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.gitattributes

@@ -56,3 +56,15 @@ saved_model/**/* filter=lfs diff=lfs merge=lfs -text
 # Video files - compressed
 *.mp4 filter=lfs diff=lfs merge=lfs -text
 *.webm filter=lfs diff=lfs merge=lfs -text
+pretrain/train/opendata/ChatMed_TCM-v0.2_.txt filter=lfs diff=lfs merge=lfs -text
+pretrain/train/papers/fix_abstract_segmentation.txt filter=lfs diff=lfs merge=lfs -text
+pretrain/train/web/2019_baidubaike.txt filter=lfs diff=lfs merge=lfs -text
+pretrain/train/web/daiy_data.txt filter=lfs diff=lfs merge=lfs -text
+sft/final_train_data_for_baichuan_format/train_baichuan.json filter=lfs diff=lfs merge=lfs -text
+sft/train/admet.json filter=lfs diff=lfs merge=lfs -text
+sft/train/choice_herb_formula.json filter=lfs diff=lfs merge=lfs -text
+sft/train/knowledge.json filter=lfs diff=lfs merge=lfs -text
+sft/train/medical_case.json filter=lfs diff=lfs merge=lfs -text
+sft/train/reading_comprehension.json filter=lfs diff=lfs merge=lfs -text
+sft/train/recommend_disease.json filter=lfs diff=lfs merge=lfs -text
+sft/train/recommend_formula.json filter=lfs diff=lfs merge=lfs -text

README.md

@@ -1,3 +1,160 @@
----
-license: apache-2.0
----
+[**中文**](./README_ZH.md) | [**English**](./README.md)
+
+<p align="center" width="100%">
+<a href="https://github.com/daiyizheng/TCMChat" target="_blank"><img src="assets/logo.png" alt="TCMChat" style="width: 25%; min-width: 300px; display: block; margin: auto;"></a>
+</p>
+
+# TCMChat: A Generative Large Language Model for Traditional Chinese Medicine
+
+[![Code License](https://img.shields.io/badge/Code%20License-Apache_2.0-green.svg)](https://github.com/SCIR-HI/Huatuo-Llama-Med-Chinese/blob/main/LICENSE) [![Python 3.10.12](https://img.shields.io/badge/python-3.10.12-blue.svg)](https://www.python.org/downloads/release/python-390/)
+
+## News
+
+[2024-5-17] Open source model weight on HuggingFace.                 
+
+## Application
+
+### Install
+
+```
+git clone https://github.com/daiyizheng/TCMChat
+cd TCMChat
+```
+First install the dependency package. python environment 3.10+ is recommended.
+
+```
+pip install -r requirements.txt
+```
+
+### Weights download
+
+- [TCMChat](https://huggingface.co/daiyizheng/TCMChat): QA and recommendation of TCM knowledge based on baichuan2-7B-Chat.
+
+### Inference
+
+#### Command line
+
+```
+python cli_infer.py \
+--model_name_or_path /your/model/path \
+--model_type  chat
+```
+
+#### Web demo
+
+```
+python gradio_demo.py
+```
+
+We provide an online tool：[https://xomics.com.cn/tcmchat](https://xomics.com.cn/tcmchat)
+
+
+### Retrain
+
+#### Dataset Download
+
+- [Pretrain dataset](https://github.com/ZJUFanLab/TCMChat/tree/master/data/pretrain) 
+- [SFT dataset](https://github.com/ZJUFanLab/TCMChat/tree/master/data/sft)
+- [Benchmark dataset](https://github.com/ZJUFanLab/TCMChat/tree/master/data/evaluate)
+
+> Note: Currently only sample data is provided. In the near future, we will fully open source the original data.
+
+
+#### Pre-training
+
+```shell
+train_type="pretrain"
+train_file="data/pretrain/train"
+validation_file="data/pretrain/test"
+block_size="1024"
+deepspeed_dir="data/resources/deepspeed_zero_stage2_config.yml"
+num_train_epochs="2"
+export WANDB_PROJECT="TCM-${train_type}"
+date_time=$(date +"%Y%m%d%H%M%S")
+run_name="${date_time}_${block_size}"
+model_name_or_path="your/path/Baichuan2-7B-Chat"
+output_dir="output/${train_type}/${date_time}_${block_size}"
+
+
+accelerate launch --config_file ${deepspeed_dir} src/pretraining.py \
+--model_name_or_path ${model_name_or_path}  \
+--train_file  ${train_file}  \
+--validation_file ${validation_file}  \
+--preprocessing_num_workers 20  \
+--cache_dir ./cache \
+--block_size  ${block_size}  \
+--seed 42  \
+--do_train  \
+--do_eval  \
+--per_device_train_batch_size  32  \
+--per_device_eval_batch_size  32  \
+--num_train_epochs ${num_train_epochs}  \
+--low_cpu_mem_usage  True \
+--torch_dtype bfloat16  \
+--bf16  \
+--ddp_find_unused_parameters False  \
+--gradient_checkpointing True  \
+--learning_rate 2e-4 \
+--warmup_ratio 0.05 \
+--weight_decay 0.01 \
+--report_to wandb  \
+--run_name ${run_name}  \
+--logging_dir  logs \
+--logging_strategy steps \
+--logging_steps 10 \
+--eval_steps 50 \
+--evaluation_strategy steps \
+--save_steps 100 \
+--save_strategy steps \
+--save_total_limit 13 \
+--output_dir  ${output_dir}  \
+--overwrite_output_dir
+```
+
+#### Fine-tuning
+
+```shell
+train_type="SFT"
+model_max_length="1024"
+date_time=$(date +"%Y%m%d%H%M%S")
+data_path="data/sft/sample_train_baichuan_data.json"
+model_name_or_path="your/path/pretrain"
+deepspeed_dir="data/resources/deepspeed_zero_stage2_confi_baichuan2.json"
+export WANDB_PROJECT="TCM-${train_type}"
+run_name="${train_type}_${date_time}"
+output_dir="output/${train_type}/${date_time}_${model_max_length}"
+
+
+deepspeed --hostfile="" src/fine-tune.py  \
+    --report_to "wandb" \
+    --run_name ${run_name}  \
+    --data_path ${data_path} \
+    --model_name_or_path ${model_name_or_path} \
+    --output_dir ${output_dir} \
+    --model_max_length ${model_max_length} \
+    --num_train_epochs 4 \
+    --per_device_train_batch_size 16 \
+    --gradient_accumulation_steps 1 \
+    --save_strategy epoch \
+    --learning_rate 2e-5 \
+    --lr_scheduler_type constant \
+    --adam_beta1 0.9 \
+    --adam_beta2 0.98 \
+    --adam_epsilon 1e-8 \
+    --max_grad_norm 1.0 \
+    --weight_decay 1e-4 \
+    --warmup_ratio 0.0 \
+    --logging_steps 1 \
+    --gradient_checkpointing True \
+    --deepspeed ${deepspeed_dir} \
+    --bf16 True \
+    --tf32 True
+```
+
+### Training details
+
+Please refer to the experimental section of the paper for instructions.
+
+
+
+

README_ZH.md

@@ -0,0 +1,156 @@
+[**中文**](./README_ZH.md) | [**English**](./README.md)
+
+<p align="center" width="100%">
+<a href="https://github.com/daiyizheng/TCMChat" target="_blank"><img src="assets/logo.png" alt="TCMChat" style="width: 25%; min-width: 300px; display: block; margin: auto;"></a>
+</p>
+
+# TCMChat: Traditional Chinese Medicine Recommendation System based on Large Language Model
+
+[![Code License](https://img.shields.io/badge/Code%20License-Apache_2.0-green.svg)](https://github.com/SCIR-HI/Huatuo-Llama-Med-Chinese/blob/main/LICENSE) [![Python 3.10.12](https://img.shields.io/badge/python-3.10.12-blue.svg)](https://www.python.org/downloads/release/python-390/)
+
+## 新闻
+
+[2024-5-17] huggingface 开源模型权重
+
+## 应用
+
+### 安装
+
+```
+git clone https://github.com/daiyizheng/TCMChat
+cd TCMChat
+```
+
+首先安装依赖包，python环境建议3.10+
+
+```
+pip install -r requirements.txt
+```
+
+### 权重下载
+
+- [TCMChat](https://huggingface.co/daiyizheng/TCMChat): 基于baichuan2-7B-Chat的中药、方剂知识问答与推荐。
+
+### 推理
+
+#### 命令行测试
+
+```
+python cli_infer.py \
+--model_name_or_path /your/model/path \
+--model_type  chat
+```
+
+#### Web页面测试
+
+```
+python gradio_demo.py
+```
+
+我们提供了一个在线的体验工具：[https://xomics.com.cn/tcmchat](https://xomics.com.cn/tcmchat)
+
+
+### 重新训练
+#### 数据集下载
+
+- [预训练数据](https://github.com/ZJUFanLab/TCMChat/tree/master/data/pretrain) 
+- [微调数据](https://github.com/ZJUFanLab/TCMChat/tree/master/data/sft)
+- [基准评测数据](https://github.com/ZJUFanLab/TCMChat/tree/master/data/evaluate)
+
+> 注意：目前只提供样例数据，不久将来，我们将完全开源原始数据
+
+
+#### 预训练
+
+```shell
+train_type="pretrain"
+train_file="data/pretrain/train"
+validation_file="data/pretrain/test"
+block_size="1024"
+deepspeed_dir="data/resources/deepspeed_zero_stage2_config.yml"
+num_train_epochs="2"
+export WANDB_PROJECT="TCM-${train_type}"
+date_time=$(date +"%Y%m%d%H%M%S")
+run_name="${date_time}_${block_size}"
+model_name_or_path="your/path/Baichuan2-7B-Chat"
+output_dir="output/${train_type}/${date_time}_${block_size}"
+
+
+accelerate launch --config_file ${deepspeed_dir} src/pretraining.py \
+--model_name_or_path ${model_name_or_path}  \
+--train_file  ${train_file}  \
+--validation_file ${validation_file}  \
+--preprocessing_num_workers 20  \
+--cache_dir ./cache \
+--block_size  ${block_size}  \
+--seed 42  \
+--do_train  \
+--do_eval  \
+--per_device_train_batch_size  32  \
+--per_device_eval_batch_size  32  \
+--num_train_epochs ${num_train_epochs}  \
+--low_cpu_mem_usage  True \
+--torch_dtype bfloat16  \
+--bf16  \
+--ddp_find_unused_parameters False  \
+--gradient_checkpointing True  \
+--learning_rate 2e-4 \
+--warmup_ratio 0.05 \
+--weight_decay 0.01 \
+--report_to wandb  \
+--run_name ${run_name}  \
+--logging_dir  logs \
+--logging_strategy steps \
+--logging_steps 10 \
+--eval_steps 50 \
+--evaluation_strategy steps \
+--save_steps 100 \
+--save_strategy steps \
+--save_total_limit 13 \
+--output_dir  ${output_dir}  \
+--overwrite_output_dir
+```
+
+#### 微调
+```shell
+train_type="SFT"
+model_max_length="1024"
+date_time=$(date +"%Y%m%d%H%M%S")
+data_path="data/sft/sample_train_baichuan_data.json"
+model_name_or_path="your/path/pretrain"
+deepspeed_dir="data/resources/deepspeed_zero_stage2_confi_baichuan2.json"
+export WANDB_PROJECT="TCM-${train_type}"
+run_name="${train_type}_${date_time}"
+output_dir="output/${train_type}/${date_time}_${model_max_length}"
+
+
+deepspeed --hostfile="" src/fine-tune.py  \
+    --report_to "wandb" \
+    --run_name ${run_name}  \
+    --data_path ${data_path} \
+    --model_name_or_path ${model_name_or_path} \
+    --output_dir ${output_dir} \
+    --model_max_length ${model_max_length} \
+    --num_train_epochs 4 \
+    --per_device_train_batch_size 16 \
+    --gradient_accumulation_steps 1 \
+    --save_strategy epoch \
+    --learning_rate 2e-5 \
+    --lr_scheduler_type constant \
+    --adam_beta1 0.9 \
+    --adam_beta2 0.98 \
+    --adam_epsilon 1e-8 \
+    --max_grad_norm 1.0 \
+    --weight_decay 1e-4 \
+    --warmup_ratio 0.0 \
+    --logging_steps 1 \
+    --gradient_checkpointing True \
+    --deepspeed ${deepspeed_dir} \
+    --bf16 True \
+    --tf32 True
+```
+
+### 训练细节
+
+请参考论文实验部分说明。
+

pretrain/train/books/textbook/伤寒论.txt

@@ -0,0 +1,506 @@
+桂枝汤类方
+一、桂枝汤
+1、太阳病，发热汗出，恶风而脉浮弱者。
+2、病常自汗出，或时发热汗出者。
+3、发汗或下之，而表未解者。
+4、阳明病，脉迟，虽汗出多。而微恶寒，表未解者。
+5、病下利而脉浮弱者。
+6、霍乱吐利止，而身疼不休者。
+二、桂枝加桂汤方
+【辨证要点】治桂枝汤证而气上冲剧甚者。
+三、桂枝加芍药汤方
+【辨证要点】桂枝汤证见腹拘急而满痛者。
+四、桂枝加大黄汤方
+【辨证要点】桂枝加大黄汤证，即桂枝加芍药汤证又见里实拒按，或大便不通者。
+五、桂枝加葛根汤方
+【辨证要点】桂枝汤证，又见项背肌肉强急。
+六、栝蒌桂枝汤方
+【辨证要点】病见桂枝汤证，又见痉挛拘急症状，口渴、脉沉者，可辨为本方证。
+七、桂枝加黄芪汤方
+【辨证要点】桂枝汤证更汗出恶风、不渴者，即表虚不固甚者宜用本方治之。
+八、黄芪芍药桂枝苦酒汤方
+【辨证要点】桂枝汤证汗出恶风、汗色黄粘、口渴者本方主之。
+九、桂枝加附子汤方
+【辨证要点】桂枝汤证更见汗出恶风明显，小便难，脉沉细、四肢微急者。
+十、桂枝加芍药生姜各一两人参三两新加汤方
+【辨证要点】桂枝汤证更见身疼明显，纳差、脉沉迟者可选用本方。
+十一、桂枝加厚朴杏子汤方
+【辨证要点】桂枝汤证，咳喘病人不论新久，见汗出恶风脉缓者宜用本方。
+十二、桂枝加龙骨牡蛎汤方
+【辨证要点】桂枝汤证兼见失精梦交、脉见虚象者多可与本方。
+十三、小建中汤方
+【辨证要点】桂枝汤证兼见腹中急痛，或见心悸而不呕者。
+十四、当归建中汤方
+【辨证要点】桂枝汤证又见血虚明显者。
+十五、黄芪建中汤方
+小建中汤证而有黄芪证者。
+【辨证要点】里急腹痛，汗出恶风甚者宜本方主之。
+十六、黄芪桂枝五物汤方
+【辨证要点】肢体麻木不仁，脉虚弱，无实象者可选用本方。
+十七、桂枝去芍药汤方
+【辨证要点】桂枝杨证又见寸脉浮关尺脉沉，症见胸满，或心悸头晕，或气上冲者可用本方治之。
+十八、桂枝去芍药加附子汤方
+【辨证要点】桂枝去芍药汤证又见脉沉细，症有恶寒者宜用本方。
+十九、桂枝附子汤方
+【辨证要点】表虚寒，关节痛疼，脉浮虚而涩者；可用本方治之。
+二十、去桂加白术汤方
+【辨证要点】桂枝附子汤证无气上冲，而见小便自利、大便偏干者。
+二十一、桂枝去芍药加茯苓白术汤方
+【辨证要点】身痛、关节痛、小便不利者可选用本方。
+二十二、甘草附子汤方
+【辨证要点】表虚寒证见关节痛剧，汗出恶风，小便不利者。
+二十三、桂枝去芍药加皂荚汤方
+【辨证要点】桂枝去芍药汤证而痰涎多者。
+二十四、桂枝去芍药加蜀漆牡蛎龙骨汤方
+【辨证要点】桂枝去芍药汤证有痰饮惊狂者。
+二十五、桂枝甘草汤方
+【辨证要点】心下悸欲得按而无里实证者。
+二十六、半夏散及汤方
+【辨证要点】咽痛，有表证而口不渴者。
+二十七、桂枝甘草龙骨牡蛎汤方
+【辨证要点】桂枝甘草汤证又见烦躁惊悸者。
+二十八、防己茯苓汤方
+【辨证要点】表虚伴见四肢肿者。
+二十九、防己黄芪汤方
+【辨证要点】四肢浮肿、汗出恶风明显者。
+三十、桂枝人参汤方
+【辨证要点】桂枝甘草汤证又见理中汤证者。
+三十一、白虎加桂枝汤方
+【辨证要点】桂枝甘草汤证又见白虎汤证者。
+三十二、苓桂术甘汤方
+【辨证要点】头晕目眩、或短气小便不利见气上冲者。
+三十三、苓桂枣甘汤方
+【辨证要点】桂枝甘草汤证见脐下悸动、气上冲者。
+三十四、茯苓甘草汤方
+【辨证要点】桂枝甘草汤证又见心下悸者。
+三十五、茯苓泽泻汤方
+【辨证要点】茯苓甘草汤证又见口渴思饮而呕吐明显者。
+三十六、苓桂五味甘草汤方
+【辨证要点】桂枝甘草汤证又见咳逆上气有痰饮者。
+三十七、苓甘五味姜辛汤方
+【辨证要点】咳而胸满，吐白痰，口不渴者。
+三十八、苓甘五味姜辛夏汤方
+【辨证要点】咳而胸满，吐稀白痰，头晕呕逆者。
+三十九、苓甘五味姜辛夏杏汤方
+【辨证要点】苓甘五味姜辛夏汤证兼见头面或四肢浮肿者。
+四十、苓甘五味姜辛夏杏大黄汤方
+【辨证要点】苓甘五味姜辛夏杏汤证兼见上热而大便难者。
+四十一、五苓散方
+【辨证要点】表虚证兼见心下停饮、小便不利者。
+麻黄汤类方
+一、麻黄汤方
+【辨证要点】
+1、太阳病，头痛，发热、身疼、腰痛、骨节疼痛、恶风、无汗而喘者。
+2、太阳阳明合病，喘而胸满者。
+3、太阳病，脉浮紧、无汗、发热、身疼痛者.
+4、太阳���寒脉浮紧、不发汗因致衄者。
+5、阳明病，脉浮、无汗而喘者。
+二、麻黄加术汤方
+【辨证要点】麻黄汤证而见湿痹烦痛者。
+三、麻黄杏仁薏苡甘草汤方
+【辨证要点】周身关节痛、发热身重或肿者。
+四、麻杏甘石汤方
+【辨证要点】汗出而喘，口干烦满而不恶风者。
+五、越婢汤方
+【辨证要点】周身浮肿、脉浮、恶风者有汗，
+六、越婢加术汤方
+【辨证要点】越婢加术汤用于越婢汤方证见小便不利、或湿痹痛者。
+七、越婢加半夏汤方
+咳逆喘息气粗，痰黄或白，粘稠难咯，胸满烦躁，目胀睛突，或发热汗出，或微恶寒，溲黄便干，口渴欲饮，舌质暗红，苔黄或黄腻，脉滑数（肺气肿）
+【辨证要点】越婢汤证兼见咳逆上气、两目发胀或头痛者。
+八、甘草麻黄汤方
+【辨证要点】浮肿表实无汗者。
+九、麻黄附子甘草汤方
+【辨证要点】表虚寒证见恶寒、无汗、脉微细。
+十、麻黄附子汤方
+【辨证要点】少阴病兼见浮肿明显、无汗恶寒者。
+十一、麻黄附子细辛汤方
+【辨证要点】少阴病兼寒饮，即恶寒无汗脉沉者。
+十二、葛根汤方
+【辨证要点】太阳病，项背强几几、无汗恶风或见下利者。
+十三、葛根加半夏汤方
+【辨证要点】葛根汤证兼见呕逆或下利者。
+十四、葛根黄芩黄连汤方（热下利腹不痛）黄芩汤（热下利）黄芩加半夏汤（热下利腹痛）黄连汤（腹中痛欲呕吐，寒热并结）
+【辨证要点】下利、汗出、不恶寒、脉浮数者。
+-------------------------------------
+【附】临床常用的葛根汤加味方
+1、葛根加生石膏汤
+即于葛根汤再加生石膏45～100克。煎服法同原方，治葛根汤证口舌干燥者。
+2、葛根加桔梗汤
+即于葛根汤加桔梗9克。煎服法同原方。治葛根汤证咽痛或排痰困难者。
+3、葛根加薏苡仁汤
+即于葛根汤加薏苡仁15～30克。煎服法同原方，治葛根汤证关节痛或有痈脓者
+4、葛根加术附汤
+即于葛根汤加白术、附子各10克。煎服法同原方，治葛根汤证而关节疼烦者。
+5、葛根加苓术附汤
+即于葛根汤加术附汤再加茯苓10克。煎服法同原方，治葛根加术附汤证而有茯苓证者。此和上方对于腰背拘急痛尤效，试用于脊髓炎亦有良效。
+--------------------------------------------------
+十五、桂枝麻黄各半汤方
+【辨证要点】太阳病发热恶寒见身痒者。
+十六、桂枝二麻黄一汤
+【辨证要点】桂枝汤证多而麻黄汤证少者。
+十七、桂枝二越婢一汤方
+【辨证要点】桂枝汤证多，越婢汤证少者。
+十八、大青龙汤方
+【辨证要点】桂枝扬证、越婢汤证并见者。
+十九、文蛤汤方
+【辨证要点】麻杏甘石汤证合并越婢汤证又见口渴明显者。
+二十、小青龙汤方
+【辨证要点】外邪里饮而致咳喘者。
+二十一、小青龙加石膏汤方
+【辨证要点】小青龙汤证兼烦躁者。
+二十二、射干麻黄汤方
+【辨证要点】小青龙汤证喉中痰鸣明显者。
+二十三、厚朴麻黄汤方
+【辨证要点】咳喘胸满，脉浮者。
+二十四、桂枝去芍药加麻黄附子细辛汤方
+【辨证要点】手足逆冷、恶寒、身痛者。
+二十五、麻黄连翘赤小豆汤方
+【辨证要点】表实无汗、或身黄、目黄、或身痒者。
+二十六、续命汤方
+【辨证要点】中虚身痛或麻木者。
+二十七、桂枝芍药知母汤方
+【辨证要点】关节痛疼、肢体肿而气冲呕逆者。
+二十八、三黄汤方
+【辨证要点】关节疼痛、无汗恶寒而烦热者。
+二十九、牡蛎汤方
+【辨证要点】疟疾寒多热少，无汗身疼者。
+三十、麻黄升麻汤方
+【辨证要点】伤寒表里不解，上热下寒，症见咽喉不利、腹泄、手足逆冷、脉沉迟者。
+三十一、升麻鳖甲汤万
+【方解】升麻伍以蜀椒解肌致汗，伍以甘草解百毒，并治咽痛。
+复用鳖甲、当归和血驱痛，用雄黄攻肿毒痈脓，故此治疫证咽喉痛而有痈脓或瘀血之变者。
+承气汤类方
+一、大承气汤方
+（堵在大肠，肚脐周围，不放屁）
+【辨证要点】
+1、阳明病脉迟、汗出、不恶寒、发潮热、手足濈然而汗出者。
+2、不大便、发潮热而谵语者。
+3、阳明病谵语有潮热、不能食有燥屎、能食屎定硬者。
+4、汗出谵语、无太阳证者。
+5、发潮热、手足漐漐汗出、大便难而谵语者。
+6、心中懊憹而烦、胃中有燥屎者。
+7、不大便五六日、绕脐痛、烦躁发作有时者。
+8、病人烦热汗出则解，日晡发热而脉实者。
+9、大下后六七日不大便、烦不解、腹满痛者。
+10、小便不利、大便乍难乍易、有时微热、喘冒不能卧者。
+11、脉弱、烦躁心下硬、六七日不大便、小便利者。
+12、伤寒六七日，目中不了了、睛不和，无表里证，大便难身微热者；
+13、少阴病自利清水，色纯青、心下必痛、口干燥者。
+14、少阴病六七日腹胀不大便者。
+15、下利脉滑而数、或脉迟而滑、不欲食者。
+二、小承气汤方
+（堵在小肠，肚脐以下，会放屁）
+【辨证要点】阳明病，胃中燥、大便硬、而无潮热者。
+三、调胃承气汤方
+（堵在十二指肠，中脘下有压痛点）
+【辨证要点】阳明病，见腹实证，心烦、或谵语、发热者。
+四、桃仁承气汤
+【辨证要点】小便利
+五、大黄甘草汤方
+（实证，在胃，吃嘛吐嘛）吴茱萸汤（虚证，食谷欲吐）
+【辨证要点】阳明病，大便难而急迫者。
+六、厚朴三物汤方
+【辨证要点】胸腹胀满而痛、大便闭结者。
+七、厚朴七物汤方
+厚朴三物汤与桂枝去芍药汤的合方，故治二方合并证。
+【辨证要点】发热腹满，大便干结者。
+八、麻子仁丸方
+【辨证要点】经常便秘而无所苦者
+白虎汤类方
+一、白虎汤方
+【辨证要点】阳明病，自汗出，脉滑数者。
+二、白虎加人参汤方
+【辨证要点】白虎汤证见口渴明显者。治疗消渴（上消）
+下瘀血汤类方
+一、下瘀血汤方
+【辨证要点】少腹痛、硬满，大便干结者。
+二、桃核承气汤方
+（小便不利）
+【辨证要点】调胃承气汤证，见腹痛有定处、气上冲者。
+三、大黄牡丹皮汤方
+（右脚弓，足三里下一寸阑尾穴有压痛）苡附子败酱散，类似阑尾炎，隐隐痛，右脚不弓，手上生命线处有紫斑）
+【辨证要点】右腹痛拒按、里实者。
+四、抵当汤方
+（小便利）
+【辨证要点】少腹硬满、小便利、或喜忘、或狂躁不安者。
+五、抵当丸方
+【辨证要点】抵当汤证较轻者。
+六、大黄蟅虫丸方
+【辨证要点】虚劳证见面目黯黑、肌肤甲错者。
+七、桂枝茯苓丸方
+【辨证要点】久有瘀血、腹痛胁痛，或有肿块、或下血者。
+八、土瓜根散方
+【辨证要点】腹满痛、痛有定处而有热者。
+大陷胸类汤
+一、大陷胸汤方
+（痛往下走）
+【辨证要点】心下结硬、满痛拒按而烦躁者。
+二、大陷胸丸方
+（痛往上走）
+【辨证要点】心下结硬，疼痛较轻而项背强急者。
+三、十枣汤方
+（围绕肋骨一圈痛）
+【辨证要点】咳而胸闷胁痛、心下痞硬满、脉沉弦者。
+四、甘遂半夏汤方
+【辨证要点】心下坚满，腹挛急者。
+五、大黄甘遂汤方
+（血与水并结）
+【辨证要点】少腹满痛、小便不利、大便不畅者。
+六、己椒苈黄丸方
+【辨证要点】腹满、肠鸣、便干者。
+七、小陷胸汤
+【辨证要点】胸膈满闷、心烦、按之心下痛者。
+泻心汤类方
+一、泻心汤方
+【辨证要点】心烦吐衄、大便干者。
+二、大黄黄连泻心汤方
+【辨证要点】心烦、心下痞者。
+三、附子泻心汤方
+【辨证要点】心下痞、恶寒汗出者。
+四、大黄硝石汤方
+【辨证要点】实热黄疸，大便干、小便黄少者。
+五、茵陈蒿汤方
+（上热中湿下实）栀子柏皮汤（无表证无里实，上热下热）麻黄连翘赤小豆汤（有表证，无汗）
+【辨证要点】阳黄见大便干，小便不利者。
+六、栀子大黄汤方
+【辨证要点】栀子豉汤证又见腹胀满、大便难者。
+七、大黄汤或丸方
+【辨证要点】心烦、心下痞满、大便难者
+干姜附子类
+一、干姜附子汤
+（少阴病，烦躁昼甚夜安）
+【辨证要点】四逆身冷脉沉微者
+二、四逆汤
+（温中祛寒，回阳救逆）
+【辨证要点】四逆脉微欲绝，里虚寒甚者
+三、通脉四逆汤
+（破阴回阳，通达内外）
+【辨证要点】四逆汤证虚寒更甚
+四、通脉四逆加猪胆汁汤
+（回阳救阴）
+【辨证要点】通脉四逆汤证沉衰更甚，脉欲绝或脉不出
+五、四逆加人参汤
+（阳虚血脱。吐利之后，汗多恶寒，四肢厥逆，脉微；或吐利未止）
+【辨证要点】吐利后，胃气虚衰，脉微弱者
+六、茯苓四逆汤
+（回阳益阴，兼伐水邪，伤寒，发汗或下后，病仍不解，烦躁者）
+【辨证要点】四逆加人参汤证又见心下悸，烦躁及小便不利
+七、白通汤
+（少阴病，寒利不止，破阴回阳，宣通上下，少阴病，下利脉微者，与白通汤）
+【辨证要点】少阴病见下利者。桃花汤（热利不止）
+甘草干姜汤类方
+一、甘草干姜汤方
+【辨证要点】胃虚寒，吐涎沫呕逆者。
+二、理中汤或丸方
+【辨证要点】心下痞，大便溏泄，小便少者。
+三、大建中汤方
+（中焦寒重）小建中汤（少腹寒）乌梅赤石脂丸（胸的寒痛）
+【辨证要点】心腹痛剧、呕逆不能食属虚寒者。
+四、吴茱萸汤方
+【辨证要点】胃虚寒干呕吐涎沫、胸闷或头痛者。
+附子汤类
+一、附子汤
+胃虚寒饮，骨节痛���下肢拘急痛而脉沉
+【辨证要点】四逆身冷脉沉微者
+二、真武汤
+(阳虚水泛)
+【辨证要点】头晕心悸，下肢浮肿或痛，脉沉
+三、附子粳米汤
+（小肠套叠）
+【辨证要点】里虚寒，腹痛肠鸣、恶心
+四、大乌头煎
+【辨证要点】寒疝腹痛、手足厥逆、脉沉弦者
+五、大黄附子汤
+（下焦寒实）
+【辨证要点】寒湿偏注而见身体某侧、某处疼痛者
+赤石脂禹余粮类
+一、赤石脂禹余粮汤。
+【辨证要点】久利而虚寒者
+二、桃花汤
+【辨证要点】虚寒久利，或见脓血者
+半夏汤类
+一、小半夏汤。
+【辨证要点】呕逆或头痛、口不渴者
+二、生姜半夏汤
+【辨证要点】小半夏汤证而饮剧者
+三、小半夏加茯苓汤
+【辨证要点】小半夏汤证又见心悸头晕者
+四、半夏干姜散
+【辨证要点】干呕、吐涎沫而属胃虚寒者
+五、大半夏汤
+【辨证要点】胃虚之心下痞、呕吐者
+六、干姜半夏人参丸
+【辨证要点】呕吐甚而心下痞硬者
+七、厚朴生姜半夏甘草人参汤
+【辨证要点】中气虚之腹胀满者
+八、半夏厚朴汤
+【辨证要点】痰饮气结所致胸满、咽堵、咳逆者
+九、旋覆代赭汤
+【辨证要点】心下痞、噫气呕逆者
+十、泽漆汤
+【辨证要点】痰饮咳逆而无外感多热者
+十一、苦酒汤
+【辨证要点】咽干痛、声音嘶哑表证不明显者
+橘皮汤类
+一、橘皮汤
+【辨证要点】干呕纳差者
+二、橘皮枳实生姜汤
+【辨证要点】胸痹短气堵闷者
+三、橘皮竹茹汤
+【辨证要点】胃虚嗝逆、呕哕咳逆者
+四、外台茯苓饮
+【辨证要点】胸满、腹胀、心下痞、纳差、小便不利
+黄芩黄连汤类
+一、黄芩汤
+【辨证要点】发热腹痛、腹泻者
+二、黄芩加半夏生姜汤
+【辨证要点】黄芩汤证见恶心、呕吐者
+三、六物黄芩汤
+【辨证要点】干呕下利而心下痞硬者
+四、三物黄芩汤
+【辨证要点】里热血热见心烦、手足心热者
+五、黄连汤
+【辨证要点】心烦、心下痞满、腹痛或干呕下利者
+六、黄连阿胶汤
+【辨证要点】虚烦心悸不得眠、手足心热、或下利便脓血者
+七、白头翁汤
+【辨证要点】热痢下重、腹痛者
+八、白头翁加甘草阿胶汤
+【辨证要点】白头翁汤证又见血便、粘血便而虚乏少气者
+九、干姜黄连黄芩人参汤
+【辨证要点】胸中烦热、恶心呕吐而大便溏者
+十、半夏泻心汤
+【辨证要点】上热下寒因见呕而肠鸣、心下痞硬者
+十一、甘草泻心汤
+【辨证要点】半夏泻心汤证中气更虚、或见口舌糜烂、肠鸣腹泻、前后阴溃疡者
+十二、生姜泻心汤
+【辨证要点】心下痞满、干噫食臭、肠鸣下利者
+栀子汤类
+一、栀子豉汤
+【辨证要点】胸中窒塞而烦闷者
+二、栀子甘草豉汤
+【辨证要点】栀子豉汤证而少气者
+三、栀子生姜豉汤
+【辨证要点】栀子豉汤证而呕者
+四、枳实栀子豉汤
+【辨证要点】栀子豉汤证而心下涨满者
+五、栀子厚朴汤
+【辨证要点】胸烦热和腹涨满者
+六、栀子柏皮汤
+【辨证要点】黄疸病发热心烦者
+七、栀子干姜汤
+【辨证要点】身热微烦而呕逆或下利者
+甘草汤类
+一、甘草汤
+【辨证要点】咽喉痛之轻证者
+二、桔梗汤
+【辨证要点】咽痛、咳吐浓痰、或胸痛者
+三、芍药甘草汤
+【辨证要点】四肢、胃腹等处挛急疼痛者
+四、芍药甘草附予汤
+【辨证要点】芍药甘草汤证更见阳虚寒证者
+五、甘草小麦大枣汤
+【辨证要点】无故苦笑难以自控而偏虚者
+六、甘草粉蜜汤
+【辨证要点】胃脘疼痛急迫而涨满不甚者
+七、生姜甘草汤
+【辨证要点】咳吐白痰而呕、胃虚纳差者
+八、排脓汤
+【辨证要点】咳唾浊痰、胸痛而病久者
+枳术汤类
+一、枳术汤。
+【辨证要点】心下坚满而边界清楚又见小便不利者
+二、枳实芍药散
+【辨证要点】腹满挛痛或有心烦不安者
+三、排脓散
+【辨证要点】枳实芍药散证而有痈脓者
+四、桂枝生姜枳实汤
+（治疗心包炎）
+【辨证要点】心下痞塞、胸肋闷痛者
+瓜蒌薤白汤类
+一、瓜蒌薤白白酒汤。
+（心脏结构受损，后背第五椎有压痛点）
+【辨证要点】胸闷、胸背痛、短气或喘息者
+二、瓜蒌薤白半夏汤
+（病更重）
+【辨证要点】胸闷心痛、咳逆短气甚者
+三、枳实薤白桂枝汤
+（胃胀满、肋下痛、胸闷、拒按）
+【辨证要点】
+瓜蒌薤白白酒汤证胸腹逆满明显者
+茯苓杏仁甘草汤（缓痛，心脏有积水、寸脉弦可以确定水包围在心包、不渴）
+四、瓜蒌瞿麦丸
+【辨证要点】小便不利、口渴，尿粘稠（淋病）与五苓散区别
+芎归胶艾汤类
+一、芎归胶艾汤
+【辨证要点】诸失血证属虚证而见腹中痛者
+二、当归芍药散
+【辨证要���】腹痛拘急、头晕心悸、小便不利者
+三、温经汤
+【辨证要点】芎归胶艾汤、当归芍药散、吴茱萸汤、麦门冬汤诸方证合并证者
+四、当归散
+【辨证要点】当归芍药散证腹痛较轻、或妊娠血虚有热者
+五、当归四逆汤
+【辨证要点】手足凉表虚而里寒不甚者
+六、当归四逆加吴茱萸生姜汤
+【辨证要点】当归四逆汤证更见心腹痛、呕逆或头痛者
+七、当归生姜羊肉汤
+【辨证要点】血虚腹痛里急者
+八、赤小豆当归散
+【辨证要点】诸疮有痈脓者恶血者
+九、黄土汤
+【辨证要点】大便溏而下血黑紫、兼见四肢冷痹反心烦热者
+十、炙甘草汤
+【辨证要点】心动悸、脉结代气阴两虚者
+十一、酸枣仁汤
+【辨证要点】因血虚见心悸虚烦不得眠者
+麦冬汤类
+一、麦冬汤
+【辨证要点】咳逆上气、咽干口燥者
+二、竹叶石膏汤
+【辨证要点】虚热上炎、气逆欲吐、烦渴者
+木防己汤类
+一、木防己汤
+【辨证要点】喘满心下痞坚烦渴者
+二、木防己去石膏加茯苓芒硝汤
+【辨证要点】木防己汤证心下痞坚甚、二便不利者
+薏苡附子散类
+一、薏苡附子散
+【辨证要点】寒湿痹痛、胸痹疼痛、时缓时急者
+二、薏苡附子败酱散
+【辨证要点】肠痈腹痛、皮肤甲错、或肿痒流黄水者
+三、苇茎汤
+【辨证要点】咳吐黄脓痰、微热烦满者
+猪苓汤类
+一、猪苓汤
+【辨证要点】小便不利、或淋痛尿血而渴欲饮水者
+二、猪苓散
+【辨证要点】呕咳而小便不利者
+三、泽泻汤
+【辨证要点】心下停饮见眩晕、小便不利者
+四、茯苓杏仁甘草汤
+【辨证要点】（缓痛，心脏有积水、寸脉弦可以确定水包围在心包、不渴）
+五、茯苓泽泻汤
+【辨证要点】呕吐、小便不利、渴欲饮水者
+六、甘姜苓术汤
+【辨证要点】腰冷重小便自利者
+七、茯苓杏仁甘草汤
+【辨证要点】咳喘胸闷、小便不利者
+八、葵子茯苓散
+【辨证要点】妊娠浮肿者
+其他
+一、乌梅丸
+【辨证要点】厥逆烦躁、或腹痛呕吐时缓时作、或虚寒久利者
+二、柏叶汤
+【辨证要点】吐血下血、烦热腹痛而脉无力者
+三、蜀漆散
+【辨证要点】疟寒多热少者
+四、百合地黄汤
+【辨证要点】百合病口苦、小便赤、脉微数者
+五、瓜蒌牡蛎散
+【辨证要点】虚热而渴、或胸腹动悸者
+六、猪膏发煎
+【辨证要点】少腹满、大便干结、小便不利者
+七、猪肤汤
+【辨证要点】口干咽痛心烦、舌红少津、脉细数

