query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
168 | Bariatric surgery reduces colorectal cancer. | [
{
"docid": "5824985",
"title": "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.",
"text": "BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contempor... | [
{
"docid": "7627167",
"title": "Brief, four-session group CBT reduces binge eating behaviors among bariatric surgery candidates.",
"text": "BACKGROUND The objective of this study was to evaluate the effectiveness of a brief, 4-session cognitive behavioral, group psychotherapy for binge eating among bari... |
169 | Bariatric surgery reduces postmenopausal breast cancer. | [
{
"docid": "5824985",
"title": "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.",
"text": "BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contempor... | [
{
"docid": "7627167",
"title": "Brief, four-session group CBT reduces binge eating behaviors among bariatric surgery candidates.",
"text": "BACKGROUND The objective of this study was to evaluate the effectiveness of a brief, 4-session cognitive behavioral, group psychotherapy for binge eating among bari... |
172 | Basophils promote disease development in patients with systemic lupus erythematosus (SLE). | [
{
"docid": "12670680",
"title": "BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS",
"text": "In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report tha... | [
{
"docid": "14938990",
"title": "Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene",
"text": "Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed ... |
173 | Bcp1 is a chaperone for Rpl23. | [
{
"docid": "8126244",
"title": "Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics",
"text": "Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ri... | [
{
"docid": "20524091",
"title": "Chaperoning stem cells: a role for heat shock proteins in the modulation of stem cell self-renewal and differentiation?",
"text": "Self-renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chapero... |
174 | Beta-band coherence is diminished for visible stimuli over invisible stimuli. | [
{
"docid": "1710116",
"title": "Converging Intracranial Markers of Conscious Access",
"text": "We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of ... | [
{
"docid": "6985854",
"title": "Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension.",
"text": "Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms... |
175 | Beta-band coherence is enhanced for visible stimuli over invisible stimuli. | [
{
"docid": "1710116",
"title": "Converging Intracranial Markers of Conscious Access",
"text": "We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of ... | [
{
"docid": "6985854",
"title": "Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension.",
"text": "Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms... |
176 | BiP is a general endoplasmic reticulum stress marker. | [
{
"docid": "32587939",
"title": "Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion",
"text": "Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes.... | [
{
"docid": "25510546",
"title": "Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes",
"text": "Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is ne... |
177 | Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs. | [
{
"docid": "9669099",
"title": "eRNAs are required for p53-dependent enhancer activity and gene transcription.",
"text": "Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Us... | [
{
"docid": "43880096",
"title": "Regulation of p53 in response to DNA damage",
"text": "Activation of p53 can occur in response to a number of cellular stresses, including DNA damage, hypoxia and nucleotide deprivation. Several forms of DNA damage have been shown to activate p53, including those generat... |
178 | Birth-weight is negatively associated with breast cancer. | [
{
"docid": "16322674",
"title": "Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies",
"text": "BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have... | [
{
"docid": "37480103",
"title": "Pregnancy characteristics and maternal risk of breast cancer.",
"text": "CONTEXT During pregnancy, serum levels of estrogen, progesterone, and other hormones are markedly higher than during other periods of life. Pregnancy hormones primarily are produced in the placenta,... |
181 | Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss. | [
{
"docid": "16966326",
"title": "The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity",
"text": "Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TAR... | [
{
"docid": "9217800",
"title": "The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.",
"text": "The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD)... |
182 | Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML) | [
{
"docid": "11369420",
"title": "Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.",
"text": "Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed... | [
{
"docid": "6374918",
"title": "Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.",
"text": "The CXCR4-SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow (BM) microenvironment. He... |
184 | Bone marrow cells don't contribute to adult macrophage compartments. | [
{
"docid": "12827098",
"title": "Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.",
"text": "Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tiss... | [
{
"docid": "8137081",
"title": "Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen",
"text": "Leukocyte trafficking between the various body compartments has an important surveillance function that ensures the detection of antigen and enables the immu... |
186 | British female students are bullied more than British male students. | [
{
"docid": "16855829",
"title": "Bullying in school: are short pupils at risk? Questionnaire study in a cohort.",
"text": "Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adu... | [
{
"docid": "2867345",
"title": "Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome",
"text": "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored t... |
187 | British male students are bullied more than British female students. | [
{
"docid": "16855829",
"title": "Bullying in school: are short pupils at risk? Questionnaire study in a cohort.",
"text": "Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adu... | [
{
"docid": "2867345",
