Datasets:

ClarusC64
/

ABX-HT-005_neurotoxicity_threshold_shift-v0.1

row_id string	series_id string	timepoint_h int64	host_model string	drug string	plasma_conc_mg_L float64	csf_conc_mg_L float64	expected_csf_conc_mg_L float64	csf_deviation float64	bbb_penetration_ratio float64	expected_bbb_ratio float64	ratio_deviation float64	neuro_marker_index float64	neuro_coherence_index float64	exposure_index float64	stress_index float64	later_severe_neuro_flag int64	assay_method string	source_type string	neuro_threshold_shift_signal int64	earliest_neuro_threshold_shift int64	notes string
ABXHT005-TR-0001	S1	0	human_sim	cefepime	10	0.5	0.5	0	0.05	0.05	0	0.1	0.9	0.1	0.1	0	pk_csf_neuro_panel	simulated	0	0	baseline
ABXHT005-TR-0002	S1	12	human_sim	cefepime	12	0.6	0.6	0	0.05	0.05	0	0.12	0.88	0.85	0.9	0	pk_csf_neuro_panel	simulated	0	0	tracks expected
ABXHT005-TR-0003	S1	24	human_sim	cefepime	12	1.1	0.6	0.5	0.092	0.05	0.042	0.55	0.35	0.9	0.9	0	pk_csf_neuro_panel	simulated	0	0	first shift
ABXHT005-TR-0004	S1	36	human_sim	cefepime	12	1.3	0.6	0.7	0.108	0.05	0.058	0.62	0.3	0.9	0.9	0	pk_csf_neuro_panel	simulated	1	1	confirmed onset
ABXHT005-TR-0005	S1	72	human_sim	cefepime	12	2.4	0.6	1.8	0.2	0.05	0.15	0.85	0.2	0.9	0.9	1	pk_csf_neuro_panel	simulated	1	0	severe later
ABXHT005-TR-0006	S2	0	human_sim	meropenem	15	0.3	0.3	0	0.02	0.02	0	0.1	0.9	0.1	0.1	0	pk_csf_neuro_panel	simulated	0	0	baseline
ABXHT005-TR-0007	S2	24	human_sim	meropenem	16	0.32	0.32	0	0.02	0.02	0	0.12	0.86	0.9	0.9	0	pk_csf_neuro_panel	simulated	0	0	stable
ABXHT005-TR-0008	S2	48	human_sim	meropenem	16	0.33	0.33	0	0.021	0.02	0.001	0.12	0.84	0.9	0.9	0	pk_csf_neuro_panel	simulated	0	0	stable
ABXHT005-TR-0009	S3	0	human_sim	cefepime	10	1.8	0.5	1.3	0.18	0.05	0.13	0.7	0.3	0.9	0.9	1	pk_csf_neuro_panel	simulated	0	0	baseline ratio high
ABXHT005-TR-0010	S4	0	human_sim	cefepime	12	1.3	0.6	0.7	0.108	0.05	0.058	0.62	0.3	0.9	0.3	1	pk_csf_neuro_panel	simulated	0	0	stress low

ABX-HT-005 Neurotoxicity Threshold Shift

Purpose

Detect early neurotoxicity risk when blood-brain barrier penetration stops tracking plasma levels before severe neuro events.

Core pattern

stress_index high
exposure_index high
neuro_coherence_index drops
BBB ratio deviation stays high
neuro_marker_index rises
later_severe_neuro_flag appears

Files

data/train.csv
data/test.csv
scorer.py

Schema

Each row is one timepoint in a within series time course.

Required columns

row_id
series_id
timepoint_h
host_model
drug
plasma_conc_mg_L
csf_conc_mg_L
expected_csf_conc_mg_L
csf_deviation
bbb_penetration_ratio
expected_bbb_ratio
ratio_deviation
neuro_marker_index
neuro_coherence_index
exposure_index
stress_index
later_severe_neuro_flag
assay_method
source_type
neuro_threshold_shift_signal
earliest_neuro_threshold_shift

Labels

neuro_threshold_shift_signal
- 1 for rows at or after first confirmed threshold shift onset
earliest_neuro_threshold_shift
- 1 only for the first onset row in that series

Scorer logic in v1

exclude series with high baseline BBB ratio
candidate onset point
- stress_index at least 0.80
- exposure_index at least 0.80
- neuro_coherence_index at most 0.40
- ratio_deviation at least 0.04
- neuro_marker_index at least 0.50
- for two consecutive points
- ignore one point ratio spike then recovery artifacts
confirmation
- later_severe_neuro_flag equals 1 later in series

Evaluation

Run

python scorer.py --path data/test.csv

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16.7 kB