC(C)(C)C1.	CCCC(CCBr)CC1(C)C[C@@H](C)CN(c2nnc(-c3ccccc3)n2C[C@@H]2CC2(C)C)C1
help me reduce hydrogen bond acceptors and molecular weight and synthetic accessibility and improve LogP value and QED score of molecule CC(C[NH+](CC(=O)N[C@@H](c1cccs1)C1CC1)C[C@H]1Oc2ccccc2NC1=O)C(=O)[O-].	O=C(C[C@H]1Oc2ccccc2NC1=O)N[C@@H](c1cccs1)C1CC1
help me reduce DRD2 binding affinity and molecular weight and synthetic accessibility and improve LogP value of molecule CCCNC(=O)c1coc(C[NH+](CC(C)C(=O)[O-])CN2CCN(c3cccc(Cl)c3)CC2)n1.	CCCNC(=O)c1coc(CN2CCN(c3cccc(Cl)c3)CC2)n1
help me reduce molecular weight and rotatable bonds and synthetic accessibility of molecule CCC(CC)(CC)SC(C)(C)OC(=O)N1CC[C@H](N[C@@H](C)c2ccc(SC)cc2)C1.	CSc1ccc([C@H](C)N[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1
help me reduce GSK3β inhibitory activity and improve QED score of molecule CC/C=C(\C)C(=O)NCCC(NC(=O)CCN1CCCCC1)C(N)=[NH2+].	CC/C=C(\C)C(=O)NCC[C@H](C)NC(=O)CCN1CCCCC1
help me improve GSK3β inhibitory activity and molecular weight of molecule CC[C@@H](F)C(=O)NC[C@H](C)NC(=O)c1cc2cc(F)ccc2[nH]1.	CCCC(CCBr)C[C@@H](CNC(=O)[C@H](F)CC)NC(=O)c1cc2cc(F)ccc2[nH]1
help me reduce GSK3β inhibitory activity and JNK3 binding affinity of molecule CC(c1ccccc1)N(CC=Cc1ccccc1)C(=O)c1ccc(-c2ccc(Br)c(Cl)c2)c([N+](=O)[O-])c1.	Cc1ccc(C(=O)N(CC=Cc2ccccc2)C(C)c2ccccc2)cc1[N+](=O)[O-]
help me improve H-bond donors and JNK3 binding affinity of molecule Cc1ccc(Nc2cc(N3CCCCC3)ncn2)cc1Cl.	NC(=[NH2+])c1ccc(Nc2cc(N3CCCCC3)ncn2)cc1Cl
Help me reduce the number of hydrogen bond acceptors in molecule CC(C)(C#N)c1cccc(C(=O)N(c2cncc(N(Cl)c3cc(Br)cn3C3CC3)c2)c2ccccc2C(N)=O)c1Cl	CN(Cl)c1cncc(N(C(=O)c2cccc(C(C)(C)C#N)c2Cl)c2ccccc2C(N)=O)c1
help me reduce rotatable bonds and improve LogP value of molecule CC(C)C[NH+](CC(=O)[O-])[C@@H](F)C(=O)N[C@@H]1CN(C(=O)CC2CCC(C)(C)CC2)CC1(C)C.	CC1(C)CCC(CC(=O)N2C[C@@H](NC(=O)C(F)F)C(C)(C)C2)CC1
help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and synthetic accessibility of molecule CC[C@@H](CC1CCCC1)C(=O)Nc1c(O)n[nH]c1-c1ccccc1.	CC[C@@H](C[NH+](CC1CCCC1)CC(C)C(=O)[O-])C(=O)Nc1c(O)n[nH]c1-c1ccccc1
help me reduce synthetic accessibility and improve QED score of molecule CCC(CC)(CC)SN(CC(=O)Nc1cc(Cl)ccc1OC)C(=O)C(C)(C)c1ccccc1.	COc1ccc(Cl)cc1NC(=O)CN(C)C(=O)C(C)(C)c1ccccc1
Help me make the molecule COc1cccc2c(=O)c(C(=O)Nc3nc(-c4ccc(Cl)cc4)cs3)c[nH]c12 with more hydrogen bond acceptors	O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1c[nH]c2c(Oc3cc(Br)cn3C3CC3)cccc2c1=O
help me improve GSK3β inhibitory activity and JNK3 binding affinity and LogP value of molecule Cc1nc(C(=O)N2CCO[C@@]3(COCCN(C(=O)c4cnc5c(c4)NC(=O)CS5)C3)C2)cs1.	O=C1CSc2ncc(C(=O)N3CCOC[C@@]4(C3)CN(C(=O)c3csc(-c5cc(Br)ccc5Br)n3)CCO4)cc2N1
help me improve molecular weight and synthetic accessibility of molecule CN=C(NCC(C)Oc1ccc(OC)cc1)NC1CCN(CC(N)=O)CC1.	CCC(CC)(CC)SC(CNC(=NC)NC1CCN(CC(N)=O)CC1)Oc1ccc(OC)cc1
help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and rotatable bonds of molecule O=C(NCc1cccc(Cl)c1)N[C@H]1CCCOc2cc(F)ccc21.	CC(C[NH+](CNC(=O)N[C@H]1CCCOc2cc(F)ccc21)Cc1cccc(Cl)c1)C(=O)[O-]
help me improve rotatable bonds and synthetic accessibility of molecule Cc1nn(C)cc1C(=O)C1=C(C(F)(F)F)Nc2ncnn2C1c1ccc(Cl)cc1.	Cc1nn(C)cc1C(=O)C1=C(C(F)(F)C[NH+](C)C2CC[NH+](C)CC2)Nc2ncnn2C1c1ccc(Cl)cc1
help me improve hydrogen bond acceptors and H-bond donors of molecule CCNC(=NCc1ccc(C)cc1OCC)NCC1(C)COC1.	CCNC(=NCc1ccc(B(O)O)cc1OCC)NCC1(C)COC1
help me reduce DRD2 binding affinity and improve LogP value of molecule NC(=O)CN1CCC[C@H]1CNC(=O)c1cccc(-c2ccoc2)c1.	O=C(NC[C@@H]1CCCN1Cc1ccccc1)c1cccc(-c2ccoc2)c1
Help me improve the QED of molecule CCCC(CCBr)C[C@@H](CNC(=O)[C@@H](C)Cc1ccc(C)cc1)N(C)Cc1nccs1 to make it more like a drug	Cc1ccc(C[C@H](C)C(=O)NC[C@H](C)N(C)Cc2nccs2)cc1
help me improve DRD2 binding affinity and QED score of molecule CC(O)C1OC(CN(CC(=O)O)C2CC(NC(=O)c3cccc(-c4ncn[nH]4)c3)C2)C(O)C1O.	O=C(O)CN(CC1CC1)C1CC(NC(=O)c2cccc(-c3ncn[nH]3)c2)C1
