Unnamed: 0_x int64 0 469 | ReviewID stringlengths 8 8 | Target stringlengths 68 3.62k | PMID int64 20.3k 23.8M | Title stringlengths 14 334 | Abstract stringlengths 180 4.35k ⌀ | Unnamed: 0_y int64 0 469 |
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0 | CD007016 | At present, there is insufficient RCT evidence to enable evaluation of the effect of TPD in patients with AKI. Well-designed and larger RCTs are required to better understand the risks and benefits of TPD for AKI. | 11,849,419 | Is peritoneal dialysis adequate for hypercatabolic acute renal failure in developing countries? | Peritoneal dialysis (PD) is a therapeutic option for acute renal failure (ARF) in developing countries, despite concerns about inadequacy. Shorter and more efficient tidal peritoneal dialysis (TPD) was compared with continuous equilibrating peritoneal dialysis (CEPD) therapy in ARF by using their adequacies as accepted... | 0 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 16,809,729 | Phase II trial of alfimeprase, a novel-acting fibrin degradation agent, for occluded central venous access devices. | Alfimeprase is a recombinantly produced, genetically modified variant of the metalloproteinase, fibrolase. Alfimeprase proteolytically cleaves fibrin, independent of plasminogen activation to plasmin, and directly dissolves thrombi. Based on the direct fibrin degradation effect of alfimeprase, rapid activity in patient... | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 15,178,717 | Dose-ranging trial with a recombinant urokinase (urokinase alfa) for occluded central venous catheters in oncology patients. | Recombinant urokinase (r-UK) is a high-molecular-weight urokinase produced in transfected, non-human, mammalian cells. A Phase II, randomized, double-blind, parallel, placebo-controlled, dose-ranging study was performed to compare the safety and efficacy of one or two instillations of three intraluminal concentrations ... | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 11,487,675 | Recombinant tissue plasminogen activator (alteplase) for restoration of flow in occluded central venous access devices: a double-blind placebo-controlled trial--the Cardiovascular Thrombolytic to Open Occluded Lines (COOL) efficacy trial. | Central venous access devices (CVADs) are a mainstay of current medical therapy but often become occluded by thrombus. Tissue plasminogen activator (alteplase), at a dose of 2 mg per 2 mL, has been shown to be effective in restoring flow to catheters proven by radiographic contrast injection to be occluded by thrombus.... | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 14,742,778 | Alteplase for central catheter clearance: 1 mg/mL versus 2 mg/2 mL. | null | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 7,878,629 | Urokinase versus recombinant tissue plasminogen activator in thrombosed central venous catheters: a double-blinded, randomized trial. | Fifty dysfunctional central venous catheters proven radiographically to be occluded by thrombus were blindly randomized to be injected with either 2 mg recombinant tissue plasminogen activator (t-PA) or 10,000 units of urokinase (UK) and allowed to incubate for 2 h. A second dose was allowed if catheter function was no... | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 15,351,854 | Recombinant urokinase for restoration of patency in occluded central venous access devices. A double-blind, placebo-controlled trial. | The interval occlusion of central venous access devices (CVADs) remains a significant clinical problem, often requiring re-intervention for catheter exchange or replacement. The purpose of this Phase 3, multi-center, double-blinded study was to test the hypothesis that instillation of recombinant urokinase (r-UK) 5000 ... | 1 |
1 | CD007119 | There is inadequate evidence to draw strong conclusions on the efficacy or safety of the drug interventions included in this review. There is some low quality evidence from a meta-analysis of two studies investigating urokinase (various strengths) and some very low evidence from two single studies investigating altepla... | 9,215,844 | Low-dose urokinase infusions to treat fibrinous obstruction of venous access devices in cancer patients. | This study was undertaken to determine the role of low-dose urokinase infusions in treating fibrinous occlusions of venous access devices (VADs) in cancer patients.
Forty-two patients with VAD occlusions refractory to routine urokinase instillations were documented by x-ray (cathetergram) to have fibrin... | 1 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,285,973 | Improving access to geriatric mental health services: a randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use. | The authors sought to determine whether integrated mental health services or enhanced referral to specialty mental health clinics results in greater engagement in mental health/substance abuse services by older primary care patients.