"title": "Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome",
"text": "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored t... |
189 | Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids. | [
{
"docid": "4421578",
"title": "Broad and potent neutralization of HIV-1 by a gp41-specific human antibody",
"text": "Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external r... | [
{
"docid": "3566945",
"title": "Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage",
"text": "Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adap... |
196 | C2 works synergistically with A-769662 to activate dephosphorylated AMPK. | [
{
"docid": "19313533",
"title": "Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.",
"text": "The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and dem... | [
{
"docid": "24294572",
"title": "PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K",
"text": "The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or... |
197 | CCL19 is a ligand for CCR7. | [
{
"docid": "2177022",
"title": "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.",
"text": "Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induc... | [
{
"docid": "40590358",
"title": "The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.",
"text": "The pro-drug FTY720 is undergoing phase III clinical trials for prevention of allograft rejection. After phosphorylation, FTY720 targets the G protein-coupled-sph... |
199 | CCL19 is predominantly present within dLNs. | [
{
"docid": "2177022",
"title": "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.",
"text": "Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induc... | [
{
"docid": "13778710",
"title": "Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties.",
"text": "Chemokine-like receptor 1 (CMKLR1), also known as ChemR23, and chemokine (C-C motif) receptor-like 2 (CCRL2) are 7-tran... |
200 | CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency. | [
{
"docid": "18231807",
"title": "4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors",
"text": "Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely ... | [
{
"docid": "35651106",
"title": "Critical role of CD28 in protective immunity against Salmonella typhimurium.",
"text": "Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in... |
201 | CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues. | [
{
"docid": "2462673",
"title": "CD28 and ITK signals regulate autoreactive T cell trafficking",
"text": "Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) de... | [
{
"docid": "28006126",
"title": "CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters.",
"text": "CD28 is one of the most important costimulatory receptors necessary for full T lymphocyte activation. The CD28 receptor can... |
203 | CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis. | [
{
"docid": "9558539",
"title": "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.",
"text": "Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cance... | [
{
"docid": "25513319",
"title": "Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.",
"text": "Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cel... |
204 | CDK6 shows impaired binding to loss-of-function variants of p18 INK4C. | [
{
"docid": "7898952",
"title": "Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development",
"text": "We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent... | [
{
"docid": "470625",
"title": "Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.",
"text": "Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of gliobl... |
205 | CDK6 shows improved binding to loss-of-function variants of p18 INK4C. | [
{
"docid": "7898952",
"title": "Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development",
"text": "We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent... | [
{
"docid": "3127341",
"title": "Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.",
"text": "The glucagon-like peptide-1 receptor (GLP-1R) is a key physiological regulator of insulin secretion and a majo... |
209 | CHOP is a general endoplasmic reticulum stress marker. | [
{
"docid": "32587939",
"title": "Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion",
"text": "Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes.... | [
{
"docid": "25510546",
"title": "Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes",
"text": "Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is ne... |
210 | COPI coatmer is involved in lipid homeostasis. | [
{
"docid": "13794374",
"title": "COPI Complex Is a Regulator of Lipid Homeostasis",
"text": "Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it ... | [
{
"docid": "21547032",
"title": "Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole",
"text": "Objective:In mice and in humans, treatment with the second-generation antipsychotic drug olanzapine (OLZ) produces excessive weight gain, adiposity and se... |
211 | COPI coatmer is involved in viral replication. | [
{
"docid": "13794374",
"title": "COPI Complex Is a Regulator of Lipid Homeostasis",
"text": "Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it ... | [
{
"docid": "44737533",
"title": "Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences.",
"text": "METHODS To define potential common features of simian immunodeficiency virus (SIV) infections in different naturally infe... |
214 | CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. | [
{
"docid": "13625993",
"title": "Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery",
"text": "OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating ... | [
{
"docid": "27054878",
"title": "Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting.",
"text": "BACKGROUND Preoperative C-reactive protein (CRP) levels more than 10 mg/l have been shown to be associated with... |
220 | Ca2+ cycling controls whole-body energy homeostasis in beige fat. | [
{
"docid": "19205437",
"title": "UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis",
"text": "Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat... | [
{
"docid": "14865329",
"title": "Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders",
"text": "Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and n... |
221 | Ca2+ cycling is a UCP1-dependent thermogenic mechanism. | [
{
"docid": "19205437",
"title": "UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis",