help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors of molecule CC(C)(C)OC(=O)N[C@H](C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)CCc3cn[nH]c3)[C@H]2C1)C1CC1.	CC(C)(C)OC(=O)NC(NC(=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)CCc3cn[nH]c3)[C@H]2C1)C(N)=O
Help me improve the QED of molecule CCC(NC(C)c1nc2sc3c(c2c(=O)[nH]1)CCC(C)C3)c1ccc(-c2csc(C(C)Cl)c2Cl)cc1 to make it more like a drug	CCC(NC(C)c1nc2sc3c(c2c(=O)[nH]1)CCC(C)C3)c1ccc(OC)cc1
help me reduce LogP value and QED score of molecule NS(=O)(=O)c1ccc(CNc2nc(C(F)(F)F)cc(=O)[nH]2)cc1.	NNC(=O)C(=O)NC(F)(F)c1cc(=O)[nH]c(NCc2ccc(S(N)(=O)=O)cc2)n1
help me improve hydrogen bond acceptors and H-bond donors of molecule CC(C)=CCCC1(C)C(CC=C(C)C)CC2(C)C(=O)C1(C(=O)c1ccccc1)C(=O)C1=C2OC(C(C)(C)O)C1O.	CC(=O)NCC(=O)NCC1(C)C(CC=C(C)C)CC2(C)C(=O)C1(C(=O)c1ccccc1)C(=O)C1=C2OC(C(C)(C)O)C1O
help me reduce LogP value and improve H-bond donors of molecule CC(=O)N1CCN(CC(=O)c2ccc3c(c2)OCCO3)CC1.	NC(=[NH2+])C(=O)N1CCN(CC(=O)c2ccc3c(c2)OCCO3)CC1
help me improve GSK3β inhibitory activity and synthetic accessibility of molecule COc1c(F)cccc1C1CCNC1.	NC(=[NH2+])Oc1c(F)cccc1C1CCNC1
help me reduce DRD2 binding affinity and molecular weight of molecule CCCC[C@@H](NC(=O)c1c(F)cc(OC)cc1F)c1ccc(Oc2ccc(F)c(Cl)c2)cc1.	CCCC[C@@H](NC(=O)c1c(F)cc(OC)cc1F)c1ccc(OC)cc1
help me reduce rotatable bonds and improve QED score of molecule CC[Si](CC)(CC)CC(=O)c1cccc(Oc2nn(C)c(C(F)(F)F)c2Cl)c1.	Cn1nc(Oc2cccc(C(=O)CN)c2)c(Cl)c1C(F)(F)F
help me reduce LogP value and improve hydrogen bond acceptors of molecule Cc1cccc(-n2nc3c(c2NC(=O)c2cccs2)CS(=O)C3)c1C.	Cc1c(B(O)O)cccc1-n1nc2c(c1NC(=O)c1cccs1)CS(=O)C2
help me reduce rotatable bonds and synthetic accessibility of molecule CCC(C)CCC(C)c1ccc(-c2nc(C#N)c3[nH]c(=O)c(-c4ccc([N+](=O)[O-])cc4)cc3n2)cc1.	CCOc1ccc(-c2nc(C#N)c3[nH]c(=O)c(-c4ccc([N+](=O)[O-])cc4)cc3n2)cc1
help me improve hydrogen bond acceptors and JNK3 binding affinity and rotatable bonds of molecule NC(=O)C1C2C(=O)OC(c3ccccc3)C(c3ccccc3)N2C(c2ccc(O)cc2)C12C(=O)Nc1ccc(C#CC3=CCCCC3)cc12.	CCC(O)[C@H](O)CNS(=O)(=O)C1N2C(C(=O)OC(c3ccccc3)C2c2ccccc2)C(C(N)=O)C12C(=O)Nc1ccc(C#CC3=CCCCC3)cc12
help me improve hydrogen bond acceptors and H-bond donors of molecule Cc1coc(C)c1C(=O)N[C@H]1CCC[C@@H](NC(=O)OC(C)(C)C)C1.	Cc1coc(B(O)O)c1C(=O)N[C@H]1CCC[C@@H](NC(=O)OC(C)(C)C)C1
help me improve molecular weight and synthetic accessibility of molecule Cc1cc(C)c(NCC(=O)NCCc2cccc(Cl)c2)c(C)c1.	CCC(CC)(CC)Sc1cc(C)c(NCC(=O)NCCc2cccc(Cl)c2)c(C)c1
Help me make the molecule CCOC(=O)N[C@H](O)C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@H]2CCc3ccccc3O2)CC1 with more hydrogen bond acceptors	C=CC(=CC=CO)OC(C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@H]2CCc3ccccc3O2)CC1)C(C)NC(=O)OCC
help me reduce hydrogen bond acceptors and rotatable bonds and synthetic accessibility and improve LogP value and QED score of molecule CC(C[NH+](COc1cccnc1NC(=O)[C@H]1CCC[C@@H](O)C1)Cc1ccccc1)C(=O)[O-].	O=C(Nc1ncccc1OCc1ccccc1)[C@H]1CCC[C@@H](O)C1
help me reduce LogP value and improve molecular weight and rotatable bonds of molecule C[C@@H](c1ccccc1)N1CCC(NC(=O)NCc2ccco2)CC1.	CC(C[NH+](CNC(=O)NC1CCN([C@@H](C)c2ccccc2)CC1)Cc1ccco1)C(=O)[O-]
Help me reduce the QED of molecule CCCCC(=O)N[C@@]1(C)CCN(C(=O)C2(c3ccccc3C)CC2)C1 to make it less like a drug	CCCCC(=O)N[C@@]1(C)CCN(C(=O)C2(c3ccccc3-c3ccc(Cl)c(Cl)c3)CC2)C1
help me reduce hydrogen bond acceptors and improve DRD2 binding affinity of molecule COC(=O)C1CCCN1CC(=O)N(C)Cc1ccc2cc(OC)ccc2c1.	CCC(C)=C(CC)C1CCCN1CC(=O)N(C)Cc1ccc2cc(OC)ccc2c1
Help me make the molecule CSCC[C@@H](O)C(=O)N1CCCC12CN(C(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1F)C2 with more hydrogen bond acceptors	CC(C)(C)OC(=O)N1CC[C@@H](C(=O)N2CC3(CCCN3C(=O)[C@H](O)CCSSc3cccc(Cl)c3)C2)[C@@H](F)C1
Help me reduce the QED of molecule Cc1ccc([C@@H](C)N(C)C(=S)N[C@@H]2CCOc3ccccc32)cc1 to make it less like a drug	CCCCCCCCN(C(=S)N[C@@H]1CCOc2ccccc21)[C@H](C)c1ccc(C)cc1
help me reduce QED score and improve hydrogen bond acceptors and molecular weight and rotatable bonds of molecule C[C@@H]1CN(Cc2ccccc2F)C[C@H]1CNC(=O)C1CC2(CC2)C1.	CC(C[NH+](CNC(=O)C1CC2(CC2)C1)C[C@@H]1CN(Cc2ccccc2F)C[C@H]1C)C(=O)[O-]
