Daily Papers

Efficiently serving Large Language Models (LLMs) requires selecting an optimal parallel execution plan, balancing computation, memory, and communication overhead. However, determining the best strategy is challenging due to varying parallelism techniques (data, pipeline, tensor) and workload characteristics (e.g., compute-intensive tasks with long prompts vs. memory-intensive tasks with long generation). We propose APEX, an LLM serving system simulator that efficiently identifies optimal parallel execution plans by considering key factors of LLM serving systems, such as memory usage, batching behavior, etc. APEX performs dynamism-aware simulation to model iteration-level batching, and leverages LLMs' repetitive structure to reduce design space, scaling efficiently to trillion-scale models. APEX abstracts the key components of LLM serving systems, including the model, batching module, quantization formats, and device clusters, enabling the simulator to be general and extensible. Simulating on a CPU, APEX evaluates execution plans for various device clusters, covering diverse LLMs and workloads. APEX finds plans up to 3.37x faster than heuristics, and also plans that reduce energy consumption by up to 45% compared to latency-optimal plans. APEX performs comprehensive evaluations, reporting key system metrics like time per output token and time to first token, which can help service providers meet SLOs. APEX identifies an optimal plan within 15 minutes on a CPU, making it 71x faster and 1234x more cost-effective than cloud-based GPU deployment. APEX can be accessed at https://github.com/microsoft/apex_plus

Antimicrobial resistance (AMR) is escalating and outpacing current antibiotic development. Thus, discovering antibiotics effective against emerging pathogens is becoming increasingly critical. However, existing approaches cannot rapidly identify effective molecules against novel pathogens or emerging drug-resistant strains. Here, we introduce ApexOracle, an artificial intelligence (AI) model that both predicts the antibacterial potency of existing compounds and designs de novo molecules active against strains it has never encountered. Departing from models that rely solely on molecular features, ApexOracle incorporates pathogen-specific context through the integration of molecular features captured via a foundational discrete diffusion language model and a dual-embedding framework that combines genomic- and literature-derived strain representations. Across diverse bacterial species and chemical modalities, ApexOracle consistently outperformed state-of-the-art approaches in activity prediction and demonstrated reliable transferability to novel pathogens with little or no antimicrobial data. Its unified representation-generation architecture further enables the in silico creation of "new-to-nature" molecules with high predicted efficacy against priority threats. By pairing rapid activity prediction with targeted molecular generation, ApexOracle offers a scalable strategy for countering AMR and preparing for future infectious-disease outbreaks.

Navigating unknown environments to find a target object is a significant challenge. While semantic information is crucial for navigation, relying solely on it for decision-making may not always be efficient, especially in environments with weak semantic cues. Additionally, many methods are susceptible to misdetections, especially in environments with visually similar objects. To address these limitations, we propose ApexNav, a zero-shot object navigation framework that is both more efficient and reliable. For efficiency, ApexNav adaptively utilizes semantic information by analyzing its distribution in the environment, guiding exploration through semantic reasoning when cues are strong, and switching to geometry-based exploration when they are weak. For reliability, we propose a target-centric semantic fusion method that preserves long-term memory of the target object and similar objects, reducing false detections and minimizing task failures. We evaluate ApexNav on the HM3Dv1, HM3Dv2, and MP3D datasets, where it outperforms state-of-the-art methods in both SR and SPL metrics. Comprehensive ablation studies further demonstrate the effectiveness of each module. Furthermore, real-world experiments validate the practicality of ApexNav in physical environments. Project page is available at https://robotics-star.com/ApexNav.