"text": "Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat... | [
{
"docid": "4319174",
"title": "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis",
"text": "All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environment... |
222 | Ca2+ cycling is a UCP1-independent thermogenic mechanism. | [
{
"docid": "19205437",
"title": "UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis",
"text": "Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat... | [
{
"docid": "14865329",
"title": "Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders",
"text": "Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and n... |
223 | Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production. | [
{
"docid": "2014909",
"title": "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation",
"text": "Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harb... | [
{
"docid": "188911",
"title": "Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor",
"text": "Antigen-presenting, major histocompatibility complex (MHC) class II-rich dendritic cells are known to arise from bon... |
224 | Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments | [
{
"docid": "6944800",
"title": "Microenvironmental regulation of tumor progression and metastasis",
"text": "Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) ... | [
{
"docid": "952111",
"title": "Cancer associated fibroblasts (CAFs) in tumor microenvironment.",
"text": "Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrat... |
225 | Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs. | [
{
"docid": "6944800",
"title": "Microenvironmental regulation of tumor progression and metastasis",
"text": "Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) ... | [
{
"docid": "3727986",
"title": "A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion",
"text": "Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables... |
226 | Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs. | [
{
"docid": "6944800",
"title": "Microenvironmental regulation of tumor progression and metastasis",
"text": "Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) ... | [
{
"docid": "3727986",
"title": "A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion",
"text": "Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables... |
227 | Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms. | [
{
"docid": "26973393",
"title": "The quest to overcome resistance to EGFR-targeted therapies in cancer",
"text": "All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually develop re... | [
{
"docid": "22980205",
"title": "Targeted therapies in urothelial carcinoma.",
"text": "PURPOSE OF REVIEW Greater understanding of the biology and genetics of urothelial carcinoma is helping to identify and define the role of molecules and pathways appropriate for novel-targeted therapies. Here, we revi... |
228 | Cardiac tissue-resident macrophages directly contribute to electrical activity. | [
{
"docid": "4928057",
"title": "Macrophages Facilitate Electrical Conduction in the Heart",
"text": "Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular ... | [
{
"docid": "12827098",
"title": "Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.",
"text": "Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tiss... |
229 | Carriers of HNF4A mutations are at reduced risk for diabetes. | [
{
"docid": "56893404",
"title": "Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene",
"text": "Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increase... | [
{
"docid": "9394119",
"title": "Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.",
"text": "IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. \n OBJECTIVE To identify... |
235 | Cell autonomous sex determination in somatic cells occurs in Galliformes. | [
{
"docid": "4388470",
"title": "Somatic sex identity is cell-autonomous in the chicken",
"text": "In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is ... | [
{
"docid": "5597586",
"title": "Stem cell transplantation in patients with autonomic neuropathy due to primary (AL) amyloidosis.",
"text": "OBJECTIVES Patients with AL amyloidosis can benefit from high-dose chemotherapy and autologous stem cell transplantation (ASCT). Transplantation can be challenging ... |
241 | Cellular clocks are associated with mitosis timing in NIH 3T3 cells. | [
{
"docid": "2212067",
"title": "Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells",
"text": "Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to ... | [
{
"docid": "11557602",
"title": "Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.",
"text": "LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription f... |
242 | Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells. | [
{
"docid": "2212067",
"title": "Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells",
"text": "Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to ... | [
{
"docid": "11557602",
"title": "Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.",
"text": "LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription f... |
243 | Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization. | [
{
"docid": "8148122",
"title": "Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation",
"text": "DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase... | [
{
"docid": "27279525",
"title": "Detection, characterization, and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary.",
"text": "The present study was undertaken to detect, characterize, and study differentiation potential of stem cells in adul... |
244 | Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells. | [
{
"docid": "21498497",
"title": "TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells",
"text": "Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease pr... | [
{
"docid": "8596357",
"title": "Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells.",
"text": "Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcin... |
245 | Charcoal is an effective treatment for acute paraquat poisoning. | [
{
"docid": "8447873",
"title": "Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.",
"text": "BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to g... | [
{
"docid": "25104843",
"title": "Hemoperfusion-hemodialysis ineffective for paraquat removal in life-threatening poisoning?",