This multisite randomized trial included 10 sites consisting of primar... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 18,802,161 | Randomized controlled trial of collaborative care management of depression among low-income patients with cancer. | To determine the effectiveness of the Alleviating Depression Among Patients With Cancer (ADAPt-C) collaborative care management for major depression or dysthymia.
Study patients included 472 low-income, predominantly female Hispanic patients with cancer age >or= 18 years with major depression (49%), dys... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 10,634,337 | Impact of disseminating quality improvement programs for depression in managed primary care: a randomized controlled trial. | Care of patients with depression in managed primary care settings often fails to meet guideline standards, but the long-term impact of quality improvement (QI) programs for depression care in such settings is unknown.
To determine if QI programs in managed care practices for depressed primary care patie... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 8,857,869 | A multifaceted intervention to improve treatment of depression in primary care. | This research study evaluates the effectiveness of a multifaceted intervention program to improve the management of depression in primary care.
One hundred fifty-three primary care patients with current depression were entered into a randomized controlled trial. Intervention patients received a structur... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,504,586 | A randomised controlled trial to test the feasibility of a collaborative care model for the management of depression in older people. | Depression is the most common mental health disorder in people aged over 65 years. Late-life depression is associated with chronic illness and disability.
To investigate the feasibility of a collaborative care model for depression in older people in a primary care setting.
Randomised con... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 16,330,624 | Systematic detection and multidisciplinary care of depression in older medical inpatients: a randomized trial. | Major depression is a frequent and serious disorder in older medical inpatients. Because the condition goes undetected and untreated in most of these patients, we conducted a randomized clinical trial to evaluate the effectiveness of a strategy of systematic detection and multidisciplinary treatment of depression in th... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 22,032,247 | Implementing collaborative care for depression treatment in primary care: a cluster randomized evaluation of a quality improvement practice redesign. | Meta-analyses show collaborative care models (CCMs) with nurse care management are effective for improving primary care for depression. This study aimed to develop CCM approaches that could be sustained and spread within Veterans Affairs (VA). Evidence-based quality improvement (EBQI) uses QI approaches within a resear... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,748,029 | The pilot study of a telephone disease management program for depression. | Most depressed patients are seen and treated exclusively by primary care clinicians. However, primary care patients with depression are often not adequately treated. The aims of this pilot study were to measure the impact of a telephone disease management program on patient outcome and clinician adherence to practice g... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,384,219 | Randomized trial of depression follow-up care by online messaging. | Quality of antidepressant treatment remains disturbingly poor. Rates of medication adherence and follow-up contact are especially low in primary care, where most depression treatment begins. Telephone care management programs can address these gaps, but reliance on live contact makes such programs less available, less ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,123,819 | Collaborative care for depressed patients with chronic medical conditions: a randomized trial in Puerto Rico. | This study examined whether a collaborative care model for depression would improve clinical and functional outcomes for depressed patients with chronic general medical conditions in primary care practices in Puerto Rico.
A total of 179 primary care patients with major depression and chronic general med... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 10,591,288 | Stepped collaborative care for primary care patients with persistent symptoms of depression: a randomized trial. | Despite improvements in the accuracy of diagnosing depression and use of medications with fewer side effects, many patients treated with antidepressant medications by primary care physicians have persistent symptoms.
A group of 228 patients recognized as depressed by their primary care physicians and gi... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,804,354 | Managing depression in home health care: a randomized clinical trial. | A prospective randomized trial was conducted to examine the effectiveness, feasibility, and degree of implementation of home health care quality improvement interventions when implemented under usual conditions by usual care providers. A total of 311 older adults were randomized to enhanced usual care (EUC) that includ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,993,363 | Treatment of postnatal depression in low-income mothers in primary-care clinics in Santiago, Chile: a randomised controlled trial. | The optimum way to improve the recognition and treatment of postnatal depression in developing countries is uncertain. We compared the effectiveness of a multicomponent intervention with usual care to treat postnatal depression in low-income mothers in primary-care clinics in Santiago, Chile.