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+O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21,0
+O=C(O)C(Cl)Br,1
+O=C(O)/C=C/c1c[nH]cn1,0
+O=C(Nc1ccon1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1,0
+O=C(Nc1ccccc1Cl)c1csc([N+](=O)[O-])c1,1
+O=C(Nc1ccc(/C=C/c2ccc(NC(=O)[C@@H]3CCCN3C(=O)Cc3ccccc3)cc2)cc1)[C@@H]1CCCN1C(=O)Cc1ccccc1,0
+O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(Oc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1,0
+O=C(Cl)c1ccccc1[N+](=O)[O-],1
+O=C(CCl)Nc1snc2ccc(Cl)cc12,1
+O=C(/C=C/c1ccc(O)cc1)c1ccccc1,0
+Nc1nc[nH]n1,0
+Nc1nc(-c2ccc(Cl)cc2)c2c(n1)-c1ccccc1C2=O,0
+Nc1ccn(C2C=C(CO)C(O)C2O)c(=O)n1,0
+Nc1cccc2cccc(N)c12,1
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+Nc1ccc2cc3ccccc3nc2c1,1
+Nc1ccc([N+](=O)[O-])cc1O,1
+Nc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1,1
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+Nc1ccc(-c2ccc(N)cc2[N+](=O)[O-])cc1,1
+Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl,1
+Nc1cc([N+](=O)[O-])ccc1O,1
+Nc1c2c(nc3ccccc13)CCCC2,1
+Nc1c(Oc2ccccc2)cc(O)c2c1C(=O)c1ccccc1C2=O,1
+NP(=O)(OCCC(=O)O)N(CCCl)CCCl,1
+NNc1nncc2ncccc12,1
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+NC1=NS(=O)(=O)N(Cc2ccccc2)c2nc(-c3ccccc3)n(Cc3ccccc3)c21,0
+NC(CCC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(=O)O,1
+NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1,0
+NC(=O)c1cnccn1,0
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+N/C(=N\OS(=O)(=O)O)c1ccccc1,0
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+N#Cc1cc(Cl)ccc1-c1ccc(N)cc1F,0
+N#CCBr,0
+N#C/C(=C\C=C\c1ccccc1)c1ccc(F)cc1,1
+Cn1cnc(S(=O)(=O)N2C[C@H](Nc3ccc(F)c(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1,0
+Cn1c(N=[N+]=[N-])nc2c3ccccc3ccc21,1
+Clc1ccc([C@H](c2ccccc2Cl)C(Cl)Cl)cc1,0
+ClCc1cccnc1,1
+Cc1nnc2sc(C(=O)NC3CN(c4cccc(F)c4F)C3)c(N)c2c1C,0
+Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1,0
+Cc1nc(-c2ccc([N+](=O)[O-])o2)cs1,1
+Cc1n[n+]([O-])c(-c2ccccc2)c(=O)n1N,1
+Cc1cccc(O)c1N,0
+Cc1ccc2nsc(NC(=O)CCl)c2c1,1
+Cc1ccc2ccccc2c1[N+](=O)[O-],1
+Cc1ccc2cc3ccccc3cc2c1,1
+Cc1ccc2c(ccc3ccccc32)c1,1
+Cc1ccc2c(c1)C(=O)c1ccccc1C2=O,0
+Cc1ccc2c(c1)-c1ccccc1C2C,1
+Cc1ccc([N+](=O)[O-])cc1,0
+Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1,1
+Cc1ccc(O)c(N)c1,1
+Cc1ccc(NS(=O)(=O)N(C)C)c(O)c1,0
+Cc1ccc(NCCO)cc1O,0
+Cc1ccc(N)cc1N,1
+Cc1ccc(C)c([N+](=O)[O-])c1,1
+Cc1ccc(-c2nc3n(c2[N+](=O)[O-])CCS3)cc1,1
+Cc1ccc(-c2cc3nc(NC(C)(C)C)[nH]c(=O)c3s2)cc1,0
+Cc1cc2c(c3ccc4ccccc4c13)CC(O)C2=O,1
+Cc1cc(N2C[C@H]3CC[C@@H](C2)[C@@H]3Nc2nc3n(n2)CCCN3c2cc(F)cc(F)c2)ncn1,0
+Cc1cc(N)cc([N+](=O)[O-])c1N,1
+Cc1cc(C2(c3cc(C)c(O)cc3C)OS(=O)(=O)c3ccccc32)c(C)cc1O,0
+Cc1cc(C)c2nsnc2c1N,1
+Cc1cc(C)c(N)c(C)c1,1
+Cc1c2ccccc2c(CO)c2ccccc12,1
+Cc1c2ccccc2c(C)c2ccccc12,1
+Cc1c2cc(CO)ccc2nc2c1ccc1ccccc12,1
+Cc1c(NO)cc(NO)cc1[N+](=O)[O-],1
+Cc1c(N=[N+]([O-])c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2C)cc([N+](=O)[O-])cc1[N+](=O)[O-],1
+Cc1c(C)c2c(N)c3ccccc3nc2c2ccccc12,1
+C[Si](C)(C)N[Si](C)(C)C,0
+C[C@]1(c2ccc([N+](=O)[O-])cc2)CO1,1
+C[C@H](N)CNc1cnc(C(N)=O)c(-c2cnn(C)c2)n1,0
+C[C@H](C(=O)O)n1nc(Cn2cc3cc(OCC4CC4)c(Cl)cc3n2)c2ccccc2c1=O,0
+C[C@@H](Nc1[nH]cnc2nc(-c3ccc(CCl)cc3)cc1-2)c1ccccc1,1
+CSCCC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)O,0
+CSCCC(N)C(=O)O,0
+CS(=O)(=O)c1ccc(O)c(N)c1,0
+COc1nncc2cnccc12,0
+COc1cccc2c1cc1c3c(cc4c(c32)OCO4)C(=O)N1,1
+COc1ccc(OC)c(N=Nc2c(O)ccc3ccccc23)c1,1
+COc1ccc(C(=O)ON(OCc2ccccc2)C(=O)c2ccccc2)cc1,1
+COc1cc2c(CCNC(C)=O)c[nH]c2cc1O,0
+COc1c2ccoc2nc2c(O)c3c(c(CC=C(C)C)c12)OCO3,0
+COc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl,1
+COP(=O)(SC)SC,0
+COP(=O)(O)O,0
+COC(=O)C1=C(C)NC(C)=C(C(=O)OCC=Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1,0
+COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1,0
+CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CSC12)c1csc(N)n1,0
+CO/N=C(/C(=O)O)c1ccccc1COc1cc(O)ccc1C,0
+CNc1ccc2ncc(C)nc2c1C,1
+CNC(C)Cc1ccccc1,0
+CNC(=O)c1cc(C(=O)O)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl,0
+CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)n([C@@H](C)c2ccccc2)n1,0
+CN1CCC=C2c3nc(N)sc3CCC21,1
+CN(CCC#N)c1ccc(N=Nc2ccccc2)cc1,1
+CN(C)c1ccc(CCO)cc1,1
+CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2c(O)c(S(=O)(=O)O)cc3cc(S(=O)(=O)O)ccc23)cc1,0
+CN(C)CCO[C@@](C)(c1ccccc1)c1ccccn1,0
+CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1O2,1
+CN(C)CCCNc1c2ccccc2nc2ccccc12,1
+CN(C)/C(=N/c1ccc2c(c1)C(=O)c1ccc(/N=C(\C3CC3)N(C)C)cc1C2=O)C1CC1,0
+CCc1cccc2cc([C@H](O)CNC(C)(C)C)oc12,0
+CCc1cccc2c3c([nH]c12)[C@](CC)(CC(=O)O)OCC3,0
+CCc1cccc(CC)c1N,1
+CCc1ccc2nc(N3CCC(N[C@@H]4CCCOC4)CC3)c(-c3nc(C)no3)cc2c1,1
+CCc1ccc2c(c1)c(-c1ccc[nH]c1=O)c(C(=O)O)n2Cc1cc([N+](=O)[O-])ccc1F,0
+CCc1cc2ccccc2c2ccc3c(c12)C1OC1C(O)C3O,1
+CC[n+]1c2ccccc2nc2ccccc21,1
+CC[Si](Cl)(Cl)CC,0
+CC[C@@H](C)N,0
+CCS(=O)(=O)c1nc2ccccn2c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,0
+CCON(OC(C)=O)C(=O)c1ccccc1,1
+CCOCCO,0
+CCOC(C)=O,0
+CCOC(=O)c1c(C(F)(F)F)[n+]([O-])c2ccc(OC)cc2[n+]1[O-],1
+CCOC(=O)c1c(C(F)(F)F)[n+]([O-])c2ccc(C)cc2[n+]1[O-],1
+CCOC(=O)[C@@H]1O[C@]1(C)c1ccccc1,0
+CCOC(=O)N(CC)N=O,1
+CCOC(=O)N(C)N=O,1
+CCOC(=O)COc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl,0
+CCOC(=O)C(Cl)Cc1cc(-n2nc(C)n(C(F)F)c2=O)c(F)cc1Cl,0
+CCOC(=O)C(=NNc1ccc(-c2ccc(NN=C(C(=O)OCC)C(=O)OCC)c(OC)c2)cc1OC)C(=O)OCC,0
+CCN=c1cc2oc3cc(NCC)c(C)cc3c(-c3ccccc3C(=O)OCC)c-2cc1C,0
+CCN(CCO)c1ccc(NCCO)c([N+](=O)[O-])c1,1
+CCN(CC)CCn1nc2ccc(CO)c3c2c1Sc1cc(Cl)ccc1-3,1
+CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12,1
+CCCn1cc2c3c(cccc31)C1C=C(C)CN(C)C1C2,1
+CCCOS(C)(=O)=O,1
+CCCN(CC)CC1COC2(CCC(C(C)(C)C)CC2)O1,0
+CCCCON(OC(C)=O)C(=O)c1ccc(Br)cc1,1
+CCCCOC(=O)c1ccccc1N,0
+CCCCN(CCCO)N=O,1
+CCCCN(CCC(C)O)N=O,1
+CCCCCCN(N=O)C(N)=O,1
+CCCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1,0
+CCCCCCCCCCCCCCC1CO1,0
+CCCCCCCCCCCC(=O)O,0
+CCCCCCCCCCC1CO1,0
+CCCCC(CC)COCCCN,0
+CCCC(=O)c1cnn(-c2cnc(N)cn2)c1C,0
+CCCC(=O)Nc1snc2ccc(Cl)cc12,0
+CCC(C)COC(=O)Nc1nc(=O)n([C@@H]2O[C@H](C)[C@@H](O)[C@H]2O)cc1F,0
+CC1Cc2c(Cl)cc(C(=O)NC(Cc3ccccc3)C(=O)O)c(O)c2C(=O)O1,0
+CC1CCc2c1ccc1c2ccc2ccccc21,1
+CC1CCN(N=O)CC1,1
+CC1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1,0
+CC1=CCC2C(C)=CCC(C(C)(C)C)C2C1,0
+CC1=CC(O)C2CC1C2(C)C,0
+CC12OOC1(CO)Oc1ccccc12,0
+CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O,0
+CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O,0
+CC/C=C/C=C/C=C/C=C/C=O,0
+CC(OP(C)(=O)F)C(C)(C)C,0
+CC(Cl)CO,1
+CC(C)[C@@H]1CC[C@@H](C)CC1=O,1
+CC(C)C1C2CCC1c1c(NC(=O)c3cn(C)nc3C(F)F)cccc12,0
+CC(C)(C)OC(=O)CN=[N+]=[N-],1
+CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2,0
+CC(C(O)CC(=O)O)C(O)(Cn1cncn1)c1ccc(Cl)cc1,0
+CC(Br)c1ccccc1,0
+CC(Br)C(=O)NCc1ccc(Cl)cc1,1
+CC(Br)(CO)CBr,0
+CC(=O)n1ncc(Cl)c(Cl)c1=O,0
+CC(=O)c1cc2c(cc1C)C(C)(C)C(C)CC2(C)C,0
+CC(=O)c1c([N+](=O)[O-])cc([N+](=O)[O-])n1[N+](=O)[O-],1
+CC(=O)OC1C(=O)OC2C(OC(C)=O)C(=O)OC12,0
+CC(=O)Nc1ccc(C)c(N=[N+]([O-])c2cc(NC(C)=O)ccc2C)c1,0
+CC(=O)Nc1ccc(/C=C/C(=O)c2ccccc2)cc1,1
+CC(=O)Nc1ccc(-c2ccc(N)cc2)cc1,1
+CC(=O)Nc1cc2c(cc1OC(C)=O)-c1ccccc1C2,0
+CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C,0
+CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccccc1,0
+CC(=N)S,0
+CC(=C\C1=CCOC1=O)/C=C(C)/C=C/C=C(\C)C(=O)C12OC1C(O)(CCO)NC2=O,1
+CC#N,0
+C=CC(=O)OCCCCCOC(=O)C=C,0
+C=CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C,0
+C=C1C(=O)OC2C1CCC(C)C1=CCC(=O)C12C,0
+C=C(F)F,1
+C=C(C)[C@H]1CC=C(C)[C@@H](OC(C)=O)C1,0
+C=C(C)[C@H]1C=C2C(COC(=O)CCCCCCCCCCCCCCCCC)=CC=C2C(C)=CC1,1
+C=C(C)C(=O)OCCOC(=O)NCCC(C)CC(C)(C)CNC(=O)OCCOC(=O)C(=C)C,0
+C=C(C)C(=O)OCCO,0
+C=C(C)C(=O)OCCCCCCCC,0
+C=C(C)C(=O)N[N+](C)(C)CC(C)O,0
+C1C[C@H](O[C@H]2CC[C@@H]3O[C@@H]32)[C@H]2O[C@@H]12,0
+C1CCC(NC2CCCCC2)CC1,0
+C1=CC2OC2C=C1,1
+C1=CC2CCCCC2c2ccccc21,1
+C/C=C/C=C/CCCCCCCO,0
+C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1,0
+C/C(C=O)=C(/Cl)C(=O)O,1
+BrCc1ccc2c(c1)-c1cccc3cccc-2c13,1
+BrCC1CO1,1
+BrCBr,1