"text": "We report on a patient treated with hemoperfusion-hemodialysis (HP-HD) for severe paraquat poisoning. This procedure was adopted since the combination of adsorption and ... |
246 | Charcoal shows no benefit for acute paraquat poisoning. | [
{
"docid": "8447873",
"title": "Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.",
"text": "BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to g... | [
{
"docid": "25104843",
"title": "Hemoperfusion-hemodialysis ineffective for paraquat removal in life-threatening poisoning?",
"text": "We report on a patient treated with hemoperfusion-hemodialysis (HP-HD) for severe paraquat poisoning. This procedure was adopted since the combination of adsorption and ... |
247 | Chemical injury represses transglutaminase 2 activity. | [
{
"docid": "13578199",
"title": "Transglutaminase 2 Undergoes a Large Conformational Change upon Activation ",
"text": "Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues an... | [
{
"docid": "10474873",
"title": "Recovery of visual response of injured adult rat optic nerves treated with transglutaminase.",
"text": "Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with ... |
250 | Chenodeoxycholic acid treatment decreases brown adipose tissue activity. | [
{
"docid": "1568684",
"title": "The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.",
"text": "The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can b... | [
{
"docid": "4319174",
"title": "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis",
"text": "All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environment... |
251 | Chenodeoxycholic acid treatment increases brown adipose tissue activity. | [
{
"docid": "1568684",
"title": "The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.",
"text": "The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can b... | [
{
"docid": "4319174",
"title": "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis",
"text": "All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environment... |
253 | Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake. | [
{
"docid": "37424881",
"title": "The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.",
"text": "OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothro... | [
{
"docid": "42441846",
"title": "Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.",
"text": "INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CA... |
254 | Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake. | [
{
"docid": "37424881",
"title": "The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.",
"text": "OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothro... | [
{
"docid": "42441846",
"title": "Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.",
"text": "INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CA... |
255 | Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s. | [
{
"docid": "5850219",
"title": "Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)",
"text": "BACKGROUND Population-based estimates of prevalence, risk distribution, and inte... | [
{
"docid": "3413083",
"title": "Patterns of chlamydia testing in different settings and implications for wider STI diagnosis and care: a probability sample survey of the British population",
"text": "BACKGROUND Following widespread rollout of chlamydia testing to non-specialist and community settings in... |
256 | Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24. | [
{
"docid": "5850219",
"title": "Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)",
"text": "BACKGROUND Population-based estimates of prevalence, risk distribution, and inte... | [
{
"docid": "3413083",
"title": "Patterns of chlamydia testing in different settings and implications for wider STI diagnosis and care: a probability sample survey of the British population",
"text": "BACKGROUND Following widespread rollout of chlamydia testing to non-specialist and community settings in... |
258 | Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines. | [
{
"docid": "22080671",
"title": "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis",
"text": "Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controv... | [
{
"docid": "6397191",
"title": "Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.",
"text": "Endothelin-1 (ET-1) is the predominant endothelin isopeptide generated by the vascular wall and therefore appears to be the most... |
259 | Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells. | [
{
"docid": "8883846",
"title": "Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions",
"text": "The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and... | [
{
"docid": "20261352",
"title": "Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection.",
"text": "OBJECTIVE To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. \n DESIGN Progressive HIV infection is mark... |
262 | Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites. | [
{
"docid": "14610165",
"title": "Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription",
"text": "Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding ... | [
{
"docid": "14050257",
"title": "Gene regulation by the act of long non-coding RNA transcription",
"text": "Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how... |
263 | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle. | [
{
"docid": "11328820",
"title": "NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.",
"text": "The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein anti... | [
{
"docid": "17967608",
"title": "PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps",
"text": "Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that hist... |
264 | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies. | [
{
"docid": "11328820",
"title": "NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.",
"text": "The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein anti... | [
{
"docid": "14853989",
"title": "Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity",
"text": "Autoantibodies to DNA and histones (chromatin) are the defining antigen specificity in systemic lupus erythematosus (SLE) and related musculoskeletal disorders but the mech... |
265 | Clathrin stabilizes the spindle fiber apparatus during mitosis. | [
{
"docid": "2033917",
"title": "Clathrin is required for the function of the mitotic spindle",