help me improve hydrogen bond acceptors and H-bond donors of molecule Clc1ccn2ncc(CN3CCC[C@H](c4ccccn4)C3)c2n1.	NN=C(NN)c1ccn2ncc(CN3CCC[C@H](c4ccccn4)C3)c2n1
help me reduce synthetic accessibility and improve LogP value of molecule C[NH+]1CCN(C(=O)Cn2c(CNC(=O)CCCc3cccc(F)c3)nc3cccnc32)CC1.	O=C(CCCc1cccc(F)c1)NCc1nc2cccnc2n1CC1CC1
help me reduce QED score and improve JNK3 binding affinity of molecule Cc1ccc([C@@H](C)N[C@@H](C)C(=O)Nc2ccc(N3CCCC3)cc2)cc1.	C[C@H](N[C@H](C)c1ccc(-c2ccc(Cl)c(Cl)c2)cc1)C(=O)Nc1ccc(N2CCCC2)cc1
help me reduce GSK3β inhibitory activity and improve QED score of molecule Cc1cc(-c2cc(C)c(Br)c(F)c2)c2[nH]c(-c3cccc(Cl)c3)c(CC(=O)O)c2c1.	Cc1cc(C)c2[nH]c(-c3cccc(Cl)c3)c(CC(=O)O)c2c1
help me improve hydrogen bond acceptors and synthetic accessibility of molecule C[C@H](NC(=O)NC[C@H](CO)CC1CC1)c1cccc(OC(F)F)c1.	CC(C[NH+](CC1CC1)C[C@@H](CO)CNC(=O)N[C@@H](C)c1cccc(OC(F)F)c1)C(=O)[O-]
Help me make the molecule C=C(C=CC(=CC)c1c(OC)cc(Cn2c([C@H](C)NS(C)(=O)=O)nnc2N2CC[C@H](C)C2)cc1OC)C(C)CC with more hydrogen bond acceptors	COc1cc(Cn2c([C@H](C)NS(C)(=O)=O)nnc2N2CC[C@H](C)C2)cc(OC)c1OC
help me reduce GSK3β inhibitory activity and improve LogP value of molecule C=CCn1c(C(=O)NC(C)C(N)=[NH2+])nnc1N1CCC([C@@H](O)c2ccc(F)cc2)CC1.	C=CCn1c(C(=O)NC(C)C)nnc1N1CCC([C@@H](O)c2ccc(F)cc2)CC1
Help me make the molecule Cc1nc2cc(OCc3ccc(F)cc3)ccc2cc1C(=O)O with more hydrogen bond donors	O=C(O)c1cc2ccc(OCc3ccc(F)cc3)cc2nc1B(O)O
help me reduce molecular weight and rotatable bonds of molecule CC(C[NH+](COC(=O)C[C@H]1OCCc2ccccc21)Cc1ccc(F)cc1Cl)C(=O)[O-].	O=C(C[C@H]1OCCc2ccccc21)OCc1ccc(F)cc1Cl
help me reduce GSK3β inhibitory activity and H-bond donors of molecule CC1(C(=O)N2CCC3(CCN(C[C@@H]4CCO[C@@H](C(N)=[NH2+])C4)CC3)CC2)CC1.	C[C@H]1C[C@H](CN2CCC3(CC2)CCN(C(=O)C2(C)CC2)CC3)CCO1
help me reduce rotatable bonds and improve LogP value and QED score of molecule CC(C[NH+](Cc1cccc(Cl)c1)CC1(O)CCN(C(=O)CN2CC(=O)NC2=O)C1)C(=O)[O-].	O=C1CN(CC(=O)N2CCC(O)(Cc3cccc(Cl)c3)C2)C(=O)N1
help me reduce LogP value and improve GSK3β inhibitory activity and hydrogen bond acceptors and molecular weight of molecule C[C@H](NCc1ccon1)c1ccc(CNC(=O)CC(C)(F)F)cc1.	CC(C[NH+](CNC(=O)CC(C)(F)F)Cc1ccc([C@H](C)NCc2ccon2)cc1)C(=O)[O-]
help me reduce GSK3β inhibitory activity and JNK3 binding affinity and LogP value of molecule CC(C)(C)[S@](=O)CCn1c(-c2cccc(-c3ccc(Br)c(Cl)c3)n2)nnc1N1CCN(C(=O)[C@H]2CCCO2)CC1.	Cc1cccc(-c2nnc(N3CCN(C(=O)[C@H]4CCCO4)CC3)n2CC[S@@](=O)C(C)(C)C)n1
Help me reduce the QED of molecule COc1cc(N2C[C@H](C(=O)O[C@H]3CCC[C@@H](C#N)C3)CC2=O)cc(OC)c1OC to make it less like a drug	C=C[C@@H](CCCCCCC)Oc1cc(N2C[C@H](C(=O)O[C@H]3CCC[C@@H](C#N)C3)CC2=O)cc(OC)c1OC
help me reduce QED score and improve rotatable bonds of molecule Cc1cc(C(=O)N2CCCCC2C)ccc1NC(=O)c1ccc(N2CCOC2=O)cc1.	CCCC(CCBr)CC1CCCCN1C(=O)c1ccc(NC(=O)c2ccc(N3CCOC3=O)cc2)c(C)c1
Help me reduce the number of hydrogen bond acceptors in molecule CN(C)CC(C)(C)CNC(=O)C1CCN(C(=O)COc2cccc(NC(=O)c3ccco3)c2)CC1	CC(C)C(C)C(C)CCC(C)(C)CNC(=O)C1CCN(C(=O)COc2cccc(NC(=O)c3ccco3)c2)CC1
Help me make the molecule Cc1nsc(N2CC[C@@H](NC(=O)c3ccccc3CC(C)C)C2)n1 with more hydrogen bond donors	CC(C)Cc1ccccc1C(=O)N[C@@H]1CCN(c2nc(B(O)O)ns2)C1
help me reduce H-bond donors and synthetic accessibility and improve LogP value of molecule CN(Cc1cccnc1)C(=O)CCn1c(C(N)=[NH2+])csc1=O.	Cc1csc(=O)n1CCC(=O)N(C)Cc1cccnc1
help me improve JNK3 binding affinity and synthetic accessibility of molecule N#Cc1ccc(Cn2cncc2CNC2CCN(C(Cc3cccc(Cl)c3)c3cccc(O)c3)C2=O)cc1F.	C=C(C)C(C(C)C)(C1CCN(C(Cc2cccc(Cl)c2)c2cccc(O)c2)C1=O)C(C)c1cncn1Cc1ccc(C#N)c(F)c1
help me improve hydrogen bond acceptors and H-bond donors of molecule CC(C)NC(N)=NCc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.	CC(C)NC(N)=NCc1cc([N+](=O)[O-])cc(C(F)(F)NC(=O)C(=O)NN)c1
help me improve molecular weight and synthetic accessibility of molecule COc1ccc(Cl)cc1C(=O)NCCn1ncccc1=O.	Cc1csc(Oc2ccc(Cl)cc2C(=O)NCCn2ncccc2=O)c1Cl