sft/test/admet_cls.json

@@ -0,0 +1,2502 @@
+[
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "c1ccc2c(c1)CCNC2",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "Oc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)NCC[C@@]341",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子BBB吗？",
+    "input": "Oc1ccc2[nH]cc(CCCCN3CC=C(c4ccccc4)CC3)c2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O[C@H](OCC(CO[C@@H](O)C(Cl)(Cl)Cl)(CO[C@H](O)C(Cl)(Cl)Cl)CO[C@H](O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "OCc1ccccc1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "OCc1ccccc1OC1OC(CO)C(O)C(O)C1O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "OCCN1CCN(CC/C=C2/c3ccccc3COc3ccc(Cl)cc32)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "OC(c1ccccc1)(c1ccccc1)C1CCCCN1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "O=P(O)(O)C(Cc1ccc(Cl)cc1)P(=O)(O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "O=NN(CCCl)C(=O)NC1CCCCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=C1c2c(O)cc(O)cc2CC(c2ccc(O)c(O)c2)C1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O=C1NC(CCCl)Oc2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的血脑屏障很感兴趣，你能告诉我它是多少吗？",
+    "input": "O=C1C[C@@H](c2cccnc2)c2c(ccc3c2OC2(CCCCC2)CC3=O)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "O=C1CNC(c2ccccc2)=c2c3c(sc2=N1)CCCC3",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=C1CN2CCOC2(c2ccccc2F)c2cc(Cl)ccc2N1CCO",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的BBB。",
+    "input": "O=C1CN2CCOC2(c2ccccc2F)c2cc(Br)ccc2N1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "O=C1CN(/N=C\\c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O=C1CCC(c2ccccc2)(C2CCN(CC=Cc3ccccc3)CC2)C(=O)N1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O=C1C(Cc2ccccc2)N(S(=O)(=O)c2cccc(O)c2)C(=O)C(Cc2ccccc2)N1S(=O)(=O)c1cccc(O)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O=C1C(CC[S+]([O-])c2ccccc2)C(=O)N(c2ccccc2)N1c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "O=C(OC1CC2CCC(C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障值吗？",
+    "input": "O=C(O)c1ccccc1C(=O)OC1CCc2ccccc2C1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=C(O)c1cc[nH]c1NCCSCc1ncccc1Br",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB值。",
+    "input": "O=C(O)c1cc(=O)c2ccccc2o1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "O=C(O)C1=C(CSc2nnnn2CS(=O)(=O)O)CS[C@H]2[C@@H](NC(=O)[C@H](O)c3ccccc3)C(=O)N12",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "O=C(Nc1nc2ccccc2s1)c1ccc(N2CCOCC2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "O=C(N[C@H]1CC[C@H](O)CC1)C1CC(CCc2ccccc2)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "O=C(N[C@@H](Cc1ccccn1)C1CC(O)C1)c1n[nH]c2ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "O=C(NC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2cc(O)ccc2o1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的血脑屏障���感兴趣，你能告诉我它是多少吗？",
+    "input": "O=C(Cc1ccc(Cl)c(Cl)c1)N1CCn2ccnc2C1CN1CCCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "O=C(C[S+]([O-])Cc1ccco1)NC/C=C/COc1cc(CN2CCCCC2)ccn1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的血脑屏障。",
+    "input": "O=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccc(O)cc12",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "Nc1nc2c(c(=O)[nH]1)N(C=O)[C@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB值吗？",
+    "input": "Nc1nc(OC(C(F)(F)F)C(F)(F)F)ccc1[N+](=O)[O-]",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子血脑屏障吗？",
+    "input": "Nc1nc(/C(=C\\CC(=O)O)C(=O)NC2C(=O)N3C(C(=O)O)=CCS[C@@H]23)cs1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "NC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](N)C[C@@H](N)[C@@H]3O[C@@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@@H](N)[C@H](O)[C@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "NC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](N)C[C@@H]2N)[C@@H](N)[C@H](O)[C@@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "NCC[C@H](O)C(=O)N[C@H]1C[C@H](N)[C@@H](O[C@H]2O[C@@H](CN)CC[C@@H]2N)[C@H](O)[C@H]1O[C@H]1O[C@@H](CO)[C@H](O)[C@H](N)[C@@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB。",
+    "input": "NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](OC2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1OC1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@H](O[C@@H]2O[C@@H](CN)[C@@H](O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H]1O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](N)[C@@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "NC(=O)c1ncn(C2OC(CO)C(O)C2O)c1O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "NC(=O)c1ccc(F)c2c1C[C@@H](N(C1CCC1)C1CCC1)CO2",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "N#Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "N#CCN[C@@H]1CCc2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "Fc1ccccc1C1=NCCN(CC(F)(F)F)c2ccc(Cl)cc21",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "Fc1cc2[nH]c(-c3cccc(N4CCc5ccccc5C4)c3)nc2cc1Cl",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](OC=O)c3ccccc3)[C@H]2SC1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "Cn1c(=O)c2c(ncn2CCNC[C@H](O)c2ccc(O)c(O)c2)n(C)c1=O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "Cc1nnc(SCC2=C(C(=O)OCc3oc(=O)oc3C)N3C(=O)[C@H](NC(=O)[C@H](OC(=O)[C@H](C)N)c4ccccc4)[C@@H]3SC2)s1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB值吗？",
+    "input": "Cc1ccc2nc(NC(=O)c3ccc(N4CCOCC4)cc3)sc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "Cc1ccc2[nH]c(CCC(=O)N[C@H](C)Cc3cnccn3)nc2c1C",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "Cc1ccc([C@H](C)NC(=O)CCSc2ccccc2)cc1C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "Cc1ccc(S(=O)(=O)NC(=O)NN2C[C@H]3CCC[C@H]3C2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "Cc1ccc(S(=O)(=O)CCN2C(=O)CN=C(c3ccccc3Cl)c3cc(Cl)ccc32)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "Cc1cc(C2CCCCC2)n(O)c(=O)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "Cc1cc(C)c(=O)[nH]n1",
+    "output": "有"
+  },
+  {
+    "instruction": "���提供该分子的BBB。",
+    "input": "Cc1cc(C(=O)N(C)[C@@H](C)c2ccncn2)ccc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "Cc1[nH]ccc2c1[nH]c1cc(=O)ccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是什么吗？",
+    "input": "C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "C[C@H]1c2cccc(O)c2C(O)=C2C(=O)[C@]3(O)C(=O)/C(=C(/N)O)C(=O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是什么吗？",
+    "input": "C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)C(C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "C[C@H]1C[C@H]2[C@H]3C[C@H](F)C4=CC(=O)C=C[C@@]4(C)[C@@]3(Cl)[C@H](O)C[C@@]2(C)[C@H]1C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=CC4(C)[C@H]3[C@@H](O)CC2(C)C1C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子BBB吗？",
+    "input": "C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=CC4(C)C3(F)C(=O)CC2(C)C1(O)C(=O)CCl",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@H](C)N1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "C[C@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(F)S[C@@H]12",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@H](O)C[C@]2(C)[C@H]1C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CS(=O)(=O)c1ccc([C@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是多少吗？",
+    "input": "CS(=O)(=O)c1ccc([C@@H](O)[C@H](CF)NC(=O)C(Cl)Cl)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "COc1ccccc1CNC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@](O)(C(=O)CO)C[C@H]3O[C@H]1C[C@@H](NC(=O)[C@H](N)CC(C)C)[C@H](O)[C@H](C)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "COc1ccc2c3c1OC1C(O)CCC4C(C2)N(C)CCC341",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "COc1ccc2c(c1OC)C(=O)O[C@H]2[C@@H]1c2c(cc3c(c2OC)OCO3)CCN1C",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "COc1ccc([C@H]2[C@@H](S(=O)(=O)c3ccc(C)cc3)[C@]2(C#N)C=O)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障值。",
+    "input": "COc1ccc(S(N)(=O)=O)cc1C(=O)NC[C@@H]1CCCN1C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB吗？",
+    "input": "COc1ccc(OC(F)(F)F)cc1CNC1CCCNC1c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "COc1ccc(CN(CCN(C)C)c2ccccn2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是多少吗？",
+    "input": "COc1cc2c(cc1OC)C(c1cccc(Cl)c1)=NN=C(C)C2",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "COc1cc2c(cc1OC)C(=O)[C@@H](CC1CCN(Cc3ccccc3)CC1)C2",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "COc1cc2c(cc1O)CCC(C)(CC(=O)NCCc1ccc(O)c(O)c1)O2",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障值吗？",
+    "input": "COc1cc(O)c2c(c1)O/C(=C\\c1ccc(N3CCCCC3)cc1)C2=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "COc1cc(C(=O)N[C@@H]2CC(C)(C)Oc3cc(C)ccc32)cc(OC)c1OC",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB值吗？",
+    "input": "COc1cc(Br)c2oc(C3CCNCC3)cc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CO[C@]1(NC(=O)C2SC(=C(C#N)C(=O)O)S2)C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CS[C@@H]21",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障值吗？",
+    "input": "CO[C@@H]1[C@@H](O)[C@H](N)[C@H](O[C@@H]2O[C@H]([C@H](C)N)CC[C@@H]2N)[C@@H](O)[C@@H]1N(C)C(=O)CN",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "CON=CC1=CCCN(C)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB值。",
+    "input": "COCc1c(C(C)C)nc(C(C)C)c(C=CC(O)CC(O)CC(=O)O)c1-c1ccc(F)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "COC[C@]1(C(N)=S)[C@@H](c2ccc3c(c2)OCO3)[C@@H]1S(C)(=O)=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "COCC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)/C(=N\\OC)c3csc(N)n3)[C@H]2SC1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "COC12CC[C@@]3(C[C@@H]1C(C)(O)C(C)(C)C)[C@@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "COC(=O)C[C@@H](c1cc(OC)c2c(c1)OCCO2)c1c(O)c(C(=O)OC)c[nH]c1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CO/N=C(\\C(=O)N[C@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(=O)[nH]n3C)CS[C@H]12)c1csc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CO/N=C(\\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CS[C@H]12)c1csc(N)n1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB？",
+    "input": "CO/N=C(\\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@@H]12)c1csc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CO/N=C(\\C(=O)NC1C(=O)N2C(C(=O)O)=C(/C=C\\c3scnc3C)CS[C@H]12)c1csc(N)n1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[n+]3ccn4ncccc43)CS[C@H]12)c1nsc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子血脑屏障吗？",
+    "input": "CO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C/Sc3n[nH]c(=O)c(=O)n3CC=O)CS[C@@H]12)c1csc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CO/N=C(/C(=O)NC1C(=O)N(OCC(=O)O)C1C)c1csc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "CNCC[C@H](O)[C@H]1C[C@H](SC2=C(C(=O)O)N3C(=O)[C@H]([C@@H](C)O)[C@H]3[C@@H]2C)CN1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CNC(C[N+](=O)[O-])=NCCSc1ccc(CN(C)C)o1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CNC(=O)CCN1CCN(CCC=C2c3ccccc3Sc3ccc(Cl)cc32)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的BBB。",
+    "input": "CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB吗？",
+    "input": "CN1CCN(CCC(=O)N2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是多少吗？",
+    "input": "CN1CCN(C2=Nc3cscc3C(=CC#N)c3cscc32)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CN1CC(O)c2cc(N=NC(N)=O)c(O)cc21",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的血脑屏障很感兴趣，你能告诉我它是什么吗？",
+    "input": "CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障。",
+    "input": "CN1C(=O)CCC1c1cccnc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1CC1CC3C(N(C)C)C(=O)C(C(N)=O)=C(O)C3(O)C(=O)C1=C2O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CN(C)[C@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(ccc(N)c4O)C[C@H]3C[C@@H]12",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "CN(C)[C@H]1C(=O)C(C(N)=O)=C(O)[C@@]2(O)C(=O)C3=C(O)c4c(O)cccc4[C@@](C)(O)[C@@H]3[C@H](O)[C@@H]12",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障值。",
+    "input": "CN(C)Cc1ccc(SCCNc2[nH]ccc2[N+](=O)[O-])o1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CN(C)C[C@@H](CN1c2ccccc2Sc2ccccc21)N(C)C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CN(C)CCOC(c1ccccc1)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CN(C)CCN(c1ccc(Cl)cc1)c1ccccn1",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "CN(C)CCN(Cc1cccs1)c1ccccn1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的血脑屏障很感兴趣，你能告诉我它是什么吗？",
+    "input": "CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CN(C)CCCN1c2ccccc2CC(=O)c2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(ccc(N)c4O)CC3CC12",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "CN(C(=O)Cc1cccc2sccc12)[C@@H]1CCCC[C@H]1N1CCCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCc1c(C)nn(CC(=O)NC[C@H]2CCCN(c3ccccn3)C2)c1C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC[C@](C)(O)[C@@H]1[C@H]2[C@@H]3C[C@@]34[C@@H]3Cc5ccc(OC)c6c5[C@@]4(CCN3CC3CC3)[C@@H](O6)[C@]21OC",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的BBB吗？",
+    "input": "CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@H](C)C[C@@H](N(C)C)[C@@H]2O)[C@](C)(OC)C[C@H](C)C(=O)[C@H](C)[C@H](O)[C@@]1(C)O",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC[C@H](C)Nc1ccc(I)c(N[C@@H](C)CC)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC[C@@]1(c2ccccc2)C(=O)NC(=O)N(C(=O)c2ccccc2)C1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCOC1CCN(C(=O)c2cc(-c3ccccc3)c(=O)n3c2-c2cc(Cl)ccc2CC3)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCOC(=O)c1cncn1C(C)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的血脑屏障。",
+    "input": "CCOC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)N(Cc1ccccc1)CCC3",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CCOC(=O)Cc1cc2c(c(N)n1)N=C(c1ccccc1)C(C)N2",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CCOC(=O)C[C@H](O)C[C@H](O)/C=C/C1=C(c2ccc(F)cc2)c2ccccc2OC12CCCC2",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1Cc2cc(OC)c(OC)cc2CC1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的血脑屏障。",
+    "input": "CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1CC2(CC1C(=O)O)SCCS2",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(C(=O)O)CC2CCCC21",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCNC1CC(C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCNC1(c2ccccc2)CCCCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "CCN=C1Nc2ccc(Cl)cc2[C@@H](c2ccccc2)S1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)[C@@H](C)Cc1ccc(OC)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分���的BBB是多少？",
+    "input": "CCN(CC)CCn1cnc2c1c(=O)n(C)c(=O)n2C",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CCN(CC)CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CCN(CC)C(=O)N[C@H]1CC2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB值吗？",
+    "input": "CCN(CC)/C(C)=N/N=C/c1c2c(O)c3c(O)c(C)c4c(c3c1O)C(=O)C(C)(O/C=C/[C@H](OC)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(/C)C(=O)N2)O4",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB值。",
+    "input": "CCC[C@@](C)(O)[C@H]1CC23C=CC1(OC)[C@H]1Oc4c(OC(C)=O)ccc5c4C12CCN(C)C3C5",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB值。",
+    "input": "CCC[C@@H]1O[C@@H]2C[C@@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCC[C@@H]1C[C@H](C(=O)N[C@H]([C@@H]2O[C@@H](SC)[C@@H](O)[C@@H](O)[C@@H]2O)[C@H](C)Cl)N(C)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@H](C)Cl)N(C)C1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障值吗？",
+    "input": "CCCNC(=O)c1ccc2c(c1)N(CCN1CCCC1)c1ccccc1S2",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的血脑屏障。",
+    "input": "CCCN(CCC)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCCCn1c(=O)c2c(ncn2CC(C)=O)n(CCCC)c1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CCCCN1C2CC[C@@H]1C[C@@H](OC(c1ccc(F)cc1)c1ccc(F)cc1)C2",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "CCCC(NC(C)C(=O)N1C(C(=O)O)CC2CCCCC21)C(=O)OCC",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CCCC(C)(O)C1CC23C=CC1(OC)[C@H]1Oc4c(OC(C)=O)ccc5c4C12CCN(C)C3C5",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CCCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB吗？",
+    "input": "CCCC(=O)O[C@@]1(C(C)=O)CCC[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@@H]3[C@@H](O)C[C@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCCC(=O)OC1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CCC4(C)[C@H]3[C@@H](O)CC21C",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CCCC(=O)OC1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4(C)[C@H]3[C@@H](O)CC21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCCC(=O)N(C)Cc1c(-c2ccc(Cl)cc2)nc2ccccn12",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的血脑屏障值。",
+    "input": "CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(CC=O)CC(C)C(=O)C=CC2(C)OC2C1C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CCC1C(=O)NC(=O)C1(C)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CCC1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)C(C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@@H]3C(O)(C(=O)OC)[C@@H](OC(C)=O)C5(CC)C=CCN6CCC43[C@H]65)C2)C1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CCC(O)(CC(N)=O)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的BBB。",
+    "input": "CCC(C)(C)OC",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CCC(C)(C)C(=O)O[C@@H]1C[C@H](C)C=C2C=C[C@@H](C)[C@H](CC[C@@H]3C[C@H](O)CC(=O)O3)[C@H]21",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子��BBB。",
+    "input": "CCC(=O)OCC(=O)C1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=CC4(C)C3(F)[C@@H](O)CC21C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB值。",
+    "input": "CCC(=O)OC1(C(=O)SC)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CC=C(CC)C(=O)NC(N)=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC1NC(=O)C2(CCCC2)NC1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(C)C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC1=CC[C@@H]2C3Cc4ccc(O)c5c4C2(CN3C)[C@H]1O5",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "CC12C=CC(=O)C=C1[C@@H](Cl)C[C@@H]1[C@@H]2C(=O)CC2(C)[C@H]1CCC2(O)C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC1(c2ccccc2)CC(=O)N(CN2CCOCC2)C1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC1(C)S[C@H]2[C@@H](N3C(=O)[C@H](c4ccccc4)NC3(C)C)C(=O)N2[C@H]1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障吗？",
+    "input": "CC1(C)S[C@H]2C(NC(=O)C34C[C@@H]5C[C@H](CC(N)(C5)C3)C4)C(=O)N2[C@H]1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC1(C)S[C@H]2C(N3C(=O)[C@H](c4ccc(O)cc4)NC3(C)C)C(=O)N2[C@H]1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的BBB很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC1(C)S[C@@H]2[C@H](N3C(=O)[C@@H](c4ccc(O)cc4)NC3(C)C)C(=O)N2[C@H]1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的BBB值。",
+    "input": "CC1(C)S[C@@H]2[C@@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@@H]1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CC1(C)SC2C(NC(=O)C(Oc3ccccc3)c3ccccc3)C(=O)C2C1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CC1(C)O[C@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(C(=O)COC(=O)C2CC2)O1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CC1(C)O[C@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(C(=O)CO)O1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=CC5(C)[C@@]4(Cl)C(Cl)CC3(C)[C@]2(C(=O)CO)O1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的血脑屏障吗？",
+    "input": "CC1(C)OC2COC3(COS(N)(=O)=O)OC(C)(C)OC3C2O1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的血脑屏障很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子BBB吗？",
+    "input": "CC(NN)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1C=CC(O)CC(O)CC(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CC(C)Oc1cccc(CC(=O)N2CCC[C@](CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB。",
+    "input": "CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "CC(C)COC[C@@H](CN(Cc1ccccc1)c1ccccc1)N1CCCC1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子BBB吗？",
+    "input": "CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我需要知道这个分子的BBB，你能提供吗？",
+    "input": "CC(C)(C)OC(=O)CCCc1ccc(N(CCCl)CCCl)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC(C)(C)O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CC(C)(C)NC[C@H](O)c1ccc(O)c(NC(N)=O)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC(C)(C)NCC(O)c1cc(Br)no1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC(C)(C)NC(=O)[C@H]1C[C@H]2CCCC[C@H]2CN1C[C@H](O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CC(=O)c1ccc2c(c1)Sc1ccccc1N2CCCN1CCN(CCO)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@H](O)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H](N3CC[N+](C)(C)CC3)[C@@H]4OC(C)=O)[C@@]2(C)C[C@@H]1N1CC[N+](C)(C)CC1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC(=O)O[C@@H]1C[C@H]2C(COC(=O)CC(C)C)=CO[C@@H](OC(=O)CC(C)C)[C@@H]2[C@]12CO2",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC(=O)OCC1=CO[C@@H](OC(=O)CC(C)C)[C@H]2C1=C[C@H](OC(=O)CC(C)C)[C@]21CO1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障？",
+    "input": "CC(=O)OCC1=CO[C@@H](OC(=O)CC(C)(C)OC(C)=O)[C@@H]2C1=C[C@H](OC(=O)CC(C)C)[C@]21CO1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC(=O)OCC/C(SC(C)=O)=C(\\C)N(C=O)Cc1cnc(C)nc1N",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB。",
+    "input": "CC(=O)OCC(=O)[C@]1(OC(=O)C(C)C)[C@H](C)C[C@H]2[C@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@@]3(F)[C@H](O)C[C@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CC(=O)OCC(=O)[C@@]1(O)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC(=O)OC1CCC2(C)C3CCC4(C)C(C(C)CCCC(C)C)CCC4C3CC(Br)C2(Br)C1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC(=O)OC1CC2(C)[C@H](C[C@H](O)[C@H]3C4(C)CC[C@H](O)[C@@H](C)[C@@H]4CCC32C)/C1=C(\\CCC=C(C)C)C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的BBB。",
+    "input": "CC(=O)N1CCN(c2ccc(OCC3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "CC(=O)N1CCN(C(=O)Cc2ccc(C(F)(F)F)cc2)[C@@H](CN2CC[C@H](O)C2)C1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的血脑屏障吗？",
+    "input": "CC(=O)CC(=O)[C@@]1(O)CC[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@]3(Cl)[C@@H](Cl)C[C@@]21C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "CC(=O)C1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@@H](O)CO2)C1)C(=O)c1ccccc1C3=O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的BBB，你能提供吗？",
+    "input": "CC(=C1CCOC(=O)S1)N(C=O)Cc1cnc(C)nc1N",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的BBB吗？",
+    "input": "C=C[C@@H]1CN2CC[C@@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子血脑屏障吗？",
+    "input": "C=CC[C@@]1([C@@H](C)CCC)C(=C)NC(O)=NC1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的血脑屏障。",
+    "input": "C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(=O)O)c3csc(N)n3)C2SC1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的BBB。",
+    "input": "C=C1C[C@H]2[C@@H]3CCC4=CC(=O)C=CC4(C)C3(F)[C@@H](O)CC2(C)C1(O)C(=O)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "C=C1C(=O)OC2C1CCC1(C)OC13CC=C(C)C23",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的血脑屏障是多少？",
+    "input": "C/C(=C\\C(N)C(=O)O)CP(=O)(O)O",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的血脑屏障，你能提供吗？",
+    "input": "C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的BBB是多少？",
+    "input": "Brc1ccc(-c2nnc(N3CCN(c4ccccn4)CC3)o2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES值。",
+    "input": "c1ccc(C2NC2c2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分���的毒性。",
+    "input": "c1ccc(-c2ccccn2)nc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "c1ccc(-c2ccccc2OCC2CO2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "c1cc[n+]2c(c1)-c1cccc[n+]1CC2",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "[O-][n+]1cccc2ccccc21",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "[O-][Cl+]O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "[O-][Cl+3]([O-])([O-])[O-]",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "[N-]=[N+]=NCc1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "[N-]=[N+]=NCC1OC(O)C(O)C(O)C1O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "Oc1cnnc(O)n1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性值。",
+    "input": "Oc1cccc(Cl)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的致突变性很感兴趣，你能告诉我它是多少吗？",
+    "input": "Oc1ccc2ncccc2c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "Oc1ccc2[nH]ccc2c1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "Oc1cc(O)ncn1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "Oc1cc(O)c2cc(O)c(-c3cc(O)c(O)c(O)c3)[o+]c2c1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "Oc1cc(Cl)c(Cl)c(Cl)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的致突变性。",
+    "input": "Oc1c(Cl)cccc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "ONc1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "OCCOCCO",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "OCC1CCC(n2cnc3c(O)ncnc32)O1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "OC1c2ccccc2-c2cc3ccccc3c(Cl)c2C1O",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "OC1c2ccc3c(c2C2OC2C1O)-c1cccc2cccc-3c12",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的致突变性，你能提供吗？",
+    "input": "OC1C=Cc2cccnc2C1O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "OC1C=Cc2c(ccc3cc4c(cc23)C(O)C(O)c2ccccc2-4)C1O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的毒性吗？",
+    "input": "O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "O=c1[nH]c2ccc(F)cc2c(=O)n1-c1ccc(Cl)cc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "O=[NH+][O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是多少吗？",
+    "input": "O=[N+]([O-])c1cccc2c1ccc1ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是什么吗？",
+    "input": "O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "O=[N+]([O-])c1ccc2ccc3cccc4cc(O)c1c2c34",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "O=[N+]([O-])c1ccc2ccc3c4c(cc5ccc1c2c53)[C@@H](O)[C@H](O)C=C4",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "O=[N+]([O-])c1ccc2ccc3c(O)ccc4c5ccccc5c1c2c34",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子AMES吗？",
+    "input": "O=[N+]([O-])c1ccc2c(c1)CCc1cc([N+](=O)[O-])ccc1-2",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "O=[N+]([O-])c1ccc2c(Cl)nsc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "O=[N+]([O-])c1ccc([N+](=O)[O-])cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "O=[N+]([O-])c1ccc(Nc2ccc(O)cc2)c([N+](=O)[O-])c1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "O=[N+]([O-])c1ccc(NCCO)c(OCCO)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的致突变性吗？",
+    "input": "O=[N+]([O-])c1ccc(N=Nc2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的AMES值吗？",
+    "input": "O=[N+]([O-])c1cc2[nH]c3ccc4ccccc4c3c2c2cccc(O)c12",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "O=[N+]([O-])c1c(CS(=O)(=O)Cc2ccccc2)nc2c(Br)cc(Br)cn12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "O=[N+]([O-])OC1COC2C(O[N+](=O)[O-])COC12",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "O=[N+]([O-])NC1=NCC(O)N1Cc1ccc(Cl)nc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "O=S(=O)(O)c1c(N=Nc2c(O)ccc3ccccc23)ccc2ccccc12",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "O=P(O)(O)CCCl",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES值。",
+    "input": "O=Nc1ccc(Oc2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "O=NN1CCNCC1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性？",
+    "input": "O=NN1CCCC1c1cccnc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "O=C1c2ccccc2C(=O)c2c1ccc(OC1OC(COC3OCC(O)C(O)C3O)C(O)C(O)C1O)c2O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "O=C1c2c(ccc3ccccc23)-c2ccc3ccccc3c21",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是多少吗？",
+    "input": "O=C1OC(=O)c2cc([N+](=O)[O-])ccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的AMES，你能提供吗？",
+    "input": "O=C1N[C@@H](c2ccc([N+](=O)[O-])s2)Nc2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的AMES，你能提供吗？",
+    "input": "O=C1CCCO1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "O=C1C=Cc2ccc3c4c(ccc1c24)C=CC3=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "O=C1C=Cc2ccc3c4c(ccc1c24)C(=O)C=C3",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "O=C1C=CC(=O)C(Cl)=C1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子致突变性吗？",
+    "input": "O=C1C=C2C(=CCOC2O)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "O=C1C(Cl)=C(Cl)C(=O)c2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的致突变性值吗？",
+    "input": "O=C(c1ccccc1)C1OC1c1ccc([N+](=O)[O-])cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "O=C(O)c1occ(-c2ccccc2)c1-c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "O=C(O)c1c(O)c(C2(c3ccc(Cl)cc3)CC2)nc2c(C(F)(F)F)cccc12",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的致突变性很感兴趣，你能告诉我它是多少吗？",
+    "input": "O=C(O)C[C@H](Cl)C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "O=C(O)C(Cl)Br",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的致突变性，你能提供吗？",
+    "input": "O=C(O)/C=C/c1c[nH]cn1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的致突变性。",
+    "input": "O=C(Nc1ccon1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "O=C(Nc1ccccc1Cl)c1csc([N+](=O)[O-])c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "O=C(Nc1ccc(/C=C/c2ccc(NC(=O)[C@@H]3CCCN3C(=O)Cc3ccccc3)cc2)cc1)[C@@H]1CCCN1C(=O)Cc1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我需要知道这个分子的毒性，你能提供吗？",
+    "input": "O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(Oc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "O=C(Cl)c1ccccc1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "O=C(CCl)Nc1snc2ccc(Cl)cc12",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "O=C(/C=C/c1ccc(O)cc1)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "Nc1nc[nH]n1",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是多少吗？",
+    "input": "Nc1nc(-c2ccc(Cl)cc2)c2c(n1)-c1ccccc1C2=O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Nc1ccn(C2C=C(CO)C(O)C2O)c(=O)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Nc1cccc2cccc(N)c12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "Nc1cccc2[nH]c(=O)ccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的致突变性值。",
+    "input": "Nc1ccc2nc3ccc(N)cc3[s+]c2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "Nc1ccc2cc3ccccc3nc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "Nc1ccc([N+](=O)[O-])cc1O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "Nc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "Nc1ccc(O)c(N)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的致突变性值。",
+    "input": "Nc1ccc(N=Nc2ccc(-c3ccc(N=Nc4c(S(=O)(=O)[O-])cc5cc(S(=O)(=O)[O-])c(N=Nc6ccccc6)c(O)c5c4N)cc3)cc2)c(N)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "Nc1ccc(-c2ccc(N)cc2[N+](=O)[O-])cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的毒性值。",
+    "input": "Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "Nc1cc([N+](=O)[O-])ccc1O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Nc1c2c(nc3ccccc13)CCCC2",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Nc1c(Oc2ccccc2)cc(O)c2c1C(=O)c1ccccc1C2=O",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的毒性吗？",
+    "input": "NP(=O)(OCCC(=O)O)N(CCCl)CCCl",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "NNc1nncc2ncccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是什么吗？",
+    "input": "NN",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "NC1=NS(=O)(=O)N(Cc2ccccc2)c2nc(-c3ccccc3)n(Cc3ccccc3)c21",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "NC(CCC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(=O)O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "NC(=O)c1cnccn1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "NC(=O)CNC(=O)N(CCCl)N=O",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "N=C(N)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是多少吗？",
+    "input": "N/C(=N\\OS(=O)(=O)O)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "N#Cc1cc(Cl)ccc1-c1ccc(N)cc1F",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "N#CCBr",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "N#C/C(=C\\C=C\\c1ccccc1)c1ccc(F)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我提供这个分子的致突变性值。",
+    "input": "Cn1cnc(S(=O)(=O)N2C[C@H](Nc3ccc(F)c(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Cn1c(N=[N+]=[N-])nc2c3ccccc3ccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的致突变性值吗？",
+    "input": "Clc1ccc([C@H](c2ccccc2Cl)C(Cl)Cl)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "ClCc1cccnc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "Cc1nnc2sc(C(=O)NC3CN(c4cccc(F)c4F)C3)c(N)c2c1C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "Cc1nc(-c2ccc([N+](=O)[O-])o2)cs1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "Cc1n[n+]([O-])c(-c2ccccc2)c(=O)n1N",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "Cc1cccc(O)c1N",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "Cc1ccc2nsc(NC(=O)CCl)c2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "Cc1ccc2ccccc2c1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "Cc1ccc2cc3ccccc3cc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "Cc1ccc2c(ccc3ccccc32)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "Cc1ccc2c(c1)C(=O)c1ccccc1C2=O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Cc1ccc2c(c1)-c1ccccc1C2C",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "Cc1ccc([N+](=O)[O-])cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "Cc1ccc(O)c(N)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的毒性，你能提供吗？",
+    "input": "Cc1ccc(NS(=O)(=O)N(C)C)c(O)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "Cc1ccc(NCCO)cc1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "Cc1ccc(N)cc1N",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子毒性吗？",
+    "input": "Cc1ccc(C)c([N+](=O)[O-])c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "Cc1ccc(-c2nc3n(c2[N+](=O)[O-])CCS3)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "Cc1ccc(-c2cc3nc(NC(C)(C)C)[nH]c(=O)c3s2)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Cc1cc2c(c3ccc4ccccc4c13)CC(O)C2=O",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "Cc1cc(N2C[C@H]3CC[C@@H](C2)[C@@H]3Nc2nc3n(n2)CCCN3c2cc(F)cc(F)c2)ncn1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的AMES吗？",
+    "input": "Cc1cc(N)cc([N+](=O)[O-])c1N",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "Cc1cc(C2(c3cc(C)c(O)cc3C)OS(=O)(=O)c3ccccc32)c(C)cc1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "Cc1cc(C)c2nsnc2c1N",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "Cc1cc(C)c(N)c(C)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "Cc1c2ccccc2c(CO)c2ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "Cc1c2ccccc2c(C)c2ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性值。",
+    "input": "Cc1c2cc(CO)ccc2nc2c1ccc1ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "Cc1c(NO)cc(NO)cc1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的致突变性。",
+    "input": "Cc1c(N=[N+]([O-])c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2C)cc([N+](=O)[O-])cc1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "Cc1c(C)c2c(N)c3ccccc3nc2c2ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的致突变性吗？",
+    "input": "C[Si](C)(C)N[Si](C)(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的AMES��感兴趣，你能告诉我它是什么吗？",
+    "input": "C[C@]1(c2ccc([N+](=O)[O-])cc2)CO1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "C[C@H](N)CNc1cnc(C(N)=O)c(-c2cnn(C)c2)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的致突变性。",
+    "input": "C[C@H](C(=O)O)n1nc(Cn2cc3cc(OCC4CC4)c(Cl)cc3n2)c2ccccc2c1=O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "C[C@@H](Nc1[nH]cnc2nc(-c3ccc(CCl)cc3)cc1-2)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "CSCCC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CSCCC(N)C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性？",
+    "input": "CS(=O)(=O)c1ccc(O)c(N)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的毒性值吗？",
+    "input": "COc1nncc2cnccc12",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "COc1cccc2c1cc1c3c(cc4c(c32)OCO4)C(=O)N1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "COc1ccc(OC)c(N=Nc2c(O)ccc3ccccc23)c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "COc1ccc(C(=O)ON(OCc2ccccc2)C(=O)c2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "COc1cc2c(CCNC(C)=O)c[nH]c2cc1O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "COc1c2ccoc2nc2c(O)c3c(c(CC=C(C)C)c12)OCO3",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "COc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "COP(=O)(SC)SC",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是什么吗？",
+    "input": "COP(=O)(O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "COC(=O)C1=C(C)NC(C)=C(C(=O)OCC=Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "CO/N=C(\\C(=O)NC1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CSC12)c1csc(N)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子毒性吗？",
+    "input": "CO/N=C(/C(=O)O)c1ccccc1COc1cc(O)ccc1C",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是什么吗？",
+    "input": "CNc1ccc2ncc(C)nc2c1C",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CNC(C)Cc1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "CNC(=O)c1cc(C(=O)O)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)n([C@@H](C)c2ccccc2)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CN1CCC=C2c3nc(N)sc3CCC21",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "CN(CCC#N)c1ccc(N=Nc2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "CN(C)c1ccc(CCO)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2c(O)c(S(=O)(=O)O)cc3cc(S(=O)(=O)O)ccc23)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CN(C)CCO[C@@](C)(c1ccccc1)c1ccccn1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "CN(C)CCNC(=O)c1cccc2c1Oc1ccccc1O2",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的致突变性，你能提供吗？",
+    "input": "CN(C)CCCNc1c2ccccc2nc2ccccc12",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CN(C)/C(=N/c1ccc2c(c1)C(=O)c1ccc(/N=C(\\C3CC3)N(C)C)cc1C2=O)C1CC1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CCc1cccc2cc([C@H](O)CNC(C)(C)C)oc12",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "CCc1cccc2c3c([nH]c12)[C@](CC)(CC(=O)O)OCC3",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CCc1cccc(CC)c1N",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CCc1ccc2nc(N3CCC(N[C@@H]4CCCOC4)CC3)c(-c3nc(C)no3)cc2c1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCc1ccc2c(c1)c(-c1ccc[nH]c1=O)c(C(=O)O)n2Cc1cc([N+](=O)[O-])ccc1F",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "CCc1cc2ccccc2c2ccc3c(c12)C1OC1C(O)C3O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CC[n+]1c2ccccc2nc2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CC[Si](Cl)(Cl)CC",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CC[C@@H](C)N",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "CCS(=O)(=O)c1nc2ccccn2c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "CCON(OC(C)=O)C(=O)c1ccccc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的致突变性值吗？",
+    "input": "CCOCCO",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "CCOC(C)=O",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的AMES吗？",
+    "input": "CCOC(=O)c1c(C(F)(F)F)[n+]([O-])c2ccc(OC)cc2[n+]1[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CCOC(=O)c1c(C(F)(F)F)[n+]([O-])c2ccc(C)cc2[n+]1[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "CCOC(=O)[C@@H]1O[C@]1(C)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "CCOC(=O)N(CC)N=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CCOC(=O)N(C)N=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CCOC(=O)COc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCOC(=O)C(Cl)Cc1cc(-n2nc(C)n(C(F)F)c2=O)c(F)cc1Cl",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "CCOC(=O)C(=NNc1ccc(-c2ccc(NN=C(C(=O)OCC)C(=O)OCC)c(OC)c2)cc1OC)C(=O)OCC",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CCN=c1cc2oc3cc(NCC)c(C)cc3c(-c3ccccc3C(=O)OCC)c-2cc1C",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CCN(CCO)c1ccc(NCCO)c([N+](=O)[O-])c1",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CCN(CC)CCn1nc2ccc(CO)c3c2c1Sc1cc(Cl)ccc1-3",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "CCCn1cc2c3c(cccc31)C1C=C(C)CN(C)C1C2",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CCCOS(C)(=O)=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的毒性值。",
+    "input": "CCCN(CC)CC1COC2(CCC(C(C)(C)C)CC2)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "CCCCON(OC(C)=O)C(=O)c1ccc(Br)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "CCCCOC(=O)c1ccccc1N",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是多少吗？",
+    "input": "CCCCN(CCCO)N=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "CCCCN(CCC(C)O)N=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CCCCCCN(N=O)C(N)=O",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的AMES很感兴趣，你能告诉我它是多少吗？",
+    "input": "CCCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "CCCCCCCCCCCCCCC1CO1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "CCCCCCCCCCCC(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的毒性值。",
+    "input": "CCCCCCCCCCC1CO1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性值。",
+    "input": "CCCCC(CC)COCCCN",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的毒性值。",
+    "input": "CCCC(=O)c1cnn(-c2cnc(N)cn2)c1C",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "CCCC(=O)Nc1snc2ccc(Cl)cc12",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CCC(C)COC(=O)Nc1nc(=O)n([C@@H]2O[C@H](C)[C@@H](O)[C@H]2O)cc1F",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的毒性。",
+    "input": "CC1Cc2c(Cl)cc(C(=O)NC(Cc3ccccc3)C(=O)O)c(O)c2C(=O)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "CC1CCc2c1ccc1c2ccc2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的致突变性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1CCN(N=O)CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子的AMES值吗？",
+    "input": "CC1CCCC(=O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CC1=CCC2C(C)=CCC(C(C)(C)C)C2C1",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "CC1=CC(O)C2CC1C2(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我这个分子的AMES。",
+    "input": "CC12OOC1(CO)Oc1ccccc12",
+    "output": "无"
+  },
+  {
+    "instruction": "我对这个分子的致突变性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CC/C=C/C=C/C=C/C=C/C=O",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CC(OP(C)(=O)F)C(C)(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "CC(Cl)CO",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CC(C)[C@@H]1CC[C@@H](C)CC1=O",
+    "output": "有"
+  },
+  {
+    "instruction": "请提供该分子的致突变性。",
+    "input": "CC(C)C1C2CCC1c1c(NC(=O)c3cn(C)nc3C(F)F)cccc12",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CC(C)(C)OC(=O)CN=[N+]=[N-]",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CC(C(O)CC(=O)O)C(O)(Cn1cncn1)c1ccc(Cl)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "CC(Br)c1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "CC(Br)C(=O)NCc1ccc(Cl)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "你能告诉我这个分子致突变性吗？",
+    "input": "CC(Br)(CO)CBr",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CC(=O)n1ncc(Cl)c(Cl)c1=O",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CC(=O)c1cc2c(cc1C)C(C)(C)C(C)CC2(C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CC(=O)c1c([N+](=O)[O-])cc([N+](=O)[O-])n1[N+](=O)[O-]",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CC(=O)OC1C(=O)OC2C(OC(C)=O)C(=O)OC12",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES值。",
+    "input": "CC(=O)Nc1ccc(C)c(N=[N+]([O-])c2cc(NC(C)=O)ccc2C)c1",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的毒性。",
+    "input": "CC(=O)Nc1ccc(/C=C/C(=O)c2ccccc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我需要知道这个分子的致突变性，你能提供吗？",
+    "input": "CC(=O)Nc1ccc(-c2ccc(N)cc2)cc1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "CC(=O)Nc1cc2c(cc1OC(C)=O)-c1ccccc1C2",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccccc1",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "CC(=N)S",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的AMES是多少？",
+    "input": "CC(=C\\C1=CCOC1=O)/C=C(C)/C=C/C=C(\\C)C(=O)C12OC1C(O)(CCO)NC2=O",
+    "output": "有"
+  },
+  {
+    "instruction": "这个分子的毒性是多少？",
+    "input": "CC#N",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "C=CC(=O)OCCCCCOC(=O)C=C",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "C=CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的毒性吗？",
+    "input": "C=C1C(=O)OC2C1CCC(C)C1=CCC(=O)C12C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "C=C(F)F",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的AMES吗？",
+    "input": "C=C(C)[C@H]1CC=C(C)[C@@H](OC(C)=O)C1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能告诉我这个分子的AMES吗？",
+    "input": "C=C(C)[C@H]1C=C2C(COC(=O)CCCCCCCCCCCCCCCCC)=CC=C2C(C)=CC1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "C=C(C)C(=O)OCCOC(=O)NCCC(C)CC(C)(C)CNC(=O)OCCOC(=O)C(=C)C",
+    "output": "无"
+  },
+  {
+    "instruction": "这个分子的致突变性是多少？",
+    "input": "C=C(C)C(=O)OCCO",
+    "output": "无"
+  },
+  {
+    "instruction": "请给我提供这个分子的AMES。",
+    "input": "C=C(C)C(=O)OCCCCCCCC",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "C=C(C)C(=O)N[N+](C)(C)CC(C)O",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的毒性。",
+    "input": "C1C[C@H](O[C@H]2CC[C@@H]3O[C@@H]32)[C@H]2O[C@@H]12",
+    "output": "无"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "C1CCC(NC2CCCCC2)CC1",
+    "output": "无"
+  },
+  {
+    "instruction": "你能给我这个分子的致突变性吗？",
+    "input": "C1=CC2OC2C=C1",
+    "output": "有"
+  },
+  {
+    "instruction": "我对这个分子的毒性很感兴趣，你能告诉我它是什么吗？",
+    "input": "C1=CC2CCCCC2c2ccccc21",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的AMES，你能提供吗？",
+    "input": "C/C=C/C=C/CCCCCCCO",
+    "output": "无"
+  },
+  {
+    "instruction": "请提供该分子的AMES。",
+    "input": "C/C=C(C(=C/C)/c1ccc(O)cc1)\\c1ccc(O)cc1",
+    "output": "无"
+  },
+  {
+    "instruction": "我需要知道这个分子的AMES，你能提供吗？",
+    "input": "C/C(C=O)=C(/Cl)C(=O)O",
+    "output": "有"
+  },
+  {
+    "instruction": "你能给我这个分子的AMES？",
+    "input": "BrCc1ccc2c(c1)-c1cccc3cccc-2c13",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的致突变性，你能提供吗？",
+    "input": "BrCC1CO1",
+    "output": "有"
+  },
+  {
+    "instruction": "我想知道这个分子的毒性，你能提供吗？",
+    "input": "BrCBr",
+    "output": "有"
+  }
+]