"text": "Clathrin has an established function in the generation of vesicles that transfer membrane and proteins around the cell. The formation of clathrin-coated vesicles occurs continuously in non-dividing ce... | [
{
"docid": "14205246",
"title": "A Role for NuSAP in Linking Microtubules to Mitotic Chromosomes",
"text": "The spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates the chromosomes during mitosis and meiosis. Self-organization of the spindle around chromatin involves t... |
266 | Cnn1 recruitment varies with cell cycle timing. | [
{
"docid": "22405338",
"title": "Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore",
"text": "Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segrega... | [
{
"docid": "7878807",
"title": "A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.",
"text": "The Ndc80 complex is the key microtubule-binding element of the kinetochore. In contrast to the well-characterized interaction of Ndc80-Nuf2 heads with mi... |
267 | Cognitive behavioral therapy is an ineffective treatment for insomnia | [
{
"docid": "5912283",
"title": "Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.",
"text": "CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychologi... | [
{
"docid": "24865781",
"title": "A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches.",
"text": "Forty-one recurrent tension headache sufferers were randomly assigned to either cognitive-behavioral therapy (administere... |
272 | Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy. | [
{
"docid": "11614737",
"title": "Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.",
"text": "IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. \n OBJECTIVE To determine efficacy an... | [
{
"docid": "5114940",
"title": "Pharmacological interventions for smoking cessation: an overview and network meta-analysis.",
"text": "BACKGROUND Smoking is the leading preventable cause of illness and premature death worldwide. Some medications have been proven to help people to quit, with three licens... |
277 | Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD. | [
{
"docid": "14376683",
"title": "Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.",
"text": "The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of... | [
{
"docid": "37677954",
"title": "Characterization of complete genome and small RNA profile of pagoda yellow mosaic associated virus, a novel badnavirus in China.",
"text": "A new badnavirus was discovered from pagoda trees showing yellow mosaic symptoms on the leaves by high throughput sequencing of sma... |
278 | Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs. | [
{
"docid": "14376683",
"title": "Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.",
"text": "The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of... | [
{
"docid": "83667891",
"title": "Identification and transmission of Piper yellow mottle virus and Cucumber mosaic virus infecting black pepper (Piper nigrum) in Sri Lanka",
"text": "Sri Lankan black pepper with symptoms of yellow mottle disease contained a mixture of viruses: Piper yellow mottle virus (... |
280 | Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function. | [
{
"docid": "25001628",
"title": "Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.",
"text": "To identify previously unknown platelet receptors we compared the transcriptomes of in vitr... | [
{
"docid": "2931832",
"title": "The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer",
"text": "Activated platelets promote tumor cell growth, angiogenesis, and invasion. Platelet activity can be inferred by platelet volume indices (PVIs), which... |
281 | Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells. | [
{
"docid": "4632921",
"title": "Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells.",
"text": "In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines fro... | [
{
"docid": "6401675",
"title": "Transposable elements have rewired the core regulatory network of human embryonic stem cells",
"text": "Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locatio... |
283 | Consumption of whole fruits increases the risk of type 2 diabetes. | [
{
"docid": "1974176",
"title": "Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies",
"text": "OBJECTIVE To determine whether individual fruits are differentially associated with risk of type 2 diabetes. \n DESIGN Prospective longitudinal cohort st... | [
{
"docid": "9822397",
"title": "Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women.",
"text": "CONTEXT Sugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain an... |
285 | Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact. | [
{
"docid": "5548081",
"title": "Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic.",
"text": "CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the U... | [
{
"docid": "21216726",
"title": "Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women.",
"text": "Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 i... |
286 | Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons. | [
{
"docid": "4709641",
"title": "Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector",
"text": "Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a p... | [
{
"docid": "15347087",
"title": "Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats",
"text": "The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (... |
287 | Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons. | [
{
"docid": "4709641",
"title": "Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector",
"text": "Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a p... | [
{
"docid": "15347087",
"title": "Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats",
"text": "The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (... |
290 | Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice. | [
{
"docid": "15048300",
"title": "A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example",
"text": "BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on ... | [
{
"docid": "13625993",
"title": "Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery",
"text": "OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating ... |
292 | Cost effectiveness evaluations based on cRCT data lack external validity. | [
{
"docid": "15048300",
"title": "A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example",
"text": "BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on ... | [