help me improve hydrogen bond acceptors and H-bond donors of molecule CCOc1c(Cl)cccc1CC(=O)N1Cc2ccccc2OC[C@H]1C.

CCOc1c(CC(=O)N2Cc3ccccc3OC[C@H]2C)cccc1C(=NN)NN

help me improve H-bond donors and JNK3 binding affinity of molecule Cc1csc(Cn2c(=S)[nH]c3cc(Br)ccc32)n1.

OB(O)c1csc(Cn2c(=S)[nH]c3cc(Br)ccc32)n1

help me improve JNK3 binding affinity and molecular weight of molecule CCc1oc(C(=O)N[C@@H]2CCC[C@@H]2CNc2ncc(F)cn2)cc1C.

CCC=CC=CC(C)C(C)c1oc(C(=O)N[C@@H]2CCC[C@@H]2CNc2ncc(F)cn2)cc1C

help me reduce QED score and improve DRD2 binding affinity and molecular weight and rotatable bonds of molecule COc1cccc(C[C@H]2CCCCCN2C[C@H](O)CC2(O)CCC2)c1.

COc1cccc(C[C@H]2CCCCCN2C[C@H](O)CC2(C(C)=CCCBr)CCC2)c1

help me improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule COc1ccc(CC(=O)N2CCO[C@@]3(CCN(C(=O)c4cc(O)ccc4F)C3)C2)c(Cl)c1.

CC[NH2+]C(COc1ccc(F)c(C(=O)N2CC[C@]3(CN(C(=O)Cc4ccc(OC)cc4Cl)CCO3)C2)c1)C(=O)[O-]

help me improve GSK3β inhibitory activity and JNK3 binding affinity of molecule CC[C@@H](CNC(=O)c1cscc1C)NC(=O)[C@@H](OC)C1CC1.

CC[C@@H](CNC(=O)c1cscc1-c1cc(C)c(Br)c(F)c1)NC(=O)[C@@H](OC)C1CC1

Help me reduce the number of hydrogen bond donors in molecule Cc1cccc(Cn2c(=O)c(C(=O)NCN)nn(-c3ccc(F)cc3)c2=O)c1

Cc1cccc(Cn2c(=O)c(C(=O)Nc3ccccc3)nn(-c3ccc(F)cc3)c2=O)c1

help me improve H-bond donors and synthetic accessibility of molecule Cc1cc([N+](=O)[O-])nn1CC(=O)N(C)C1CCCCC1.

CN(C(=O)Cn1nc([N+](=O)[O-])cc1C(N)=[NH2+])C1CCCCC1

help me improve JNK3 binding affinity and LogP value and molecular weight of molecule COC(=O)c1ccc2c(c1)[nH]c(=O)c1cnn(C3CCOCC3)c12.

O=C(Oc1ccc(Cl)cc1Cl)c1ccc2c(c1)[nH]c(=O)c1cnn(C3CCOCC3)c12

help me reduce molecular weight and improve QED score of molecule CCOc1cccc([C@H]2C[C@H]2NC(=O)c2cnn(C3CCCCC3)c2-c2cc(Cl)cc(Cl)c2)c1.

CCOc1cccc([C@H]2C[C@H]2NC(=O)c2cnn(C3CCCCC3)c2C)c1

Help me reduce the number of hydrogen bond donors in molecule Cc1nc(C[NH+]2CCC(C(=O)NCCC(C)O)CC2)cs1

CCC(C)(C)C(C)CCNC(=O)C1CC[NH+](Cc2csc(C)n2)CC1

help me reduce H-bond donors and improve QED score of molecule NC(=[NH2+])c1nc[nH]c1C(=O)N[C@@H]1CCN([C@H]2CCNC2=O)C1.

Cc1nc[nH]c1C(=O)N[C@@H]1CCN([C@H]2CCNC2=O)C1

Help me make the molecule COCCN1CC[C@H](NC(=O)Cn2ccnc2C)[C@H](C(C)=CCCBr)C1 with more hydrogen bond donors

COCCN1CC[C@H](NC(=O)Cn2ccnc2C)[C@H](O)C1

help me reduce QED score and improve molecular weight of molecule CC(C)[C@H](CNc1cc(N(C)C)ccn1)c1ccccc1.

Cc1cccc(N(C)c2ccnc(NC[C@H](c3ccccc3)C(C)C)c2)c1Cl

Help me reduce the QED of molecule COc1cc(F)cc(CNc2ccc(S[C@@H](C)C(=O)O)cc2)c1 to make it less like a drug

CC(C)c1cccc(Oc2cc(F)cc(CNc3ccc(S[C@@H](C)C(=O)O)cc3)c2)c1

help me reduce hydrogen bond acceptors and molecular weight and synthetic accessibility and improve QED score of molecule CC(C)C[NH+](CC(=O)[O-])C(F)(F)C[C@@H](NC(=O)N1CCCC[C@@H]1C[C@H](C)O)c1ccccc1.

C[C@H](O)C[C@H]1CCCCN1C(=O)N[C@H](CC(F)(F)F)c1ccccc1

Help me reduce the number of hydrogen bond donors in molecule C=CC(=CC(=CC)c1ccc(NC)c(C(=C)c2nc3c(-c4ccsc4)cncc3[nH]2)c1)N(C)C

C=CC(=CC(=CC)c1ccc(-c2ccc(C(C)(C)C)cc2)c(C(=C)c2nc3c(-c4ccsc4)cncc3[nH]2)c1)N(C)C

Help me make the molecule O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(C2CCC(CCCC3CCCC3)CC2)C1 with more hydrogen bond acceptors

O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(NCC2CCCC2)C1

help me improve GSK3β inhibitory activity and hydrogen bond acceptors of molecule O=C(NC[C@@H]1CCC[C@@H]1O)c1cccc(Nc2cnccn2)c1.

CC(C[NH+](CNC(=O)c1cccc(Nc2cnccn2)c1)C[C@@H]1CCC[C@@H]1O)C(=O)[O-]

help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors and synthetic accessibility of molecule Cc1ccc(C)n1-c1ccc(C#N)cc1N.