sft/test/admet_extract.json

@@ -0,0 +1,2502 @@
+[
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCCCCCCCCCCCCCCCC=CC(O)C(O)C(O)CO",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(O)c3ccccc3)C(C)=C1C2(C)C",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CC1CCC(C(C)C2CCC3C4CC(=O)C5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6O)CCC5(C)C4CCC23C)NC1",
+    "output": "酮-CC(C)=O,醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1c(OC2OC(CO)C(O)C(O)C2O)cc(O)c2c(=O)cc(-c3ccccc3)oc12",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CC(=O)OCC12C(O)C(OC(C)=O)C3OC(=O)C(C)C(C)c4ccncc4C(=O)OCC4(C)OC1(C(OC(C)=O)C4C(OC(C)=O)C2OC(C)=O)C3(C)O",
+    "output": "酯-CC(=O)OC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6O)CC(O)C5(C)C4CCC3(C)C2C1C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc(-c2c(O)c(C=O)cc3cc(OC)c(O)cc23)ccc1O",
+    "output": "醚-COC,醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "O=c1cc(-c2ccc(O)cc2)oc2c(C3OC(COC4OC(O)C(O)C(O)C4O)C(O)C(O)C3O)c(O)cc(O)c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CC(C)(O)CCC1(C)C2=C(C(OC(C)=O)C(OC(C)=O)C1C)C(C)(C)CCC2",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)Oc1c(C)c(OC2OC(CO)C(O)C(O)C2O)c(C)c2oc(C)cc(=O)c12",
+    "output": "醚-COC,醚-COC,醇-O,酯-COC(C)=O,醚-COC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC(C)=CCc1c(O)cc(O)c2c(=O)c(-c3ccc4c(c3)C=CC(C)(C)O4)coc12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O",
+    "output": "酮-CC(C)=O,醚-COC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(=O)c1c(OC2OC(CO)C(O)C(O)C2O)ccc(OC2OC(CO)C(O)C(O)C2O)c1CCc1ccc(O)cc1",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "COc1ccc2c(c1)C(=O)c1c(NCCc3ccc(O)cc3)c(OC)c(OC)c3ccnc-2c13",
+    "output": "醚-COC,酮-CC(C)=O,胺-N,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC(=O)OC1CC2C3(C)C=CC(=O)C(C)(C)C3CC(OC(C)=O)C2(C)C2=CCC(C3=CC(=O)OC3O)C21C",
+    "output": "酮-CC(C)=O,酯-CC(=O)OC,酯-COC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1C2=CCC(c3ccoc3)C2(C)C(O)C(OC(C)=O)C1C1(C)C=CC(=O)C(C)(C)C1CC(=O)OC",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C(O)c1cc(O)c(OC2OC(COS(=O)(=O)[O-])C(O)C(O)C2O)c(O)c1",
+    "output": "羧酸-O=CO,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc2c(OC3OCC(O)(CO)C3O)c3c(c(-c4ccc5c(c4)OCO5)c2cc1OC)C(=O)OC3",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "NC(N)=NCCCC1NCCc2c1[nH]c1ccccc21",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)OCC12C(OC(=O)c3ccccc3)C(OC(C)=O)CC(C)(O)C13OC(C)(C)C(C(OC(C)=O)C2OC(=O)c1ccccc1)C3OC(C)=O",
+    "output": "酯-CC(=O)OC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "COC(=O)CC(CC(=O)OC)C(=O)OC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(CCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C)C(C)C(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(CCC1(O)OC2CC3C4CCC5CC(OC6OC(CO)C(O)C(O)C6OC6OC(C)C(O)C(O)C6O)C(O)CC5(C)C4CCC3(C)C2C1C)COC1OC(CO)C(O)C(O)C1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "C#CC1(O)CCC2C3CCc4cc(O)ccc4C3CCC21C.C#CC1(OC(C)=O)CCC2C3CCC4=CC(=NO)CCC4C3CCC21CC",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)C(C)C4=O)OC(C)(C)C=C3",
+    "output": "酮-CC(C)=O,醚-COC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(OC)c2ccc(=O)oc2c1C=CC(C)=O",
+    "output": "醚-COC,酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC1=CCC2(C)CC=CC(C)(C)C23CC13",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=CC(=O)CC(C)(C)C12CCC(C)O2",
+    "output": "酮-CC(C)=O,醚-COC"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC=C(C)C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(OC7OCC(O)C(O)C7OC7OCC(O)C(O)C7O)C6OC6OC(CO)C(O)C(O)C6O)C(C)(C=O)C5CCC43C)C2CC1(C)C",
+    "output": "酯-CC(=O)OC,酯-COC(C)=O,醚-COC,醇-O,羧酸-O=CO,醛-CC=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCCCCc1cc2c(c(O)c1C(=O)O)C1C=C(C)CCC1C(C)(C)O2",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(CC2c3cc(OC)c4c(c3CCN2C)OCO4)c(Oc2cc3c(cc2OC)-c2c(OC)c(OC)c(OC)c4c2C(C3)N(C)CC4)cc1OC",
+    "output": "醚-COC,醚-COC,胺-N"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "[Tl]",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc2c(cc1O)C(Cc1cc(OC)c(OC)cc1Oc1cc3c(cc1OC)-c1c(OC)c(OC)c(OC)c4c1C(C3)N(C)CC4)N(C)CC2",
+    "output": "醚-COC,醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "c1cncc(-c2ncc(-c3ccc4c(c3)OCO4)o2)c1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CCCc1ccc(O)c(-c2cc(CCC)ccc2O)c1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC1OC(OC2C(OC3C(O)C(C(=O)O)OC(OC4CCC5(C)C(CCC6(C)C5CC=C5C7CC(C)(C)CC(O)C7(CO)C(O)CC56C)C4(C)C)C3OC3OC(CO)C(O)C(O)C3O)OC(CO)C(O)C2O)C(O)C(O)C1O",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COc1cc2c(cc1OC)C1(O)C(=O)c3ccc4c(c3OC1CO2)C=CC(C)(C)O4",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CCC(C)C(=O)OC(C)C1(O)CCC2(O)C3CCC4CC(OC5CC(O)C(OC6CC(OC)C(OC7CC(OC)C(O)C(C)O7)C(C)O6)C(C)O5)CCC4(C)C3CC(OC(C)=O)C12C",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CCC(C)C(=O)OC(C)C1(O)CCC2(O)C3CCC4CC(OC5CC(OC)C(OC6CC(OC)C(OC7OC(C)C(OC8OC(CO)C(O)C(O)C8O)C(OC)C7O)C(C)O6)C(C)O5)CCC4(C)C3CC(OC(C)=O)C12C",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1C(OC(C)=O)CCC2(C)CC(=O)C3=C(C)C(OC(C)=O)CC(CC12)C3(C)C",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1CC2(C(C)(C)O)C(=C1C)C(OC(=O)c1ccccc1)C(OC(=O)c1ccccc1)C1(C)C(OC(C)=O)CC3OCC3(OC(C)=O)C1C2OC(=O)c1ccccc1",
+    "output": "酯-CC(=O)OC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1C2=C(C)C(O)CC2(C(C)(C)O)C(OC(C)=O)C2C3(OC(C)=O)COC3CC(OC(C)=O)C2(C)C1OC(C)=O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CCCCCCCCCCCCCOS(=O)OCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "Oc1ccc2ccccc2c1N=Nc1ccc(N=Nc2ccccc2)cc1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=CC1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)O)C1CC1NCCc2c1[nH]c1ccccc21",
+    "output": "羧酸-O=CO,醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C1C=CCC(C=CCC(O)CC(O)CCc2ccccc2)O1",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1ccc(-c2cc(=O)c3c(O)c(-c4c(-c5ccc(OC)cc5)oc5cc(OC)cc(O)c5c4=O)c(OC)cc3o2)cc1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "O=c1cccc2n1CC1CCCN3CCCC2C13",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "O=C1C=CCC2C3CCCN4CCCC(CN12)C34",
+    "output": "胺-N,酰胺-CC(N)=O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1=C2C(O)C3OC3(C)C2C2OC(=O)C(C)=C2CC1",
+    "output": "醚-COC,醚-C1CO1,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(C2Oc3c(O)cc(C4CC(=O)c5c(O)cc(O)cc5O4)cc3C2CO)ccc1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)=CCc1cc2c(cc1O)oc(=O)c1c3ccc(O)c(CC=C(C)C)c3oc21",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "O=c1c2cc(O)ccc2oc2cc(O)c(C3OC(COC4OCC(O)(CO)C4O)C(O)C(O)C3O)c(O)c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "O=C(CCc1ccc(O)c(O)c1)CC(CCc1ccc(O)c(O)c1)S(=O)(=O)O",
+    "output": "酮-CC(C)=O,磺酸-O=S(=O)O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC(C)=CCC(OC(=O)C=C(C)C)c1coc(-c2cc(O)ccc2O)c1",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC(C)=CCC(OC(=O)CC(C)C)c1coc(-c2cc(O)ccc2O)c1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC(C)=C1C=C2C(C)CCCC2(C)CC1",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC1CCN2C3C=CC4=CC(=O)OC4(C3)C2C1",
+    "output": "醚-COC,胺-N,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC1OC(OC2CCC3(C=O)C(CCC4C3C(O)CC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C(O)C(O)C1O",
+    "output": "醚-COC,醛-CC=O,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "C=CCC1(C(C)CCC)C(=O)NC(=O)NC1=O",
+    "output": "胺-N,酰胺-CC(N)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(=O)OC1C(O)C(C)OC(OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C3(CO)OC23)C1OC(=O)C=Cc1ccccc1",
+    "output": "酯-CC(=O)OC,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1CC2(CC(C)C3(CCC4(C)C5=C(CCC43C)C3(C)CCC(OC4OC(COC6OCC(O)C(O)C6OC6OC(CO)C(O)C(OC7OC(CO)C(O)C(O)C7O)C6OC6OC(C)C(O)C(O)C6O)C(O)C(O)C4O)C(C)(CO)C3CC5)O2)OC1=O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)OC6OC(COC7OC(CO)C(O)C(O)C7O)C(O)C(O)C6O)CCC45C)C3(C)C)OCC(OC3OC(CO)C(O)C(O)C3O)C2O)C(O)C(OC2OCC(OC3OC(CO)C(O)C(O)C3O)C(O)C2O)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1CCC2C(CN3CCCC3C(=O)O)C(=O)OC2C2C(=C)CCC12",
+    "output": "酯-COC(C)=O,胺-N,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CC1(C)CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC1OC(OC2C(CO)OC(OCC3OC(OC4CCC5(C)C(CCC6(C)C5C=CC57OCC8(CCC(C)(C)CC85)C(O)CC67C)C4(C)CO)C(O)C(O)C3O)C(O)C2O)C(O)C(O)C1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CC1(C)CCC23COC4(C=CC5C6(C)CCC(O)C(C)(C)C6CCC5(C)C4(C)CC2O)C3C1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC=CSCC([NH3+])C(=O)[O-]",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C(CI)OCCOC(=O)CI",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)(O)C1Cc2cc3ccc(=O)oc3c(OC3OC(CO)C(O)C(O)C3O)c2O1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc(C(=O)c2nccc3cc4c(cc23)OCO4)c(O)c1OC",
+    "output": "醚-COC,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "Cc1cc(O)c2c(OC3OC(CO)C(O)C(O)C3O)ccc(O)c2c1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "C=C(C)C1CCC2=C(C1)C(C)C(O)C(O)C2",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "O=C1CCC(=O)O1",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1(C)OC23C(OC(=O)c4cccnc4)C1CC(OC(=O)c1ccccc1)C2(C)C(OC(=O)c1ccccc1)CCC3(C)O",
+    "output": "酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(C=CC(=O)OCC(O)COC2OC(CO)C(O)C(O)C2O)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它���多少吗？",
+    "input": "CC(=CC(=O)O)c1c(O)c(C2OC(CO)C(O)C(O)C2O)c2c(c1O)C1OC(CO)C(O)C(O)C1O2",
+    "output": "羧酸-O=CO,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "C=C1C2CC(=O)C3C4(C)CCC(O)C(C)(C)C4C(OC(C)=O)C(OC(C)=O)C3(C2)C1OC(C)=O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1C2CCC(=O)C3(C)CCC(OC(C)=O)C(C)(C)C3CC=C(C2)C1O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC1CC(O)C(C(C)C2CCC3=C(CC4C3=CC(=O)C3CC(O)CCC34C)C2C)N(C)C1",
+    "output": "酮-CC(C)=O,胺-N,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C(OCC(O)C(O)C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)OC1C3O)c1cc(O)c(O)c(O)c1",
+    "output": "酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC(C)=C1CCC(C)CC1=O",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "Cc1ccc(C(=O)Cl)cc1",
+    "output": ""
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COc1c(N)c2c3c(cc4ccccc4c3c1OC)N(C)C(=O)C2=O",
+    "output": "酮-CC(C)=O,醚-COC,酰胺-CC(N)=O,胺-N"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C(O)c1c(O)c(O)c2c(c1O)C(=O)c1ccccc1C2=O",
+    "output": "羧酸-O=CO,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC(=O)C1=CCC23CCC(C(C)(C=CC=C(C)C(=O)[O-])OC2=O)C3(O)CC1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "Cc1cc(=O)c2c(O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(O)c7c(=O)cc(CO)cc7c(c65)c(c2c1)c34",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "C=C1C(O)CC2C(C(=O)OCC=C(C)CCC=C(C)COC(=O)C3=COC(OC4OC(CO)C(O)C(O)C4O)C4C3CCC4(C)O)=COC(OC3OC(CO)C(O)C(O)C3O)C12",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "COc1ccc2c(c1)OC(C)(C)C=C2",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc2c(cc1O)c(=O)n1ccc3cccc2c31",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC(C)=CC(=O)OCC(C)C1Cc2cc3ccc(=O)oc3cc2O1",
+    "output": "醚-COC,醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CC(O)C#CC#CC(O)C1OC1CCCCCCC",
+    "output": "醚-C1CO1,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc2c(=O)c3c(O)cc(O)cc3oc2cc1OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)C1C=CC(CO)CC1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1cc(CC=C(C)C)c2c(=O)c3c(O)cc(OC)c(CC=C(C)C)c3oc2c1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "Cc1cc(OC2OC(CO)C(O)C(O)C2O)c2c(O)cccc2c1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1c(OC)c(O)c2c3c(cc4ccccc42)NC(=O)c13",
+    "output": "醚-COC,酰胺-CC(N)=O,胺-N,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "C=CCC1=CC2=C(OC)C(C1=O)C2(C)C(O)c1ccc2c(c1)OCO2",
+    "output": "醚-COC,酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COC1=CC(C)C2CC3OC(O)CC4C(C)C5OCOC5C(C2(C)C1=O)C34C",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "OCC1OC(Oc2ccc(C=Cc3cc(O)cc(O)c3)cc2O)C(O)C(O)C1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CCCCCCCCCCCCCCCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCC1(c2cccc(O)c2)CCN(CCc2ccc(O)cc2)C1",
+    "output": "胺-N,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cc2c(cc1OC1OCC3C(c4cc5c(cc4OC)OCO5)OCC13OC(C)=O)OCO2",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C(CCC(C)C1CCC2(C)C3CCC4C(C)(C)C(OC(=O)C=Cc5ccc(O)cc5)CCC45CC35CCC12C)C(C)C",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)COc1ccccc1",
+    "output": "醚-COC,酮-CC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)(O)CCc1c(OC2OC(CO)C(O)C(O)C2O)cc2oc(-c3ccc(O)cc3)c(O)c(=O)c2c1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1CN=C(C(=O)C(C)C2CCC3C4CC(=O)C5CC(O)CCC5(C)C4CCC23C)C1",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(O)c2c(c1)OC(c1ccc(OC)c(OC3OC(CO)C(O)C(O)C3O)c1)CC2=O",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "Cc1cncc(C(O)C(O)C(O)CO)n1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc(C(=O)OCC2OC(Oc3ccc(CC(CO)C(CO)Cc4ccc(O)c(OC)c4)cc3OC)C(O)C(O)C2O)cc1",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1CCC2(O)C(C)CCC3C(C12)C3(C)C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC(O)C1CC=CC2CC(=O)NCCCCNCCCN21",
+    "output": "胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1C(OC)OC2(OC3OC(CO)C(O)C(O)C3O)CC1C(=O)C=C2C",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCOC(=O)C(=O)OCC",
+    "output": "醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)=CCc1c(O)ccc2ccc(=O)oc12",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=CC1(C)CC(=O)C2C3(C)C=C(OC(C)=O)C(=O)C(C)(C)C3CC(O)C2(O)C1=O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1=C2C(CC1)C1(C)CCC(C(C)C)(O1)C2O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "C=C(C)C1Cc2c(OC)c3cc(OC)cc(OC)c3[n+](C)c2O1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "C=C1C(=O)C23OC2C1CCC(=O)C1(C)CCC(OC(C)=O)C(C)(C)C1CC3OC",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "COc1cc(CC2(O)COC(c3ccc(OC4OC(CO)C(O)C(O)C4O)c(OC)c3)C2CO)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)C1=CC2(CC1=O)C(=O)CCC1C(C)(C)CCCC12C",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCCCCCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "C1=CN(c2ccccc2)Cc2ccccc21",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC1=C2C(=O)C=C(C(=O)O)C2C2OC(=O)C(C)C2CC1",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3C(OC3OC(CO)C(O)C(O)C3OC3OCC(O)C(O)C3O)CC12C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OC1C2C(=O)c3ccoc3CC2C2(C)C(=O)CCC(C)(C)C2(O)C1OC(C)=O",
+    "output": "酮-CC(C)=O,酮-CC(C)=O,酯-COC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C=CC=C(C)C=CC(=O)O)=CC=CC=C(C)C=CC=C(C)C=CC(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CCCCCCCCCCCCCCCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "C=C1C(=O)OC2C=C(C)C(O)CC=C(C)CC(OC(=O)C(C)=CC)C12",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C#CC1(O)C(O)CC2C3CCc4cc(OC5CCCC5)ccc4C3CCC21C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1(C)C=Cc2c(c(O)cc3c(=O)c4c(O)cccc4oc23)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "O=c1c(C2OCCC2O)coc2cc(O)cc(O)c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC1=CC(C)C2CC3OC(=O)CC4(O)C(C)C(O)C(O)C(C2(C)C1=O)C34C",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "COC1=CC(C)C2CC3OC(=O)CC4(O)C(C)(O)C(OC)C(O)C(C2(C)C1=O)C34C",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "COC1=CC(C)C2CC3OC(=O)CC4C(C)C(OC)C(O)C(C2(C)C1=O)C34C",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CN(C=O)CCc1cc2c(cc1-c1cc3ccc4c(c3cn1)OCO4)OCO2",
+    "output": "醚-COC,胺-N"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)C(OC(C)=O)CC43O)C2)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "Oc1ccc(C2Oc3cc(O)c(C4c5cc(C6C(c7ccc(O)cc7)OC(c7ccc(O)cc7)C6c6cc(O)cc(O)c6)c(O)cc5OC4c4ccc(O)cc4)cc3C2c2cc(O)cc(O)c2)cc1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "Cc1cc(O)c2c(c1)C(=O)C=C(c1c(C)cc(O)c3c1C(=O)C=CC3=O)C2=O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "O=C(O)c1cc(C=CN2c3cc(O)c(OC4OC(CO)C(O)C(O)C4O)cc3CC2C(=O)O)cc(C(=O)O)n1",
+    "output": "醚-COC,胺-N,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CNC(Cc1c[nH]c2ccccc12)C(=O)OC",
+    "output": "胺-N,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=C2CC(C(C)C(=O)O)C(C(=O)OC3OC(CO)C(O)C(O)C3O)C=C2CCC1",
+    "output": "羧酸-O=CO,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C",
+    "output": "羧酸-O=CO,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC(=CCCC(C)=CCCC(C)=CCCC1C(C)(O)CCC2C(C)(C)C(=O)CCC12C)CO",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCCCCCCCCCCCCC=O",
+    "output": "醛-CC=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc(O)c(C(=O)CCc2ccccc2)c(O)c1C",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=CCCC(C)=CCOC1OC(CO)C(O)C(OC2OC(C)C(O)C(O)C2O)C1OC1OC(C)C(O)C(O)C1O)CCC=C(C)COC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C(OC(C(=O)O)C(O)C(O)C(O)C(=O)O)c1cc(O)c(O)c(O)c1",
+    "output": "羧酸-O=CO,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC1(O)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C(OC7OCC(O)C(O)C7O)C6OC6OCC(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc(OC)c(C2C(C)C(C)C2c2cc(OC)c3c(c2OC)OCO3)cc1OC",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc(C=CC(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C3(CO)OC23)cc1O",
+    "output": "酯-CC(=O)OC,醚-COC,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COC(=O)C=Cc1ccc(O)cc1",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC(=O)c1ccc(OC)cc1",
+    "output": "醚-COC,醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCCCCCCCCCCC(=O)OC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COC(=O)CCC(C)C1CC(=O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC1(CO)OC(CO)C(O)C1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "COC(=O)C1(C)CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(O)C(C)(CO)C5CCC43C)C2C1",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CCCCC(C)CC(C)CC(C)C(=O)OC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "COC(=O)C1(C)CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(O)C(C)(C)C5CCC43C)C2(O)C1",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(C(=O)O)c(C(=O)O)cc1OC",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc2c(c1OC)C(=O)OC2",
+    "output": "醚-COC,醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "Oc1ccc(C2Oc3ccc(C=Cc4cc(O)cc(O)c4)cc3C2c2cc(O)cc(O)c2)cc1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COc1cc(C2Oc3c(OC)cc(CCCO)cc3C2COC2OC(C)C(O)C(O)C2O)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1=CC(=O)c2c(O)ccc(-c3ccc(O)c4c3C(=O)C(C)=CC4=O)c2C1=O",
+    "output": "酮-CC(C)=O,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1C2CCC3C45CCCC(C)(C)C4C(OC(C)=O)C(O)(OC5)C3(C2)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C1CCC2C3CCC4CC([N+](C)(C)C)CCC4(C)C3CCC21C)[N+](C)(C)C.[I-].[I-]",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CCc1ccc(Oc2cc(C(O)C(O)Cc3c(CC=C)cc(O)c(O)c3Oc3ccc(CC=C)cc3)cc(O)c2O)cc1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "[Mg]",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cccc(OC(C)=O)c1",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(CCC(=O)OC2C(OC(C)=O)C3CC(C)CC45C3CCCN4CCCC25)ccc1O",
+    "output": "醚-COC,酯-COC(C)=O,胺-N,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CC1=CC2C(O)C(O)C3CCCN4CCCC2C34C1",
+    "output": "胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1C(OC2OC(CO)C(O)C(O)C2O)C(C)CNC12OC1CC3C4CCC5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(OC8OCC(O)C(O)C8O)C7OC7OC(CO)C(O)C(O)C7O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C",
+    "output": "胺-N,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC12CCC3C(C)(CO)C(O)CCC3(C)C1CCC1C(=CCC3C(C)(C)C(O)C(O)CC13C)C2",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "O=c1cc(-c2ccc(OC3OC(CO)C(O)C(O)C3O)c(O)c2)oc2cc(O)cc(O)c12",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1C(=O)C23CC(=O)C4C(C)(C)C(OC(C)=O)C(OC(C)=O)C(O)C4(C)C2C(O)CC1C3",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COc1ccc2c(=O)cc(-c3ccc4c(c3)OCO4)n(C)c2c1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc2c(cc1O)C1(Cc3ccc4c(c3C1O)OCO4)N(C)CC2",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(CCC(O)C(C)(C)O)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(=O)C(C)(C)C1CC3=O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "O=C(O)C(O)Cc1ccccc1",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=CC1(C)CCC(C(C)CO)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCN1CC2(COC)CCC(O)C34C5C(O)C6C(OC)CC(O)(C5C6O)C(O)(C(OC)C23)C14",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1ccc2c(c1)OCc1c-2oc2cc(O)ccc12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=C(CCC2=CC(=O)OC2)C2(C)CCCC(C)(C)C2CC1=O",
+    "output": "酮-CC(C)=O,醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCCCCCCCCCCCBr",
+    "output": ""
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "COc1cc2c(cc1OC)-c1c(O)c(O)cc3c1C(C2)N(C)CC3",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "COc1cc(C(=O)C2=Cc3cc(O)c(OC)cc3CC2CO)ccc1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC#CC#COC1=CC2(CCC(OC(=O)CC(C)C)CO2)C2OC12",
+    "output": "醚-COC,酯-COC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC1(C)CC2C3=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(O)C6OC6OC(C(=O)O)C(O)C(O)C6O)C(C)(CO)C5CCC4(C)C3(C)CCC2(C)C(OC2OCC(O)C(O)C2O)C1O",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4C=CC4=C6C7(CCC(C)(OC7=O)C6(C)O)CCC45C)C3(C)C)OCC(O)C2OC2OC(CO)C(O)C(O)C2OC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)(O)CCC(=O)C(C)(O)C1C(O)CC2(C)C3C(O)C=C4C(C=C(OC5OC(CO)C(O)C(O)C5O)C(=O)C4(C)C)C3(C)C(=O)CC12C",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)=CCc1cc(C2Oc3c(ccc4c3C=CC(C)(C)O4)C(=O)C2O)ccc1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC=C(C)C(=O)OC1C2=CC(=O)C(OC)=C(OC)C23COc2c4c(cc(c23)C(OC(C)=O)C(C)C1(C)O)OCO4",
+    "output": "酮-CC(C)=O,酯-CC(=O)OC,醚-COC,酯-COC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CC(C)(CCC=C(C)C(=O)OC1C(C)OC(OC(C)(C=C)CCC=C(CO)C(=O)OC2CC3(C(=O)OC4OC(CO)C(O)C(O)C4OC4OC(C)C(OC5OC(CO)C(O)C5O)C(OC5OC(CO)C(O)C(O)C5O)C4O)C(O)CC4(C)C(=CCC5C6(C)CCC(OC7OC(COC8OCC(O)C(O)C8OC8OCC(O)C(O)C8O)C(O)C(O)C7NC(C)=O)C(C)(C)C6CCC54C)C3CC2(C)C)C(O)C1O)OC1OC(C)C(O)C(O)C1O",
+    "output": "酯-CC(=O)OC,胺-N,酯-COC(C)=O,醚-COC,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CC1=C(COC2OC(CO)C(O)C(O)C2O)C(C)(C)CCC1=O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=CC(O)C#CC#CC(C=CCCCCCCC)OC(C)(C)C(O)COc1c2occc2c(OC)c2ccc(=O)oc12",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1OC(OC2C(O)C(OCCc3ccc(O)c(O)c3)OC(CO)C2OC(=O)C=Cc2ccc(O)cc2)C(O)C(O)C1O",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1cc(-c2oc3cc(O)cc(OC4OC(CO)C(O)C(O)C4O)c3c(=O)c2O)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc(-c2oc3cc(O)cc(O)c3c(=O)c2OC2OC(COC(=O)C=Cc3ccc(O)cc3)C(O)C(O)C2O)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC=C1C(=O)OC23C=CC4C(C(=O)OC)=COC(OC12)C43",
+    "output": "醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "O=C1CC(c2ccc(O)c(O)c2)Oc2c1ccc(OC1OC(CO)C(O)C(O)C1O)c2O",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1OC(=O)C(=CCCCCCC=CCCCCCCCC)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "COc1ccc(CC=Cc2ccccc2)c(OC)c1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)CCc1ccc(OC2OC(CO)C(O)C(O)C2OC(=O)c2cc(O)c(O)c(O)c2)cc1",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "O=C1c2ccccc2OCC1c1ccccc1",
+    "output": "酮-CC(C)=O,醚-COC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(C)C(C)C=CC(C)C1CCC2C3C=CC4=CC(=O)CCC4(C)C3CCC12C",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)(O)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(=O)C(O)C4(C)C)C3(C)C(=O)CC12C",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CCCCCCCCCCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)C1OC(=O)C=C2C1=CC1OC(=O)C3(C)C(O)C4OC4C2(C)C13",
+    "output": "酯-CC(=O)OC,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)C1CCC(C)(C2C(O)CC3(C)C4CC(=O)C5C(C)(C)C(OC6OC(CO)C(O)C(O)C6O)CCC56CC46CCC23C)O1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "COc1cc(C=CC(=O)c2ccc(O)cc2O)ccc1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCCCCCS",
+    "output": ""
+  },
+  {
+    "instruction": "我需要知道这个分子的��能团，你能提供吗？",
+    "input": "CCCCCCCCCCCCCCCC(=O)OC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCCCCCCCCCCCCCCC=O",
+    "output": "醛-CC=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C(OC1COC(=O)c2cc(Oc3c(C(=O)OC4OC5COC(=O)c6cc(O)c(O)c(O)c6-c6c(cc(O)c(O)c6O)C(=O)OC5C(OC(=O)c5cc(O)c(O)c(O)c5)C4OC(=O)c4cc(O)c(O)c(O)c4)cc(O)c(O)c3O)c(O)c(O)c2-c2c(cc(O)c(O)c2O)C(=O)OC1C1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)c3c2C(=O)OC1C3O)c1cc(O)c(O)c(O)c1",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCCCCCCCCCCCCCCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CC(C)=CCCC(C)(OC1OC(COC2OC(C)C(O)C(O)C2O)C(O)C(O)C1O)C1CCC2(C)C1CCC1C3(C)CC(O)C(OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC12C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC=C(C)C(=O)OC1c2cc3c(c(OC)c2-c2c(cc(OC)c(OC)c2OC)CC(C)C1(C)O)OCO3",
+    "output": "醚-COC,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC(C)=CCc1cc(-c2coc3cc(O)cc(O)c3c2=O)cc(O)c1O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CC(C)=CCc1cc2c(cc1O)OCC1(O)c3ccc(O)cc3OC21",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C(O)c1cc([O-])c2c(c1)C(=O)c1c(C3OC(CO)C(O)C(O)C3O)ccc([O-])c1C2=O.[Ca+2]",
+    "output": "羧酸-O=CO,酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(CC(CO)C(CO)Cc2cc(OC)c(OC3OC(COC(=O)c4ccc(O)c(OC)c4)C(O)C(O)C3O)c(OC)c2)ccc1O",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC1C(=O)OC2C1C13OC4OC(=O)C(O)C45C(C(C)(C)C)C(O)C(OC1=O)C35C2O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCC=CCC=CCC=CCCCCCCCC(=O)OC1(O)C(O)C(COC2OC(CO)C(O)C(O)C2O)OC(OCCC)C1(O)O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)=CCc1cc2c(=O)c3c(O)c4c(cc3oc2c(O)c1O)OC(C)C4(C)C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CC(=O)OCC(C)C1=C(O)C2=C(C(=O)C1=O)C1(C)CCCC(C)(C)C1CC2OC(C)=O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=C(C)C12OC3(c4ccccc4)OC1C1C4OC4(COC(=O)CCCCCCCCCCCCCCC)C(O)C4(O)C(=O)C(C)=CC4C1(O3)C(C)C2OC(=O)c1ccccc1",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "C=C1C(O)CC2C(C(=O)OC)=COC(OC3OC(CO)C(O)C(O)C3O)C12",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)=CCCC(C)=CCc1c(O)c(O)c2oc3cc(O)cc(O)c3c(=O)c2c1CC=C(C)C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC(=O)OC1CC(C(C)CCC=C(C)C(=O)O)C2(C)CCC3=C(C(O)CC4C(C)(C)C(=O)CCC34C)C12C",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=CCCC(C)C1CC(O)C2(C)C3=CCC4C(C)(C)C(=O)CCC4(C)C3=CCC12C)C(=O)O",
+    "output": "羧酸-O=CO,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(CC(=O)CC(C)(O)C1CC(=O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O)C(=O)O",
+    "output": "羧酸-O=CO,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(C)=CCc1c(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1ccc(-c2coc3cc(O)c(CC=C(C)C)c(O)c3c2=O)cc1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCCC1CCC(=O)O1",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O",
+    "output": "羧酸-O=CO,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "OCC(CO)OC1OC(C(O)CO)C(OC2OC(C(O)CO)C(O)C2O)C1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想��道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc2c(cc1OC)C13CC(OC)C=CC1=CCN3CCC2",
+    "output": "醚-COC,醚-COC,胺-N"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)=CCCC(C(=O)OC1OC(CO)C(O)C(O)C1O)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(O)C(C)(C)C1CC3",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "Cc1sc(COS(C)=O)c(C)c1C",
+    "output": ""
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC1C(O)C(O)C2C3(C)C(OC(=O)C13)C(O)C1C(C)(O)C=CC(OC3OC(CO)C(O)C(O)C3O)C12C",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(=O)OC1CC(OC(C)=O)C2(C)OC2C2C(OC(=O)c3ccccc3)C(C)CC23OC(C(=O)C1(C)C)C(C)C3=O",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-C1CO1,醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "C=C1C(=O)OC2C1C(OC(=O)C(C)=CCO)CC(O)(CCl)C1C(OC(C)=O)C3OC3(C)C21",
+    "output": "酯-CC(=O)OC,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(=O)c4ccccc4)C14OC3(C)COC(=O)c1cccnc1C(C)C(C)C(=O)OC(C(OC(C)=O)C2OC(=O)c1ccccc1)C4(C)O",
+    "output": "酯-CC(=O)OC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC1=CCCC2(C)CCC(O)(C(C)C)CC12",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCCCOC(=O)C1OC(OC2CCC3(C)C(CCC4(C)C3C(=O)C=C3C5CC(C)(C(=O)O)CCC5(C)CCC34C)C2(C)C)C(OC2OC(C(=O)OCC)C(O)C(O)C2O)C(O)C1O",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OC1CC2CC(OC(=O)C=Cc3ccccc3)CC1N2C",