{
"docid": "16705338",
"title": "Prediction of Chemical-Protein Interactions Network with Weighted Network-Based Inference Method",
"text": "Chemical-protein interaction (CPI) is the central topic of target identification and drug discovery. However, large scale determination of CPI is a big challenge f... |
293 | Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae. | [
{
"docid": "10874408",
"title": "Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae",
"text": "DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad... | [
{
"docid": "21170174",
"title": "Crossover and noncrossover pathways in mouse meiosis.",
"text": "During meiosis, recombination between homologous chromosomes generates crossover (CR) and noncrossover (NCR) products. CRs establish connections between homologs, whereas intermediates leading to NCRs have ... |
296 | Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis. | [
{
"docid": "4398832",
"title": "Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation",
"text": "The most conspicuous event in the cell cycle is the alignment of chromosomes in metaphase. Chromosome alignment fosters faithful segregation through the formation of bi-orien... | [
{
"docid": "45875990",
"title": "Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation",
"text": "Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot elevate cyclin A... |
299 | Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis. | [
{
"docid": "39381118",
"title": "At the gates of death.",
"text": "Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential ... | [
{
"docid": "23403754",
"title": "Bioenergetic aspects of apoptosis, necrosis and mitoptosis",
"text": "In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis). The followi... |
301 | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1. | [
{
"docid": "3553087",
"title": "Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice",
"text": "Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-bi... | [
{
"docid": "16120395",
"title": "Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.",
"text": "Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracell... |
304 | DMS3 protein enables Pol V transcription in vivo. | [
{
"docid": "14797520",
"title": "Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes",
"text": "Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The fu... | [
{
"docid": "32275758",
"title": "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.",
"text": "DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of ... |
305 | DRD1 proteins enable Pol V transcription in vivo. | [
{
"docid": "14797520",
"title": "Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes",
"text": "Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The fu... | [
{
"docid": "1354567",
"title": "The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center",
"text": "In Arabidopsis thaliana, small interfering RNAs (siRNAs) direct cytosine methylation at endogenous DNA repeats in a pathway involving two forms of nuclear RNA p... |
306 | DUSP4 decreases apoptosis. | [
{
"docid": "7821634",
"title": "Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance",
"text": "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many... | [
{
"docid": "24190159",
"title": "Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.",
"text": "Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth fac... |
308 | DUSP4 downregulation deactivates the Ras-ERK pathway | [
{
"docid": "7821634",
"title": "Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance",
"text": "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many... | [
{
"docid": "28651643",
"title": "Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.",
"text": "Activating mutations within the K-ras gene occur in a high percentage of human pancreatic carcinomas. We reported previously that the presenc... |
309 | DUSP4 increases apoptosis. | [
{
"docid": "7821634",
"title": "Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance",
"text": "Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many... | [
{
"docid": "24190159",
"title": "Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.",
"text": "Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth fac... |
310 | De novo assembly of sequence data has fewer specific contigs than unassembled sequence data. | [
{
"docid": "6173523",
"title": "A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.",
"text": "IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditiona... | [
{
"docid": "14464451",
"title": "Effects of GC Bias in Next-Generation-Sequencing Data on De Novo Genome Assembly",
"text": "Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger se... |
313 | De novo assembly of sequence data has shorter contigs than unassembled sequence data. | [
{
"docid": "6173523",
"title": "A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.",
"text": "IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditiona... | [
{
"docid": "14464451",
"title": "Effects of GC Bias in Next-Generation-Sequencing Data on De Novo Genome Assembly",
"text": "Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger se... |
315 | Decrease of p62 in prostate tumor stroma results in defective autophagy. | [
{
"docid": "3701541",
"title": "p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.",
"text": "Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs ... | [
{
"docid": "26735905",
"title": "Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.",
"text": "The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the epithel... |
316 | Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE. | [
{
"docid": "712078",
"title": "Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice",
"text": "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical ch... | [
{
"docid": "20732789",
"title": "Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.",
"text": "Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammati... |
317 | Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm. | [
{
"docid": "4506414",
"title": "Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people",
"text": "BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascu... | [
{
"docid": "12549585",
"title": "Aortic and large artery compliance in end-stage renal failure.",