230 mother... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 18,603,157 | Management of depression for people with cancer (SMaRT oncology 1): a randomised trial. | Major depressive disorder severely impairs the quality of life of patients with medical disorders such as cancer, but evidence to guide its management is scarce. We aimed to assess the efficacy and cost of a nurse-delivered complex intervention that was designed to treat major depressive disorder in patients who have c... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 19,734,392 | Stepped care treatment of postpartum depression: impact on treatment, health, and work outcomes. | The purpose of this study was to pilot a stepped collaborative care intervention for women with postpartum depression and evaluate health differences between self-diagnosed depressed and nondepressed women.
Five hundred six mothers of infants from 7 clinics completed surveys at 0 to 1, 2, 4, 6, and 9 mo... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 14,645,769 | Disease management for depression and at-risk drinking via telephone in an older population of veterans. | The purpose of this study was to explore the efficacy in a primary care setting of a telephone-based disease management program for the acute management of depression and/or at-risk drinking.
Veterans (N= 97) with depression and/or at-risk drinking were identified by systematic screening and assessment.... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,805,900 | A randomized, controlled trial of disease management modules, including telepsychiatric care, for depression in rural primary care. | Introduction. Disease management modules (DMM), including education, tracking, support, and medical care, have improved health for patients with asthma and diabetes. For rural patients, novel ways of delivery are needed to access clinical expertise from urban or academic specialists. Telemedicine (telephone and televid... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,159,375 | Effectiveness of an intervention led by lay health counsellors for depressive and anxiety disorders in primary care in Goa, India (MANAS): a cluster randomised controlled trial. | Depression and anxiety disorders are common mental disorders worldwide. The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders.
In this cluster randomised trial, primary care facilities ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,534,758 | Effectiveness of collaborative care depression treatment in Veterans' Affairs primary care. | To compare collaborative care for treatment of depression in primary care with consult-liaison (CL) care. In collaborative care, a mental health team provided a treatment plan to the primary care provider, telephoned patients to support adherence to the plan, reviewed treatment results, and suggested modifications to t... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,040,705 | Integrating type 2 diabetes mellitus and depression treatment among African Americans: a randomized controlled pilot trial. | The purpose of this study was to examine whether integrating depression treatment into care for type 2 diabetes mellitus among older African Americans improved medication adherence, glycemic control, and depression outcomes.
Older African Americans prescribed pharmacotherapy for type 2 diabetes mellitus... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,338,822 | Generalist care managers for the treatment of depressed medicaid patients in North Carolina: a pilot study. | In most states, mental illness costs are an increasing share of Medicaid expenditures. Specialized depression care managers (CM) have consistently demonstrated improvements in patient outcomes relative to usual primary care (UC), but are costly and may not be fully utilized in smaller practices. A generalist care manag... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,300,192 | A collaborative care depression management program for cardiac inpatients: depression characteristics and in-hospital outcomes. | Depression in cardiac patients is common, under-recognized, and independently associated with mortality.
Our objectives in this initial report from a 6-month longitudinal trial were to determine whether a collaborative care program improves rates of depression treatment by discharge among patients hospi... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,478,777 | A randomized trial of telephonic counseling plus walking for depressed diabetes patients. | Patients with diabetes and depression often have self-management needs that require between-visit support. This study evaluated the impact of telephone-delivered cognitive behavioral therapy (CBT) targeting patients' management of depressive symptoms, physical activity levels, and diabetes-related outcomes.
... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,492,326 | A randomized trial of telemedicine-based collaborative care for depression. | Evidence-based practices designed for large urban clinics are not necessarily portable into smaller isolated clinics. Implementing practice-based collaborative care for depression in smaller primary care clinics presents unique challenges because it is often not feasible to employ on-site psychiatrists.
... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,743,276 | Treatment of depression improves physical functioning in older adults. | To determine the effect of collaborative care management for depression on physical functioning in older adults.
Multisite randomized clinical trial.
Eighteen primary care clinics from eight healthcare organizations.