+    "output": "胺-N,醚-COC,酯-COC(C)=O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1(C)CCC2(CO)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CC1OC(Oc2cc(O)c3c(c2)OC(c2ccc(O)c(O)c2)CC3=O)C(O)C(O)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)C1=C2C3CC=C4C(O)C5(O)COC6OC(C4C6(O)C5O)C3(C)CCC2(C)CC1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COc1cc2c(c(O)c1CC=C(C)CC(O)C=C(C)C)COC2=O",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "Oc1ccc(C=Cc2cc(O)cc3c2C(c2cc(O)cc(O)c2)C(c2ccc(O)cc2)O3)cc1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C(OC1Cc2c(OC3OC(CO)C(O)C(O)C3O)cc(O)cc2OC1c1ccc(O)c(O)c1)c1ccccc1",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "C=C1CC23CCC4C(C)(C)CCCC4(C)C2CCC1C3",
+    "output": ""
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC1CCC23C(C)CCC(C(C)(C)O)C2C13",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC(=O)C1OC(OC2CCC3(C)C(CCC4(C)C3CC=C3C5CC(C)(C)CCC5(C(=O)O)C(O)CC34C)C2(C)C)C(O)C(O)C1O",
+    "output": "羧酸-O=CO,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)=CC(O)CC(C)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(=O)C(C)(C)C1CC3O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C(O)C=CC(C)(C)O)C1CCC2(C)C3=CCC4C(C)(C)C(=O)CCC4(C)C3CCC12C",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC(C)=CCCC(C)(O)C1CCC2(C)C1CCC1C3(C)CCC(=O)C(C)(C)C3CCC12C",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C(OC1CC2C3CC=C4CC(OC5OC(CO)C(OC6OC(C)C(O)C(O)C6O)C(O)C5OC5OC(C)C(O)C(O)C5O)CCC4(C)C3CCC2(C)C1CC)C(CC(C)COC1OC(CO)C(O)C(O)C1O)OC",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCCCN(C)C",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC(=O)C1=COC(OC2OC(COC(=O)C3=COC(OC4OC(CO)C(O)C(O)C4O)C4C(COC(=O)SC)=CC(O)C34)C(O)C(O)C2O)C2C(COC(=O)SC)=CC(O)C12",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC(C)C1C2OC(=O)C1C1(O)C3OC3C3(CO3)C1(C)C2O",
+    "output": "醚-COC,醚-C1CO1,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "OCC1OC(OC2OCCC3C(O)C4OC4(CO)C23)C(O)C(O)C1O",
+    "output": "醚-COC,醚-C1CO1,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "C=CC1(C)CCC=C(C)C(=O)OCC2OC(OC(C)(C=C)CCC=C(C)C(=O)OCC3OC(O1)C(O)C(O)C3O)C(O)C(O)C2O",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(CCC(=O)O)cc(-c2cc(CCC(=O)O)cc(OC)c2OC2OC(CO)C(O)C(O)C2O)c1O",
+    "output": "羧酸-O=CO,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=C(O)c1cc2c([nH]c3ccccc32)c(C(O)CO)n1",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC(C)C1NC(=O)C(CO)NC(=O)C(Cc2ccccc2)NC(=O)C(C(C)C)NC(=O)CNC(=O)C2CCCN2C1=O",
+    "output": "胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1=CC2c3cc(C4COc5cc(O)c(C)c(O)c5C4=O)c(O)cc3OC(C)(C)C2CC1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "COC(=O)Cc1cc(O)cc(CC=C(C)CCC=C(C)C)c1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "COC(=O)CC1C2CCC3C4C(=O)OC(C4C(C)C)C(N1C)C32C",
+    "output": "胺-N,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "OCC1OC(Oc2cc3c(O)cc(O)cc3[o+]c2-c2cc(O)c(O)c(O)c2)C(O)C(O)C1O.[Cl-]",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CCN1CC2(CO)CCC(OC)C34C5CC6C(OC)CC(O)(C5C6O)C(O)(C(OC)C23)C14",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC1CCC2(OC1)OC1CC3C4CCC5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(OC8OCC(O)C(O)C8O)C7OC7OC(CO)C(O)C(O)C7O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CC(C)(C)c1[nH]c2cc(Br)ccc2c1CCNC",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2cc1OC",
+    "output": "醚-COC,醚-COC"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O",
+    "output": "醚-COC,酮-CC(C)=O,醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C(CCC=C(C)C)C1CCC2(C)C1CCC1C3(C)CCCC(C)(C)C3CCC12C",
+    "output": ""
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cc2oc(=O)cc(-c3ccccc3)c2cc1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CC1=C2CC3CCC(C)C2(C=C1)C3(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "O=C1C=CCC1",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1=C(C)CCCCCC1",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "OCC1CCCCCCC1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C1CCCCCCC1",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C(C)C(C)(C)CCC(C)C1CCC2(C)C3CCC4C(C)(C)C(=O)CCC45CC35CCC12C",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)(OC1OC(CO)C(O)C(O)C1O)C1CCC(C)(C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(OC6OC(CO)C(O)C(O)C6O)CCC56CC46CCC23C)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "Oc1cc(O)c2cc(OC3OC(COC4OCC(O)C(O)C4O)C(O)C(O)C3O)c(-c3ccc(O)c(O)c3)[o+]c2c1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1OC(OCC2OC(Oc3cc4c(O)cc(O)cc4[o+]c3-c3ccc(O)c(O)c3)C(O)C(O)C2O)C(O)C(O)C1O.[Cl-]",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C(C)C1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(CCC4C5(C)CCC(OC6OCC(O)C(O)C6OC6OC(C)C(O)C(O)C6O)C(C)(C)C5CCC43C)C12",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "O=C(OCC1(O)COC(OC2C(Oc3ccc(O)cc3)OC(CO)C(O)C2O)C1O)c1ccccc1",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC=C1CC(C)C(C)(O)C(=O)OCC2=CCN3CC(O)C(OC1=O)C23",
+    "output": "酯-CC(=O)OC,胺-N,酯-COC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1=CCC2C3C(C(C)C)C(O)CC2(C)C13",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC=C1CN(C)C2Cc3c([nH]c4ccccc34)C(c3cc4c5c([nH]c4cc3OC)C3(C(=O)OC)CC4CC(CC)C3N(CC5)C4)CC1C2C(=O)OC",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O,胺-N"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC(C1OC1C1OC1(C)C)C1CCC2(C)C3=CCC4C(C)(C)C(=O)CCC4(C)C3CCC12C",
+    "output": "酮-CC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)O)CCC45C)C3(C)C)OCC(O)C2O)C(O)C(OC2OCC(OC3OC(CO)C(O)C(O)C3O)C(O)C2O)C1O",
+    "output": "羧酸-O=CO,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1OC(OC2C(CO)OC(OCC3OC(OC(=O)C45CCC(C)(C)CC4C4=CCC6C7(C)CCC(OC8OCC(O)C(O)C8OC8OC(C)C(O)C(OC9OCC(OC%10OC(CO)C(O)C(O)C%10O)C(O)C9O)C8O)C(C)(CO)C7CCC6(C)C4(C)CC5)C(O)C(O)C3O)C(O)C2O)C(O)C(O)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C6O)C(C)(C)C5CCC43C)C2C1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC(=O)C=C=C1C(C)(C)CC(O)CC1(C)OC1OC(CO)C(O)C(O)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC=CC=CC(O)CC(O)CCO",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "C=CC(O)C#CC#CC(O)C=CCCCCCCC",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)C=C=C1C(C)(C)CC(OC2OC(COC3OCC(O)(CO)C3O)C(O)C(O)C2O)CC1(C)O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O",
+    "output": "醚-COC,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "C=Cc1c(C)c2cc3nc(c(CC(=O)[O-])c4[n-]c(cc5nc(cc1[n-]2)C(C)=C5CC)c(C)c4C(=O)[O-])C(CCC(=O)[O-])C3C.[Cu+2].[Na+].[Na+].[Na+]",
+    "output": ""
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC12C=CCN3CCC4(c5ccccc5N(C)C4C(O)(C(=O)OC)C1O)C32",
+    "output": "胺-N,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "Oc1cc(O)c2c(c1)CC1c3cc(O)c(O)cc3C2c2c(O)cc(O)cc21",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "OC1CC=C2CCN3Cc4cc5c(cc4C1C23)OCO5",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc(-c2oc3c(CC=C(C)C)c(OC4OC(CO)C(O)C(O)C4O)cc(O)c3c(=O)c2OC2OC(C)C(OC(C)=O)C(OC3OC(COC(C)=O)C(OC(C)=O)C(O)C3O)C2O)cc1",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=C(C)C1CCC2(C)C(O)CC(O)C(=C)C2(O)C1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(C2c3cc(O)c(OC)cc3C=C(C(=O)NCCc3ccc(O)cc3)C2C(=O)NCCc2ccc(O)cc2)ccc1O",
+    "output": "醚-COC,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)=CCCC1(C)C2CCC1(C)C(O)C2",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "OCC1OC(Oc2cc3c(O)cc(O)cc3[o+]c2-c2ccc(O)cc2)C(O)C(O)C1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)OC(C)C(C)C3O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "C=C1C(NC)CCC23CC24CCC2(C)C(C(C)=O)C(O)CC2(C)C4CCC13",
+    "output": "酮-CC(C)=O,胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCCOC(=O)CC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "CCC(C)CCC(O)C1C(=O)OCC1CO",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC12CC3OC(=O)CC3(CCO1)O2",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1C=CC(O)C2(C)C1CC1OC(=O)C(O)C3(O)C4(C)OCC13C2C(O)C4O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)=CCc1cc(C(=O)C=Cc2ccc(O)c(O)c2)c(O)cc1O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(CCC(O)C(C)(C)O)C1C(O)CC2(C)C3CC(OC4OC(CO)C(O)C(O)C4O)C4C(C)(C)C(OC5OCC(O)C(OC6OCC(O)C(O)C6O)C5O)CCC45CC35CCC12C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "COC1C(O)C(C)OC(OC2CCC3(C)C4C(O)CC5(C)C(C6=CC(=O)OC6)CCC5(O)C4CCC3(O)C2)C1O",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COc1ccc(-c2coc3cc(OC4OC(COC5OCC(O)(COC6OCC(O)(CO)C6O)C5O)C(O)C(O)C4O)cc(O)c3c2=O)cc1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC=CC=CC(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C1CC2CC(C1)C2",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC12CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C(C)C1(CCC(C)CO1)O2",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "C=CC(=C)CCC=C(C)CCC=C(C)C=O",
+    "output": "醛-CC=O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc2c3cc1Oc1c(OC)c(OC)cc4c1C(Cc1ccc(O)c(c1)Oc1ccc(cc1)CC3N(C)CC2)N(C)CC4",
+    "output": "醚-COC,醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "O=C(Cc1ccccc1)OCC=Cc1ccccc1",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CN1C2CCC1CC(OC(=O)C1CCC(C(=O)OC3CC4CCC(C3)N4C)(c3ccccc3)c3ccccc31)C2",
+    "output": "胺-N,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC(=O)OC1C(O)C(C2(C)CCC(C(C)(C)O)O2)C2(C)C(O)CC34CC35CCC(OC3OCC(O)C(O)C3O)C(C)(C)C5CCC4C12C",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "OCC1=CCC2C=COC(OC3OC(CO)C(O)C(O)C3O)C12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "O=C(O)C1CCN(Cc2ccccc2)C1",
+    "output": "羧酸-O=CO,胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1C(=O)OC2CC(C)=CC(O)CC3(C)OC3CC12",
+    "output": "醚-COC,醚-C1CO1,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "O=c1cc(-c2ccccc2)oc2cc(OC3OC(CO)C(O)C(O)C3O)c(O)c(O)c12",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC(C)=CC1CC(C)(O)C2C3CCC4C5(C)CCC(OC6OCC(O)C(OC7OC(CO)C(O)C(O)C7O)C6O)C(C)(C)C5CCC4(C)C34COC2(C4)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1CC2C(C)(C)C(OC3OCC(O)C(O)C3O)C=CC2(C)C2CCC3(C)C(c4ccoc4)OC(=O)C4OC43C12C",
+    "output": "醚-COC,醚-C1CO1,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)CC(=O)OCCC(O)C=CC=CC#CC#CC=CCO",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C5C(C)(C)C(OC6OCC(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC56CC46CCC23C)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(CCC(O)C(C)(C)O)C1C(OC2OC(CO)C(O)C(O)C2O)CC2(C)C3CC(O)C4C(C)(C)C(OC5OCC(O)C(O)C5OC5OC(C)C(O)C(O)C5O)CCC45CC35CCC12C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1C",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1OC(OC2C(O)C(C)OC(OC3C(CO)OC(Oc4c(-c5ccc(O)cc5)oc5cc(O)cc(O)c5c4=O)C(O)C3O)C2O)C(O)C(O)C1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC(=O)c1cc2c(c3c1c([N+](=O)[O-])cc1ccccc13)OCO2",
+    "output": "醚-COC,醚-COC,胺-[N+],酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1OC(OC2C(OC3COC(OC4CCC5(C)C(CCC6(C)C5CCC57OCC8(CCC(C)(C=O)CC85)C(=O)CC67C)C4(C)C)C(OC4OC(CO)C(O)C(O)C4O)C3O)OC(CO)C(O)C2O)C(O)C(O)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(CC2COC(=O)C2Cc2ccc(OC(CO)C(O)c3ccc(O)c(OC)c3)c(OC)c2)ccc1O",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1c(O)c(O)c(OC2OC(C(=O)O)C(O)C(O)C2O)c2oc(-c3ccc(O)cc3)cc(=O)c12",
+    "output": "羧酸-O=CO,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC1OC(OC2C(Oc3cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc4c3)OC(CO)C(O)C2O)C(O)C(O)C1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCCCCCCCCCC(O)C1CCC(C2CCC(C(O)CCCCC(O)CCCCCC(O)CC3=CC(C)OC3=O)O2)O1",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC1=C(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CCC5CC(OC6OC(CO)C(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COc1cc(OC)c2c(c1-c1ccc(OC)c3c(OC)cc(C)cc13)CC(C)N(C)C2C",
+    "output": "醚-COC,胺-N"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CN(C)NC(=O)CCC(=O)O",
+    "output": "羧酸-O=CO,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC=C1C(=O)OCC2C3Cc4c(n(C)c5ccccc45)C(CC12)N3",
+    "output": "醚-COC,胺-N,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1(C)C=Cc2c(cc3occ(-c4ccc(O)cc4)c(=O)c3c2O)O1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC(C)=CCc1occc1C",
+    "output": ""
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CC(C(O)CCC(C)(C)O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)OC(C)(C)c1ccccc1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC1OC(OCc2cc(O)c3c(c2)C(C2OC(CO)C(O)C(O)C2O)c2cccc(O)c2C3=O)C(O)C(O)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "O=C1c2c(O)cccc2C(C2c3cccc(O)c3C(=O)c3c(O)cc(CO)cc32)c2cc(CO)cc(O)c21",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COC(=O)C1=COC2OC3C(C(C)O)C(=O)OC34C=CC1C24",
+    "output": "醚-COC,酯-COC(C)=O,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "O=CC(O)C(O)C(O)C(O)CO",
+    "output": "醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)=CCc1c(-c2ccc(O)cc2O)oc2c(C=CC3(C)CC(C)=CC(c4c(O)cc(O)c5c(=O)c(CC=C(C)C)c(-c6ccc(O)cc6O)oc45)C3)c(O)cc(O)c2c1=O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "CC1=C(CO)C(=O)OC(C(C)(O)C2(O)CCC3(O)C4CC=C5C=CCC(=O)C5(C)C4CCC32C)C1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OC1C(OC2CCC34CC35CCC3(C)C(C6(C)CCC(C(C)(C)OC7OC(CO)C(O)C(O)C7O)O6)C(O)CC3(C)C5CC(OC3OC(CO)C(O)C(O)C3O)C4C2(C)C)OCC(O)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc(-c2cc(=O)c3c(O)cc(OC4OC(COC(C)=O)C(O)C(O)C4O)cc3o2)cc1",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC=C1CN2C3CC1C(CO)C2Cc1c3n(C)c2ccccc12",
+    "output": "胺-N,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC1(C(=O)O)CCCC2(C)C1CCC13CC(CC(O)C12)C(O)(CO)C3=O",
+    "output": "羧酸-O=CO,酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CCCCCCCCCC=C1C(=O)OC(C)(OC)C1O",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1CCC(O)C(C)(C)C1CCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC(=O)OCC1=COC(OC(=O)CC(C)C)C2C1=CC(OC(=O)CC(C)(C)OC(C)=O)C21CO1",
+    "output": "醚-COC,酯-COC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC=C1COC(C=C(C)C(=O)OC2CC3(C(=O)O)C(O)CC4(C)C(=CCC5C6(C)CCC(O)C(C)(C)C6CCC54C)C3CC2(C)C)C1",
+    "output": "羧酸-O=CO,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC(=O)C1OC(OC2C(OC3CCC45CC46CCC4(C)C(C(C)C7CC=C(C)C(=O)O7)CCC4(C)C6CCC5C3(C)C(=O)O)OC(CO)C(O)C2O)C(O)C(O)C1O",
+    "output": "酯-CC(=O)OC,酯-COC(C)=O,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCCCCC=CC=CC(O)CCCCCCCC(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "Cc1ccc(C(C)CO)c(O)c1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=CC1(C)C=C2C(=O)CC3C(C)(C)CCCC3(C)C2(O)CC1",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "Cc1cc(O)cc2c1OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "COc1c2c3c(ccc2c2ccc4cc5c(cc4c2[n+]1C)OCO5)OCO3",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1ccc2c(c(OC)nc3c4cc5c(cc4ccc23)OCO5)c1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1ccc2ccc(=O)oc2c1C=O",
+    "output": "醚-COC,醛-CC=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1C(=O)OC2C1C(OC(=O)C1(C)CO1)CC(C)C1(O)C=CC(=O)C21C",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCN1CC2CCC(OC)C34C2CC(C13)C1(OC(C)=O)CC(OC)C2CC4C1C2OC(C)=O",
+    "output": "胺-N,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CCC=CCC=CCC=CCCCCCC(=O)O",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCCCCCCC(C)CCCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc2c(O)c3c4c(c(OC)c(OC)c(OC)c4c2cc1OC)CCN3C",
+    "output": "醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1c(O)ccc2oc3ccccc3c(=O)c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CCCCCCCC(C)CC(C)CCCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCC=CCC=CCC=CCCCC(C)=O",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "COc1ccc(C2Cc3cc(OC)cc(OC4OC(CO)C(O)C(O)C4O)c3C(=O)O2)cc1",
+    "output": "醚-COC,酯-CC(=O)OC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1c(O)cc2oc(-c3ccc(O)cc3)c(O)c(=O)c2c1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1c(O)c(C=O)c2c(O)cc(C)cc2c1C(C)C",
+    "output": "醚-COC,醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CCCCCC(CC(=O)CCc1ccc(O)c(OC)c1)S(=O)(=O)O",
+    "output": "醚-COC,酮-CC(C)=O,磺酸-O=S(=O)O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1ccc2c(c1OC)C(CC(C)=O)N(C)c1c-2ccc2cc3c(cc12)OCO3",
+    "output": "醚-COC,酮-CC(C)=O,胺-N"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COC(=O)C1(c2cc3ccccc3[nH]2)COCC2OC23CN(C)CCC13",
+    "output": "胺-N,醚-COC,酯-COC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)Oc1cc2oc(=O)ccc2cc1CC(O)C(C)(C)O",
+    "output": "醚-COC,醇-O,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是多少吗？",
+    "input": "COc1cc(OCC=C(C)C)c2ccc(=O)oc2c1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CCCCCCCCCCCCCCCCCc1cc(O)cc(O)c1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "O=C1CCCC=CCCCCCCCC1",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1ccc(CCc2cc(=O)c3c(o2)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C3OC(C)=O)cc1",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "O=c1cc(CCc2ccccc2O)oc2c1C(O)C(O)C(O)C2O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cc(-c2cc(=O)c3c(O)c(OC)c(O)cc3o2)cc(O)c1O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COc1c(OC)c(O)c2c(=O)cc(-c3cc(O)ccc3O)oc2c1OC",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C(C)C(CC)CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=CCCC2(C)OC2CC(=C(C)C)C(=O)C1",
+    "output": "酮-CC(C)=O,醚-C1CO1"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1ccc2c(c1)OC1c3ccc(OC)c(O)c3OCC21",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1cc(O)ccc1C(=O)C=Cc1ccccc1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "COc1ccc(C(=O)CCc2ccc(O)cc2)c(OC)c1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "O=C(O)CCCCl",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)(O)C(O)COc1c2ccoc2cc2oc(=O)ccc12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "Oc1cc(O)c2c(c1)OC1(c3ccc(O)c(O)c3)Oc3cc(O)c4c(c3C2C1OC1OCC(O)C(O)C1O)OC(c1ccc(O)c(O)c1)C(O)C4c1c(O)cc(O)c2c1OC(c1ccc(O)c(O)c1)C(O)C2",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(CCC(CC(CCc2ccc(O)c(OC)c2)OC(C)=O)OC(C)=O)ccc1O",
+    "output": "醚-COC,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "C=CCCCCCC=CC(O)C#CC#CC(O)C=C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(CCC(CC(O)CCc2ccc(O)c(O)c2)OC2OC(CO)C(O)C(O)C2O)ccc1O",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=CC(=O)OC(CC)CCCCCCCCC",
+    "output": "醚-COC,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC1CN(CCC2(O)C(=O)Nc3ccccc32)C(=O)CC1C(=COC)C(=O)OC",
+    "output": "酯-CC(=O)OC,胺-N,醚-COC,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(C)C(=O)C(O)C3O)O2)c(=O)[nH]c1=O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "O=c1c2cc(O)c(O)cc2oc2c(-c3cc(O)c4oc5cc(O)cc(O)c5c(=O)c4c3O)c(O)c(C3OC(CO)C(O)C(O)C3O)c(O)c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(OC(=O)C=Cc6ccc(O)cc6)C(C)(C)C5CCC43C)C2C1(C)O",
+    "output": "羧酸-O=CO,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1CCCCCCCCCCC(=O)C1",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "COCCCOC(C)=O",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1CC(=O)C=C(C(C)C)C1",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "C=CCSCCC(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCCC(O)CC",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)OC1CC2C(OC(C)=O)C=C(CO)C(O)CC=C(C)C(=O)C(OC(C)=O)C(=C1C)C2(C)C",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=C1C(C)CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(CO)C5CCC43C)C12",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)OC1CCC2(C)C(CCC3(C)C2CCC2C4C(C)C5(C)OC5C(O)C4(C)CCC23C)C1(C)C",
+    "output": "醚-COC,醚-C1CO1,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCCC(C)C(=O)OC1C(=O)OC2CC3C(C)CC(O)C(O)C3(C)C3C4(O)OCC23C1C(C)C4O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "OCC(O)CCCCC(O)CO",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(OC2OC(C(=O)O)C(O)C(O)C2O)cc2c1C(=O)CC(c1ccccc1O)O2",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O,羧酸-O=CO"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OCC1=CC(OC(C)=O)C2CC(OC(C)=O)C(C)=C(C(OC(C)=O)C(OC(C)=O)=C(C)C(OC(C)=O)CC1OC(=O)C(O)C(c1ccccc1)N(C)C)C2(C)C",
+    "output": "胺-N,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C(C)C1CCC(=C)C(OO)C1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "Cc1cc2c(c(C)c1CCO)C(=O)C(C)C2O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=CC(O)CC2(C)OC2CC(C)(C)C=CC1=O",
+    "output": "酮-CC(C)=O,醚-C1CO1,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)=CCCC1(C)C(CC=C(C)C)CC(CC=C(C)C)C(=O)C1C(=O)C(C)C",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC=C(C=O)c1ccccc1",
+    "output": "醛-CC=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1NCCS1",
+    "output": "胺-N"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC1=CC(=O)c2c(O)ccc(O)c2C1=O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCC(=O)c1ccc(O)c(OC)c1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC1OCCO1",
+    "output": "醚-COC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "O=C(C=Cc1ccccc1O)c1ccccc1",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "COc1ccc(O)c(C(C)=O)c1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC(C)=CCC=C(C)C(=O)OC1OC(CO)C(O)C(O)C1O",
+    "output": "醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "Cc1ccc([N+](=O)[O-])c(Cl)c1C",
+    "output": "胺-[N+]"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "Cc1ccc2c(c1C)C1=CCC3C4(C)CC(O)C(O)C(C)(C(=O)O)C4CCC3(C)C1(C)CC2",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子官能团吗？",
+    "input": "C=C(CCC(C(=O)O)C1C(O)CC2(C)C3=CCC4C(C)(CCC(O)C4(C)CO)C3=CCC12C)C(C)C",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CC(C)CCCCCCC(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C(C)C1CCC2(CO)CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C12",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "CC1=CCc2c(OC3OC(COC4OCC(O)C(O)C4O)C(O)C(O)C3O)cc(C)c(O)c2C1",
+    "output": "醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1=C(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CCC5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6O)CCC5(C)C4CC(=O)C3(C)C12",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(CCC1(O)OC2CC3C4CCC5CC(OC6OC(CO)C(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC5(C)C4CC(=O)C3(C)C2C1C)COC1OC(CO)C(O)C(O)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(O)CC(=O)CC(C)C1CC(O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(O)C(C)(C)C1CC3O",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "c1cc2nc(c1)CCCCCCCCC2",
+    "output": ""
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CCC(C)CCCCC(C)CCCC(C)CCCC(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OCC1OC(OC2CCC3(C)C(=CCC4C3CCC3(C)C4CC4OC(CCC(C)COC5OC(CO)C(O)C(O)C5O)=C(C)C43)C2)C(OC2OC(C)C(O)C(O)C2O)C(OC2OC(C)C(OC3OC(CO)C(O)C(O)C3O)C(O)C2O)C1O",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CC(O)C56CC5CC(OC5OC(CO)C(O)C(O)C5O)C6(C)C4CCC3(C)C2C1C",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CCCCCCCCCC(=O)CCCCCCCCCCCCCCC(C)CCCCC",
+    "output": "酮-CC(C)=O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)c1cc2c(c(O)c1O)C1(C(=O)O)CCCC(C)(C)C1CC2",
+    "output": "羧酸-O=CO,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "Cc1ccc(C(C)(C)O)cc1",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "Cc1c[nH]c(C)c1",
+    "output": ""
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "C=C(C)C(O)Cc1cc(C(=O)COC)ccc1OC",
+    "output": "酮-CC(C)=O,醚-COC,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)CC(C)(C)CC(C)(C)c1ccccc1",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC1CCC2(C)CCC3(C)C(=CCC4C(C)(CC(=O)O)C(C(C)(C)C=O)CCC43C)C2C1C",
+    "output": "羧酸-O=CO,醛-CC=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(C5CC(=O)c6c(O)cc(O)cc6O5)ccc4O)c3o2)cc1",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "N#CCC1C(=O)Nc2cccc(O)c21",
+    "output": "胺-N,酰胺-CC(N)=O,醇-O,氰基-C#N"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CCC(C)CCC(C)CC(C)C(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC(C)C(C)C(C)C",
+    "output": ""
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC1OC1(C)C",
+    "output": "醚-C1CO1"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "O=c1cc(CCc2ccccc2)oc2ccc(O)c(-c3ccc(O)c4oc(CCc5ccccc5)cc(=O)c34)c12",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "C=CCCCCCCCCCCCC",
+    "output": ""
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "C=C1CCC(C(C)C)=CC2C1CCC2(C)O",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我需要知道这个分子的官能团，你能提供吗？",
+    "input": "CCCC(C)CO",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "C=CC(O)CCCCCC",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "Cn1c(=O)[nH]c2c(ncn2C2OC(CO)C(O)C2O)c1=O",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC(=O)OC1CC2(O)C(OC(C)=O)C3C4(CO4)C(OC(C)=O)CC(OC(C)=O)C3(C)C(OC(C)=O)C(OC(C)=O)C(=C1C)C2(C)C",
+    "output": "醚-COC,醚-C1CO1,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "C=C1CCC(O)C2(C)CCC(C(C)C)C=C12",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CC1C(=O)CC23CC(=O)OCC1(C)C2(O)C(O)CC3(C)O",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CCCCCCCCCCCCCCCCCCCC(O)CCCCCCCCO",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CCC(C)(O)C(=O)NC1CCCN1C(=O)C1C(c2ccccc2)C2(c3ccc(OC)c(OC)c3)Oc3cc(OC)cc(OC)c3C1(O)C2O",
+    "output": "醚-COC,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团吗？",
+    "input": "COc1cc(O)c(Cc2ccc(O)cc2)c2ccc3c(Cc4ccc(O)cc4)c(O)ccc3c12",
+    "output": "醚-COC,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "O=C(C=C(O)C=Cc1ccccc1)CCc1ccccc1",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COc1cc(C=CC(=O)OCC2OC(OC(=O)C=Cc3cc(OC)c(O)c(OC)c3)C(O)C(O)C2O)cc(OC)c1O",
+    "output": "醚-COC,醚-COC,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "COC1CC(OC2C(O)CC(OC3C(O)CC(OC4C(C)OC(OC5CCC6(C)C(=CCC7(O)C6CC(O)C6(C)C(C(C)=O)CC(O)C76O)C5)CC4OC)OC3C)OC2C)OC(C)C1O",
+    "output": "酮-CC(C)=O,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团。",
+    "input": "CCN1CC2(COC)CCC(O)C34C5CC6C(OC)CC(O)(C5C6OC(=O)c5ccc(OC)c(OC)c5)C(C(OC)C23)C14",
+    "output": "醚-COC,胺-N,醚-COC,酯-CC(=O)OC,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "CCC1NC2CC3(C(=O)N(OC)c4ccccc43)C3OCC2C1C3O",
+    "output": "醚-COC,胺-N,酰胺-CC(N)=O,醇-O"
+  },
+  {
+    "instruction": "我对这个分子的官能团很感兴趣，你能告诉我它是什么吗？",
+    "input": "C=CCC=CCCCCCCCCCCCCC(=O)OC",
+    "output": "醚-COC,酯-COC(C)=O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CN1CCCC1CC(=O)CC1CCCN1C",
+    "output": "酮-CC(C)=O,胺-N"
+  },
+  {
+    "instruction": "请给我这个分子的官能团。",
+    "input": "CC(C)C1(O)C=C2C(=O)CC3C(C)(C)CCCC3(C)C2CC1",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COC(=O)C(C)(O)C1CCC(C)(CCC2(O)C(C)CCC3C(C)(C)CCCC32C)O1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(=O)OC1C(OC(C)=O)C2(C)C(OC(=O)C(C)C)OCC3(C1O)C2CC(O)C1(C)C3C(=O)C(O)C2(C)C(c3ccoc3)CC3OC321",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团值。",
+    "input": "CC(=O)OC1CC(O)C23COC(OC(=O)C(C)C)C1(C)C2CC(O)C1(C)C3C(=O)C(OC(C)=O)C2(C)C(c3ccoc3)CC3OC321",
+    "output": "酮-CC(C)=O,酯-COC(C)=O,醚-C1CO1,醚-COC,醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "CC(=O)OC1CC(O)C23COC(O)C1(C)C2CC(O)C1(C)C2C(=O)CC(c4ccoc4)C2(C)C(O)C(=O)C13",
+    "output": "酮-CC(C)=O,醚-COC,酯-COC(C)=O,醇-O"
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CC1CC=CC2=CCC3C(C3(C)C)C21C",
+    "output": ""
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团值吗？",
+    "input": "CCc1ccc(CC)c(CC)c1",
+    "output": ""
+  },
+  {
+    "instruction": "请给我提供这个分子的官能团值。",
+    "input": "CC1C2CCC3(C)CC(=O)C=C(CC1(C)O)C23",
+    "output": "酮-CC(C)=O,醇-O"
+  },
+  {
+    "instruction": "这个分子的官能团是多少？",
+    "input": "COC1=CC23CCCN2CC(O)c2cc4c(cc2C3C1O)OCO4",
+    "output": "醚-COC,醚-COC,胺-N,醇-O"
+  },
+  {
+    "instruction": "你能给我这个分子的官能团？",
+    "input": "C1=CC2C=CC1C13CCC21CC3",
+    "output": ""
+  },
+  {
+    "instruction": "你能告诉我这个分子的官能团吗？",
+    "input": "CC1=CC2OC(=O)C(C)C2CCC(C(=O)OC2OC(CO)C(O)C(O)C2O)=CCC1",
+    "output": "醚-COC,酯-COC(C)=O,醇-O,酯-CC(=O)OC"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "C=C1CCC2C(C3C1CCC3(C)O)C2(C)C",
+    "output": "醇-O"
+  },
+  {
+    "instruction": "请提供该分子的官能团。",
+    "input": "COc1cc(OC)c2c3c(cc4ccccc42)NC(=O)c13",
+    "output": "醚-COC,酰胺-CC(N)=O,胺-N"
+  },
+  {
+    "instruction": "我想知道这个分子的官能团，你能提供吗？",
+    "input": "CC(C)C1CCC(C)(O)C2CCC(C=O)=CC12",
+    "output": "醛-CC=O,醇-O"
+  }
+]