"text": "Pulse wave velocity (PWV) was measured in the aorta, right leg and arm of 90 control subjects (CS) and 92 hemodialysis patients (HD) of the same age and mean arterial pressure (MAP). Blood chemistr... |
323 | Deleting Raptor increases G-CSF levels. | [
{
"docid": "2014909",
"title": "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation",
"text": "Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harb... | [
{
"docid": "4658268",
"title": "Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton",
"text": "The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process where... |
325 | Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss. | [
{
"docid": "40349336",
"title": "Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.",
"text": "Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the AT... | [
{
"docid": "12909503",
"title": "Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress",
"text": "DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint sy... |
326 | Deletion of ATM and Rad3 related protein leads to acute tissue loss. | [
{
"docid": "40349336",
"title": "Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.",
"text": "Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the AT... | [
{
"docid": "12909503",
"title": "Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress",
"text": "DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint sy... |
330 | Deltex has no known interactions with eIF3f. | [
{
"docid": "9505448",
"title": "The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation",
"text": "Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubi... | [
{
"docid": "25942757",
"title": "PSGL-1 function in immunity and steady state homeostasis.",
"text": "The substantial importance of P-selectin glycoprotein ligand 1 (PSGL-1) in leukocyte trafficking has continued to emerge beyond its initial identification as a selectin ligand. PSGL-1 seemed to be a rel... |
331 | Deltex interacts with eIF3. There is no known interaction between Deltex and elF3 | [
{
"docid": "9505448",
"title": "The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation",
"text": "Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubi... | [
{
"docid": "13794374",
"title": "COPI Complex Is a Regulator of Lipid Homeostasis",
"text": "Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it ... |
332 | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut. | [
{
"docid": "29023309",
"title": "Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut",
"text": "Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-t... | [
{
"docid": "8300657",
"title": "Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.",
"text": "Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. ... |
333 | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut. | [
{
"docid": "29023309",
"title": "Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut",
"text": "Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-t... | [
{
"docid": "8300657",
"title": "Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.",
"text": "Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. ... |
334 | Depletion of nitric oxide is responsible for vasospasm. | [
{
"docid": "25079962",
"title": "Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.",
"text": "CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for r... | [
{
"docid": "23100962",
"title": "Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.",
"text": "Besides synthesizing nitric oxide (NO), purified neuronal NO synthase (nNOS) can produce superoxide (.O2-) at lower L-Arg ... |
335 | Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice. | [
{
"docid": "1780819",
"title": "Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development",
"text": "BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer developmen... | [
{
"docid": "4767806",
"title": "Exploring and exploiting the systemic effects of deregulated replication licensing.",
"text": "Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for rep... |
336 | Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... |
337 | Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... |
339 | Dexamethasone increases risk of postoperative bleeding. | [
{
"docid": "23349986",
"title": "Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.",
"text": "CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric tonsillectomy. \n OBJECTIVE To... | [
{
"docid": "36288526",
"title": "Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials.",
"text": "OBJECTIVE The effects of hydroxyethyl starch on bleeding after cardiopulmonary bypass were determined. \n METHODS A meta-analysis was performed of p... |
340 | Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | [
{
"docid": "7098463",
"title": "Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.",
"text": "CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. \n OBJECTIVE To determine if sur... | [
{
"docid": "5824985",
"title": "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.",
"text": "BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contempor... |
341 | Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | [
{
"docid": "7098463",
"title": "Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.",
"text": "CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. \n OBJECTIVE To determine if sur... | [
{
"docid": "5824985",
"title": "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.",
"text": "BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contempor... |
342 | Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | [
{
"docid": "7873737",
"title": "Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.",
"text": "BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this d... | [
{
"docid": "19308127",
"title": "In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence, predictors and short-term outcome.",
"text": "BACKGROUND P2Y12 inhibitor switching has appeared in clinical practic... |
345 | Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis. | [
{
"docid": "4394817",
"title": "E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells",
"text": "In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f ... | [
{
"docid": "9641846",
"title": "G1 arrest and differentiation can occur independently of Rb family function",
"text": "The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully un... |
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