One thousand eight hundred one patients aged 60 and old... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,220,657 | Effectiveness of collaborative care for depression in human immunodeficiency virus clinics. | Depression is common among persons with the human immunodeficiency virus (HIV) and is associated with unfavorable outcomes.
A single-blind randomized controlled effectiveness trial at 3 Veterans Affairs HIV clinics (HIV Translating Initiatives for Depression Into Effective Solutions [HITIDES]). The HITI... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,011,764 | Randomized trial of pharmacist interventions to improve depression care and outcomes in primary care. | The impact of pharmacist interventions on the care and outcomes of patients with depression in a primary care setting was evaluated.
Patients diagnosed with a new episode of depression and started on anti-depressant medications were randomized to enhanced care (EC) or usual care (UC) for one year. EC co... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,052,041 | Patient outcomes with education, drug therapy, and support: a study of venlafaxine ER-treated outpatients with major depressive disorder. | Dialogues Time to Talk (Dialogues) is a care management program that provides additional follow-up care and patient education for outpatients with major depressive disorder (MDD) starting venlafaxine extended release (ER) therapy. This study examined the effect of the Dialogues program on patient treatment satisfaction... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,807,834 | Telephone-based cognitive-behavioral therapy for Latino patients living in rural areas: a randomized pilot study. | This pilot study tested the effectiveness of culturally tailored, telephone-based cognitive-behavioral therapy (CBT) for improving depression outcomes among Latino primary care patients living in rural settings.
A total of 101 Latino patients at a rural family medical center who met criteria for probabl... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,041,350 | Effectiveness of collaborative care in addressing depression treatment preferences among low-income Latinos. | This study assessed treatment preferences among low-income Latino patients in public-sector primary care clinics and examined whether a collaborative care intervention that included patient education and allowed patients to choose between medication, therapy, or both would increase the likelihood that patients received... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,328,325 | Telephone psychotherapy and telephone care management for primary care patients starting antidepressant treatment: a randomized controlled trial. | Both antidepressant medication and structured psychotherapy have been proven efficacious, but less than one third of people with depressive disorders receive effective levels of either treatment.
To compare usual primary care for depression with 2 intervention programs: telephone care management and tel... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 14,524,649 | Impact of a collaborative care model on depression in a primary care setting: a randomized controlled trial. | To measure the effects of a collaborative care model that emphasized the role of clinical pharmacists in providing drug therapy management and treatment follow-up to patients with depression, we conducted a randomized controlled trial at a staff model health maintenance organization. We compared the outcomes of subject... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 8,475,211 | The role of the practice nurse in the management of depression in general practice: treatment adherence to antidepressant medication. | This pilot study demonstrated the feasibility of providing practice nurse support as an adjunct to standard general practitioner treatment to patients with depressive disorders prescribed antidepressant medication. With respect to the measures used and pilot study objectives identified, there were no statistically sign... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,628,129 | Effect of telecare management on pain and depression in patients with cancer: a randomized trial. | Pain and depression are 2 of the most prevalent and treatable cancer-related symptoms, yet they frequently go unrecognized, undertreated, or both.
To determine whether centralized telephone-based care management coupled with automated symptom monitoring can improve depression and pain in patients with c... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,878,782 | Telephone depression care management for Latino Medicaid health plan members: a pilot randomized controlled trial. | The objective of this pilot study was to provide a preliminary test of feasibility, acceptability, and efficacy of telephone depression care management among Latino Medicaid health plan members. Thirty-eight depressed primary care patients were enrolled in a pilot randomized trial of telephone depression care managemen... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,472,325 | Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. | Few depressed older adults receive effective treatment in primary care settings.
To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) collaborative care management program for late-life depression.
Randomized controlled trial with recr... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,123,495 | A randomized effectiveness trial of stepped collaborative care for acutely injured trauma survivors. | Although posttraumatic stress disorder (PTSD) and alcohol abuse frequently occur among acutely injured trauma survivors, few real-world interventions have targeted these disorders.
We tested the effectiveness of a multifaceted collaborative care (CC) intervention for PTSD and alcohol abuse.
... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 11,427,243 | Collaborative interventions for physically injured trauma survivors: a pilot randomized effectiveness trial. | Posttraumatic behavioral and emotional disturbances occur frequently among physically injured hospitalized trauma survivors. This investigation was a pilot randomized effectiveness trial of a 4-month collaborative care intervention for injured motor vehicle crash and assault victims. As surgical inpatients, interventio... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 10,688,563 | Randomised trial of monitoring, feedback, and management of care by telephone to improve treatment of depression in primary care. | To test the effectiveness of two programmes to improve the treatment of acute depression in primary care.
Randomised trial.
Primary care clinics in Seattle.
613 patients starting antidepressant treatment.
Patients were randomly assigned to continued usual ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,236,381 | Understanding team-based quality improvement for depression in primary care. | To assess the impacts of the characteristics of quality improvement (QI) teams and their environments on team success in designing and implementing high quality, enduring depression care improvement programs in primary care (PC) practices.
Two nonprofit managed care organizations sponsored five QI teams... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,345,600 | Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial. | To test the effectiveness of an evidence based model for management of depression in primary care with support from quality improvement resources.
Cluster randomised controlled trial.
Five healthcare organisations in the United States and 60 affiliated practices.
405 pati... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,883,143 | Can collaborative care address the needs of low-income Latinas with comorbid depression and cancer? Results from a randomized pilot study. | In a pilot study, 55 low-income Latina patients with breast or cervical cancer and comorbid depression were randomly assigned to receive collaborative care as part of the Multifaceted Oncology Depression Program or usual care. Relative to patients in the usual care condition, patients receiving collaborative care were ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 9,604,408 | An evaluation of practice nurses working with general practitioners to treat people with depression. | The diagnosis and treatment of depression constitutes a significant component of a general practitioner's workload. A pilot study has suggested that the practice nurse may have an important contribution to make in the care of patients with depression.
To evaluate an extended role for practice nurses in ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,657,327 | [A randomized trial of pharmacotherapy with telephone monitoring to improve treatment of depression in primary care in Santiago, Chile]. | Depression is a public health problem, due to its high prevalence and its associated disability.
To compare a pharmacological intervention for depression controlled by phone from a central level (TM) and the usual treatment (TH) in a randomized clinical trial.
Three hundred and forty fiv... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 16,330,721 | A randomized trial to improve the quality of treatment for panic and generalized anxiety disorders in primary care. | Panic disorder and generalized anxiety disorder are prevalent in primary care, associated with poor functional outcomes, and are often unrecognized and ineffectively treated by primary care physicians.
To examine whether telephone-based collaborative care for panic and generalized anxiety disorders impr... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 14,996,777 | Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. | Suicide rates are highest in late life; the majority of older adults who die by suicide have seen a primary care physician in preceding months. Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation.
To determine the effect of a primary care interven... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 19,918,088 | Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. | Depressive symptoms commonly follow coronary artery bypass graft (CABG) surgery and are associated with less positive clinical outcomes.
To test the effectiveness of telephone-delivered collaborative care for post-CABG depression vs usual physician care.
Single-blind effectiveness trial ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 19,832,996 | Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression--study protocol. | Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative ca... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 19,755,362 | Case management for depression by health care assistants in small primary care practices: a cluster randomized trial. | Case management by health care assistants in small primary care practices provides unclear benefit for improving depression symptoms.
To determine whether case management provided by health care assistants in small primary care practices is more effective than usual care in improving depression symptoms... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,483,968 | Delivery of evidence-based treatment for multiple anxiety disorders in primary care: a randomized controlled trial. | Improving the quality of mental health care requires moving clinical interventions from controlled research settings into real-world practice settings. Although such advances have been made for depression, little work has been performed for anxiety disorders.
To determine whether a flexible treatment-de... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 16,113,617 | A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. | To test a collaborative-care, cognitive-behavioral therapy (CBT) program adjunctive to selective serotonin reuptake inhibitor (SSRI) treatment in HMO pediatric primary care.
A randomized effectiveness trial comparing a treatment-as-usual (TAU) control condition consisting primarily of SSRI medication de... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,399,343 | Managing depression as a chronic disease: a randomised trial of ongoing treatment in primary care. | To evaluate the long term effect of ongoing intervention to improve treatment of depression in primary care.