sft/test/admet_reg.csv

@@ -0,0 +1,501 @@
+smiles,y
+Cc1nc2c(N[C@H]3c4ccccc4C[C@@H]3O)cc(-n3cncn3)cn2c1C,5.3
+CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2,8.8
+Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc([S+](C)[O-])cc2)cc1,26.0
+COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1,3.0
+CC(C)Cn1c(=O)n(C)c(=O)c2c(SCCCO)c(Cc3cccc4ccccc34)sc21,0.5
+COc1cccc(-c2nc(CCOc3cccc(C[C@@H]4C(=O)N(c5ccc(C(C)(C)C)cc5)[C@@H]4C(=O)O)c3)c(C)o2)c1,0.65
+Cc1cc2cc(N/C(=N\C(=O)c3ccc[n+]([O-])c3)N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)ccc2o1,100.0
+O=C(Nc1nc(C(F)(F)F)co1)C1c2ccccc2Oc2ccccc21,0.6
+COc1nc(-c2csc(Nc3c4c(nn3CC(F)(F)F)CCC4)n2)ccc1-n1cnc(C)c1,11.0
+CC(C)(c1cc(-c2cccc(-c3cccnc3)c2)c2ncccc2c1)S(C)(=O)=O,0.63
+CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3C[C@H](O)CO3)c(Cc3c[nH]c4ncccc34)sc21,17.0
+CCn1c(C)c(C)c2cc(-n3ccccc3=O)nc(NCc3c(C)cccc3C)c21,0.7
+CCCCCCSc1nc2cc(OC)ccc2[nH]1,2.92
+CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21,14.0
+CS(=O)(=O)N1CC[C@H](N(Cc2ccccc2F)c2ccc(C#N)c(Cl)c2)C1,1.7
+CC(C)c1nc2cccnc2n1-c1ccc(C[C@H](NC2=C(Br)C(=O)C23CCCCC3)C(=O)O)cc1,18.0
+CCc1c(CCCC(=O)O)cccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)o1,7.94
+Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O,2.0
+CCCS(=O)(=O)c1ccc2[nH]c(-c3cccc(-c4ccccc4)c3)nc2c1,9.5
+O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cnc2[nH]ncc2c1,0.07
+NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2,9.4
+Nc1n[nH]cc1-c1cc(C(F)(F)F)ccc1Oc1cc(F)c(S(=O)(=O)Nc2nncs2)cc1Cl,0.66
+CN1C[C@@H]2CCC[C@]2(c2ccc(Cl)c(Cl)c2)C1,9.83
+CC(C)c1cc(Nc2ccc(Cl)cc2Cl)ncc1C(=O)NCC1CCOCC1,40.0
+N#Cc1ccc(Cl)cc1S[C@H](CCN)c1ccccc1,4.1
+CNC(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,1.2
+CNCC1(O)Cc2ccccc2C1Sc1ccccc1C,0.4
+CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1,2.0
+CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1,1.3
+Fc1ccc(O[C@@H](c2ccccc2)[C@H]2CCNC2)c(Cl)c1,0.5
+COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21,0.69
+CN(C)CCCn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)c2cc(OC(F)F)ccc21,48.0
+O=C(NCC1CCOCC1)c1cnc(Nc2ccc(Cl)cc2Cl)cc1C1CC1,55.0
+Cc1cc(/C=C/C(=O)/C=C/c2cc(C)c(O)c(C)c2)cc(C)c1O,13.2
+CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1,4.7
+CCc1ncnc2cc(OC)c(OCC(O)CNC(C)(C)Cc3cc4ccccc4[nH]3)cc12,0.07
+CC(=O)N(CC(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1,0.3
+CC(C)N1CCC[C@H](Cn2cnc3ccc(-c4ccc(Cl)cc4)cc3c2=O)C1,0.2
+CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12,6.9
+Clc1cccc(OC(c2cccnc2)[C@@H]2CCCNC2)c1Cl,2.4
+CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N(CCCCN(Cc2ccccc2)C(=O)OCc2cncs2)Cc2ccccc2)C(C)C)cs1,1.1
+COC(=O)N1CC[C@H](N(Cc2ccccc2C(F)(F)F)c2ccc(C#N)c(Cl)c2)C1,8.0
+CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O,40.0
+COc1ccc2[nH]c(SCC(C)C)nc2c1,11.6
+CN[C@H]1Cc2ccccc2N(c2ccc(Cl)c(Cl)c2)C1,0.1
+CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12,93.5
+CN(C)Cc1cc2c([nH]c(=O)c3cccc(O)c32)s1,100.0
+CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N,0.05
+Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-n3cnnc3)cc2)cc1,5.0
+O=C(CNCC1(O)CCCCC1)N1CCc2ccccc2[C@@H]1C1CCCCC1,0.6
+CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1,0.6
+COc1ncc(F)c(N2Cc3cn(-c4cccc(S(C)(=O)=O)c4)nc3[C@H]2C(C)C)n1,12.71
+CC[C@H](N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccccc2)cc1,12.61
+Oc1cccc(-c2ccc3c(-c4cccc(O)c4)c(O)ccc3c2)c1,24.8
+COc1cnc2ccc(=O)n(CCN3CCC(c4nc5cc(C#N)c(C)cc5[nH]4)CC3)c2c1,28.0
+O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CNC2)cc1F,20.0
+NC(=O)[C@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2,8.5
+Cc1cccc(C)c1CNc1nc(N2CCNC2=O)cc2c(C)c(C)[nH]c12,1.6
+O=C(NCC1CCOCC1)c1cnc(Nc2cc(Cl)ccc2F)nc1C(F)(F)F,68.0
+O=C(O)c1ccc(NC(=O)[C@H](C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1,37.0
+CNc1nc2ccccc2n1Cc1sc2c(c1C(=O)N1CCC1)c(=O)n(C)c(=O)n2CC(C)C,1.0
+O=c1cc(OCc2ccccc2)ccn1-c1ccc2c(cnn2CCN2CCCC2)c1,10.0
+Cn1c(-c2ccc(Cl)cn2)c(C2CCCC2)c2ccc(C(=O)NC3(C(=O)Nc4ccc(/C=C/C(=O)O)cc4)CCCC3)cc21,10.7
+COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(Br)c(-c2ccc(N=[N+]=[N-])cc2)[nH]1)C(C)C,1.5
+COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nn12,9.4
+COCCCc1cc(CN(C(=O)[C@H]2CNCC[C@@]23OC(=O)c2ccccc23)C2CC2)cc(OCCOC)c1,7.2
+Clc1ccc([C@@]23CCCC[C@@H]2CNC3)cc1Cl,12.8
+Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12,0.4
+CC(C)(CC(O)(Cc1cc2cc(N3CCOCC3)ncc2[nH]1)C(F)(F)F)c1ccccc1S(C)(=O)=O,0.01
+O=C(Nc1ccc(-c2nnc(NCCCCN3CCOCC3)o2)c(F)c1)c1ccccc1F,64.0
+CCNc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1,0.03
+CC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@@H]2c2ccc(F)c(F)c2)c(Cl)c1,20.0
+Cc1nn(C2CCN(C(=O)[C@@H](C)O)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1,21.0
+COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1,2.9
+O=c1[nH]c2cc(-c3cccnc3)ccc2c2[nH]c(-c3ccccc3Cl)nc12,24.0
+Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12,1.6
+C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCNC(N)=O)(c2ccc(F)cc2)OC1=O,4.0
+COc1cnc(-c2ccc(CCNc3nc4cc(Cl)ccc4c(=O)n3C)cc2)nc1,8.7
+Fc1ccc(-c2ccc3c(c2)CCC3c2cccnc2)cc1,1.7
+COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1,77.98
+CC[C@@H](CS(=O)(=O)C(C)(C)C)N1C(=O)[C@@](C)(Cc2noc(=O)[nH]2)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1,1.2
+CCOC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1,0.04
+Cc1cc(C(=O)N(C)C)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12,2.2
+CCCc1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,7.9
+COc1ccc(S(=O)(=O)N2CCC(=CC#Cc3cccc(C)n3)CC2)cc1,1.9
+O=C([C@H]1CNCC[C@@]12OCc1cc(F)c(F)cc12)N(Cc1cccc2cccnc12)C1CC1,8.9
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+Cc1cnn(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)c1,5.0
+Cc1cc(N[C@H]2C[C@@H]2c2ccccc2)n2nc(N[C@H](C)c3cccc(Cl)c3)nc2n1,4.9
+NC(=O)c1ccc(CCOCCCS(=O)(=O)CCNCCc2ccc(O)c3nc(O)sc23)cc1,1.1
+CC(C)Oc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1,3.4
+CC(C)C[C@H](NC(=O)C1CCCN1c1nc2ccccc2c(=O)o1)C(N)=O,1.0
+COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1,2.0
+CCc1cc(N)cc2nc(N3CCCC3C(=O)N[C@@H](CC(C)C)C(N)=O)oc(=O)c12,1.6
+CC(=O)Oc1ccccc1C(=O)O,2.57
+CC(C)c1nc(-c2cccc(S(C)(=O)=O)c2)c(-c2ccc(F)cc2)n1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-],0.6
+C=CCN(C(=O)N(CCCl)N=O)C1CCCCC1,0.91
+CC(C#Cc1cccs1)n1[nH]c(=O)c2[nH]c3cc(Cl)ccc3c(=O)c2c1=O,2.4
+Fc1cc(-c2cc([C@H]3C[C@H]4CC[C@H]3N4)cnc2Cl)ccn1,0.77
+CCS(=O)(=O)N(Cc1cccnc1)c1cccc(-c2nc3ccccc3s2)c1,3.6
+Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(CC(C)C)n1,1.4
+Cc1cc(N2CCN(C)CC2)n2nc(N[C@H](CC#N)c3cccc(Cl)c3)nc2n1,2.4
+CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)N2CCC(Cc3ccccc3)CC2)CC1,3.7
+CSc1nc2nc(C)cc(Nc3ccc(C(F)(F)F)cc3)n2n1,3.2
+CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1,4.4
+COc1ccc(NC(=N)c2cccs2)cc1COC1CCCC1,2.7
+CN(C)CCc1c[nH]c2ccc(-c3nc(Cc4ccc(NS(C)(=O)=O)cc4)no3)cc12,1.25
+O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1,2.1
+N[C@H]1C[C@]1(F)c1ccc(Cl)cc1,2.23
+O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1,2.7
+CNCc1cc(-c2ncccc2C)n(S(=O)(=O)c2cccnc2)c1,0.53
+Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(C2CCCC2)n1,2.0
+CCN1CCN(Cc2cnc(-c3ccc(C(=O)Nc4ccccc4N)cc3)c(C#N)c2)CC1,1.14
+CC(C)CCc1sc(NC(=O)c2cc(NC(=O)c3cc(NC(=N)c4cccc(F)c4)cn3C)cn2C)nc1C(=O)NCCN1CCOCC1,4.51
+Cc1ccc(CO)cc1,1.8
+COc1ccc(-c2cc(-c3cccc(S(C)(=O)=O)c3)cnc2N)cn1,2.3
+COc1ccc(-c2cc(CC[C@](C)(C(=O)NO)S(C)(=O)=O)on2)c(F)c1,1.23
+Cc1cc(C(=O)[O-])nn1C(C)c1cc(Cl)ccc1OCc1ccccc1,1.0
+COc1ccc2[nH]c(C3CCCN(C(=O)c4ccc(F)cc4)C3)cc2n1,3.39
+COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1,2.6
+CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21,1.38
+c1ccc2ccccc2c1,3.33
+CCCC/C(C)=C/C=C(\C)C(=O)c1c(O)cc(C(C)CC/C=C/NC(=O)OC)oc1=O,0.3
+COc1ccc(NC(=N)c2ccncc2)cc1CSC1CCCC1,2.9
+CC1CN(C)C(C)c2cc(C=O)[nH]c21,0.69
+CCN1C(=O)C2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)N=C1C,1.77
+O=C(NC[C@H]1CC[C@]2(CC1)OO[C@]1(O2)C2CC3CC(C2)CC1C3)c1ccccn1,5.6
+COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)O)CC3OC1CC(N2CCOCC2)C(O)C(C)O1,2.03
+COCC(=O)NC1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1,4.3
+O=C(O)CCc1ccc(OCc2ccccc2)cc1,1.96
+Cc1cccc(C)c1CNc1nc(N2CCCC2=O)cc2c(C)c(C)[nH]c12,3.77
+Cc1cccc(C)c1CNc1nc(-c2ccccc2)cc2c(C)c(C)[nH]c12,5.31
+CC(Oc1ccccc1F)C(=O)Nc1ccc(OCC(=O)O)c(F)c1,0.07
+CC1(C)N=C(N)N=C(N)N1c1cccc(O)c1,3.67
+CCN(CC)CCCNc1cc(-c2ccccc2)c(C#N)c2nc3ccccc3n12,2.0
+Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1,2.0
+N[C@@H]1CCN(c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)C1,0.86
+CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc(C(CC#N)c2ccccc2)n1,3.1
+C[C@@H](Oc1cc2onc(CCC(=O)O)c2cc1Cl)c1ccc(F)cn1,2.47
+NC(=O)c1cc(NC(=O)c2cc(-c3cccc(C(F)F)n3)ccc2Cl)n(-c2ccccc2)n1,3.5
+C[C@H](CCC(O)(P(=O)(O)O)P(=O)(O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C,3.34
+Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cc(-c3ccc4ncccc4c3)[nH]n2)cc1,5.2
+COc1cc2ncnc(Oc3ccc(NC(=O)Cn4nnc(C(C)C)n4)cc3)c2cc1OC,3.0
+CN(Cc1nc2ccccc2c(=O)[nH]1)Cc1nc(-c2ccccc2)no1,3.1
+CCNC(=O)Nc1sc2ncccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1,2.08
+CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1cn[nH]c1,1.8
+CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C#N,1.6
+CC[C@]1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(F)cc3F)ccc2NC1=O,1.7
+Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1,5.4
+O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCC2=O)CC1,1.96
+Cc1cnc(-c2ccccc2C(C)C)nc1NCc1ccc(-n2ccnn2)cc1,1.97
+COC1CCN(c2nccc(Nc3cc4c(cn3)ncn4C(C)C)n2)CC1,2.5
+CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1,0.97
+CNc1nc(NCCCN(C)C)c2sc(-c3ccc(C(F)(F)F)cc3Cl)cc2n1,4.5
+CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1,1.75
+CNCc1cc(-c2cccnc2F)n(S(=O)(=O)c2ccsc2)c1,0.83
+CC(C)=CCc1c(O)cc(O)c2c1O[C@@]13C(=C[C@H]4C(=O)C1(CC=C(C)C)OC[C@@H]3[C@H]4COC(=O)Cc1ccccc1)C2=O,5.1
+COc1ccc(C(=O)O)cc1-c1ccc(C#CCO)s1,0.79
+Cc1nn(Cc2ccncc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2,2.2
+Cc1nc2cc3ccccc3cc2c(=O)o1,2.8
+CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cn(C)cn1)NC(=O)[C@@H](CC(=O)N1CCOCC1)Cc1ccccc1,3.71
+C[C@@H](Oc1ccc(C(F)(F)F)cc1-c1cccc(C#N)c1)C(=O)O,0.2