Cc1ccc(B(O)O)n1-c1ccc(C#N)cc1N

help me improve GSK3β inhibitory activity and JNK3 binding affinity of molecule COc1cc(C(=O)N2CCC(Oc3ccccc3C(F)(F)F)CC2)ccc1-n1cnc(C)c1.

Cc1cn(-c2ccc(C(=O)N3CCC(Oc4ccccc4C(F)(F)F)CC3)cc2-c2ccc(C(F)(F)F)cc2)cn1

help me reduce LogP value and improve synthetic accessibility of molecule O=C(Cc1ccc2nc[nH]c2c1)N[C@@H]1COCc2ccccc21.

CC(C[NH+](CC(=O)N[C@@H]1COCc2ccccc21)Cc1ccc2nc[nH]c2c1)C(=O)[O-]

help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule CC(C)(C)OC(=O)NC1(C(=O)NC(C#N)Cc2ccc(-c3ccc(F)c(C#N)c3)cc2)CCOCC1.

CC(=O)NC(C(=O)O)C(O)OC(=O)NC1(C(=O)NC(C#N)Cc2ccc(-c3ccc(F)c(C#N)c3)cc2)CCOCC1

help me improve hydrogen bond acceptors and H-bond donors of molecule CCS(=O)(=O)N(CC(F)F)c1sc2ccccc2c1C.

CCS(=O)(=O)N(CC(F)F)c1sc2ccccc2c1B(O)O

help me improve GSK3β inhibitory activity and H-bond donors of molecule CC(C)[C@H]1CCO[C@H]1CNC(=O)NCc1noc2c1CC(C)(C)CC2.

CC(C)[C@H]1CCO[C@H]1CNC(=O)NCc1noc2c1CC(C)(C(N)=[NH2+])CC2

help me reduce hydrogen bond acceptors and H-bond donors of molecule O=S(=O)(Nc1cccc(-c2cn3c(B(O)O)csc3n2)c1)c1ccccc1F.

Cc1csc2nc(-c3cccc(NS(=O)(=O)c4ccccc4F)c3)cn12

help me reduce synthetic accessibility and improve QED score of molecule CCCC(CCBr)CC(C)(CCC)Sc1ccc(NC(=O)C2CCNCC2C)cc1.

CCCC(C)(C)Sc1ccc(NC(=O)C2CCNCC2C)cc1

help me reduce DRD2 binding affinity and molecular weight and rotatable bonds of molecule CCCCSC(C)n1c(C)cnc1CN1CCC[C@@H](Oc2ncccc2F)C1.

Cc1cnc(CN2CCC[C@@H](Oc3ncccc3F)C2)n1C

help me reduce H-bond donors and improve LogP value of molecule C[C@@H](CCNC(=O)C1CCC(C)(C)CC1)NC(=O)CCC(F)NC(=O)C(=O)NN.

C[C@@H](CCNC(=O)C1CCC(C)(C)CC1)NC(=O)CCC(F)F

help me reduce H-bond donors and improve LogP value of molecule C=C(Cl)CN[C@H]1C[C@H]2CC[C@H]1N(C(=O)c1c(B(O)O)coc1C)C2.

C=C(Cl)CN[C@H]1C[C@H]2CC[C@H]1N(C(=O)c1c(C)coc1C)C2

help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and synthetic accessibility of molecule O=C(c1ccc(-c2cccs2)o1)N(Cc1ccco1)C[C@H]1CCCO1.

CC(C[NH+](C[C@H]1CCCO1)CN(Cc1ccco1)C(=O)c1ccc(-c2cccs2)o1)C(=O)[O-]

help me reduce hydrogen bond acceptors and JNK3 binding affinity and improve DRD2 binding affinity and QED score of molecule C=CCCN1C[C@H](NC(=O)c2ccc(C(F)[NH+](CC(=O)[O-])CC(C)C)nc2)CC[C@@H]1C.

C=CCCN1C[C@H](NC(=O)c2ccc(C(F)F)nc2)CC[C@@H]1C

help me reduce hydrogen bond acceptors and H-bond donors of molecule O=C(Nc1ccc(B(O)O)c(S(=O)(=O)N2CCOCC2)c1)C(c1ccccc1)[NH+]1CCCC1.

Cc1ccc(NC(=O)C(c2ccccc2)[NH+]2CCCC2)cc1S(=O)(=O)N1CCOCC1

Help me reduce the number of hydrogen bond acceptors in molecule O=C1CCCN1N1CCC(COC(CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1

C=C(CC(OCC1(c2ccccc2)CCN(N2CCCC2=O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1

help me reduce LogP value and QED score and improve synthetic accessibility of molecule C=C(C)CN[C@H]1CCN(C(=O)c2ccc(CC(C)C)cc2)C1.

C=C(C)CN[C@H]1CCN(C(=O)c2ccc(C[C@@H](C)C(N)=[NH2+])cc2)C1

Help me make the molecule C[C@H](NC(=O)CCc1cncs1)[C@@H](C)Nc1nc2ccccc2o1 with more hydrogen bond acceptors

CCC(CC)(CC)SC(NC(=O)CCc1cncs1)[C@@H](C)Nc1nc2ccccc2o1

help me reduce hydrogen bond acceptors and H-bond donors of molecule CCC(=O)Nc1ccc(C(=O)NCCNS(=O)(=O)c2ccc(OC)c(B(O)O)c2)cc1.

CCC(=O)Nc1ccc(C(=O)NCCNS(=O)(=O)c2ccc(OC)c(C)c2)cc1

help me improve DRD2 binding affinity and rotatable bonds and synthetic accessibility of molecule C[C@H]1CN(c2nnc(-c3ccccc3)n2C[C@@H]2CC2(C)C)CC(C)(C)C1.

CCCC(CCBr)CC1(C)C[C@@H](C)CN(c2nnc(-c3ccccc3)n2C[C@@H]2CC2(C)C)C1

help me reduce hydrogen bond acceptors and molecular weight and synthetic accessibility and improve LogP value and QED score of molecule CC(C[NH+](CC(=O)N[C@@H](c1cccs1)C1CC1)C[C@H]1Oc2ccccc2NC1=O)C(=O)[O-].

O=C(C[C@H]1Oc2ccccc2NC1=O)N[C@@H](c1cccs1)C1CC1

help me reduce DRD2 binding affinity and molecular weight and synthetic accessibility and improve LogP value of molecule CCCNC(=O)c1coc(C[NH+](CC(C)C(=O)[O-])CN2CCN(c3cccc(Cl)c3)CC2)n1.