Randomised controlled trial.
Twelve primary care practices across the United States. Participants: 211 adults beginning a new treatment episode for major depression; 94% of patien... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,906,341 | Integrating clinical nurse specialists into the treatment of primary care patients with depression. | To examine the effectiveness of integrating generalist and specialist care for veterans with depression.
We conducted a randomized trial of patients screening positive for depression at two Veterans Affairs Medical Center general medicine clinic firms. Control firm physicians were notified prior to the ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,882,400 | Promotoras as mental health practitioners in primary care: a multi-method study of an intervention to address contextual sources of depression. | We assessed the role of promotoras--briefly trained community health workers--in depression care at community health centers. The intervention focused on four contextual sources of depression in underserved, low-income communities: underemployment, inadequate housing, food insecurity, and violence. A multi-method desig... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 11,545,671 | A randomized effectiveness trial of collaborative care for patients with panic disorder in primary care. | Effectiveness studies have tested interventions to improve quality of care for depression in primary care, but none, to our knowledge, have been completed for panic disorder (PD) in this setting. This study sought to test the clinical effectiveness of PD pharmacotherapy embedded in a disease management framework of "co... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,303,771 | Care management of poststroke depression: a randomized, controlled trial. | Poststroke depression is a prevalent and disabling disorder, yet evidence regarding the effectiveness of treating poststroke depression is inconclusive. Our objective was to determine the effectiveness of the Activate-Initiate-Monitor care management program for the treatment of poststroke depression.
W... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 12,660,056 | Treating depression in primary care in low-income women in Santiago, Chile: a randomised controlled trial. | Depression in women is one of the commonest problems encountered in primary care. We aimed to compare the effectiveness of a stepped-care programme with usual care in primary-care management of depression in low-income women in Santiago, Chile.
In a randomised controlled trial, in three primary-care cli... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,976,288 | Graduate mental health worker case management of depression in UK primary care: a pilot study. | Based on data from large multicentre US trials, the National Institute for Health and Clinical Excellence (NICE) is advocating a stepped-care model for the management of depression, with 'case management' or 'collaborative care' for selected patients in primary care.
To conduct a pilot study examining t... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,469,883 | A randomized trial of telephone psychotherapy and pharmacotherapy for depression: continuation and durability of effects. | Randomized trial evidence and expert guidelines are mixed regarding the value of combined pharmacotherapy and psychotherapy as initial treatment for depression. This study describes long-term results of a randomized trial (N = 393) evaluating telephone-based cognitive-behavioral therapy (CBT) plus care management for p... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 10,776,363 | Randomized trial of a depression management program in high utilizers of medical care. | High utilizers of nonpsychiatric health care services have disproportionally high rates of undiagnosed or undertreated depression.
To determine the impact of offering a systematic primary care-based depression treatment program to depressed "high utilizers" not in active treatment.
Rando... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,466,678 | The Pathways Study: a randomized trial of collaborative care in patients with diabetes and depression. | There is a high prevalence of depression in patients with diabetes mellitus. Depression has been shown to be associated with poor self-management (adherence to diet, exercise, checking blood glucose levels) and high hemoglobin A1c (HbA1c) levels in patients with diabetes.
To determine whether enhancing ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,121,348 | The impact of a pharmacist intervention on 6-month outcomes in depressed primary care patients. | The object of the study was to evaluate outcomes of a randomized clinical trial (RCT) of a pharmacist intervention for depressed patients in primary care (PC). We report antidepressant (AD) use and depression severity outcomes at 6-months. The RCT was conducted between 1998 and 2000 in 9 eastern Massachusetts PC practi... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,753,242 | A randomized effectiveness trial of cognitive-behavioral therapy and medication for primary care panic disorder. | Panic disorder is a prevalent, often disabling condition among patients in the primary care setting. Although numerous studies have assessed the effectiveness of treatments for depression in primary care, few such studies have been conducted for panic disorder.