sft/test/admet_reg.json

@@ -0,0 +1,2502 @@
+[
+  {
+    "instruction": "我想知道这个分子的CYP2C9酶代谢率，你能提供吗？",
+    "input": "Cc1nc2c(N[C@H]3c4ccccc4C[C@@H]3O)cc(-n3cncn3)cn2c1C",
+    "output": "5.3（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2C9酶代谢水平。",
+    "input": "CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2",
+    "output": "8.8（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶的活性水平是多少？",
+    "input": "Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc([S+](C)[O-])cc2)cc1",
+    "output": "26.0（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP2C9酶的活性水平吗？",
+    "input": "COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1",
+    "output": "3.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2C9酶代谢率。",
+    "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(SCCCO)c(Cc3cccc4ccccc34)sc21",
+    "output": "0.5（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶代谢率是多少？",
+    "input": "COc1cccc(-c2nc(CCOc3cccc(C[C@@H]4C(=O)N(c5ccc(C(C)(C)C)cc5)[C@@H]4C(=O)O)c3)c(C)o2)c1",
+    "output": "0.65（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP2C9酶的活性水平吗？",
+    "input": "Cc1cc2cc(N/C(=N\\C(=O)c3ccc[n+]([O-])c3)N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)ccc2o1",
+    "output": "100.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶代谢率是多少？",
+    "input": "O=C(Nc1nc(C(F)(F)F)co1)C1c2ccccc2Oc2ccccc21",
+    "output": "0.6（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2C9酶代谢水平，你能提供吗？",
+    "input": "COc1nc(-c2csc(Nc3c4c(nn3CC(F)(F)F)CCC4)n2)ccc1-n1cnc(C)c1",
+    "output": "11.0（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP2C9酶的活性水平值吗？",
+    "input": "CC(C)(c1cc(-c2cccc(-c3cccnc3)c2)c2ncccc2c1)S(C)(=O)=O",
+    "output": "0.63（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2C9酶的活性水平。",
+    "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3C[C@H](O)CO3)c(Cc3c[nH]c4ncccc34)sc21",
+    "output": "17.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶代谢水平是多少？",
+    "input": "CCn1c(C)c(C)c2cc(-n3ccccc3=O)nc(NCc3c(C)cccc3C)c21",
+    "output": "0.7（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶的活性水平是多少？",
+    "input": "CCCCCCSc1nc2cc(OC)ccc2[nH]1",
+    "output": "2.92（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2C9酶的活性水平。",
+    "input": "CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21",
+    "output": "14.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2C9酶代谢水平，你能提供吗？",
+    "input": "CS(=O)(=O)N1CC[C@H](N(Cc2ccccc2F)c2ccc(C#N)c(Cl)c2)C1",
+    "output": "1.7（Log10uM）"
+  },
+  {
+    "instruction": "请给我提供这个分子的CYP2C9酶代谢水平。",
+    "input": "CC(C)c1nc2cccnc2n1-c1ccc(C[C@H](NC2=C(Br)C(=O)C23CCCCC3)C(=O)O)cc1",
+    "output": "18.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶的活性水平是多少？",
+    "input": "CCc1c(CCCC(=O)O)cccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)o1",
+    "output": "7.94（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶的活性水平是多少？",
+    "input": "Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O",
+    "output": "2.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2C9酶代谢水平，你能提供吗？",
+    "input": "CCCS(=O)(=O)c1ccc2[nH]c(-c3cccc(-c4ccccc4)c3)nc2c1",
+    "output": "9.5（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2C9酶代谢率，你能提供吗？",
+    "input": "O=C(NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1)c1cnc2[nH]ncc2c1",
+    "output": "0.07（Log10uM）"
+  },
+  {
+    "instruction": "我需要知道这个分子的CYP2C9酶代谢率，你能提供吗？",
+    "input": "NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2",
+    "output": "9.4（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2C9酶代谢率。",
+    "input": "Nc1n[nH]cc1-c1cc(C(F)(F)F)ccc1Oc1cc(F)c(S(=O)(=O)Nc2nncs2)cc1Cl",
+    "output": "0.66（Log10uM）"
+  },
+  {
+    "instruction": "请给我提供这个分子的CYP2C9酶代谢率。",
+    "input": "CN1C[C@@H]2CCC[C@]2(c2ccc(Cl)c(Cl)c2)C1",
+    "output": "9.83（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2C9酶代谢水平是多少？",
+    "input": "CC(C)c1cc(Nc2ccc(Cl)cc2Cl)ncc1C(=O)NCC1CCOCC1",
+    "output": "40.0（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP2D6酶代谢水平吗？",
+    "input": "N#Cc1ccc(Cl)cc1S[C@H](CCN)c1ccccc1",
+    "output": "4.1（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子CYP2D6酶代谢率吗？",
+    "input": "CNC(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1",
+    "output": "1.2（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2D6酶的活性水平，你能提供吗？",
+    "input": "CNCC1(O)Cc2ccccc2C1Sc1ccccc1C",
+    "output": "0.4（Log10uM）"
+  },
+  {
+    "instruction": "请给我提供这个分子的CYP2D6酶代谢率。",
+    "input": "CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1",
+    "output": "2.0（Log10uM）"
+  },
+  {
+    "instruction": "我对这个分子的CYP2D6酶代谢水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1",
+    "output": "1.3（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢水平是多少？",
+    "input": "Fc1ccc(O[C@@H](c2ccccc2)[C@H]2CCNC2)c(Cl)c1",
+    "output": "0.5（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶代谢水平。",
+    "input": "COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21",
+    "output": "0.69（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP2D6酶的活性水平？",
+    "input": "CN(C)CCCn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)c2cc(OC(F)F)ccc21",
+    "output": "48.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2D6酶代谢率，你能提供吗？",
+    "input": "O=C(NCC1CCOCC1)c1cnc(Nc2ccc(Cl)cc2Cl)cc1C1CC1",
+    "output": "55.0（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子CYP2D6酶的活性水平吗？",
+    "input": "Cc1cc(/C=C/C(=O)/C=C/c2cc(C)c(O)c(C)c2)cc(C)c1O",
+    "output": "13.2（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶的活性水平是多少？",
+    "input": "CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1",
+    "output": "4.7（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子CYP2D6酶代谢率吗？",
+    "input": "CCc1ncnc2cc(OC)c(OCC(O)CNC(C)(C)Cc3cc4ccccc4[nH]3)cc12",
+    "output": "0.07（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP2D6酶代谢率吗？",
+    "input": "CC(=O)N(CC(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1",
+    "output": "0.3（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶的活性水平。",
+    "input": "CC(C)N1CCC[C@H](Cn2cnc3ccc(-c4ccc(Cl)cc4)cc3c2=O)C1",
+    "output": "0.2（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢率是多少？",
+    "input": "CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12",
+    "output": "6.9（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢率是多少？",
+    "input": "Clc1cccc(OC(c2cccnc2)[C@@H]2CCCNC2)c1Cl",
+    "output": "2.4（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢水平是多少？",
+    "input": "CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N(CCCCN(Cc2ccccc2)C(=O)OCc2cncs2)Cc2ccccc2)C(C)C)cs1",
+    "output": "1.1（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶的活性水平值。",
+    "input": "COC(=O)N1CC[C@H](N(Cc2ccccc2C(F)(F)F)c2ccc(C#N)c(Cl)c2)C1",
+    "output": "8.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶代谢率值。",
+    "input": "CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O",
+    "output": "40.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2D6酶的活性水平，你能提供吗？",
+    "input": "COc1ccc2[nH]c(SCC(C)C)nc2c1",
+    "output": "11.6（Log10uM）"
+  },
+  {
+    "instruction": "我对这个分子的CYP2D6酶代谢率很感兴趣，你能告诉我它是什么吗？",
+    "input": "CN[C@H]1Cc2ccccc2N(c2ccc(Cl)c(Cl)c2)C1",
+    "output": "0.1（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶的活性水平是多少？",
+    "input": "CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12",
+    "output": "93.5（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP2D6酶代谢水平？",
+    "input": "CN(C)Cc1cc2c([nH]c(=O)c3cccc(O)c32)s1",
+    "output": "100.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢水平是多少？",
+    "input": "CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N",
+    "output": "0.05（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢水平是多少？",
+    "input": "Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-n3cnnc3)cc2)cc1",
+    "output": "5.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶代谢水平值。",
+    "input": "O=C(CNCC1(O)CCCCC1)N1CCc2ccccc2[C@@H]1C1CCCCC1",
+    "output": "0.6（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP2D6酶代谢率吗？",
+    "input": "CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1",
+    "output": "0.6（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP2D6酶代谢率值吗？",
+    "input": "COc1ncc(F)c(N2Cc3cn(-c4cccc(S(C)(=O)=O)c4)nc3[C@H]2C(C)C)n1",
+    "output": "12.71（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP2D6酶的活性水平，你能提供��？",
+    "input": "CC[C@H](N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccccc2)cc1",
+    "output": "12.61（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP2D6酶代谢率。",
+    "input": "Oc1cccc(-c2ccc3c(-c4cccc(O)c4)c(O)ccc3c2)c1",
+    "output": "24.8（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP2D6酶代谢率是多少？",
+    "input": "COc1cnc2ccc(=O)n(CCN3CCC(c4nc5cc(C#N)c(C)cc5[nH]4)CC3)c2c1",
+    "output": "28.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CNC2)cc1F",
+    "output": "20.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP3A4酶代谢率，你能提供吗？",
+    "input": "NC(=O)[C@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2",
+    "output": "8.5（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP3A4酶代谢水平，你能提供吗？",
+    "input": "Cc1cccc(C)c1CNc1nc(N2CCNC2=O)cc2c(C)c(C)[nH]c12",
+    "output": "1.6（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP3A4酶的活性水平吗？",
+    "input": "O=C(NCC1CCOCC1)c1cnc(Nc2cc(Cl)ccc2F)nc1C(F)(F)F",
+    "output": "68.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP3A4酶代谢率，你能提供吗？",
+    "input": "O=C(O)c1ccc(NC(=O)[C@H](C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1",
+    "output": "37.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "CNc1nc2ccccc2n1Cc1sc2c(c1C(=O)N1CCC1)c(=O)n(C)c(=O)n2CC(C)C",
+    "output": "1.0（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP3A4酶代谢水平，你能提供吗？",
+    "input": "O=c1cc(OCc2ccccc2)ccn1-c1ccc2c(cnn2CCN2CCCC2)c1",
+    "output": "10.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢率。",
+    "input": "Cn1c(-c2ccc(Cl)cn2)c(C2CCCC2)c2ccc(C(=O)NC3(C(=O)Nc4ccc(/C=C/C(=O)O)cc4)CCCC3)cc21",
+    "output": "10.7（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢率值。",
+    "input": "COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(Br)c(-c2ccc(N=[N+]=[N-])cc2)[nH]1)C(C)C",
+    "output": "1.5（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶的活性水平是多少？",
+    "input": "COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nn12",
+    "output": "9.4（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "COCCCc1cc(CN(C(=O)[C@H]2CNCC[C@@]23OC(=O)c2ccccc23)C2CC2)cc(OCCOC)c1",
+    "output": "7.2（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP3A4酶的活性水平值吗？",
+    "input": "Clc1ccc([C@@]23CCCC[C@@H]2CNC3)cc1Cl",
+    "output": "12.8（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12",
+    "output": "0.4（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP3A4酶代谢水平吗？",
+    "input": "CC(C)(CC(O)(Cc1cc2cc(N3CCOCC3)ncc2[nH]1)C(F)(F)F)c1ccccc1S(C)(=O)=O",
+    "output": "0.01（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "O=C(Nc1ccc(-c2nnc(NCCCCN3CCOCC3)o2)c(F)c1)c1ccccc1F",
+    "output": "64.0（Log10uM）"
+  },
+  {
+    "instruction": "请给我提供这个分子的CYP3A4酶代谢率值。",
+    "input": "CCNc1nc2ccc(C(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OCc3cncs3)cc2o1",
+    "output": "0.03（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢水平值。",
+    "input": "CC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@@H]2c2ccc(F)c(F)c2)c(Cl)c1",
+    "output": "20.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶的活性水平是多少？",
+    "input": "Cc1nn(C2CCN(C(=O)[C@@H](C)O)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1",
+    "output": "21.0（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP3A4酶代谢水平？",
+    "input": "COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1",
+    "output": "2.9（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢率。",
+    "input": "O=c1[nH]c2cc(-c3cccnc3)ccc2c2[nH]c(-c3ccccc3Cl)nc12",
+    "output": "24.0（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP3A4酶代谢率值吗？",
+    "input": "Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12",
+    "output": "1.6（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢率值。",
+    "input": "C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCNC(N)=O)(c2ccc(F)cc2)OC1=O",
+    "output": "4.0（Log10uM）"
+  },
+  {
+    "instruction": "我对这个分子的CYP3A4酶代谢率很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cnc(-c2ccc(CCNc3nc4cc(Cl)ccc4c(=O)n3C)cc2)nc1",
+    "output": "8.7（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶的活性水平是多少？",
+    "input": "Fc1ccc(-c2ccc3c(c2)CCC3c2cccnc2)cc1",
+    "output": "1.7（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1",
+    "output": "77.98（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢水平。",
+    "input": "CC[C@@H](CS(=O)(=O)C(C)(C)C)N1C(=O)[C@@](C)(Cc2noc(=O)[nH]2)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1",
+    "output": "1.2（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平值。",
+    "input": "CCOC(=O)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]cnc34)cc2)c1",
+    "output": "0.04（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "Cc1cc(C(=O)N(C)C)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12",
+    "output": "2.2（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "CCCc1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1",
+    "output": "7.9（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶的活性水平是多少？",
+    "input": "COc1ccc(S(=O)(=O)N2CCC(=CC#Cc3cccc(C)n3)CC2)cc1",
+    "output": "1.9（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP3A4酶代谢率吗？",
+    "input": "O=C([C@H]1CNCC[C@@]12OCc1cc(F)c(F)cc12)N(Cc1cccc2cccnc12)C1CC1",
+    "output": "8.9（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C",
+    "output": "0.39（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的CYP3A4酶的活性水平，你能提供吗？",
+    "input": "Cn1c(=O)n(-c2cc(-c3ccc(F)cc3F)nc3[nH]ccc23)c2ccncc21",
+    "output": "3.98（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平值。",
+    "input": "CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4cncnc4)cc23)c1F",
+    "output": "5.0（Log10uM）"
+  },
+  {
+    "instruction": "你能告诉我这个分子的CYP3A4酶代谢水平吗？",
+    "input": "COc1ccc2[nH]c(SCc3ccc(C(C)C)cc3)nc2c1",
+    "output": "8.34（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "CCc1nc(N)nc(N)c1-c1ccc2c(c1)N(CCNC(C)=O)CCC2",
+    "output": "8.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "O=C(C(O)c1ccc(Br)cc1)N1CCC(Nc2ccc3[nH]ncc3c2)CC1",
+    "output": "3.5（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "O=c1[nH]c2cc(/C=C3\\c4ccccc4COc4cc(F)ccc43)ccc2n1[C@@H]1C[C@@H]2COCCN2C1",
+    "output": "5.81（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢率。",
+    "input": "[2H]C([2H])(N[C@H]1C[S@+]([O-])C[C@@H](Cc2cc(F)c(N)c(O[C@H](COC)C(F)(F)F)c2)[C@@H]1O)c1cccc(C(C)(C)C)c1",
+    "output": "0.1（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢率是多少？",
+    "input": "CN(C)CCCOc1cccc(CNC(=O)c2ccc(-c3ccncc3)cc2)c1",
+    "output": "2.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "C[C@@H]1CN(Cc2ccc(-c3ccccc3C(=O)N3CCC(C(=O)c4ccc(F)cc4)CC3)cc2)C[C@H](C)N1",
+    "output": "4.2（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "CC1(C)CN(C(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)c2ccccc21",
+    "output": "40.0（Log10uM）"
+  },
+  {
+    "instruction": "你能给我这个分子的CYP3A4酶代谢水平吗？",
+    "input": "CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)n(C)n3)nc21",
+    "output": "3.0（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢水平值。",
+    "input": "N[C@@H](Cc1ccccc1)C(=O)N1CCC(Nc2ccc3[nH]ncc3c2)CC1",
+    "output": "1.0（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "Cc1cc(N2CCC(N3CCOCC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12",
+    "output": "1.7（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶的活性水平。",
+    "input": "Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccnc3)c1)=N2",
+    "output": "1.8（Log10uM）"
+  },
+  {
+    "instruction": "这个分子的CYP3A4酶代谢水平是多少？",
+    "input": "CCCN(C)C(=O)CN1Cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)c2C1=O",
+    "output": "5.5（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢水平。",
+    "input": "O=C(Nc1ccn(-c2cn(Cc3cccc(C(F)(F)F)c3)cn2)c(=O)c1)c1cscn1",
+    "output": "1.9（Log10uM）"
+  },
+  {
+    "instruction": "请给我这个分子的CYP3A4酶代谢率。",
+    "input": "CN1CCN(C(=O)[C@@H](COCc2ccc3c(c2)OCCO3)NC(=O)c2cccnc2Oc2ccc(C(F)(F)F)cc2Cl)CC1",
+    "output": "3.3（Log10uM）"
+  },
+  {
+    "instruction": "请提供该分子的CYP3A4酶代谢水平值。",
+    "input": "Cc1cc(N2CCN(C)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12",
+    "output": "3.5（Log10uM）"
+  },
+  {
+    "instruction": "请给我提供这个分子的CYP3A4酶代谢率。",
+    "input": "Cc1cc(N2CCNCC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12",
+    "output": "3.0（Log10uM）"
+  },
+  {
+    "instruction": "我对这个分子的CYP3A4酶的活性水平很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC(C)C(O)(c1ccc2cc(-c3cccs3)ccc2c1)c1c[nH]nn1",
+    "output": "81.0（Log10uM）"
+  },
+  {
+    "instruction": "我对这个分子的CYP3A4酶代谢水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC[C@@H]1CCC[C@H](C2(CC(N)=O)CC2)N1S(=O)(=O)c1ccc(Cl)cc1",
+    "output": "11.5（Log10uM）"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB，你能提供吗？",
+    "input": "CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)CC(=O)N3)CC1)c1ccc(Cl)cc1",
+    "output": "0.5"
+  },
+  {
+    "instruction": "我需要知道这个分子的血浆蛋白结合率，你能提供吗？",
+    "input": "Cn1nncc1-c1cnn([C@H](CC2CC2)c2ccc(-c3c(-n4cnnn4)ccc(Cl)c3F)c[n+]2[O-])c1",
+    "output": "0.8"
+  },
+  {
+    "instruction": "这个分子的PPB结合水平是多少？",
+    "input": "Nc1cc(F)c(S(=O)(=O)N2CCC(O)CC2)cc1C(=O)Nc1ccc(F)c(F)c1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的血浆蛋白结合率。",
+    "input": "O=C(Nc1cc(-n2cnc3ccccc32)ccn1)C1CC1",
+    "output": "0.9"
+  },
+  {
+    "instruction": "你能给我这个分子的PPB？",
+    "input": "C[C@@H]1O[C@@H](NC(=O)c2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O",
+    "output": "0.8"
+  },
+  {
+    "instruction": "这个分子的血浆蛋白结合率是多少？",
+    "input": "CC(C)(O)c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12",
+    "output": "0.8"
+  },
+  {
+    "instruction": "你能给我这个分子的PPB结合水平？",
+    "input": "Cc1cc(Nc2ccc(S(F)(F)(F)(F)F)cc2)n2nc(C(F)(F)F)nc2n1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "你能告诉我这个分子PPB吗？",
+    "input": "C[C@H](O)c1nccn1Cc1cc(-c2ccc(C#CC34CC(N)(C3)C4)cc2)on1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB结合水平，你能提供吗？",
+    "input": "CN(C)c1noc(-c2cccc(CNc3ccc4[nH]nc(C(=O)O)c4c3)c2Cl)n1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的血浆蛋白结合率值。",
+    "input": "COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(C)(F)F)CC2)c2ccccc12",
+    "output": "0.9"
+  },
+  {
+    "instruction": "你能告诉我这个分子的PPB值吗？",
+    "input": "C=CCOc1ccc(C2CC(=O)Nc3nc(N)[nH]c(=O)c32)cc1OC",
+    "output": "0.7"
+  },
+  {
+    "instruction": "这个分子的PPB结合水平是多少？",
+    "input": "Cc1ccc(C(=O)N[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1",
+    "output": "0.3"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB结合水平，你能提供吗？",
+    "input": "Cc1cn2nc(-c3cc(=O)n4cc(N5CCN(C)CC5)ccc4n3)cc2c(C)n1",
+    "output": "0.8"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB，你能提供吗？",
+    "input": "O=C(O)c1c(F)ccc2c1OB(O)[C@@H]1C[C@H]21",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我对这个分子的PPB结合水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O",
+    "output": "0.9"
+  },
+  {
+    "instruction": "你能告诉我这个分子的PPB值吗？",
+    "input": "Cc1nnc2n1-c1ccccc1N(c1ccc(Cl)cc1)CC2",
+    "output": "0.9"
+  },
+  {
+    "instruction": "你能告诉我这个分子的PPB吗？",
+    "input": "CCP(=O)(O)c1ccc2oc(-c3cccc(C(F)(F)F)c3)nc2c1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "这个分子的血浆蛋白结合率是多少？",
+    "input": "Cc1nnc2n1-c1ccccc1N(c1ccc(Cl)cc1)CC2C",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的PPB结合水平值。",
+    "input": "Cc1nc2c(-c3ccc(S(C)(=O)=O)cc3)cnn2c(NCc2ccccn2)c1C",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB结合水平，你能提供吗？",
+    "input": "Nc1nc2c(c(=O)[nH]1)C(c1cccc(OC(F)(F)F)c1)CC(=O)N2",
+    "output": "0.9"
+  },
+  {
+    "instruction": "我需要知道这个分子的PPB，你能提供吗？",
+    "input": "O=C(Cc1ccc(Cl)c(Cl)c1)N1CCN(c2ccc3nncn3n2)CC1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "这个分子的PPB结合水平是多少？",
+    "input": "COc1ncc(-c2ccc3ncc(Cl)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F",
+    "output": "1.0"
+  },
+  {
+    "instruction": "这个分子的血浆蛋白结合率是多少？",
+    "input": "O=C(Nc1ccc2nc(S)sc2c1)c1ccc(OC(F)F)c(OCC2CC2)c1",
+    "output": "0.5"
+  },
+  {
+    "instruction": "请提供该分子的PPB值。",
+    "input": "COc1cc(OCc2csc(-c3ccc(C(=O)N(C)C)cc3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "这个分子的PPB是多少？",
+    "input": "NS(=O)(=O)N1CCC(C(=O)/C(=N/O)Nc2ccc(F)c(Br)c2)CC1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我对这个分子的PPB结合水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC1(CN2CC[C@H](NC(=O)c3cc(-c4ccc(F)cc4F)on3)[C@@H](C(=O)NC3(c4ncccn4)CC3)C2)CC1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我需要知道这个分子的血浆蛋白结合率，你能提供吗？",
+    "input": "Cn1cnc2ncn(Cc3nn(C[C@H](F)c4ccc(Cl)cc4)c(=O)o3)c(=O)c21",
+    "output": "0.7"
+  },
+  {
+    "instruction": "请提供该分子的血浆蛋白结合率值。",
+    "input": "CCP(=O)(OC)c1ccc2nc(-c3ccc4ccccc4c3)oc2c1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请给我这个分子的PPB结合水平。",
+    "input": "COc1cc2ccc(Br)cc2cc1[C@@H](c1ccnc(OC)c1OC)[C@@](O)(CCN(C)C)c1ccnc2c1OCCO2",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的血浆蛋白结合率。",
+    "input": "C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(SC(=S)N(C)C)[C@H](C)[C@H]12",
+    "output": "0.9"
+  },
+  {
+    "instruction": "你能给我这个分子的血浆蛋白结合率吗？",
+    "input": "O=C(NCCc1csc(-c2ccccc2)n1)N1CCCC1",
+    "output": "0.9"
+  },
+  {
+    "instruction": "这个分子的PPB是多少？",
+    "input": "CCN1CCN(c2ncc(-c3ccc4c(Nc5cnccn5)ccnc4c3)cn2)CC1",
+    "output": "0.9"
+  },
+  {
+    "instruction": "我想知道这个分子的PPB结合水平，你能提供吗？",
+    "input": "Nc1cccnc1Nc1ncnc2ccc(-c3cccc(N4CCOCC4)c3)cc12",
+    "output": "0.9"
+  },
+  {
+    "instruction": "这个分子的PPB是多少？",
+    "input": "O=C(Cn1cnc([N+](=O)[O-])n1)Nc1cccc(-c2ccccc2)c1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的PPB结合水平。",
+    "input": "Cc1cc(C)n(-c2cccc([C@H](CC(=O)O)CN3CC[C@@H](CCc4ccc5c(n4)NCCC5)C3)c2)n1",
+    "output": "0.9"
+  },
+  {
+    "instruction": "我想知道这个分子的血浆蛋白结合率，你能提供吗？",
+    "input": "Nc1nc(OCc2ccccc2)c2[nH]nnc2n1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的PPB。",
+    "input": "COC(=O)c1cccn1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1",
+    "output": "0.8"
+  },
+  {
+    "instruction": "我对这个分子的血浆蛋白结合率很感兴趣，你能告诉我它是什么吗？",
+    "input": "O=C(Nc1cccnc1)c1ccc(CNS(=O)(=O)c2ccc(N3CCOCC3)cc2)cc1",
+    "output": "0.8"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O",
+    "output": "1.22"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂性。",
+    "input": "O=c1oc2c(O)cccc2cc1-c1ccc(O)cc1",
+    "output": "2.8"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "O=c1cc(-c2ccccc2)oc2ccc(O)cc12",
+    "output": "3.6"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "O=c1c(-c2ccc(O)c(O)c2)coc2cc(O)ccc12",
+    "output": "1.88"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "O=c1[nH]n(C(c2ccccc2)c2ccncc2)c(=O)c2c(O)c3ccc(Cl)cc3nc12",
+    "output": "1.1"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1",
+    "output": "3.15"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "O=C1CN(C(=O)c2ccco2)C(c2ccccc2)c2cc(Cl)ccc2N1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "O=C1CCC(=O)N1C(CCc1ccncc1)COc1ccc(-c2cccc([N+](=O)[O-])c2)cc1",
+    "output": "3.88"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "O=C(c1ccc(F)cc1)N1CCC[C@H](c2nc(-c3ccc(F)cc3)no2)C1",
+    "output": "3.73"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "O=C(O)c1ccccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12",
+    "output": "0.0"
+  },
+  {
+    "instruction": "我需要知道这个分子的亲脂水平，你能提供吗？",
+    "input": "O=C(Nc1nnc(C(=O)Nc2ccc(N3CCOCC3)cc2)o1)c1ccccc1",
+    "output": "1.02"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "O=C(Nc1ccc(Cl)nc1)c1ccc(F)c(Cl)c1",
+    "output": "3.64"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "O=C(NCc1ccncn1)c1ccc(Oc2ccc(C#C[C@]3(O)CN4CCC3CC4)cc2)cc1",
+    "output": "1.77"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是什么吗？",
+    "input": "Nc1scc2c(C(=O)NC3CC3)nn(-c3ccc(F)cc3)c(=O)c12",
+    "output": "2.8"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "Nc1nc(SCc2ccccc2)nc2c1ncn2[C@H]1O[C@H](CO)[C@H](O)[C@@H]1O",
+    "output": "1.24"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "Nc1nc(O)c2ncn(COCCO)c2n1",
+    "output": "-1.42"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "Nc1ccccc1NC(=O)c1ccccn1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Nc1ccccc1NC(=O)c1ccc(N2CCOCC2)cc1",
+    "output": "1.2"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "Nc1cccc2c1C(=O)N(Cc1cccc(Cl)c1)C2=O",
+    "output": "3.18"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]",
+    "output": "0.77"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平值。",
+    "input": "Nc1c2c(nc3ccccc13)CCCC2",
+    "output": "0.38"
+  },
+  {
+    "instruction": "请给我这个分子的logD。",
+    "input": "NCC(O)(c1ccccc1)c1ccccc1",
+    "output": "0.9"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "NC1(c2ccc(-c3nc4ccccn4c3-c3ccccc3)cc2)CCC1",
+    "output": "2.8"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "NC(=O)c1cnc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc2c1NCCCNC(=O)C1CCC1",
+    "output": "2.48"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "NC(=O)c1ccc(Br)cc1",
+    "output": "1.75"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "NC(=O)Nc1sc(-c2ccsc2)cc1C(=O)N[C@H]1CCCNC1",
+    "output": "1.06"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "N=C(N)NC(=O)c1nc(Cl)c(NCc2ccncc2)nc1N",
+    "output": "-0.51"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性。",
+    "input": "N#Cc1ccccc1Oc1ccc(C(=O)NCc2ccncc2)cc1",
+    "output": "2.57"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "N#Cc1ccc(OC2CCN(C[C@@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl",
+    "output": "2.56"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "N#Cc1c(-c2ccc(-c3ccccc3C(F)(F)F)cc2)nc2ccncc2c1O",
+    "output": "3.3"
+  },
+  {
+    "instruction": "你能告诉我这个分子logD吗？",
+    "input": "Fc1ccc(C2CCN(C(=S)COCc3ccncc3)CC2)c(Cl)c1",
+    "output": "4.23"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1",
+    "output": "4.2"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "Cn1c2ccccc2c2cc(NC(=O)CCc3ccncc3)ccc21",
+    "output": "3.8"
+  },
+  {
+    "instruction": "请给我这个分子的logD。",
+    "input": "Clc1ccc([C@@H]2CC=CCNC2)cc1Cl",
+    "output": "1.95"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "Cc1oc2cc(O)ccc2c(=O)c1-c1ccccc1",
+    "output": "2.95"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性？",
+    "input": "Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CCCN(C)CC4)cc3)ncc2F)n1C(C)C",
+    "output": "2.02"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Cc1ncc(-c2ccnc(Nc3ccc(N4CCN(C(=O)[C@@H](C)O)CC4)cc3)n2)n1C(C)C",
+    "output": "2.15"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1ncc(-c2ccnc(Nc3ccc(C(N)=O)c(F)c3)n2)n1C(C)C",
+    "output": "2.8"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是多少吗？",
+    "input": "Cc1nc(NC(=N)N)nc2ccccc12",
+    "output": "-0.49"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1cccc(-c2nc3cc(Cl)ccc3[nH]2)n1",
+    "output": "4.1"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD值。",
+    "input": "Cc1ccc(Sc2ccccc2CN(C)C)c(N)c1",
+    "output": "2.6"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O",
+    "output": "3.3"
+  },
+  {
+    "instruction": "我需要知道这个分子的亲脂性，你能提供吗？",
+    "input": "Cc1ccc(NC(=O)c2cscn2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O",
+    "output": "2.06"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "Cc1ccc(NC(=O)c2ccoc2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O",
+    "output": "2.43"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂性。",
+    "input": "Cc1ccc(C(=O)Oc2ccc(C(O)CNC(C)(C)C)cc2OC(=O)c2ccc(C)cc2)cc1",
+    "output": "3.57"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD吗？",
+    "input": "Cc1cc2[nH]c(=O)c(O)cc(=O)c2cc1C",
+    "output": "1.99"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "Cc1cc(N)nc(CCNC(=O)c2ccc(C#N)cc2)c1",
+    "output": "1.62"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "Cc1cc(CNc2nccc(Nc3cc(C)[nH]n3)n2)on1",
+    "output": "1.86"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "Cc1cc(C)cc(-c2nnc(SCC(=O)N3CCN(C(=O)c4ccco4)CC3)o2)c1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "Cc1cc(C)cc(-c2[nH]c3ccccc3c2CCNCCCCc2ccncc2)c1",
+    "output": "3.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1",
+    "output": "4.3"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性吗？",
+    "input": "Cc1cc(C#N)oc1-c1c2c(=O)n(C)c(=O)n(CC3CC3)c2nn1Cc1ccnc2ccc(Cl)cc12",
+    "output": "4.34"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂水平吗？",
+    "input": "Cc1cc(=O)oc2cc3c(cc12)CCCN3",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平值。",
+    "input": "C[C@H]1CN(C(=O)OCC(F)(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "C[C@H]1CCCN1CCc1cc2cc(-c3ccc(C#N)cc3)ccc2o1",
+    "output": "3.51"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "C[C@@H]1C(SC2CN(C3=NCCS3)C2)=C(C(=O)OCOC(=O)C(C)(C)C)N2C(=O)[C@@H]([C@@H](C)O)[C@@H]12",
+    "output": "2.1"
+  },
+  {
+    "instruction": "你能给我这个分子的logD？",
+    "input": "C[C@@H](NC1=CC(=O)CNC1)c1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1",
+    "output": "2.49"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平。",
+    "input": "COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC",
+    "output": "-0.73"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是多少吗？",
+    "input": "COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1",
+    "output": "3.9"
+  },
+  {
+    "instruction": "你能告诉我这个分子logD吗？",
+    "input": "COc1ccc2ncc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@H](O)C3)c2c1",
+    "output": "0.77"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COc1ccc2c(C)nc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1",
+    "output": "0.29"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "COc1ccc(CN2CCc3c([nH]c4ccccc34)C2)cc1OC",
+    "output": "3.1"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COc1ccc(-c2nc3c(NCCCNC(C)=O)c(Br)cnc3[nH]2)cc1",
+    "output": "3.28"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "COc1ccc(-c2nc(N)s[n+]2-c2ccccc2)cc1",
+    "output": "2.19"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COc1ccc(-c2ccc3nc(N)sc3c2)cn1",
+    "output": "3.2"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1F",
+    "output": "2.8"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cc2ncnc(Nc3ccc(Cl)c(O)c3)c2cc1OC",
+    "output": "3.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "COc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1OC",
+    "output": "3.4"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平值。",
+    "input": "COc1cc(OC)c(S(=O)(=O)N(C)c2ccccc2)cc1NC(C)=O",
+    "output": "1.1"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cc(F)ccc1-c1cncc(CNC2CCCCC2)c1",
+    "output": "2.6"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CCC(=O)N2C",
+    "output": "2.87"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性。",
+    "input": "COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC",
+    "output": "3.23"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@@H]1NCc1cc2c(cn1)OCCO2",
+    "output": "1.05"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CO[C@H]1/C=C/O[C@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C/C=C/[C@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)[C@H](OC(C)=O)[C@@H]1C",
+    "output": "1.19"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "COCCOc1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COC(=O)c1ccc(CC(=O)N(C)C2CCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1",
+    "output": "4.0"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平值吗？",
+    "input": "CN[C@H](C)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)OC)C(c1ccccc1)c1ccccc1)C1CCCCC1",
+    "output": "2.42"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是多少吗？",
+    "input": "CN1CCN(c2ccc3ncc(C(N)=O)c(Nc4ccc(Cl)cc4Cl)c3c2)CC1",
+    "output": "3.23"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O",
+    "output": "2.63"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性值。",
+    "input": "CN(C)CC/C=C1/c2ccccc2COc2ccccc21",
+    "output": "2.15"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "CN(C(=O)Cc1ccc(Cl)c(Cl)c1)C(CN1CCCC1)c1ccccc1",
+    "output": "3.38"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21",
+    "output": "-0.83"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CCn1c(SCC(=O)Nc2c(C#N)cnn2-c2ccccc2)nnc1-c1cccs1",
+    "output": "2.1"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性值。",
+    "input": "CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1",
+    "output": "1.33"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "CCN(CC)CC#CCOC(=O)C(O)(c1ccccc1)C1CCCCC1",
+    "output": "3.65"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCN(C(=O)NCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccccc2)CC1",
+    "output": "2.86"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CCCc1c(OCc2cccc(NC(=O)c3ccccc3C(=O)O)c2)ccc(C(C)=O)c1O",
+    "output": "1.9"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平值。",
+    "input": "CCC1(c2ccc(N)cc2)CCC(=O)NC1=O",
+    "output": "0.6"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1",
+    "output": "0.27"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1",
+    "output": "0.79"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1",
+    "output": "0.56"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N(C)C)c(Cc3ccccc3C(F)(F)F)sc21",
+    "output": "2.9"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(C)C(NC(=O)Cn1c(-c2ccccc2)ccc(NC(=O)OCc2ccncc2)c1=O)C(=O)C(F)(F)F",