CCCNC(=O)c1coc(CN2CCN(c3cccc(Cl)c3)CC2)n1

help me reduce molecular weight and rotatable bonds and synthetic accessibility of molecule CCC(CC)(CC)SC(C)(C)OC(=O)N1CC[C@H](N[C@@H](C)c2ccc(SC)cc2)C1.

CSc1ccc([C@H](C)N[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1

help me reduce GSK3β inhibitory activity and improve QED score of molecule CC/C=C(\C)C(=O)NCCC(NC(=O)CCN1CCCCC1)C(N)=[NH2+].

CC/C=C(\C)C(=O)NCC[C@H](C)NC(=O)CCN1CCCCC1

help me improve GSK3β inhibitory activity and molecular weight of molecule CC[C@@H](F)C(=O)NC[C@H](C)NC(=O)c1cc2cc(F)ccc2[nH]1.

CCCC(CCBr)C[C@@H](CNC(=O)[C@H](F)CC)NC(=O)c1cc2cc(F)ccc2[nH]1

help me reduce GSK3β inhibitory activity and JNK3 binding affinity of molecule CC(c1ccccc1)N(CC=Cc1ccccc1)C(=O)c1ccc(-c2ccc(Br)c(Cl)c2)c([N+](=O)[O-])c1.

Cc1ccc(C(=O)N(CC=Cc2ccccc2)C(C)c2ccccc2)cc1[N+](=O)[O-]

help me improve H-bond donors and JNK3 binding affinity of molecule Cc1ccc(Nc2cc(N3CCCCC3)ncn2)cc1Cl.

NC(=[NH2+])c1ccc(Nc2cc(N3CCCCC3)ncn2)cc1Cl

Help me reduce the number of hydrogen bond acceptors in molecule CC(C)(C#N)c1cccc(C(=O)N(c2cncc(N(Cl)c3cc(Br)cn3C3CC3)c2)c2ccccc2C(N)=O)c1Cl

CN(Cl)c1cncc(N(C(=O)c2cccc(C(C)(C)C#N)c2Cl)c2ccccc2C(N)=O)c1

help me reduce rotatable bonds and improve LogP value of molecule CC(C)C[NH+](CC(=O)[O-])[C@@H](F)C(=O)N[C@@H]1CN(C(=O)CC2CCC(C)(C)CC2)CC1(C)C.

CC1(C)CCC(CC(=O)N2C[C@@H](NC(=O)C(F)F)C(C)(C)C2)CC1

help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and synthetic accessibility of molecule CC[C@@H](CC1CCCC1)C(=O)Nc1c(O)n[nH]c1-c1ccccc1.

CC[C@@H](C[NH+](CC1CCCC1)CC(C)C(=O)[O-])C(=O)Nc1c(O)n[nH]c1-c1ccccc1

help me reduce synthetic accessibility and improve QED score of molecule CCC(CC)(CC)SN(CC(=O)Nc1cc(Cl)ccc1OC)C(=O)C(C)(C)c1ccccc1.

COc1ccc(Cl)cc1NC(=O)CN(C)C(=O)C(C)(C)c1ccccc1

Help me make the molecule COc1cccc2c(=O)c(C(=O)Nc3nc(-c4ccc(Cl)cc4)cs3)c[nH]c12 with more hydrogen bond acceptors

O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1c[nH]c2c(Oc3cc(Br)cn3C3CC3)cccc2c1=O

help me improve GSK3β inhibitory activity and JNK3 binding affinity and LogP value of molecule Cc1nc(C(=O)N2CCO[C@@]3(COCCN(C(=O)c4cnc5c(c4)NC(=O)CS5)C3)C2)cs1.

O=C1CSc2ncc(C(=O)N3CCOC[C@@]4(C3)CN(C(=O)c3csc(-c5cc(Br)ccc5Br)n3)CCO4)cc2N1

help me improve molecular weight and synthetic accessibility of molecule CN=C(NCC(C)Oc1ccc(OC)cc1)NC1CCN(CC(N)=O)CC1.

CCC(CC)(CC)SC(CNC(=NC)NC1CCN(CC(N)=O)CC1)Oc1ccc(OC)cc1

help me reduce LogP value and improve hydrogen bond acceptors and molecular weight and rotatable bonds of molecule O=C(NCc1cccc(Cl)c1)N[C@H]1CCCOc2cc(F)ccc21.

CC(C[NH+](CNC(=O)N[C@H]1CCCOc2cc(F)ccc21)Cc1cccc(Cl)c1)C(=O)[O-]

help me improve rotatable bonds and synthetic accessibility of molecule Cc1nn(C)cc1C(=O)C1=C(C(F)(F)F)Nc2ncnn2C1c1ccc(Cl)cc1.

Cc1nn(C)cc1C(=O)C1=C(C(F)(F)C[NH+](C)C2CC[NH+](C)CC2)Nc2ncnn2C1c1ccc(Cl)cc1

help me improve hydrogen bond acceptors and H-bond donors of molecule CCNC(=NCc1ccc(C)cc1OCC)NCC1(C)COC1.

CCNC(=NCc1ccc(B(O)O)cc1OCC)NCC1(C)COC1

help me reduce DRD2 binding affinity and improve LogP value of molecule NC(=O)CN1CCC[C@H]1CNC(=O)c1cccc(-c2ccoc2)c1.

O=C(NC[C@@H]1CCCN1Cc1ccccc1)c1cccc(-c2ccoc2)c1

Help me improve the QED of molecule CCCC(CCBr)C[C@@H](CNC(=O)[C@@H](C)Cc1ccc(C)cc1)N(C)Cc1nccs1 to make it more like a drug

Cc1ccc(C[C@H](C)C(=O)NC[C@H](C)N(C)Cc2nccs2)cc1

help me improve DRD2 binding affinity and QED score of molecule CC(O)C1OC(CN(CC(=O)O)C2CC(NC(=O)c3cccc(-c4ncn[nH]4)c3)C2)C(O)C1O.

O=C(O)CN(CC1CC1)C1CC(NC(=O)c2cccc(-c3ncn[nH]3)c2)C1

help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors of molecule CC(C)(C)OC(=O)N[C@H](C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)CCc3cn[nH]c3)[C@H]2C1)C1CC1.

CC(C)(C)OC(=O)NC(NC(=O)C(=O)N1CC[C@H]2CO[C@@H](CNC(=O)CCc3cn[nH]c3)[C@H]2C1)C(N)=O

Help me improve the QED of molecule CCC(NC(C)c1nc2sc3c(c2c(=O)[nH]1)CCC(C)C3)c1ccc(-c2csc(C(C)Cl)c2Cl)cc1 to make it more like a drug

CCC(NC(C)c1nc2sc3c(c2c(=O)[nH]1)CCC(C)C3)c1ccc(OC)cc1

help me reduce LogP value and QED score of molecule NS(=O)(=O)c1ccc(CNc2nc(C(F)(F)F)cc(=O)[nH]2)cc1.