To implement and test the effectiveness of... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 11,231,831 | A randomized trial of relapse prevention of depression in primary care. | Despite high rates of relapse and recurrence, few primary care patients with recurrent or chronic depression are receiving continuation and maintenance-phase treatment. We hypothesized that a relapse prevention intervention would improve adherence to antidepressant medication and improve depression outcomes in high-ris... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,010,032 | Differential effectiveness of depression disease management for rural and urban primary care patients. | Federally qualified health centers across the country are adopting depression disease management programs following federally mandated training; however, little is known about the relative effectiveness of depression disease management in rural versus urban patient populations.
To explore whether a depr... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 10,927,707 | Efficacy of nurse telehealth care and peer support in augmenting treatment of depression in primary care. | Primary care treatment of depression needs improvement.
To evaluate the efficacy of 2 augmentations to antidepressant drug treatment.
Randomized trial comparing usual care, telehealth care, and telehealth care plus peer support; assessments were conducted at baseline, 6 weeks, and 6 mont... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,609,631 | PEARLS depression treatment for individuals with epilepsy: a randomized controlled trial. | Depression is associated with higher rates of suicide and lower levels of functioning and quality of life in individuals with epilepsy. The objective of this randomized controlled trial was to determine the effectiveness of PEARLS, a home-based program for managing depression in adult individuals with epilepsy and clin... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,664,517 | A pilot study of telephone care management and structured disease self-management groups for chronic depression. | The authors developed, implemented, and pilot-tested intervention programs to provide effective care for chronic or recurrent depression.
A total of 104 patients with chronic or recurrent depression were randomly assigned to one of four groups: continued usual behavioral health care, usual care plus tel... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 17,376,257 | Enhanced treatment for depression in primary care: long-term outcomes of a psycho-educational prevention program alone and enriched with psychiatric consultation or cognitive behavioral therapy. | The long-term outcome of major depression is often unfavorable, and because most cases of depression are managed by general practitioners (GPs), this places stress on the need to improve treatment in primary care. This study evaluated the long-term effects of enhancing the GP's usual care (UC) with three experimental i... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 16,356,293 | Short-term effects of enhanced treatment for depression in primary care: results from a randomized controlled trial. | Depression is a highly prevalent, often recurring or persistent disorder. The majority of patients are initially seen and treated in primary care. Effective treatments are available, but possibilities for providing adequate follow-up care are often limited in this setting. This study assesses the effectiveness of prima... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,966,373 | Culturally sensitive collaborative treatment for depressed chinese americans in primary care. | We examined the feasibility and effectiveness of using culturally sensitive collaborative treatment (CSCT) to improve recognition, engagement, and treatment of depressed Chinese Americans in primary care.
Chinese American patients in a primary care setting (n = 4228) were screened for depression. The pr... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 18,626,028 | Integration of depression and hypertension treatment: a pilot, randomized controlled trial. | We wanted to examine whether integrating depression treatment into care for hypertension improved adherence to antidepressant and antihypertensive medications, depression outcomes, and blood pressure control among older primary care patients.
Older adults prescribed pharmacotherapy for depression and hy... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 21,190,455 | Collaborative care for patients with depression and chronic illnesses. | Patients with depression and poorly controlled diabetes, coronary heart disease, or both have an increased risk of adverse outcomes and high health care costs. We conducted a study to determine whether coordinated care management of multiple conditions improves disease control in these patients.
We cond... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,069,044 | Community-integrated home-based depression treatment in older adults: a randomized controlled trial. | Older adults with social isolation, medical comorbidity, and physical impairment are more likely to be depressed but may be less able to seek appropriate care for depression compared with older adults without these characteristics.
To determine the effectiveness of a home-based program of detecting and ... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 20,097,780 | Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial. | To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects.
This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with clinically significant... | 2 |
2 | CD006525 | Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care, and represents a useful addition to clinical pathways for adult patients with depression and anxiety. | 15,657,324 | Effectiveness of a quality improvement intervention for adolescent depression in primary care clinics: a randomized controlled trial. | Depression is a common condition associated with significant morbidity in adolescents. Few depressed adolescents receive effective treatment for depression in primary care settings.
To evaluate the effectiveness of a quality improvement intervention aimed at increasing access to evidence-based treatment... | 2 |
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