+    "output": "2.41"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平值。",
+    "input": "CC(C)(C(N)=O)C(=O)NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br",
+    "output": "2.32"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD值。",
+    "input": "CC(=O)Nc1ccc2nc(-c3cccc(F)c3)cc(O)c2c1",
+    "output": "2.41"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性值。",
+    "input": "CC(=O)Nc1ccc2c(c1)c(-c1cc(NC3CC3)n3ncc(C#N)c3n1)cn2C",
+    "output": "2.94"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CC(=O)N1CCN(c2ccc(Nc3nccc(-c4cnc(C)n4C(C)C)n3)cc2)CC1",
+    "output": "2.39"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "COc1cc(C)ccc1-c1cnc2sc(N3CCC(O)(CN)CC3)nn12",
+    "output": "1.8"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Cc1ccccc1N1C(=O)/C(=C/c2ccc(O)c(Cl)c2)S/C1=N\\C1COC1",
+    "output": "2.6"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "O=C([C@H]1C[C@@H](c2cccc(Cl)c2)CN1)N1CCN(c2nccc3ccsc23)CC1",
+    "output": "3.9"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性值。",
+    "input": "Fc1cc(Cl)ccc1-c1ccc(Cn2nnc3ccccc32)cn1",
+    "output": "5.48"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CN(C)c1nc(=O)n(-c2ccccn2)c2cc(Cl)ccc12",
+    "output": "0.84"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平吗？",
+    "input": "c1ccc2c(c1)CCCC2CCCN1CCN(C2CCCCC2)CC1",
+    "output": "3.9"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CN(C)C(=O)CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1",
+    "output": "2.4"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "CC(Nc1ccc2c(c1)OCCO2)C(=O)Nc1ccc(-c2cnco2)cc1",
+    "output": "3.7"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性值吗？",
+    "input": "CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1",
+    "output": "2.4"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是多少吗？",
+    "input": "OC1CC2(CCNCC2)Oc2c1ccc1ccccc21",
+    "output": "2.46"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "COc1ccc2c(c1)c(Cc1nonc1O)c(C)n2C(=O)c1ccc(Cl)cc1",
+    "output": "1.8"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "COc1cc(N2CCC(N(C)C)CC2)c(-c2cnn(C)c2)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性值吗？",
+    "input": "CC1(C)NC(=O)N(c2ccc(F)c(C(F)F)c2)C1=O",
+    "output": "2.2"
+  },
+  {
+    "instruction": "你能给我这个分子的logD？",
+    "input": "CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O",
+    "output": "2.32"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平吗？",
+    "input": "Cc1cnc(C(C)(C)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C4CC4)n2C2CC3C2)o1",
+    "output": "4.4"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "CC1(c2ccncc2)NC(=O)N(CC(=O)c2ccc(F)cc2F)C1=O",
+    "output": "3.04"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COc1ccc(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](O)CC4)c3n2)c(C)c1",
+    "output": "2.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1noc(C)c1C(=O)N1CCC(c2cn(C)c3ncc(NC(=O)c4cccc(C#N)c4)c(C)c23)CC1",
+    "output": "2.0"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "COc1ccc(NC(=N)c2ccc(Cl)cc2)cc1CSC1CCCC1",
+    "output": "3.7"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "COc1cc(CCc2cnc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)c(OC)c3)nc2)c(F)c(OC)c1",
+    "output": "3.2"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "CNc1nc2nc3c1[nH]c(=O)n3Cc1cccc(c1)OCCCCO2",
+    "output": "3.1"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平值。",
+    "input": "COc1ccc(S(N)(=O)=O)cc1S(=O)(=O)N(Cc1ccccc1)Cc1ccccc1",
+    "output": "3.6"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD值。",
+    "input": "CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
+    "output": "2.31"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1ccc(C(=O)NC2CC2)cc1-n1ccnc(NCCc2ccccc2)c1=O",
+    "output": "3.0"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCc1ccc(Br)cc1)c1ccc(-c2scnc2C)cc1)C(C)(C)C",
+    "output": "4.08"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CC(Nc1ccc2c(c1)OCCO2)C(=O)Nc1ccc(C#N)cc1",
+    "output": "4.2"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1ccc2nccc(CCN3CCC(NCc4ccc(I)cc4)CC3)c2n1",
+    "output": "2.18"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cnn[nH]5)ccc4n3)cn2)CC1",
+    "output": "2.5"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平值吗？",
+    "input": "O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCOCc1ccccc1",
+    "output": "2.0"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "CC(=O)Nc1nc(C)c(-c2cc3c(c(S(=O)(=O)CCCO)c2)C(=O)N([C@@H](C)C2CC2)C3)s1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "O=c1[nH]c(Oc2cn[nH]c2)nc2cnccc12",
+    "output": "-0.6"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CN1C[C@@H]2C[C@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1",
+    "output": "1.4"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CNC(=O)c1cccc(-c2ccnc(NC(=O)C3CCOC3)c2)c1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CC3)ccc21",
+    "output": "3.0"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCc1nc(C)cn2nc(-c3cc(=O)n4cc(C5CCN(C)CC5)cc(C)c4n3)cc12",
+    "output": "2.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "N#Cc1cnn2c3cc(nc12)N1CC[C@@H](C1)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3",
+    "output": "2.4"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CN(C)CCCO/N=C1/C[C@H]2C(C)(C)O[C@H]3CC(=O)OC[C@]32[C@H]2CC[C@@]3(C)[C@H](c4ccoc4)OC(=O)[C@H]4O[C@]43[C@]12C",
+    "output": "0.37"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@@H](O)C3COC3)c(Cl)c2C1=O",
+    "output": "1.3"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平？",
+    "input": "Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-c3nncn3C)cc2)cc1",
+    "output": "3.21"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "N#CNC(=O)c1ccc(-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cc2)cc1",
+    "output": "-1.1"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "Nc1ncnc2c1sc1cc(-c3cccc(C(=O)NCCc4cccnc4)c3)ccc12",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "O=C(O)CCCOc1ccc([C@H]2CC[C@]3(CC2)OOC2(O3)C3CC4CC(C3)CC2C4)cc1",
+    "output": "3.6"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCP(=O)(OC)c1ccc2nc(-c3ccccc3C(F)F)oc2c1",
+    "output": "3.33"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性值吗？",
+    "input": "N=C(N)NC(=O)c1nc(Cl)c(N)nc1N",
+    "output": "0.3"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CCOc1nc(NC(=O)C2(NC(=O)c3ccc4c(C5CCCC5)c(-c5cncnc5)n(C)c4c3)CCC2)ccc1/C=C/C(=O)O",
+    "output": "3.4"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CN1CCN(C(=O)C(C)(C)C)C(c2ccccc2)C1",
+    "output": "4.9"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是多少吗？",
+    "input": "O=C(C1CC1)N1C2CCC1CN(c1nc(Nc3cnn(CCO)c3)ncc1F)C2",
+    "output": "1.8"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COCC(=O)N(C)C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1",
+    "output": "1.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "COc1ccc(Nc2ncc3c(n2)n([C@H]2CC[C@H](O)CC2)c(=O)n3C)cc1",
+    "output": "2.3"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@]1(C)O",
+    "output": "3.2"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "O=C(CC1SCCNC1=O)Nc1ccc(O)cc1",
+    "output": "0.1"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CC(C)(C)c1ccc(C(=O)Nc2cc(Cl)cnc2C(=O)O)cc1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CNC(=O)c1c(-c2ccc(O)c(F)c2)oc2ccc(O)c(CN3CCC4(COC4)C3)c12",
+    "output": "1.0"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O",
+    "output": "-0.95"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "N=C(N)NC(=O)c1nc(-c2cc3ccccc3o2)c(N2CCCCCC2)nc1N",
+    "output": "5.1"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1cc(-c2nc(C(N)=O)c(C)nc2C)ccc1-c1ccc(CC(=O)O)cc1",
+    "output": "0.5"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平吗？",
+    "input": "CN(C1CCCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)C1)S(C)(=O)=O",
+    "output": "4.9"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "Cn1cc(-c2cn(C)c3ccc(Oc4ccc(NC(=O)[C@@H]5CCCN5)cc4)cc23)cn1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CN1CCN(c2cc(Cl)c3nc(Nc4ccc(Br)cn4)[nH]c3c2)CC1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性值吗？",
+    "input": "O=S(=O)(Nc1ccncn1)c1cc2c(cc1F)[C@@H](N1CC[C@H](C(F)(F)F)C[C@@H]1c1ccccn1)CCO2",
+    "output": "1.4"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "C[C@@H]1[C@@H]2CN(c3nc(Nc4cnn(C)c4)ncc3F)C[C@]12NC(=O)[C@@H]1CC1(F)F",
+    "output": "2.65"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CSc1cccc(N2C(=O)CN(C3CCN(CC4=CC[C@H]5C[C@@H]4C5(C)C)CC3)C2=O)c1",
+    "output": "5.0"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "O=c1nc(Nc2ncnc3ccc(-c4cccc(N5CCOCC5)c4)cc23)c(F)c[nH]1",
+    "output": "2.2"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CNC(=O)c1c(-c2ccc(O)cc2C)oc2ccc(O)c(CN3CCC4(COC4)C3)c12",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "CNC(=O)c1c(-c2ccc(O)cn2)oc2ccc(O)c(CN3CCC4(COC4)C3)c12",
+    "output": "0.5"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Cc1ccc2c(c1)c(-c1cc(C)nc3ccccc13)c(C)n2CC(=O)O",
+    "output": "2.89"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "Cc1ccccc1C(=O)Nc1cc(C#Cc2ccccc2)ccn1",
+    "output": "4.7"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "CCc1cc2ccc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2[nH]c1=O",
+    "output": "2.8"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC(=O)N[C@H]1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1",
+    "output": "1.8"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "Cn1c(C(=O)NC2(c3ccc(C(CC(=O)O)c4cccnc4)cc3)COC2)cc2c(Cl)c(Cl)ccc21",
+    "output": "2.61"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂水平。",
+    "input": "CCOc1cc2oc(=O)n(CCC(=O)O)c2cc1Cl",
+    "output": "1.49"
+  },
+  {
+    "instruction": "你能告诉我这个分子logD吗？",
+    "input": "CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3C[C@@H](O)C[C@@H]32)cc(Cc2ccccc2)n1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性吗？",
+    "input": "CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(c2cccc(C(=N)N)c2)C1",
+    "output": "-0.49"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD值吗？",
+    "input": "CCC(C(C)=O)N1CCC(N(c2ccc(C(F)(F)F)cc2)c2cccnc2)CC1",
+    "output": "4.6"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CC(=O)N1C[C@@H]2C[C@H]1C[C@H]2c1ccc(-c2cc(C(=O)O)cc3cc(-c4ccc(C(F)(F)F)cc4)ccc23)cc1",
+    "output": "0.74"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性？",
+    "input": "O=C(C1CC1)N1CCC(N(c2ccc(Cl)cc2)c2cccnc2)CC1",
+    "output": "3.4"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂水平吗？",
+    "input": "CC(C)c1cc(C(=O)N2Cc3ccccc3C2)c(O)cc1O",
+    "output": "3.7"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COC(=O)N1CC[C@@H](Cc2cccc([C@@H](CC#N)Nc3nc4nc(C)ccc4[nH]3)c2)C1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD吗？",
+    "input": "C[C@H]1[C@H](F)C[C@@H](C(=O)NCc2cc(-c3cnc(C(F)(F)F)cn3)ncn2)N1S(=O)(=O)c1ccc(F)cc1",
+    "output": "2.3"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CCCC(=O)Nc1n[nH]c2cc(Cl)c(-c3ccccc3)cc12",
+    "output": "3.7"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCC[C@@]3(C2)CC(C)(C)OC3=O)CC1",
+    "output": "3.01"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(C)c1cccc(OCC(=O)Nc2ccc(OCC(=O)O)c(F)c2)c1",
+    "output": "0.15"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CCC1CN(Cc2ccccc2)c2cc(Br)ccc2N1C(C)=O",
+    "output": "7.4"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "COc1ccccc1[C@H](N)CNc1cc(C)nc2nc(N[C@H](CC#N)c3cccc(Cl)c3)nn12",
+    "output": "3.1"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是多少吗？",
+    "input": "Cc1cc2c(cc1C)-c1oc(C(=O)N3CCN(Cc4ccccc4)CC3)c(C)c1C(=O)C2=O",
+    "output": "4.82"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "O=C(NOCCO)c1ccc2cnsc2c1Nc1ccc(I)cc1F",
+    "output": "3.1"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "Cc1c(F)ccc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CCNCC4)cc32)c1F",
+    "output": "-1.12"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl",
+    "output": "1.13"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平。",
+    "input": "O=C(C1CCN(c2ccccn2)CC1)N1N=CC[C@H]1c1ccccc1",
+    "output": "5.1"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O",
+    "output": "-1.6"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性。",
+    "input": "CCCc1ccc(N2C[C@H](C[C@](C)(C(=O)NO)S(C)(=O)=O)OC2=O)cc1",
+    "output": "1.6"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "CN(CCc1ccc(O)c2nc(O)sc12)CCN(C)C(=O)CCOCCc1ccccc1",
+    "output": "2.59"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "CN1CCCN[C@@H](Cc2ccc(Cl)cc2)CC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N[C@H](Cc3ccc(Cl)c(Cl)c3)CC1=O)C2=O",
+    "output": "4.3"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O",
+    "output": "1.3"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CC(C)(C)OC(=O)N1CCCC(c2cn3nc(Cl)ccc3n2)C1",
+    "output": "4.04"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CS(=O)(=O)NC(=O)COc1ccc([C@H]2CC[C@]3(CC2)OOC2(O3)C3CC4CC(C3)CC2C4)cc1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "C=CC(=O)N1C[C@H](COc2nc(Nc3cnn(C)c3)nc3[nH]ccc23)[C@@H](C(F)(F)F)C1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CC(C)(C)CCNc1cc(N2CCN(C3CCCCC3)CC2)ncn1",
+    "output": "3.84"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "CCN(CC)C(=O)c1ccc2c(C(=O)O)ccc(O)c2n1",
+    "output": "1.5"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CC(=O)Nc1ccc(Cc2noc(-c3ccc4[nH]cc(CCN)c4c3)n2)cc1",
+    "output": "0.48"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cnc(N2CCOCC2)nc1C1CCCC1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "c1ccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)cc1",
+    "output": "4.96"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CCC[C@H](c1ccc(C(=O)O)c(Oc2cccc(Cl)c2)c1)N1CCC[C@H](n2cc(C)c(=O)[nH]c2=O)C1",
+    "output": "0.6"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Cc1cc(-c2cc3[nH]nc(N[C@@H]4CCNC[C@H]4F)c3cc2C2CC2)cc(C)n1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD值。",
+    "input": "Cc1ccc(S(=O)(=O)NCCc2ccc(Oc3ccc(F)c(F)c3)cc2)cc1C(=O)O",
+    "output": "1.6"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD值吗？",
+    "input": "CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C(F)(F)F)c2)C2CCN(S(C)(=O)=O)CC2)CC1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Oc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21",
+    "output": "3.08"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "Cc1ccc(-c2cc(-c3ccc(S(C)(=O)=O)cc3)cnc2N)c2cccnc12",
+    "output": "2.6"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CCCC(Nc1cnc(-n2cc(C(F)(F)F)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1",
+    "output": "1.3"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "C=CC(=O)CCC(=O)OCC(O)COc1ccc(Cl)cc1",
+    "output": "2.44"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CCCC(Oc1ccc(-n2cc(Cl)cn2)cc1)c1ccc(C(=O)NCCC(=O)O)cc1",
+    "output": "2.6"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CC(C)N(C(=O)CN1C(=O)C(Cc2ccccc2)c2nnc(-c3ccccc3)n2-c2ccccc21)c1ccccc1",
+    "output": "3.13"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂水平。",
+    "input": "CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)C2CCN(S(=O)(=O)CC(F)(F)F)CC2)CC1",
+    "output": "2.2"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "c1cc(-c2ccc3ncnc(Nc4ccncn4)c3c2)cc(N2CCOCC2)c1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC(C)CS(=O)(=O)N[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1",
+    "output": "2.4"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性值吗？",
+    "input": "O=C(CCCCCNCCc1ccc(O)c2nc(O)sc12)NCCc1ccccc1",
+    "output": "1.29"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(Cl)cn4)n(C)c3c2)ccc1/C=C/C(=O)O",
+    "output": "4.4"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD。",
+    "input": "COc1ccc2c(c1Cl)C(=O)N(Cc1c(C)cc(C)[nH]c1=O)CCC2",
+    "output": "1.7"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COc1ccc2cc(CCC(C)=O)ccc2c1",
+    "output": "3.18"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平吗？",
+    "input": "O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1",
+    "output": "2.19"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性？",
+    "input": "CS(=O)(=O)N1C[C@H](C(=O)Nc2ccc(Cl)cn2)[C@@H](C(=O)Nc2ccc(-n3ccccc3=O)cc2F)C1",
+    "output": "1.46"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CNCc1cc(-c2ccccc2CO)n(S(=O)(=O)c2cccnc2)c1",
+    "output": "-0.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "C/C=C1/NC(=O)CC[C@H](C(=O)O)NC(=O)[C@@H](C)[C@H](/C=C/C(C)=C/[C@H](C)[C@H](Cc2ccccc2)OC)NC(=O)[C@H](CCC/N=C2/N=C(c3ccccc3)C(O)N2)NC(=O)[C@@H](C)[C@H](C(=O)O)NC1=O",
+    "output": "-4.8"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "Nc1ccc(-c2ccc(/C=C3\\Oc4ccccc4C3=O)cc2)cn1",
+    "output": "3.67"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "CCN(CC)CCNC(=O)c1cc(I)c(N)cc1OC",
+    "output": "1.62"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "C[n+]1ccn(COCCC[Si](C)(C)C)c1/C=N/O",
+    "output": "0.43"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CC(C)(C)c1ccc(C(=O)Nc2cn3cc(Br)ccc3n2)cc1",
+    "output": "4.17"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性？",
+    "input": "Cc1cn([C@H]2CCCN([C@@H](CC(C)(C)C)c3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3)C2)c(=O)[nH]c1=O",
+    "output": "1.2"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CCC(C)(CC)C[C@H](c1ccc(C(=O)O)c(Oc2cccc(Br)c2)c1)N1CCC[C@H](n2cc(C)c(=O)[nH]c2=O)C1",
+    "output": "1.99"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1",
+    "output": "5.07"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OCC3CC(=O)O)c1",
+    "output": "2.77"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1",
+    "output": "3.8"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CN(C)CCc1c[nH]c2ccc(Cc3ncn(C)n3)cc12",
+    "output": "-1.01"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂性吗？",
+    "input": "COc1ccc(-c2cc(-c3ccc(S(C)(=O)=O)c(F)c3)cnc2N)cn1",
+    "output": "2.5"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是什么吗？",
+    "input": "CCNCCN(CC)c1cc(-c2ccc(C(F)(F)F)cc2)c(C#N)c2nc3ccccc3n12",
+    "output": "3.52"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-n3cnc(C)c3)cc2)cc1",
+    "output": "4.08"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "Cc1ccc(-c2cc(-c3ccc(S(C)(=O)=O)cc3)cnc2N)cn1",
+    "output": "1.8"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Cc1cc(OCCCN2CCCC2=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1",
+    "output": "3.22"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CN(Cc1c(C(=O)N[C@@H]2CCC[C@H](O)C2)noc1-c1ccc(C(F)(F)F)cc1)[C@@H]1CCOC1",
+    "output": "4.5"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是什么吗？",
+    "input": "Cc1c(CN2CCCC2)cc(-c2ccc(Cl)cc2)n1CCCNc1ccnc2cc(Cl)ccc12",
+    "output": "2.35"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COc1cc2c(cc1OC)CN(CCCCNC(=O)c1cc(C)ccc1OC)CC2",
+    "output": "2.83"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "COc1cc(O)c2c(c1C)C(=O)OCCCCC(=S)N[C@H](c1nc(C)no1)CSC2",
+    "output": "3.09"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO",
+    "output": "1.46"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "O=c1c2c([nH]c3cccc(Cl)c13)CCCC2",
+    "output": "1.8"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COc1ccc2c(=O)c3c([nH]c2c1)CC(C)(C)CC3",
+    "output": "2.2"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是多少吗？",
+    "input": "CCc1nc2nc(C)cc(Nc3ccc(C(F)(F)F)cc3)n2n1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平？",
+    "input": "CC(C)(C)c1cc(C(=O)Nc2cccnc2)n(Cc2ccccc2)n1",
+    "output": "3.8"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂水平。",
+    "input": "C=CC(=O)Nc1cccc(Oc2nc(Nc3cnn(C)c3)nc3[nH]ccc23)c1",
+    "output": "3.2"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD。",
+    "input": "N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3[nH]c4cc(F)ccc4c3C2)CC1",
+    "output": "3.0"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](NS(C)(=O)=O)CC4)nc3cc2Cl)CC1",
+    "output": "2.5"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1",
+    "output": "2.3"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "C[C@@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@H](C)N1",
+    "output": "0.82"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CS(=O)(=O)Nc1ccc(Cc2noc(-c3ccc4[nH]cc(CCN)c4c3)n2)cc1",
+    "output": "0.25"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Nc1nc(O)c2[nH]c(N)c(Cc3ccsc3)c2n1",
+    "output": "1.08"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "COc1cc(OC)c(S(=O)(=O)N2c3ccccc3CCC2C)cc1NC(=O)CCc1nn[nH]n1",
+    "output": "-0.34"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "COc1ccc(OC)c(S(=O)(=O)N(C)Cc2ccc(F)cc2)c1",
+    "output": "3.7"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "O=C(c1csc2ccccc12)N(CCc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2",
+    "output": "5.0"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Cc1ncsc1CCOCCCS(=O)(=O)CCNCCc1ccc(O)c2nc(O)sc12",
+    "output": "1.44"
+  },
+  {
+    "instruction": "我���知道这个分子的logD，你能提供吗？",
+    "input": "O=C1c2ccccc2CCN1CCCN1CCN(C2CCCCC2)CC1",
+    "output": "1.49"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "O=C(C1CCN(C(=O)C(F)(F)F)CC1)N1N=CCC1c1ccccc1",
+    "output": "4.9"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "COc1cc2c(cc1OC)C1CC(N)C(N3CCC(C)CC3=O)CN1CC2",
+    "output": "-0.2"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c[nH]c2ccccc12",
+    "output": "0.5"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "O=C(c1c(Cl)cccc1C(F)(F)F)c1nc([C@H]2CC[C@@H](C(=O)O)CC2)c2ccccn12",
+    "output": "1.8"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平值吗？",
+    "input": "CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1-c1ccn[nH]1",
+    "output": "3.9"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "COc1cc(O)c2c(c1C)C(=O)OCC(=O)NCC(=S)N[C@H](c1nc(C)no1)CSC2",
+    "output": "2.32"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平？",
+    "input": "CCN1Cc2cc(-c3nnn(-c4cccnc4F)c3C)ccc2C1=O",
+    "output": "1.8"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CCN(CCNC(=O)c1cnc2cc(I)ccc2n1)CCOCCOCCOCC[18F]",
+    "output": "1.52"
+  },
+  {
+    "instruction": "我对这个分子的亲脂水平很感兴趣，你能告诉我它是什么吗？",
+    "input": "COc1cccc2c(=O)c3c([nH]c12)CC(C)(C)CC3",
+    "output": "2.4"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂水平。",
+    "input": "O=C(c1cc(C(F)(F)F)no1)N1CCC(c2cc3ncccc3[nH]2)C1",
+    "output": "3.12"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CCCC(Oc1cnc(-n2cc(C(F)(F)F)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1",
+    "output": "1.5"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1cccnc1CN1CCC(Oc2ncnc3c2ccn3Cc2ccccc2)CC1",
+    "output": "4.15"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "C[C@@H](CO)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1",
+    "output": "2.67"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "c1cc(Nc2cc(C3CC3)[nH]n2)nc(NCc2ccc3[nH]cnc3c2)n1",
+    "output": "2.5"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)CC2CC2)c2ccccc2)CC1",
+    "output": "1.9"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平值。",
+    "input": "CCNC(=O)c1ccc(Nc2nccc(N3C[C@H]4CC[C@H](C3)N4C(=O)C3CC3)n2)cc1",
+    "output": "1.86"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "O=c1c2c([nH]c3c(F)c(F)ccc13)CCCC2",
+    "output": "1.9"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc12",
+    "output": "2.72"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Cc1ccc2oc(N3CCN4CCC3CC4)nc2n1",
+    "output": "0.36"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1",
+    "output": "-2.17"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CNC(=O)c1cccc2c1c(Sc1ccc(Cl)cc1)c(C)n2CC(=O)O",
+    "output": "-0.9"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Cc1cnn(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)c1",
+    "output": "5.0"
+  },
+  {
+    "instruction": "我需要知道这个分子的亲脂水平，你能提供吗？",
+    "input": "Cc1cc(N[C@H]2C[C@@H]2c2ccccc2)n2nc(N[C@H](C)c3cccc(Cl)c3)nc2n1",
+    "output": "4.9"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性值。",
+    "input": "NC(=O)c1ccc(CCOCCCS(=O)(=O)CCNCCc2ccc(O)c3nc(O)sc23)cc1",
+    "output": "1.1"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(C)Oc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1",
+    "output": "3.4"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平值。",
+    "input": "CC(C)C[C@H](NC(=O)C1CCCN1c1nc2ccccc2c(=O)o1)C(N)=O",
+    "output": "1.0"
+  },
+  {
+    "instruction": "我需要知道这个分子的亲脂性，你能提供吗？",
+    "input": "COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1",
+    "output": "2.0"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CCc1cc(N)cc2nc(N3CCCC3C(=O)N[C@@H](CC(C)C)C(N)=O)oc(=O)c12",
+    "output": "1.6"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CC(=O)Oc1ccccc1C(=O)O",
+    "output": "-2.57"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "CC(C)c1nc(-c2cccc(S(C)(=O)=O)c2)c(-c2ccc(F)cc2)n1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-]",
+    "output": "-0.6"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "C=CCN(C(=O)N(CCCl)N=O)C1CCCCC1",
+    "output": "0.91"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "CC(C#Cc1cccs1)n1[nH]c(=O)c2[nH]c3cc(Cl)ccc3c(=O)c2c1=O",
+    "output": "2.4"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "Fc1cc(-c2cc([C@H]3C[C@H]4CC[C@H]3N4)cnc2Cl)ccn1",
+    "output": "0.77"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "CCS(=O)(=O)N(Cc1cccnc1)c1cccc(-c2nc3ccccc3s2)c1",
+    "output": "3.6"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(CC(C)C)n1",
+    "output": "1.4"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "Cc1cc(N2CCN(C)CC2)n2nc(N[C@H](CC#N)c3cccc(Cl)c3)nc2n1",
+    "output": "2.4"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD值吗？",
+    "input": "CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)N2CCC(Cc3ccccc3)CC2)CC1",
+    "output": "3.7"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CSc1nc2nc(C)cc(Nc3ccc(C(F)(F)F)cc3)n2n1",
+    "output": "3.2"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1",
+    "output": "4.4"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COc1ccc(NC(=N)c2cccs2)cc1COC1CCCC1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CN(C)CCc1c[nH]c2ccc(-c3nc(Cc4ccc(NS(C)(=O)=O)cc4)no3)cc12",
+    "output": "1.25"
+  },
+  {
+    "instruction": "你能告诉我这个分子logD吗？",
+    "input": "O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1",
+    "output": "2.1"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "N[C@H]1C[C@]1(F)c1ccc(Cl)cc1",
+    "output": "2.23"
+  },
+  {
+    "instruction": "你能告诉我这个分子亲脂性吗？",
+    "input": "O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1",
+    "output": "2.7"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "CNCc1cc(-c2ncccc2C)n(S(=O)(=O)c2cccnc2)c1",
+    "output": "0.53"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂性。",
+    "input": "Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(C2CCCC2)n1",
+    "output": "2.0"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性？",
+    "input": "CCN1CCN(Cc2cnc(-c3ccc(C(=O)Nc4ccccc4N)cc3)c(C#N)c2)CC1",
+    "output": "1.14"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC(C)CCc1sc(NC(=O)c2cc(NC(=O)c3cc(NC(=N)c4cccc(F)c4)cn3C)cn2C)nc1C(=O)NCCN1CCOCC1",
+    "output": "4.51"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "Cc1ccc(CO)cc1",
+    "output": "1.8"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "COc1ccc(-c2cc(-c3cccc(S(C)(=O)=O)c3)cnc2N)cn1",
+    "output": "2.3"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "COc1ccc(-c2cc(CC[C@](C)(C(=O)NO)S(C)(=O)=O)on2)c(F)c1",
+    "output": "1.23"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "Cc1cc(C(=O)[O-])nn1C(C)c1cc(Cl)ccc1OCc1ccccc1",
+    "output": "1.0"
+  },
+  {
+    "instruction": "请提供该分子的亲脂性。",
+    "input": "COc1ccc2[nH]c(C3CCCN(C(=O)c4ccc(F)cc4)C3)cc2n1",
+    "output": "3.39"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1",
+    "output": "2.6"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21",
+    "output": "1.38"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是多少吗？",
+    "input": "c1ccc2ccccc2c1",
+    "output": "3.33"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "CCCC/C(C)=C/C=C(\\C)C(=O)c1c(O)cc(C(C)CC/C=C/NC(=O)OC)oc1=O",
+    "output": "-0.3"
+  },
+  {
+    "instruction": "请提供该分子的logD值。",
+    "input": "COc1ccc(NC(=N)c2ccncc2)cc1CSC1CCCC1",
+    "output": "2.9"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CC1CN(C)C(C)c2cc(C=O)[nH]c21",
+    "output": "0.69"
+  },
+  {
+    "instruction": "请给我这个分子的logD。",
+    "input": "CCN1C(=O)C2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)N=C1C",
+    "output": "1.77"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "O=C(NC[C@H]1CC[C@]2(CC1)OO[C@]1(O2)C2CC3CC(C2)CC1C3)c1ccccn1",
+    "output": "5.6"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平。",
+    "input": "COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)O)CC3OC1CC(N2CCOCC2)C(O)C(C)O1",
+    "output": "2.03"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "COCC(=O)NC1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1",
+    "output": "4.3"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "O=C(O)CCc1ccc(OCc2ccccc2)cc1",
+    "output": "1.96"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "Cc1cccc(C)c1CNc1nc(N2CCCC2=O)cc2c(C)c(C)[nH]c12",
+    "output": "3.77"
+  },
+  {
+    "instruction": "你能给我这个分子的logD吗？",
+    "input": "Cc1cccc(C)c1CNc1nc(-c2ccccc2)cc2c(C)c(C)[nH]c12",
+    "output": "5.31"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "CC(Oc1ccccc1F)C(=O)Nc1ccc(OCC(=O)O)c(F)c1",
+    "output": "0.07"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC1(C)N=C(N)N=C(N)N1c1cccc(O)c1",
+    "output": "-3.67"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "CCN(CC)CCCNc1cc(-c2ccccc2)c(C#N)c2nc3ccccc3n12",
+    "output": "2.0"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1",
+    "output": "2.0"
+  },
+  {
+    "instruction": "请给我这个分子的亲脂性。",
+    "input": "N[C@@H]1CCN(c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)C1",
+    "output": "0.86"
+  },
+  {
+    "instruction": "请给我这个分子的logD。",
+    "input": "CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc(C(CC#N)c2ccccc2)n1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "你能告诉我这个分子的logD值吗？",
+    "input": "C[C@@H](Oc1cc2onc(CCC(=O)O)c2cc1Cl)c1ccc(F)cn1",
+    "output": "2.47"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平吗？",
+    "input": "NC(=O)c1cc(NC(=O)c2cc(-c3cccc(C(F)F)n3)ccc2Cl)n(-c2ccccc2)n1",
+    "output": "3.5"
+  },
+  {
+    "instruction": "请给我提供这个分子的亲脂水平。",
+    "input": "C[C@H](CCC(O)(P(=O)(O)O)P(=O)(O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C",
+    "output": "-3.34"
+  },
+  {
+    "instruction": "请提供该分子的亲脂水平。",
+    "input": "Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cc(-c3ccc4ncccc4c3)[nH]n2)cc1",
+    "output": "5.2"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "COc1cc2ncnc(Oc3ccc(NC(=O)Cn4nnc(C(C)C)n4)cc3)c2cc1OC",
+    "output": "3.0"
+  },
+  {
+    "instruction": "我想知道这个分子的logD，你能提供吗？",
+    "input": "CN(Cc1nc2ccccc2c(=O)[nH]1)Cc1nc(-c2ccccc2)no1",
+    "output": "3.1"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂水平？",
+    "input": "CCNC(=O)Nc1sc2ncccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1",
+    "output": "2.08"
+  },
+  {
+    "instruction": "我需要知道这个分子的亲脂性，你能提供吗？",
+    "input": "CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1cn[nH]c1",
+    "output": "1.8"
+  },
+  {
+    "instruction": "我对这个分子的logD很感兴趣，你能告诉我它是多少吗？",
+    "input": "CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C#N",
+    "output": "1.6"
+  },
+  {
+    "instruction": "你能给我这个分子的亲脂性吗？",
+    "input": "CC[C@]1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(F)cc3F)ccc2NC1=O",
+    "output": "1.7"
+  },
+  {
+    "instruction": "这个分子的亲脂性是多少？",
+    "input": "Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1",
+    "output": "5.4"
+  },
+  {
+    "instruction": "请提供该分子的logD。",
+    "input": "O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCC2=O)CC1",
+    "output": "1.96"
+  },
+  {
+    "instruction": "请给我这个分子的logD。",
+    "input": "Cc1cnc(-c2ccccc2C(C)C)nc1NCc1ccc(-n2ccnn2)cc1",
+    "output": "1.97"
+  },
+  {
+    "instruction": "我需要知道这个分子的logD，你能提供吗？",
+    "input": "COC1CCN(c2nccc(Nc3cc4c(cn3)ncn4C(C)C)n2)CC1",
+    "output": "2.5"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1",
+    "output": "0.97"
+  },
+  {
+    "instruction": "我对这个分子的亲脂性很感兴趣，你能告诉我它是什么吗？",
+    "input": "CNc1nc(NCCCN(C)C)c2sc(-c3ccc(C(F)(F)F)cc3Cl)cc2n1",
+    "output": "4.5"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "CN1CCN(c2cc(NCC(C)(C)C)ncn2)CC1",
+    "output": "1.75"
+  },
+  {
+    "instruction": "这个分子的亲脂水平是多少？",
+    "input": "CNCc1cc(-c2cccnc2F)n(S(=O)(=O)c2ccsc2)c1",
+    "output": "-0.83"
+  },
+  {
+    "instruction": "你能告诉我这个分子的亲脂水平值吗？",
+    "input": "CC(C)=CCc1c(O)cc(O)c2c1O[C@@]13C(=C[C@H]4C(=O)C1(CC=C(C)C)OC[C@@H]3[C@H]4COC(=O)Cc1ccccc1)C2=O",
+    "output": "5.1"
+  },
+  {
+    "instruction": "请给我提供这个分子的logD。",
+    "input": "COc1ccc(C(=O)O)cc1-c1ccc(C#CCO)s1",
+    "output": "0.79"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "Cc1nn(Cc2ccncc2)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2",
+    "output": "2.2"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂性，你能提供吗？",
+    "input": "Cc1nc2cc3ccccc3cc2c(=O)o1",
+    "output": "2.8"
+  },
+  {
+    "instruction": "这个分子的logD是多少？",
+    "input": "CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cn(C)cn1)NC(=O)[C@@H](CC(=O)N1CCOCC1)Cc1ccccc1",
+    "output": "3.71"
+  },
+  {
+    "instruction": "我想知道这个分子的亲脂水平，你能提供吗？",
+    "input": "C[C@@H](Oc1ccc(C(F)(F)F)cc1-c1cccc(C#N)c1)C(=O)O",
+    "output": "0.2"
+  }
+]