NNC(=O)C(=O)NC(F)(F)c1cc(=O)[nH]c(NCc2ccc(S(N)(=O)=O)cc2)n1

help me improve hydrogen bond acceptors and H-bond donors of molecule CC(C)=CCCC1(C)C(CC=C(C)C)CC2(C)C(=O)C1(C(=O)c1ccccc1)C(=O)C1=C2OC(C(C)(C)O)C1O.

CC(=O)NCC(=O)NCC1(C)C(CC=C(C)C)CC2(C)C(=O)C1(C(=O)c1ccccc1)C(=O)C1=C2OC(C(C)(C)O)C1O

help me reduce LogP value and improve H-bond donors of molecule CC(=O)N1CCN(CC(=O)c2ccc3c(c2)OCCO3)CC1.

NC(=[NH2+])C(=O)N1CCN(CC(=O)c2ccc3c(c2)OCCO3)CC1

help me improve GSK3β inhibitory activity and synthetic accessibility of molecule COc1c(F)cccc1C1CCNC1.

NC(=[NH2+])Oc1c(F)cccc1C1CCNC1

help me reduce DRD2 binding affinity and molecular weight of molecule CCCC[C@@H](NC(=O)c1c(F)cc(OC)cc1F)c1ccc(Oc2ccc(F)c(Cl)c2)cc1.

CCCC[C@@H](NC(=O)c1c(F)cc(OC)cc1F)c1ccc(OC)cc1

help me reduce rotatable bonds and improve QED score of molecule CC[Si](CC)(CC)CC(=O)c1cccc(Oc2nn(C)c(C(F)(F)F)c2Cl)c1.

Cn1nc(Oc2cccc(C(=O)CN)c2)c(Cl)c1C(F)(F)F

help me reduce LogP value and improve hydrogen bond acceptors of molecule Cc1cccc(-n2nc3c(c2NC(=O)c2cccs2)CS(=O)C3)c1C.

Cc1c(B(O)O)cccc1-n1nc2c(c1NC(=O)c1cccs1)CS(=O)C2

help me reduce rotatable bonds and synthetic accessibility of molecule CCC(C)CCC(C)c1ccc(-c2nc(C#N)c3[nH]c(=O)c(-c4ccc([N+](=O)[O-])cc4)cc3n2)cc1.

CCOc1ccc(-c2nc(C#N)c3[nH]c(=O)c(-c4ccc([N+](=O)[O-])cc4)cc3n2)cc1

help me improve hydrogen bond acceptors and JNK3 binding affinity and rotatable bonds of molecule NC(=O)C1C2C(=O)OC(c3ccccc3)C(c3ccccc3)N2C(c2ccc(O)cc2)C12C(=O)Nc1ccc(C#CC3=CCCCC3)cc12.

CCC(O)[C@H](O)CNS(=O)(=O)C1N2C(C(=O)OC(c3ccccc3)C2c2ccccc2)C(C(N)=O)C12C(=O)Nc1ccc(C#CC3=CCCCC3)cc12

help me improve hydrogen bond acceptors and H-bond donors of molecule Cc1coc(C)c1C(=O)N[C@H]1CCC[C@@H](NC(=O)OC(C)(C)C)C1.

Cc1coc(B(O)O)c1C(=O)N[C@H]1CCC[C@@H](NC(=O)OC(C)(C)C)C1

help me improve molecular weight and synthetic accessibility of molecule Cc1cc(C)c(NCC(=O)NCCc2cccc(Cl)c2)c(C)c1.

CCC(CC)(CC)Sc1cc(C)c(NCC(=O)NCCc2cccc(Cl)c2)c(C)c1

Help me make the molecule CCOC(=O)N[C@H](O)C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@H]2CCc3ccccc3O2)CC1 with more hydrogen bond acceptors

C=CC(=CC=CO)OC(C(=O)N1CCCC[C@@H]1C1CCN(C(=O)[C@H]2CCc3ccccc3O2)CC1)C(C)NC(=O)OCC

help me reduce hydrogen bond acceptors and rotatable bonds and synthetic accessibility and improve LogP value and QED score of molecule CC(C[NH+](COc1cccnc1NC(=O)[C@H]1CCC[C@@H](O)C1)Cc1ccccc1)C(=O)[O-].

O=C(Nc1ncccc1OCc1ccccc1)[C@H]1CCC[C@@H](O)C1

help me reduce LogP value and improve molecular weight and rotatable bonds of molecule C[C@@H](c1ccccc1)N1CCC(NC(=O)NCc2ccco2)CC1.

CC(C[NH+](CNC(=O)NC1CCN([C@@H](C)c2ccccc2)CC1)Cc1ccco1)C(=O)[O-]

Help me reduce the QED of molecule CCCCC(=O)N[C@@]1(C)CCN(C(=O)C2(c3ccccc3C)CC2)C1 to make it less like a drug

CCCCC(=O)N[C@@]1(C)CCN(C(=O)C2(c3ccccc3-c3ccc(Cl)c(Cl)c3)CC2)C1

help me reduce hydrogen bond acceptors and improve DRD2 binding affinity of molecule COC(=O)C1CCCN1CC(=O)N(C)Cc1ccc2cc(OC)ccc2c1.

CCC(C)=C(CC)C1CCCN1CC(=O)N(C)Cc1ccc2cc(OC)ccc2c1

Help me make the molecule CSCC[C@@H](O)C(=O)N1CCCC12CN(C(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1F)C2 with more hydrogen bond acceptors

CC(C)(C)OC(=O)N1CC[C@@H](C(=O)N2CC3(CCCN3C(=O)[C@H](O)CCSSc3cccc(Cl)c3)C2)[C@@H](F)C1

Help me reduce the QED of molecule Cc1ccc([C@@H](C)N(C)C(=S)N[C@@H]2CCOc3ccccc32)cc1 to make it less like a drug

CCCCCCCCN(C(=S)N[C@@H]1CCOc2ccccc21)[C@H](C)c1ccc(C)cc1

help me reduce QED score and improve hydrogen bond acceptors and molecular weight and rotatable bonds of molecule C[C@@H]1CN(Cc2ccccc2F)C[C@H]1CNC(=O)C1CC2(CC2)C1.

CC(C[NH+](CNC(=O)C1CC2(CC2)C1)C[C@@H]1CN(Cc2ccccc2F)C[C@H]1C)C(=O)[O-]

help me improve hydrogen bond acceptors and H-bond donors of molecule Clc1ccn2ncc(CN3CCC[C@H](c4ccccn4)C3)c2n1.

NN=C(NN)c1ccn2ncc(CN3CCC[C@H](c4ccccn4)C3)c2n1

help me reduce synthetic accessibility and improve LogP value of molecule C[NH+]1CCN(C(=O)Cn2c(CNC(=O)CCCc3cccc(F)c3)nc3cccnc32)CC1.

O=C(CCCc1cccc(F)c1)NCc1nc2cccnc2n1CC1CC1

help me reduce QED score and improve JNK3 binding affinity of molecule Cc1ccc([C@@H](C)N[C@@H](C)C(=O)Nc2ccc(N3CCCC3)cc2)cc1.

C[C@H](N[C@H](C)c1ccc(-c2ccc(Cl)c(Cl)c2)cc1)C(=O)Nc1ccc(N2CCCC2)cc1

help me reduce GSK3β inhibitory activity and improve QED score of molecule Cc1cc(-c2cc(C)c(Br)c(F)c2)c2[nH]c(-c3cccc(Cl)c3)c(CC(=O)O)c2c1.

Cc1cc(C)c2[nH]c(-c3cccc(Cl)c3)c(CC(=O)O)c2c1

help me improve hydrogen bond acceptors and synthetic accessibility of molecule C[C@H](NC(=O)NC[C@H](CO)CC1CC1)c1cccc(OC(F)F)c1.

CC(C[NH+](CC1CC1)C[C@@H](CO)CNC(=O)N[C@@H](C)c1cccc(OC(F)F)c1)C(=O)[O-]

Help me make the molecule C=C(C=CC(=CC)c1c(OC)cc(Cn2c([C@H](C)NS(C)(=O)=O)nnc2N2CC[C@H](C)C2)cc1OC)C(C)CC with more hydrogen bond acceptors

COc1cc(Cn2c([C@H](C)NS(C)(=O)=O)nnc2N2CC[C@H](C)C2)cc(OC)c1OC

help me reduce GSK3β inhibitory activity and improve LogP value of molecule C=CCn1c(C(=O)NC(C)C(N)=[NH2+])nnc1N1CCC([C@@H](O)c2ccc(F)cc2)CC1.

C=CCn1c(C(=O)NC(C)C)nnc1N1CCC([C@@H](O)c2ccc(F)cc2)CC1

Help me make the molecule Cc1nc2cc(OCc3ccc(F)cc3)ccc2cc1C(=O)O with more hydrogen bond donors

O=C(O)c1cc2ccc(OCc3ccc(F)cc3)cc2nc1B(O)O

help me reduce molecular weight and rotatable bonds of molecule CC(C[NH+](COC(=O)C[C@H]1OCCc2ccccc21)Cc1ccc(F)cc1Cl)C(=O)[O-].

O=C(C[C@H]1OCCc2ccccc21)OCc1ccc(F)cc1Cl

help me reduce GSK3β inhibitory activity and H-bond donors of molecule CC1(C(=O)N2CCC3(CCN(C[C@@H]4CCO[C@@H](C(N)=[NH2+])C4)CC3)CC2)CC1.

C[C@H]1C[C@H](CN2CCC3(CC2)CCN(C(=O)C2(C)CC2)CC3)CCO1

help me reduce rotatable bonds and improve LogP value and QED score of molecule CC(C[NH+](Cc1cccc(Cl)c1)CC1(O)CCN(C(=O)CN2CC(=O)NC2=O)C1)C(=O)[O-].

O=C1CN(CC(=O)N2CCC(O)(Cc3cccc(Cl)c3)C2)C(=O)N1

help me reduce LogP value and improve GSK3β inhibitory activity and hydrogen bond acceptors and molecular weight of molecule C[C@H](NCc1ccon1)c1ccc(CNC(=O)CC(C)(F)F)cc1.

CC(C[NH+](CNC(=O)CC(C)(F)F)Cc1ccc([C@H](C)NCc2ccon2)cc1)C(=O)[O-]

help me reduce GSK3β inhibitory activity and JNK3 binding affinity and LogP value of molecule CC(C)(C)[S@](=O)CCn1c(-c2cccc(-c3ccc(Br)c(Cl)c3)n2)nnc1N1CCN(C(=O)[C@H]2CCCO2)CC1.

Cc1cccc(-c2nnc(N3CCN(C(=O)[C@H]4CCCO4)CC3)n2CC[S@@](=O)C(C)(C)C)n1

Help me reduce the QED of molecule COc1cc(N2C[C@H](C(=O)O[C@H]3CCC[C@@H](C#N)C3)CC2=O)cc(OC)c1OC to make it less like a drug

C=C[C@@H](CCCCCCC)Oc1cc(N2C[C@H](C(=O)O[C@H]3CCC[C@@H](C#N)C3)CC2=O)cc(OC)c1OC

help me reduce QED score and improve rotatable bonds of molecule Cc1cc(C(=O)N2CCCCC2C)ccc1NC(=O)c1ccc(N2CCOC2=O)cc1.

CCCC(CCBr)CC1CCCCN1C(=O)c1ccc(NC(=O)c2ccc(N3CCOC3=O)cc2)c(C)c1

Help me reduce the number of hydrogen bond acceptors in molecule CN(C)CC(C)(C)CNC(=O)C1CCN(C(=O)COc2cccc(NC(=O)c3ccco3)c2)CC1

CC(C)C(C)C(C)CCC(C)(C)CNC(=O)C1CCN(C(=O)COc2cccc(NC(=O)c3ccco3)c2)CC1

Help me make the molecule Cc1nsc(N2CC[C@@H](NC(=O)c3ccccc3CC(C)C)C2)n1 with more hydrogen bond donors

CC(C)Cc1ccccc1C(=O)N[C@@H]1CCN(c2nc(B(O)O)ns2)C1

help me reduce H-bond donors and synthetic accessibility and improve LogP value of molecule CN(Cc1cccnc1)C(=O)CCn1c(C(N)=[NH2+])csc1=O.

Cc1csc(=O)n1CCC(=O)N(C)Cc1cccnc1

help me improve JNK3 binding affinity and synthetic accessibility of molecule N#Cc1ccc(Cn2cncc2CNC2CCN(C(Cc3cccc(Cl)c3)c3cccc(O)c3)C2=O)cc1F.

C=C(C)C(C(C)C)(C1CCN(C(Cc2cccc(Cl)c2)c2cccc(O)c2)C1=O)C(C)c1cncn1Cc1ccc(C#N)c(F)c1

help me improve hydrogen bond acceptors and H-bond donors of molecule CC(C)NC(N)=NCc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.

CC(C)NC(N)=NCc1cc([N+](=O)[O-])cc(C(F)(F)NC(=O)C(=O)NN)c1

help me improve molecular weight and synthetic accessibility of molecule COc1ccc(Cl)cc1C(=O)NCCn1ncccc1=O.

Cc1csc(Oc2ccc(Cl)cc2C(=O)NCCn2ncccc2=O)c1Cl